{"id":"https://openalex.org/W4400519392","doi":"https://doi.org/10.5498/wjp.v14.i7.1095","title":"Gastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function","display_name":"Gastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function","publication_year":2024,"publication_date":"2024-07-11","ids":{"openalex":"https://openalex.org/W4400519392","doi":"https://doi.org/10.5498/wjp.v14.i7.1095","pmid":"https://pubmed.ncbi.nlm.nih.gov/39050201","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11262932"},"language":"en","primary_location":{"id":"doi:10.5498/wjp.v14.i7.1095","doi":"https://doi.org/10.5498/wjp.v14.i7.1095","is_oa":true,"landing_page_url":"https://doi.org/10.5498/wjp.v14.i7.1095","pdf_url":"https://rcastoragev2.blob.core.windows.net/1a22c965cac4dd55da277a093f4ef2ca/ss7202a1.pdf","source":{"id":"https://openalex.org/S2764369821","display_name":"World Journal of Psychiatry","issn_l":"2220-3206","issn":["2220-3206"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://rcastoragev2.blob.core.windows.net/1a22c965cac4dd55da277a093f4ef2ca/ss7202a1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100402701","display_name":"Sha Li","orcid":"https://orcid.org/0000-0002-4869-3809","observed_orcids":["https://orcid.org/0000-0002-4869-3809","https://orcid.org/0009-0007-8743-8396"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4405261629","display_name":"Institute of Basic Theory for Chinese Medicine","ror":"https://ror.org/05kf82e36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4405261629"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sha Li","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100000, China","Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100000, China","institution_ids":["https://openalex.org/I4210141683"]},{"raw_affiliation_string":"Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100000, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4405261629"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Zhang","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100000, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336237","display_name":"Li Wang","orcid":"https://orcid.org/0000-0003-3881-3149","observed_orcids":["https://orcid.org/0000-0003-3881-3149"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4405261629","display_name":"Institute of Basic Theory for Chinese Medicine","ror":"https://ror.org/05kf82e36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4405261629"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Li","raw_affiliation_strings":["Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100000, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4405261629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104347589","display_name":"Han-Lai Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han-Lai Zhang","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100000, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100719974","display_name":"Xiaoxi Wang","orcid":"https://orcid.org/0000-0003-2710-9906","observed_orcids":["https://orcid.org/0000-0003-2710-9906"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Xi Wang","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100000, China. wxxcacms@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100000, China. wxxcacms@163.com","institution_ids":["https://openalex.org/I4210141683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4963,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.8220906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"14","issue":"7","first_page":"1095","last_page":"1105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7074999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7074999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.2768999934196472,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastrointestinal-complaints","display_name":"gastrointestinal problems","score":0.8920000195503235},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9660000205039978},{"id":"https://openalex.org/keywords/prenatal-drug-exposure","display_name":"prenatal drug exposure","score":0.7580000162124634},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9660000205039978},{"id":"https://openalex.org/keywords/duodenal-motility","display_name":"duodenal motility","score":0.8849999904632568},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.7300000190734863},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.6815475225448608},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.6664679646492004},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.6374567151069641},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6115400791168213},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5230252146720886},{"id":"https://openalex.org/C2779388368","wikidata":"https://www.wikidata.org/wiki/Q3450985","display_name":"Neurodevelopmental disorder","level":3,"score":0.5064693689346313},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5005156993865967},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.48958858847618103},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4862176477909088},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.4769545793533325},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.47114554047584534},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.46909841895103455},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4482665956020355},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.4389094412326813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.422918438911438},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41741666197776794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4049961566925049},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35001140832901},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.3453572988510132},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29163041710853577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17923492193222046},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12618201971054077},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5498/wjp.v14.i7.1095","doi":"https://doi.org/10.5498/wjp.v14.i7.1095","is_oa":true,"landing_page_url":"https://doi.org/10.5498/wjp.v14.i7.1095","pdf_url":"https://rcastoragev2.blob.core.windows.net/1a22c965cac4dd55da277a093f4ef2ca/ss7202a1.pdf","source":{"id":"https://openalex.org/S2764369821","display_name":"World Journal of Psychiatry","issn_l":"2220-3206","issn":["2220-3206"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11262932","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11262932","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11262932/pdf/WJP-14-1095.