{"id":"https://openalex.org/W4400520879","doi":"https://doi.org/10.2463/mrms.mp.2023-0125","title":"Generating Synthetic MR Spectroscopic Imaging Data with Generative Adversarial Networks to Train Machine Learning Models","display_name":"Generating Synthetic MR Spectroscopic Imaging Data with Generative Adversarial Networks to Train Machine Learning Models","publication_year":2024,"publication_date":"2024-07-11","ids":{"openalex":"https://openalex.org/W4400520879","doi":"https://doi.org/10.2463/mrms.mp.2023-0125","pmid":"https://pubmed.ncbi.nlm.nih.gov/39010240","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12557876"},"language":"en","primary_location":{"id":"doi:10.2463/mrms.mp.2023-0125","doi":"https://doi.org/10.2463/mrms.mp.2023-0125","is_oa":true,"landing_page_url":"https://doi.org/10.2463/mrms.mp.2023-0125","pdf_url":"https://www.jstage.jst.go.jp/article/mrms/advpub/0/advpub_mp.2023-0125/_pdf","source":{"id":"https://openalex.org/S90653425","display_name":"Magnetic Resonance in Medical Sciences","issn_l":"1347-3182","issn":["1347-3182","1880-2206"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313210","host_organization_name":"Japan Society of Magnetic Resonance in Medicine","host_organization_lineage":["https://openalex.org/P4310313210"],"host_organization_lineage_names":["Japan Society of Magnetic Resonance in Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/mrms/advpub/0/advpub_mp.2023-0125/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113284838","display_name":"Shuki Maruyama","orcid":"https://orcid.org/0000-0002-2092-4652","observed_orcids":["https://orcid.org/0000-0002-2092-4652"]},"institutions":[{"id":"https://openalex.org/I1320697193","display_name":"Canon (Japan)","ror":"https://ror.org/05gg0gh87","country_code":"JP","type":"company","lineage":["https://openalex.org/I1320697193"]},{"id":"https://openalex.org/I4399598468","display_name":"Canon Medical Systems Corporation (Japan)","ror":"https://ror.org/01qpswk97","country_code":"JP","type":"company","lineage":["https://openalex.org/I4399598468"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shuki Maruyama","raw_affiliation_strings":["Imaging Modality Group, Advanced Technology Research Department, Research and Development Center, Canon Medical Systems Corporation, Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Modality Group, Advanced Technology Research Department, Research and Development Center, Canon Medical Systems Corporation, Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1320697193","https://openalex.org/I4399598468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019791942","display_name":"Hidenori Takeshima","orcid":"https://orcid.org/0000-0002-2557-8533","observed_orcids":["https://orcid.org/0000-0002-2557-8533"]},"institutions":[{"id":"https://openalex.org/I1320697193","display_name":"Canon (Japan)","ror":"https://ror.org/05gg0gh87","country_code":"JP","type":"company","lineage":["https://openalex.org/I1320697193"]},{"id":"https://openalex.org/I4399598468","display_name":"Canon Medical Systems Corporation (Japan)","ror":"https://ror.org/01qpswk97","country_code":"JP","type":"company","lineage":["https://openalex.org/I4399598468"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Takeshima","raw_affiliation_strings":["Advanced Technology Research Department, Research and Development Center, Canon Medical Systems Corporation, Kawasaki, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Technology Research Department, Research and Development Center, Canon Medical Systems Corporation, Kawasaki, Kanagawa, Japan","institution_ids":["https://openalex.org/I1320697193","https://openalex.org/I4399598468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113284838"],"corresponding_institution_ids":["https://openalex.org/I1320697193","https://openalex.org/I4399598468"],"apc_list":null,"apc_paid":null,"fwci":0.7804,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.63180366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"24","issue":"4","first_page":"n/a","last_page":"n/a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/generative-adversarial-networks","display_name":"generative