{"id":"https://openalex.org/W4400515784","doi":"https://doi.org/10.1055/a-2363-5033","title":"An In Silico-Guided Approach for Assessing Herb-Drug Interaction Potential: A Case Study with Cudrania tricuspidata Leaf Extracts","display_name":"An In Silico-Guided Approach for Assessing Herb-Drug Interaction Potential: A Case Study with Cudrania tricuspidata Leaf Extracts","publication_year":2024,"publication_date":"2024-07-09","ids":{"openalex":"https://openalex.org/W4400515784","doi":"https://doi.org/10.1055/a-2363-5033","pmid":"https://pubmed.ncbi.nlm.nih.gov/38981689"},"language":"en","primary_location":{"id":"doi:10.1055/a-2363-5033","doi":"https://doi.org/10.1055/a-2363-5033","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1055/a-2363-5033","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4400515784"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041118342","display_name":"Jeong In Seo","orcid":"https://orcid.org/0000-0003-0365-925X","observed_orcids":["https://orcid.org/0000-0003-0365-925X"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong In Seo","raw_affiliation_strings":["Pharmacomicrobiomics Research Center and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-Do, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-0365-925X","affiliations":[{"raw_affiliation_string":"Pharmacomicrobiomics Research Center and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-Do, Republic of Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087092636","display_name":"Young Beom Kwak","orcid":"https://orcid.org/0000-0003-0769-1572","observed_orcids":["https://orcid.org/0000-0003-0769-1572"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Beom Kwak","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Inje University, Gimhae, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Inje University, Gimhae, South Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075081845","display_name":"Seong Eun Cho","orcid":"https://orcid.org/0009-0009-7055-9284","observed_orcids":["https://orcid.org/0009-0009-7055-9284"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Eun Cho","raw_affiliation_strings":["Pharmacomicrobiomics Research Center and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-Do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacomicrobiomics Research Center and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-Do, Republic of Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068541222","display_name":"Hye Hyun Yoo","orcid":"https://orcid.org/0000-0001-8282-852X","observed_orcids":["https://orcid.org/0000-0001-8282-852X"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Hyun Yoo","raw_affiliation_strings":["Pharmacomicrobiomics Research Center and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-Do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacomicrobiomics Research Center and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-Do, Republic of Korea","institution_ids":["https://openalex.org/I4575257"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4629,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.51687226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"90","issue":"11","first_page":"858","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.357699990272522,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.357699990272522,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.15369999408721924,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cudrania-tricuspidata","display_name":"Cudrania tricuspidata","score":0.9769999980926514},{"id":"https://openalex.org/keywords/herb-drug-interactions","display_name":"herb-drug interactions","score":0.9179999828338623},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.871999979019165},{"id":"https://openalex.org/keywords/cyp1a2-inhibition","display_name":"CYP1A2 inhibition","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cyp2c8-inhibition","display_name":"CYP2C8 inhibition","score":1.0},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":1.0},{"id":"https://openalex.org/keywords/flavonoid-glycosides","display_name":"flavonoid glycosides","score":0.8610000014305115},{"id":"https://openalex.org/keywords/admet-prediction","display_name":"ADMET prediction","score":0.7129999995231628},{"id":"https://openalex.org/keywords/pkcsm","display_name":"pkCSM","score":0.7070000171661377},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8519999980926514},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.37299999594688416},{"id":"https://openalex.org/keywords/herbal-medicine-safety","display_name":"herbal medicine safety","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8438133001327515},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7039069533348083},{"id":"https://openalex.org/C2779824472","wikidata":"https://www.wikidata.org/wiki/Q207123","display_name":"Herb","level":3,"score":0.6115317344665527},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5534628629684448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39199721813201904},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3829539716243744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3223218023777008},{"id":"https://openalex.org/C2991655182","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal