{"id":"https://openalex.org/W4400530446","doi":"https://doi.org/10.1021/acs.analchem.4c01376","title":"Covalent Organic Framework-Structured Raman Probes for Ultrasensitive In Vivo Bioimaging","display_name":"Covalent Organic Framework-Structured Raman Probes for Ultrasensitive In Vivo Bioimaging","publication_year":2024,"publication_date":"2024-07-11","ids":{"openalex":"https://openalex.org/W4400530446","doi":"https://doi.org/10.1021/acs.analchem.4c01376","pmid":"https://pubmed.ncbi.nlm.nih.gov/38990771"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.4c01376","doi":"https://doi.org/10.1021/acs.analchem.4c01376","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.4c01376","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kai Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Cui","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067636329","display_name":"Ruike Li","orcid":"https://orcid.org/0009-0008-4062-0673","observed_orcids":["https://orcid.org/0009-0008-4062-0673"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruike Li","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109586579","display_name":"Meng Li","orcid":"https://orcid.org/0000-0001-9743-8591","observed_orcids":["https://orcid.org/0000-0001-9743-8591"]},"institutions":[{"id":"https://openalex.org/I21945476","display_name":"Shanghai Normal University","ror":"https://ror.org/01cxqmw89","country_code":"CN","type":"education","lineage":["https://openalex.org/I21945476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Li","raw_affiliation_strings":["College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200233, China","institution_ids":["https://openalex.org/I21945476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027490355","display_name":"Yuanyuan Qiu","orcid":"https://orcid.org/0000-0001-8426-3796","observed_orcids":["https://orcid.org/0000-0001-8426-3796"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Qiu","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102914455","display_name":"Haoze Wang","orcid":"https://orcid.org/0000-0002-6961-6554","observed_orcids":["https://orcid.org/0000-0002-6961-6554"]},"institutions":[{"id":"https://openalex.org/I21945476","display_name":"Shanghai Normal University","ror":"https://ror.org/01cxqmw89","country_code":"CN","type":"education","lineage":["https://openalex.org/I21945476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoze Wang","raw_affiliation_strings":["College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200233, China","institution_ids":["https://openalex.org/I21945476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102866710","display_name":"Wenwei Wu","orcid":"https://orcid.org/0000-0002-0790-7719","observed_orcids":["https://orcid.org/0000-0002-0790-7719"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwei Wu","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012773158","display_name":"Tize Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tize Liu","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101626078","display_name":"Wenxian Zhang","orcid":"https://orcid.org/0009-0005-4553-2398","observed_orcids":["https://orcid.org/0009-0005-4553-2398","https://orcid.org/0000-0002-5312-618X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenxian Zhang","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002354710","display_name":"Zeyu Xiao","orcid":"https://orcid.org/0000-0002-3457-5772","observed_orcids":["https://orcid.org/0000-0002-3457-5772"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zeyu Xiao","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"],"raw_orcid":"https://orcid.org/0000-0002-3457-5772","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002354710"],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.3122,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.78012176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"96","issue":"29","first_page":"11800","last_page":"11808"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12038","display_name":"Covalent Organic Framework Applications","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12038","display_name":"Covalent Organic Framework Applications","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.18700000643730164,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covalent-organic-frameworks","display_name":"covalent organic frameworks","score":0.9890000224113464},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.8240000009536743},{"id":"https://openalex.org/keywords/near-infrared-excitation","display_name":"near-infrared excitation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/azobenzene","display_name":"azobenzene","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pi-conjugation","display_name":"\u03c0-conjugation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/band-gap-tuning","display_name":"band gap tuning","score":0.753000020980835},{"id":"https://openalex.org/keywords/raman-enhancement","display_name":"Raman signal enhancement","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9569582939147949},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.6708490252494812},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5507725477218628},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.5166852474212646},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5049081444740295},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15403145551681519},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073396","descriptor_name":"Metal-Organic