{"id":"https://openalex.org/W4400514575","doi":"https://doi.org/10.1093/bbb/zbae098","title":"Discovery of an antimalarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity","display_name":"Discovery of an antimalarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity","publication_year":2024,"publication_date":"2024-07-09","ids":{"openalex":"https://openalex.org/W4400514575","doi":"https://doi.org/10.1093/bbb/zbae098","pmid":"https://pubmed.ncbi.nlm.nih.gov/38982331"},"language":"en","primary_location":{"id":"doi:10.1093/bbb/zbae098","doi":"https://doi.org/10.1093/bbb/zbae098","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bbb/zbae098","pdf_url":"https://academic.oup.com/bbb/article-pdf/88/10/1212/59210421/zbae098.pdf","source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bbb/article-pdf/88/10/1212/59210421/zbae098.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068574985","display_name":"Aoi Kimishima","orcid":"https://orcid.org/0000-0002-2625-1356","observed_orcids":["https://orcid.org/0000-0002-2625-1356"]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aoi Kimishima","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092625963","display_name":"Atsuka Nishitomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuka Nishitomi","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016271417","display_name":"Iori Tsuruoka","orcid":"https://orcid.org/0009-0002-9596-5413","observed_orcids":["https://orcid.org/0009-0002-9596-5413"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Iori Tsuruoka","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089693884","display_name":"Katsuyuki Sakai","orcid":"https://orcid.org/0000-0001-9210-6176","observed_orcids":["https://orcid.org/0000-0001-9210-6176"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyuki Sakai","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038981388","display_name":"Rei Hokari","orcid":"https://orcid.org/0000-0002-6091-0503","observed_orcids":["https://orcid.org/0000-0002-6091-0503"]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rei Hokari","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060846396","display_name":"Masako Honsho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masako Honsho","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013859564","display_name":"Sota Honma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sota Honma","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuki Ono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Ono","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083272587","display_name":"Naozumi Kondo","orcid":"https://orcid.org/0009-0009-1900-5809","observed_orcids":["https://orcid.org/0009-0009-1900-5809"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naozumi Kondo","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089981334","display_name":"Hayama Tsutsumi","orcid":"https://orcid.org/0000-0003-4735-9670","observed_orcids":["https://orcid.org/0000-0003-4735-9670"]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hayama Tsutsumi","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068963798","display_name":"Yuta Kikuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Kikuchi","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003642836","display_name":"Toshiyuki Tokiwa","orcid":"https://orcid.org/0000-0003-3726-6251","observed_orcids":["https://orcid.org/0000-0003-3726-6251"]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Tokiwa","raw_affiliation_strings":["\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039916126","display_name":"Hiroki Kojima","orcid":"https://orcid.org/0009-0007-3541-0084","observed_orcids":["https://orcid.org/0009-0007-3541-0084"]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Kojima","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054735835","display_name":"Mayuka Higo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayuka Higo","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110785856","display_name":"Kenichi Nonaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Nonaka","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047612296","display_name":"Yuki Inahashi","orcid":"https://orcid.org/0000-0001-7436-2037","observed_orcids":["https://orcid.org/0000-0001-7436-2037"]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Inahashi","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050381773","display_name":"Masato Iwatsuki","orcid":"https://orcid.org/0000-0001-8373-4314","observed_orcids":["https://orcid.org/0000-0001-8373-4314"]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Iwatsuki","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":"https://orcid.org/0000-0001-8373-4314","affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028034283","display_name":"Shin\u2010ichi