adversarial networks","score":0.9279999732971191},{"id":"https://openalex.org/keywords/single-voxel-spectroscopy","display_name":"single voxel spectroscopy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pix2pix","display_name":"Pix2Pix","score":0.8600000143051147},{"id":"https://openalex.org/keywords/data-augmentation","display_name":"data augmentation","score":0.49799999594688416},{"id":"https://openalex.org/keywords/brain-mri","display_name":"brain MRI","score":0.5149999856948853},{"id":"https://openalex.org/keywords/training-data-generation","display_name":"training data generation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/machine-learning-training-data","display_name":"machine learning training data","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9266127943992615},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6172839403152466},{"id":"https://openalex.org/C37736160","wikidata":"https://www.wikidata.org/wiki/Q1801315","display_name":"Adversarial system","level":2,"score":0.5438310503959656},{"id":"https://openalex.org/C2988773926","wikidata":"https://www.wikidata.org/wiki/Q25104379","display_name":"Generative adversarial network","level":3,"score":0.5248832106590271},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.47852790355682373},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4707762897014618},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3345206379890442},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098427","descriptor_name":"Generative Adversarial Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2463/mrms.mp.2023-0125","doi":"https://doi.org/10.2463/mrms.mp.2023-0125","is_oa":true,"landing_page_url":"https://doi.org/10.2463/mrms.mp.2023-0125","pdf_url":"https://www.jstage.jst.go.jp/article/mrms/advpub/0/advpub_mp.2023-0125/_pdf","source":{"id":"https://openalex.org/S90653425","display_name":"Magnetic Resonance in Medical Sciences","issn_l":"1347-3182","issn":["1347-3182","1880-2206"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313210","host_organization_name":"Japan Society of Magnetic Resonance in Medicine","host_organization_lineage":["https://openalex.org/P4310313210"],"host_organization_lineage_names":["Japan Society of Magnetic Resonance in Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11365952","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12557876","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12557876/pdf/mrms-24-0125.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:39010240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39010240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12557876","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12557876/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magn Reson Med Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2463/mrms.mp.2023-0125","doi":"https://doi.org/10.2463/mrms.mp.2023-0125","is_oa":true,"landing_page_url":"https://doi.org/10.2463/mrms.mp.2023-0125","pdf_url":"https://www.jstage.jst.go.jp/article/mrms/advpub/0/advpub_mp.2023-0125/_pdf","source":{"id":"https://openalex.org/S90653425","display_name":"Magnetic Resonance in Medical Sciences","issn_l":"1347-3182","issn":["1347-3182","1880-2206"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313210","host_organization_name":"Japan Society of Magnetic Resonance in Medicine","host_organization_lineage":["https://openalex.org/P4310313210"],"host_organization_lineage_names":["Japan Society of Magnetic Resonance in Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400520879.pdf","grobid_xml":"https://content.openalex.org/works/W4400520879.