Frameworks","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001391","descriptor_name":"Azo Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010655","descriptor_name":"Phenylenediamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.analchem.4c01376","doi":"https://doi.org/10.1021/acs.analchem.4c01376","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.4c01376","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:38990771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38990771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4472732101","display_name":null,"funder_award_id":"2022XD033","funder_id":"https://openalex.org/F4320317789","funder_display_name":"Shanghai Municipal Health Commission"},{"id":"https://openalex.org/G5656171160","display_name":null,"funder_award_id":"2020YFA0210800","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5732209409","display_name":null,"funder_award_id":"20YF1403200","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G6496270065","display_name":null,"funder_award_id":"23J21900700","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G7593534534","display_name":null,"funder_award_id":"52161160307","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320317789","display_name":"Shanghai Municipal Health Commission","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320335305","display_name":"School of Medicine, Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1858465226","https://openalex.org/W2006335338","https://openalex.org/W2010265091","https://openalex.org/W2018850755","https://openalex.org/W2022781082","https://openalex.org/W2052521831","https://openalex.org/W2055499045","https://openalex.org/W2071265075","https://openalex.org/W2307692627","https://openalex.org/W2317411269","https://openalex.org/W2317898558","https://openalex.org/W2331068783","https://openalex.org/W2564452316","https://openalex.org/W2565599824","https://openalex.org/W2599914631","https://openalex.org/W2610269117","https://openalex.org/W2740072387","https://openalex.org/W2749782235","https://openalex.org/W2801315699","https://openalex.org/W2883262144","https://openalex.org/W2891678333","https://openalex.org/W2895398422","https://openalex.org/W2908266099","https://openalex.org/W2918348640","https://openalex.org/W2957221787","https://openalex.org/W2962867862","https://openalex.org/W2970563833","https://openalex.org/W2970781909","https://openalex.org/W2996781336","https://openalex.org/W3001218623","https://openalex.org/W3038485868","https://openalex.org/W3090671750","https://openalex.org/W3111292427","https://openalex.org/W3141096049","https://openalex.org/W3175935032","https://openalex.org/W3195325105","https://openalex.org/W3198789186","https://openalex.org/W3212971776","https://openalex.org/W3214576255","https://openalex.org/W4200346515","https://openalex.org/W4206281444","https://openalex.org/W4220838876","https://openalex.org/W4224243900","https://openalex.org/W4225421631","https://openalex.org/W4291667655","https://openalex.org/W4309165638","https://openalex.org/W4318479131","https://openalex.org/W4321490892","https://openalex.org/W4376871869","https://openalex.org/W4385985862","https://openalex.org/W4386387123"],"related_works":["https://openalex.org/W4415783157","https://openalex.org/W4210631093","https://openalex.org/W2744441329","https://openalex.org/W7161067052","https://openalex.org/W4240881851","https://openalex.org/W4406548017","https://openalex.org/W2996781336","https://openalex.org/W4309165638","https://openalex.org/W2121870183","https://openalex.org/W4404742803"],"abstract_inverted_index":{"Organic":[0],"Raman":[1,25,52,70,76,99,121,154,178,195],"probes,":[2,71,155],"including":[3],"polymers":[4],"and":[5,37,88,144,160,168],"small":[6,90],"molecules,":[7],"have":[8],"attracted":[9],"great":[10],"attention":[11],"in":[12,73,198],"biomedical":[13],"imaging":[14],"owing":[15],"to":[16,44,49,129,189],"their":[17,34,74,130,158,182],"excellent":[18],"biocompatibility.":[19],"However,":[20],"the":[21,63,96,114,119,142,150,173,191],"development":[22],"of":[23,68,108,146,153,176],"organic":[24,59,69,177,194],"probes":[26,122,179,196],"is":[27],"usually":[28],"hindered":[29],"by":[30],"a":[31,57,82,89,166],"mismatch":[32],"between":[33],"absorption":[35,65,102,161],"spectra":[36],"wavelength-fixed":[38],"excitation,":[39],"which":[40],"makes":[41],"it":[42,186],"difficult":[43],"achieve":[45],"resonance":[46],"excitation":[47],"necessary":[48],"obtain":[50,190],"strong":[51],"signals.":[53,134],"Herein,":[54],"we":[55,139],"introduce":[56],"covalent":[58],"framework":[60],"(COF)":[61],"into":[62,95],"fine":[64],"spectrum":[66],"regulation":[67],"resulting":[72],"significant":[75],"signal":[77,174],"enhancement.":[78],"In":[79],"representative":[80],"examples,":[81],"polymer":[83],"poly(diketopyrrolopyrrole-":[84],"p":[85],"-phenylenediamine)":[86],"(DPP-PD)":[87],"molecule":[91],"azobenzene":[92],"are":[93],"transformed":[94],"corresponding":[97],"COF-structured":[98,120],"probes.":[100],"Their":[101],"peaks":[103],"show":[104],"an":[105],"accurate":[106],"match":[107],"less":[109],"than":[110],"5":[111],"nm":[112],"with":[113,132],"NIR":[115],"excitation.":[116],"As":[117],"such,":[118],"acquire":[123],"highly":[124,192],"sensitive":[125,193],"bioimaging":[126],"capabilities":[127],"compared":[128],"precursors":[131],"negligible":[133],"By":[135],"further":[136],"mechanism":[137],"studies,":[138],"discover":[140],"that":[141],"crystallinity":[143],"size":[145],"COFs":[147],"directly":[148],"affect":[149],"\u03c0-conjugation":[151],"degree":[152],"thus":[156],"changing":[157,181],"bandgaps":[159],"spectra.":[162],"Our":[163],"study":[164],"offers":[165],"universal":[167],"flexible":[169],"method":[170],"for":[171,197],"improving":[172],"performance":[175],"without":[180],"structural":[183],"units,":[184],"making":[185],"more":[187],"convenient":[188],"vivo":[199],"bioimaging.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-12T00:00:00"}