{"id":"https://openalex.org/W4400513237","doi":"https://doi.org/10.2500/aap.2024.45.240041","title":"What can be learned from real-world data about chronic spontaneous urticaria?","display_name":"What can be learned from real-world data about chronic spontaneous urticaria?","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4400513237","doi":"https://doi.org/10.2500/aap.2024.45.240041","pmid":"https://pubmed.ncbi.nlm.nih.gov/38982597"},"language":"en","primary_location":{"id":"doi:10.2500/aap.2024.45.240041","doi":"https://doi.org/10.2500/aap.2024.45.240041","is_oa":false,"landing_page_url":"https://doi.org/10.2500/aap.2024.45.240041","pdf_url":null,"source":{"id":"https://openalex.org/S49250914","display_name":"Allergy and Asthma Proceedings","issn_l":"1088-5412","issn":["1088-5412","1539-6304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320401","host_organization_name":"OceanSide Publications, Inc","host_organization_lineage":["https://openalex.org/P4310320401"],"host_organization_lineage_names":["OceanSide Publications, Inc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and Asthma Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11508/53945","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088301454","display_name":"\u00d6zge Sevil Karstarl\u0131 Bakay","orcid":"https://orcid.org/0000-0002-1523-3187","observed_orcids":["https://orcid.org/0000-0002-1523-3187"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozge Sevil Karstarli Bakay","raw_affiliation_strings":["From the Department of Dermatology, Pamukkale University Faculty of Medicine, Denizli, Turkey, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Dermatology, Pamukkale University Faculty of Medicine, Denizli, Turkey, and","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059515177","display_name":"Nida Gelincik Ka\u00e7ar","orcid":"https://orcid.org/0000-0001-8730-8056","observed_orcids":["https://orcid.org/0000-0001-8730-8056"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nida Kacar","raw_affiliation_strings":["From the Department of Dermatology, Pamukkale University Faculty of Medicine, Denizli, Turkey, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Dermatology, Pamukkale University Faculty of Medicine, Denizli, Turkey, and","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100505159","display_name":"Burak Gul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Burak Gul","raw_affiliation_strings":["From the Department of Dermatology, Pamukkale University Faculty of Medicine, Denizli, Turkey, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Dermatology, Pamukkale University Faculty of Medicine, Denizli, Turkey, and","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054170690","display_name":"\u015eule G\u00f6k\u015fin","orcid":"https://orcid.org/0000-0001-8647-4298","observed_orcids":["https://orcid.org/0000-0001-8647-4298"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sule Goksin","raw_affiliation_strings":["From the Department of Dermatology, Pamukkale University Faculty of Medicine, Denizli, Turkey, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Dermatology, Pamukkale University Faculty of Medicine, Denizli, Turkey, and","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028120766","display_name":"Yunus G\u00fcral","orcid":"https://orcid.org/0000-0002-0572-453X","observed_orcids":["https://orcid.org/0000-0002-0572-453X"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yunus Gural","raw_affiliation_strings":["Division of Statistics, Firat University Faculty of Science, Elazig, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistics, Firat University Faculty of Science, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1647,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.85536445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"45","issue":"4","first_page":"255","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12438","display_name":"Urticaria and Related Conditions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12438","display_name":"Urticaria and Related Conditions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-spontaneous-urticaria","display_name":"chronic spontaneous urticaria","score":1.0},{"id":"https://openalex.org/keywords/omalizumab","display_name":"omalizumab","score":0.9449999928474426},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.871999979019165},{"id":"https://openalex.org/keywords/total-serum-ige","display_name":"total