Fuji","orcid":"https://orcid.org/0000-0002-5057-004X","observed_orcids":["https://orcid.org/0000-0002-5057-004X"]},"institutions":[{"id":"https://openalex.org/I5467274","display_name":"Akita Prefectural University","ror":"https://ror.org/05b1kx621","country_code":"JP","type":"education","lineage":["https://openalex.org/I5467274"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-ichi Fuji","raw_affiliation_strings":["Faculty of Bioresource Sciences, Akita Prefectural University , Akita, Akita , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Bioresource Sciences, Akita Prefectural University , Akita, Akita , Japan","institution_ids":["https://openalex.org/I5467274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025092055","display_name":"Jun\u2010Pil Jang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun-Pil Jang","raw_affiliation_strings":["Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju , South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033861220","display_name":"Jae\u2010Hyuk Jang","orcid":"https://orcid.org/0000-0002-4363-4252","observed_orcids":["https://orcid.org/0000-0002-4363-4252","https://orcid.org/0000-0003-3145-9300"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Hyuk Jang","raw_affiliation_strings":["Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju , South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028030557","display_name":"Takumi Chinen","orcid":"https://orcid.org/0000-0001-9836-8839","observed_orcids":["https://orcid.org/0000-0001-9836-8839"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Chinen","raw_affiliation_strings":["Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo, Tokyo , Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007827334","display_name":"Takeo Usui","orcid":"https://orcid.org/0000-0003-2377-7499","observed_orcids":["https://orcid.org/0000-0003-2377-7499"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeo Usui","raw_affiliation_strings":["Institute of Life and Environmental Sciences, University of Tsukuba , Tsukuba, Ibaraki , Japan"],"raw_orcid":"https://orcid.org/0000-0003-2377-7499","affiliations":[{"raw_affiliation_string":"Institute of Life and Environmental Sciences, University of Tsukuba , Tsukuba, Ibaraki , Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068250321","display_name":"Yukihiro Asami","orcid":"https://orcid.org/0000-0003-1821-9169","observed_orcids":["https://orcid.org/0000-0003-1821-9169"]},"institutions":[{"id":"https://openalex.org/I4405285929","display_name":"\u014cmura Satoshi Memorial Institute","ror":"https://ror.org/00pwv7630","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yukihiro Asami","raw_affiliation_strings":["Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan"],"raw_orcid":"https://orcid.org/0000-0003-1821-9169","affiliations":[{"raw_affiliation_string":"Graduate School of Infection Control Sciences, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"\u014cmura Satoshi Memorial Institute, Kitasato University , Minato-ku, Tokyo , Japan","institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068250321"],"corresponding_institution_ids":["https://openalex.org/I4405285929","https://openalex.org/I64189623"],"apc_list":{"value":3370,"currency":"USD","value_usd":3370},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"88","issue":"10","first_page":"1212","last_page":"1216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.057999998331069946,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimalarial-compounds","display_name":"antimalarial compounds","score":0.9470000267028809},{"id":"https://openalex.org/keywords/polyketide-natural-products","display_name":"polyketide natural products","score":0.7310000061988831},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.7329999804496765},{"id":"https://openalex.org/keywords/drug-discovery-platform","display_name":"drug discovery platform","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5675244331359863},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.557353138923645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.539992094039917},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5223252177238464},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4587116837501526},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4324703812599182},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4241708815097809},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3539453148841858},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.2804239094257355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07032936811447144}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bbb/zbae098","doi":"https://doi.org/10.1093/bbb/zbae098","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bbb/zbae098","pdf_url":"https://academic.oup.com/bbb/article-pdf/88/10/1212/59210421/zbae098.pdf","source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:38982331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38982331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bbb/zbae098","doi":"https://doi.org/10.1093/bbb/zbae098","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bbb/zbae098","pdf_url":"https://academic.oup.com/bbb/article-pdf/88/10/1212/59210421/zbae098.pdf","source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1191154095","display_name":null,"funder_award_id":"2021R1I1A2049704","funder_id":"https://openalex.org/F4320321408","funder_display_name":"Ministry