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Psychiatry","raw_type":"Text"},{"id":"pmid:39050201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39050201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of psychiatry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5498/wjp.v14.i7.1095","doi":"https://doi.org/10.5498/wjp.v14.i7.1095","is_oa":true,"landing_page_url":"https://doi.org/10.5498/wjp.v14.i7.1095","pdf_url":"https://rcastoragev2.blob.core.windows.net/1a22c965cac4dd55da277a093f4ef2ca/ss7202a1.pdf","source":{"id":"https://openalex.org/S2764369821","display_name":"World Journal of Psychiatry","issn_l":"2220-3206","issn":["2220-3206"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400519392.pdf","grobid_xml":"https://content.openalex.org/works/W4400519392.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1647551795","https://openalex.org/W1861307106","https://openalex.org/W1988569628","https://openalex.org/W2002625208","https://openalex.org/W2014930160","https://openalex.org/W2022116330","https://openalex.org/W2049434309","https://openalex.org/W2052554412","https://openalex.org/W2053909439","https://openalex.org/W2072652550","https://openalex.org/W2084612746","https://openalex.org/W2123304665","https://openalex.org/W2135431439","https://openalex.org/W2166935051","https://openalex.org/W2559475643","https://openalex.org/W2599051363","https://openalex.org/W2610766525","https://openalex.org/W2700710289","https://openalex.org/W2753871615","https://openalex.org/W2767809588","https://openalex.org/W2793791829","https://openalex.org/W2797402052","https://openalex.org/W2803873435","https://openalex.org/W2886989735","https://openalex.org/W2895386130","https://openalex.org/W2898104719","https://openalex.org/W2900898276","https://openalex.org/W2914944728","https://openalex.org/W2936474142","https://openalex.org/W2948003108","https://openalex.org/W2981180619","https://openalex.org/W2985368039","https://openalex.org/W2998690493","https://openalex.org/W3003912482","https://openalex.org/W3008887685","https://openalex.org/W3037172018","https://openalex.org/W3038279965","https://openalex.org/W3071539314","https://openalex.org/W3114342071","https://openalex.org/W3117358445","https://openalex.org/W3126753170","https://openalex.org/W3162541038","https://openalex.org/W3175256745","https://openalex.org/W3206211002","https://openalex.org/W3211562608","https://openalex.org/W3211958465","https://openalex.org/W3216191767","https://openalex.org/W4214757113","https://openalex.org/W4281874266","https://openalex.org/W4283072281","https://openalex.org/W4311459955","https://openalex.org/W4318480237","https://openalex.org/W4321442398","https://openalex.org/W4360600181","https://openalex.org/W4378966165","https://openalex.org/W4385225802"],"related_works":["https://openalex.org/W2049434309","https://openalex.org/W1988222049","https://openalex.org/W4392303637","https://openalex.org/W2903623817","https://openalex.org/W2048359070","https://openalex.org/W4417361633","https://openalex.org/W4414251339","https://openalex.org/W4295136061","https://openalex.org/W4282821559","https://openalex.org/W7104817845"],"abstract_inverted_index":{"BACKGROUND:":[0],"Autism":[1],"spectrum":[2],"disorder":[3,8],"(ASD)":[4],"is":[5,156],"a":[6],"developmental":[7],"characterized":[9],"by":[10],"social":[11],"deficits":[12],"and":[13,23,44,63,81,151,165],"repetitive":[14],"behavior.":[15],"Gastrointestinal":[16],"(GI)":[17],"problems,":[18],"such":[19],"as":[20,131,133],"constipation,":[21],"diarrhea,":[22],"inflammatory":[24,114,137],"bowel":[25],"disease,":[26],"commonly":[27],"occur":[28],"in":[29,55,104,106,124,128,142,170],"patients":[30,38],"with":[31,147],"ASD.":[32,171],"Previously,":[33],"GI":[34,53,90,140,168],"problems":[35,54,141,169],"of":[36,113,136,167],"ASD":[37,56,69,143],"were":[39,86],"attributed":[40],"to":[41,59,88,98,121,158],"intestinal":[42,61,101,149],"inflammation":[43,62,150],"vertical":[45],"mother-to-infant":[46],"microbiome":[47],"transmission.":[48],"AIM:":[49],"To":[50],"explore":[51],"whether":[52],"are":[57],"related":[58],"maternal":[60,100,107,148],"gut":[64,108],"microbiota":[65,152],"abnormalities.":[66],"METHODS:":[67],"An":[68],"rat":[70],"model":[71],"was":[72],"developed":[73],"using":[74],"valproic":[75],"acid":[76],"(VPA).":[77],"Enzyme-linked":[78],"immunosorbent":[79],"assay":[80],"fecal":[82],"16S":[83],"rRNA":[84],"sequencing":[85],"used":[87],"test":[89],"changes.":[91],"RESULTS:":[92],"VPA":[93,122],"exposure":[94,120],"during":[95],"pregnancy":[96],"led":[97],"pathological":[99],"changes,":[102],"resulting":[103],"alterations":[105],"microbiota.":[109],"Additionally,":[110],"the":[111,129,163],"levels":[112,135],"factors":[115],"also":[116],"increased.":[117],"Moreover,":[118],"prenatal":[119],"resulted":[123],"impaired":[125],"duodenal":[126],"motility":[127],"offspring":[130],"well":[132],"increased":[134],"factors.":[138],"CONCLUSION:":[139],"may":[144],"be":[145],"associated":[146],"abnormality.":[153],"Future":[154],"research":[155],"required":[157],"find":[159],"more":[160],"evidence":[161],"on":[162],"etiology":[164],"treatment":[166]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-07-12T00:00:00"}