IgE","score":0.8560000061988831},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.8669999837875366},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-index","display_name":"systemic inflammation response index","score":0.8299999833106995},{"id":"https://openalex.org/keywords/systemic-immune-inflammation-index","display_name":"systemic immune-inflammation index","score":0.9200000166893005},{"id":"https://openalex.org/keywords/eosinophil-count","display_name":"eosinophil count","score":0.8889999985694885},{"id":"https://openalex.org/keywords/basophil-count","display_name":"basophil count","score":0.9929999709129333},{"id":"https://openalex.org/keywords/urticaria-control-test","display_name":"Urticaria Control Test","score":0.9309999942779541},{"id":"https://openalex.org/keywords/atopy","display_name":"atopy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.5569999814033508},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.5130000114440918},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4309999942779541},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2778564945","wikidata":"https://www.wikidata.org/wiki/Q415392","display_name":"Omalizumab","level":4,"score":0.9552872776985168},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9522822499275208},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.7485281229019165},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.6987563967704773},{"id":"https://openalex.org/C2777456892","wikidata":"https://www.wikidata.org/wiki/Q107988","display_name":"Basophil","level":4,"score":0.648612380027771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5655150413513184},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47927042841911316},{"id":"https://openalex.org/C3017745231","wikidata":"https://www.wikidata.org/wiki/Q187440","display_name":"Chronic urticaria","level":2,"score":0.4369129538536072},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4344017803668976},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.345725417137146},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.14582988619804382}],"mesh":[{"descriptor_ui":"D000069444","descriptor_name":"Omalizumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000080223","descriptor_name":"Chronic Urticaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018926","descriptor_name":"Anti-Allergic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2500/aap.2024.45.240041","doi":"https://doi.org/10.2500/aap.2024.45.240041","is_oa":false,"landing_page_url":"https://doi.org/10.2500/aap.2024.45.240041","pdf_url":null,"source":{"id":"https://openalex.org/S49250914","display_name":"Allergy and Asthma Proceedings","issn_l":"1088-5412","issn":["1088-5412","1539-6304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320401","host_organization_name":"OceanSide Publications, Inc","host_organization_lineage":["https://openalex.org/P4310320401"],"host_organization_lineage_names":["OceanSide Publications, Inc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and Asthma Proceedings","raw_type":"journal-article"},{"id":"pmid:38982597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38982597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and asthma proceedings","raw_type":"Journal Article"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/53945","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/53945","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:openaccess.firat.edu.tr:11508/53945","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/53945","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W2006797613","https://openalex.org/W2007754697","https://openalex.org/W2008931469","https://openalex.org/W2090170102","https://openalex.org/W2095710479","https://openalex.org/W2556598798","https://openalex.org/W2745422379","https://openalex.org/W2765477066","https://openalex.org/W2769480787","https://openalex.org/W2794154574","https://openalex.org/W2810021766","https://openalex.org/W2887855058","https://openalex.org/W2903992590","https://openalex.org/W2934481534","https://openalex.org/W2969921938","https://openalex.org/W2970721464","https://openalex.org/W2971743604","https://openalex.org/W3000551256","https://openalex.org/W3