herbs","level":2,"score":0.31866487860679626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0828942358493805},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029586","descriptor_name":"Moraceae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D041743","descriptor_name":"Herb-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/a-2363-5033","doi":"https://doi.org/10.1055/a-2363-5033","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1055/a-2363-5033","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},{"id":"pmid:38981689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38981689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta medica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2346890866","display_name":null,"funder_award_id":"RS-2023-00271578","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2924483666","display_name":null,"funder_award_id":"(RS-2023-00217123","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1925953750","https://openalex.org/W2009867031","https://openalex.org/W2040602650","https://openalex.org/W2063997144","https://openalex.org/W2087256837","https://openalex.org/W2109989116","https://openalex.org/W2173846903","https://openalex.org/W2309728149","https://openalex.org/W2531986144","https://openalex.org/W2642025157","https://openalex.org/W2737350070","https://openalex.org/W2791528117","https://openalex.org/W2793542755","https://openalex.org/W2936909746","https://openalex.org/W2943893168","https://openalex.org/W3024441924","https://openalex.org/W3028327330","https://openalex.org/W3089204963","https://openalex.org/W3095525985","https://openalex.org/W3127124408","https://openalex.org/W3154258817","https://openalex.org/W3164423762","https://openalex.org/W3180232473","https://openalex.org/W3185823425","https://openalex.org/W3215339101","https://openalex.org/W3216238012","https://openalex.org/W4200159340","https://openalex.org/W4220970890","https://openalex.org/W4283521114","https://openalex.org/W4378471355","https://openalex.org/W4392138770"],"related_works":["https://openalex.org/W4385545769","https://openalex.org/W7167829142","https://openalex.org/W118248098","https://openalex.org/W49009688","https://openalex.org/W2607482561","https://openalex.org/W7048790892","https://openalex.org/W2788053207","https://openalex.org/W7128067201","https://openalex.org/W2124371850","https://openalex.org/W2901792824"],"abstract_inverted_index":{"Abstract":[0],"Cudrania":[1],"tricuspidata":[2,78,127,143,207,224],"leaf":[3,79,128,144,208,225],"extracts":[4,22,129,145,209,226],"have":[5],"long":[6],"been":[7],"utilized":[8],"as":[9,39,160],"traditional":[10],"oriental":[11],"medicines":[12],"across":[13],"Asian":[14],"countries":[15],"like":[16],"Korea,":[17],"China,":[18],"and":[19,34,99,110,116,151,156,174,183,195,200,213,250],"Japan.":[20],"These":[21,202],"are":[23],"renowned":[24],"for":[25,227],"their":[26,37,97,157,247],"therapeutic":[27,248],"benefits":[28,249],"in":[29,92,108,111,137,216,263],"addressing":[30],"inflammation,":[31],"tumors,":[32],"obesity,":[33],"diabetes,":[35],"maintaining":[36],"status":[38],"a":[40,67,106],"pivotal":[41],"folk":[42],"remedy.":[43],"Given":[44],"the":[45,60,73,82,121,132,161,169,190,218],"rising":[46],"trend":[47],"of":[48,69,76,86,125,149,192,222,242],"combining":[49],"medicinal":[50,87,244],"herbs":[51,88],"with":[52,131,153],"conventional":[53],"medications,":[54],"it":[55],"is":[56,66],"imperative":[57],"to":[58,119,179,197,238,259],"explore":[59],"potential":[61,122,221,262],"herb-drug":[62,74,100,123,219,240,260],"interactions.":[63,101],"However,":[64],"there":[65],"dearth":[68],"research":[70],"on":[71,168],"evaluating":[72],"interactions":[75,241],"C.":[77,126,142,206,223],"extracts.":[80],"Also,":[81],"intricate":[83],"chemical":[84,134,256],"composition":[85],"presents":[89],"methodological":[90],"hurdles":[91],"establishing":[93],"causal":[94],"relationships":[95],"between":[96],"constituents":[98],"To":[102],"overcome":[103],"these":[104],"challenges,":[105],"combined":[107],"silico":[109,165],"vitro":[112,138],"workflow":[113],"was":[114],"developed":[115],"effectively":[117],"applied":[118,237],"evaluate":[120],"interaction":[124,220,261],"along":[130],"associated":[133],"factors.":[135],"In":[136,164],"CYP":[139,180],"inhibition":[140,148],"assays,":[141],"exhibited":[146],"potent":[147],"CYP1A2":[150,212],"CYP2C8,":[152,214],"quercetin,":[154],"kaempferol,":[155],"glycosides":[158],"identified":[159,176],"major":[162],"constituents.":[163],"analysis":[166,188],"based":[167],"prediction":[170],"tools":[171],"(ADMETlab":[172],"2.0":[173],"pkCSM)":[175],"key":[177],"contributors":[178],"inhibition,":[181],"quercetin":[182],"kaempferol.":[184],"Additionally,":[185],"molecular":[186],"docking":[187],"validated":[189],"binding":[191],"ligands":[193],"(quercetin":[194],"kaempferol)":[196],"proteins":[198],"(CYP1A2":[199],"CYP2C8).":[201],"findings":[203],"suggest":[204],"that":[205],"could":[210],"inhibit":[211],"aiding":[215],"understanding":[217],"safe":[228],"clinical":[229],"application.":[230],"Furthermore,":[231],"this":[232],"approach":[233],"can":[234],"be":[235],"broadly":[236],"study":[239],"various":[243],"herbs,":[245],"enhancing":[246],"reducing":[251],"adverse":[252],"reactions":[253],"by":[254],"considering":[255],"profiles":[257],"relevant":[258],"herbal":[264],"preparations.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-11T00:00:00"}