of Education"},{"id":"https://openalex.org/G1384871578","display_name":null,"funder_award_id":"2021R1I1A2049704","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G140432535","display_name":"Search for novel plant immune-priming compounds by simple screening system using nitric oxide","funder_award_id":"23K19296","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2643849817","display_name":null,"funder_award_id":"KGM5292423","funder_id":"https://openalex.org/F4320322110","funder_display_name":"Korea Research Institute of Bioscience and Biotechnology"},{"id":"https://openalex.org/G4081873599","display_name":null,"funder_award_id":"JP22ama121035","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6377000219","display_name":null,"funder_award_id":"JP21am0101096","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6641216145","display_name":"Discovery of microorganism-derived anti-MRSA therapeutic seed compounds that inhibit drug resistance factors","funder_award_id":"21K06616","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6670503325","display_name":null,"funder_award_id":"KGM1222413","funder_id":"https://openalex.org/F4320322110","funder_display_name":"Korea Research Institute of Bioscience and Biotechnology"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320591","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89"},{"id":"https://openalex.org/F4320321408","display_name":"Ministry of Education","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322110","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07"},{"id":"https://openalex.org/F4320324670","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400514575.pdf","grobid_xml":"https://content.openalex.org/works/W4400514575.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1978489199","https://openalex.org/W2047725778","https://openalex.org/W2065056165","https://openalex.org/W2071699803","https://openalex.org/W2088181007","https://openalex.org/W2144612995","https://openalex.org/W2171102256","https://openalex.org/W2478728847","https://openalex.org/W2837299779","https://openalex.org/W2949788937","https://openalex.org/W3080922316","https://openalex.org/W3187368779","https://openalex.org/W3208694540","https://openalex.org/W4229011238","https://openalex.org/W4320709259","https://openalex.org/W4388227111","https://openalex.org/W4390692071"],"related_works":["https://openalex.org/W4403086377","https://openalex.org/W4391847057","https://openalex.org/W1969641388","https://openalex.org/W1921413285","https://openalex.org/W2224318158","https://openalex.org/W2965886803","https://openalex.org/W4281493168","https://openalex.org/W4414353948","https://openalex.org/W7099725512","https://openalex.org/W7155535145"],"abstract_inverted_index":{"In":[0],"this":[1],"paper,":[2],"we":[3,82],"describe":[4],"our":[5,29,123],"discovery":[6,88,139],"of":[7,19,54,67,69,76,80,122,140],"burnettiene":[8],"A":[9],"(1)":[10],"as":[11,42],"an":[12,43],"antimalarial":[13,86,98,103,142],"compound":[14,46],"from":[15,47],"the":[16,51,65,74,112,120,138],"culture":[17],"broth":[18],"Lecanicillium":[20],"primulinum":[21],"(current":[22],"name:":[23],"Flavocillium":[24],"primulinum)":[25],"FKI-6715":[26],"strain":[27,114],"utilizing":[28],"original":[30,124],"multidrug-sensitive":[31,130],"yeast":[32,131],"system.":[33],"This":[34],"polyene-decalin":[35],"polyketide":[36],"natural":[37],"product":[38],"was":[39],"originally":[40],"isolated":[41],"antifungal":[44,52],"active":[45],"Aspergillus":[48],"burnettii.":[49],"However,":[50],"activity":[53,99,104,136],"1":[55,70,101],"has":[56],"been":[57],"revealed":[58,119],"in":[59],"only":[60],"one":[61],"fungal":[62],"species,":[63],"and":[64,100,111,132],"mechanism":[66],"action":[68],"remains":[71],"unknown.":[72],"After":[73],"validation":[75],"mitochondrial":[77,92,133],"function":[78,93,134],"inhibitory":[79,94,135],"1,":[81],"envisioned":[83],"a":[84,129],"new":[85,141],"drug":[87,143],"platform":[89],"based":[90,127],"on":[91,128],"activity.":[95],"We":[96],"evaluated":[97],"showed":[102],"against":[105],"Plasmodium":[106],"falciparum":[107],"FCR3":[108],"(chloroquine":[109,115],"sensitive)":[110],"K1":[113],"resistant).":[116],"Our":[117],"study":[118],"utility":[121],"screening":[125],"system":[126],"for":[137],"candidates.":[144]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-07-11T00:00:00"}