006286115","https://openalex.org/W3010312266","https://openalex.org/W3013265584","https://openalex.org/W3016921965","https://openalex.org/W3025104320","https://openalex.org/W3047737090","https://openalex.org/W3087522660","https://openalex.org/W3126817223","https://openalex.org/W3127026021","https://openalex.org/W3161528352","https://openalex.org/W3200862524","https://openalex.org/W4210586291","https://openalex.org/W4280492615","https://openalex.org/W4281680487","https://openalex.org/W4362589091","https://openalex.org/W4378839878","https://openalex.org/W4381952162","https://openalex.org/W4388300717"],"related_works":["https://openalex.org/W2765477066","https://openalex.org/W4411880798","https://openalex.org/W4417107445","https://openalex.org/W4400909352","https://openalex.org/W4319082230","https://openalex.org/W7023597219","https://openalex.org/W4392558259","https://openalex.org/W4383268815","https://openalex.org/W4413788572","https://openalex.org/W4408072133"],"abstract_inverted_index":{"Background:":[0],"Chronic":[1],"spontaneous":[2],"urticaria":[3,87,94],"(CSU)":[4],"is":[5],"a":[6,93,166,243,312],"common":[7],"disease":[8],"with":[9,92,165,182,224,248,280,319],"complex":[10],"pathogenesis.":[11],"Patients'":[12],"clinical":[13,51],"characteristics":[14,52],"and":[15,47,70,90,107,123,136,233,265,302,326],"responses":[16],"to":[17,23,38,153,158,308,315],"treatment":[18,65,104,135,161],"vary.":[19],"Objective:":[20],"We":[21,298],"aimed":[22],"investigate":[24],"the":[25,36,40,50,54,73,86,130,138,149,159,163],"role":[26],"of":[27,53,60,75,129,141,146,148,162,250],"data":[28],"obtained":[29],"from":[30],"routinely":[31],"recommended":[32],"tests":[33],"in":[34,48,206,277,283],"predicting":[35],"response":[37,120,156,314],"omalizumab,":[39],"only":[41],"biologic":[42],"agent":[43],"approved":[44],"for":[45,66],"treatment,":[46],"defining":[49],"patients.":[55],"Methods:":[56],"A":[57,144],"retrospective":[58],"study":[59],"patients":[61,91,131,150,164,181,279],"who":[62],"started":[63],"omalizumab":[64,160,316],"CSU":[67,278],"between":[68],"2015":[69],"2022":[71],"at":[72,99,137],"Department":[74],"Dermatology,":[76],"Pamukkale":[77],"University,":[78],"was":[79,177,246],"conducted.":[80],"Response":[81],"criteria":[82],"were":[83,102,132,151,203,275],"based":[84],"on":[85],"control":[88,95],"test,":[89],"test":[96],"score":[97],"<12":[98],"6":[100],"months":[101],"considered":[103],"non-responders.":[105],"Eosinophil":[106,220],"basophil":[108,225],"counts,":[109],"neutrophil-lymphocyte":[110],"ratio":[111],"(NLR),":[112],"systemic":[113,118],"immune":[114],"inflammation":[115,119],"index":[116,121],"(SII),":[117],"(SIRI),":[122],"total":[124,145,167,183,320],"immunoglobulin":[125],"E":[126],"(IgE)":[127],"levels":[128,202,235,249,274,305,322],"evaluated":[133],"before":[134],"sixth":[139],"month":[140],"treatment.":[142],"Results:":[143],"23.1%":[147],"unresponsive":[152],"omalizumab.":[154],"The":[155,196],"rate":[157],"IgE":[168,184,234,321],"level":[169,185],"\u2264":[170],"30":[171,187,324],"IU/L":[172,188,325],"(n":[173,189],"=":[174,190,194,218,228,237,240,253,260,263,268,271,295],"4":[175],"[5.7%])":[176],"significantly":[178,204],"lower":[179,276],"than":[180,282],">":[186],"66":[191],"[94.3%])":[192],"(p":[193],"0.015).":[195],"mean":[197],"\u00b1":[198,211,215,288,292],"standard":[199],"deviation":[200],"SIRI":[201,258,328],"higher":[205],"non-responders":[207],"versus":[208,213],"responders":[209],"(1.53":[210],"1.03":[212],"1.15":[214],"7.76;":[216],"p":[217,230,239,255,262,270,294],"0.026).":[219],"counts":[221,226],"positively":[222],"correlated":[223],"(r":[227,236,252,259,267],"587;":[229],"<":[231,256,323],"0.001)":[232],"0.290;":[238],"0.005)":[241],"but":[242],"negative":[244],"correlation":[245],"found":[247],"NLR":[251,273,304],"\u22120.475;":[254],"0.001),":[257],"\u22120.259;":[261],"0.013),":[264],"SII":[266],"\u22120.285;":[269],"0.006).":[272],"atopy,":[281],"those":[284],"without":[285],"atopy":[286],"(1.9":[287],"0.9":[289],"vs":[290],"2.9":[291],"2.1,":[293],"0.022).":[296],"Conclusion:":[297],"suggest":[299],"that":[300],"eosinopenia":[301],"high":[303,327],"are":[306],"linked":[307],"autoimmune":[309],"CSU.":[310],"Predicting":[311],"poor":[313],"seems":[317],"possible":[318],"levels.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-11T00:00:00"}