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1730237872","https://openalex.org/W1869803090","https://openalex.org/W2000574253","https://openalex.org/W2013522256","https://openalex.org/W2029886539","https://openalex.org/W2038979894","https://openalex.org/W2051607590","https://openalex.org/W2058027749","https://openalex.org/W2064579261","https://openalex.org/W2066470779","https://openalex.org/W2075308436","https://openalex.org/W2118605251","https://openalex.org/W2125389028","https://openalex.org/W2145038624","https://openalex.org/W2163345210","https://openalex.org/W2275607732","https://openalex.org/W2432004435","https://openalex.org/W2546241758","https://openalex.org/W2552465644","https://openalex.org/W2567101557","https://openalex.org/W2785678896","https://openalex.org/W2791006545","https://openalex.org/W2794022343","https://openalex.org/W2884065486","https://openalex.org/W2888747176","https://openalex.org/W2892120196","https://openalex.org/W2898091194","https://openalex.org/W2931870777","https://openalex.org/W2932841619","https://openalex.org/W2941736865","https://openalex.org/W2962843773","https://openalex.org/W2964121744","https://openalex.org/W2985860224","https://openalex.org/W2998257661","https://openalex.org/W3014027994","https://openalex.org/W3020838097","https://openalex.org/W3027411515","https://openalex.org/W3043246085","https://openalex.org/W3046077581","https://openalex.org/W3056790882","https://openalex.org/W3133019246","https://openalex.org/W3158566850","https://openalex.org/W3169134411","https://openalex.org/W3178989684","https://openalex.org/W3189933645","https://openalex.org/W4213291192","https://openalex.org/W4293101559","https://openalex.org/W4298289240","https://openalex.org/W4365504037"],"related_works":["https://openalex.org/W4401572304","https://openalex.org/W7133340917","https://openalex.org/W7133186486","https://openalex.org/W7207530461","https://openalex.org/W7011367867","https://openalex.org/W3130709857","https://openalex.org/W2750618916","https://openalex.org/W6892095005","https://openalex.org/W4407498698","https://openalex.org/W2909950702"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"develop":[2],"a":[3],"new":[4,195],"method":[5,196,210],"to":[6,43,77,139,169,199,229],"generate":[7,44,78,200],"synthetic":[8,45,79,118,128,153],"MR":[9],"spectroscopic":[10],"imaging":[11],"(MRSI)":[12],"data":[13,47,52,62,112,120,130,155,188,202,218],"for":[14,160,220],"training":[15,219],"machine":[16,222],"learning":[17,223],"models.":[18],"METHODS:":[19],"This":[20],"study":[21],"targeted":[22],"routine":[23,230],"MRI":[24,49,205,231],"examination":[25],"protocols":[26],"with":[27,68,157],"single":[28],"voxel":[29],"spectroscopy":[30],"(SVS).":[31],"A":[32,194],"novel":[33],"model":[34,74,135],"derived":[35],"from":[36,65,132],"pix2pix":[37],"generative":[38],"adversarial":[39],"networks":[40],"was":[41,75,121,197],"proposed":[42,73,134],"MRSI":[46,61,80,119,129,154,201,217],"using":[48,123],"and":[50,56,59,96,106,206],"SVS":[51,111,187,207,227],"as":[53],"inputs.":[54],"T1-":[55],"T2-weighted,":[57],"SVS,":[58],"reference":[60,95,159],"were":[63,136,189],"acquired":[64],"healthy":[66],"brains":[67],"clinically":[69],"available":[70],"sequences.":[71],"The":[72,100,127,142,166,180],"trained":[76],"data.":[81,208],"Quantitative":[82],"evaluation":[83],"involved":[84],"the":[85,88,94,103,107,110,114,117,124,133,140,148,158,173,214],"calculation":[86],"of":[87,102,105,109,116,147,152,162,184,186,216],"mean":[89],"squared":[90],"error":[91],"(MSE)":[92],"against":[93],"metabolite":[97,149,164],"ratio":[98,150],"value.":[99],"effect":[101],"location":[104,175],"number":[108],"on":[113],"quality":[115],"investigated":[122],"MSE.":[125],"RESULTS:":[126],"generated":[131],"visually":[137],"closer":[138],"reference.":[141],"95%":[143],"confidence":[144],"interval":[145],"(CI)":[146],"value":[151],"overlapped":[156],"seven":[161],"eight":[163],"ratios.":[165],"MSEs":[167,181],"tended":[168],"be":[170],"lower":[171],"in":[172,177],"same":[174],"than":[176],"different":[178],"locations.":[179],"among":[182],"groups":[183],"numbers":[185],"not":[190],"significantly":[191],"different.":[192],"CONCLUSION:":[193],"developed":[198],"by":[203,225],"integrating":[204],"Our":[209],"can":[211],"potentially":[212],"increase":[213],"volume":[215],"other":[221],"models":[224],"adding":[226],"acquisition":[228],"examinations.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-07-12T00:00:00"}