{"id":"https://openalex.org/W4400512648","doi":"https://doi.org/10.3389/fmolb.2024.1338497","title":"Metabolomics highlights biochemical perturbations occurring in the kidney and liver of mice administered a human dose of colistin","display_name":"Metabolomics highlights biochemical perturbations occurring in the kidney and liver of mice administered a human dose of colistin","publication_year":2024,"publication_date":"2024-07-10","ids":{"openalex":"https://openalex.org/W4400512648","doi":"https://doi.org/10.3389/fmolb.2024.1338497","pmid":"https://pubmed.ncbi.nlm.nih.gov/39050734","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11266156"},"language":"en","primary_location":{"id":"doi:10.3389/fmolb.2024.1338497","doi":"https://doi.org/10.3389/fmolb.2024.1338497","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2024.1338497","pdf_url":null,"source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fmolb.2024.1338497","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003261788","display_name":"Ioanna Barla","orcid":"https://orcid.org/0000-0003-1352-7816","observed_orcids":["https://orcid.org/0000-0003-1352-7816"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I. Barla","raw_affiliation_strings":["Laboratory of Analytical Chemistry, Department of Chemistry, School of Science, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Analytical Chemistry, Department of Chemistry, School of Science, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046575282","display_name":"Ioanna Dagla","orcid":"https://orcid.org/0000-0003-1387-3532","observed_orcids":["https://orcid.org/0000-0003-1387-3532"]},"institutions":[{"id":"https://openalex.org/I4210128596","display_name":"Goulandris Natural History Museum","ror":"https://ror.org/032qvyh31","country_code":"GR","type":"archive","lineage":["https://openalex.org/I4210128596"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I. V. Dagla","raw_affiliation_strings":["GAIA Research Center, The Goulandris Natural History Museum, Kifissia, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GAIA Research Center, The Goulandris Natural History Museum, Kifissia, Greece","institution_ids":["https://openalex.org/I4210128596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070306177","display_name":"Aphrodite Daskalopoulou","orcid":"https://orcid.org/0000-0003-0789-3422","observed_orcids":["https://orcid.org/0000-0003-0789-3422"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Daskalopoulou","raw_affiliation_strings":["Laboratory of Pharmaceutical Analysis, Department of Pharmacy, School of Health Science, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmaceutical Analysis, Department of Pharmacy, School of Health Science, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Panagiotopoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M. Panagiotopoulou","raw_affiliation_strings":["Laboratory of Pharmaceutical Analysis, Department of Pharmacy, School of Health Science, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmaceutical Analysis, Department of Pharmacy, School of Health Science, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102043812","display_name":"M. Kritikaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M. Kritikaki","raw_affiliation_strings":["Laboratory of Pharmaceutical Analysis, Department of Pharmacy, School of Health Science, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmaceutical Analysis, Department of Pharmacy, School of Health Science, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017188544","display_name":"Panagiotis Dalezis","orcid":"https://orcid.org/0000-0001-7680-7685","observed_orcids":["https://orcid.org/0000-0001-7680-7685"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"P. Dalezis","raw_affiliation_strings":["Laboratory of Pharmacology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033947135","display_name":"\u039dikolaos S. \u03a4homaidis","orcid":"https://orcid.org/0000-0002-4624-4735","observed_orcids":["https://orcid.org/0000-0002-4624-4735"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"N. Thomaidis","raw_affiliation_strings":["Laboratory of Analytical Chemistry, Department of Chemistry, School of Science, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Analytical Chemistry, Department of Chemistry, School of Science, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046815019","display_name":"Anthony Tsarbopoulos","orcid":"https://orcid.org/0000-0002-6843-5575","observed_orcids":["https://orcid.org/0000-0002-6843-5575"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Tsarbopoulos","raw_affiliation_strings":["Laboratory of Pharmacology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059314345","display_name":"Dimitrios T. Trafalis","orcid":"https://orcid.org/0000-0003-4066-9780","observed_orcids":["https://orcid.org/0000-0003-4066-9780"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D. Trafalis","raw_affiliation_strings":["Laboratory of Pharmacology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068439544","display_name":"Evagelos E. Gikas","orcid":"https://orcid.org/0000-0002-0107-9991","observed_orcids":["https://orcid.org/0000-0002-0107-9991"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"E. Gikas","raw_affiliation_strings":["Laboratory of Analytical Chemistry, Department of Chemistry, School of Science, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Analytical Chemistry, Department of Chemistry, School of Science, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068439544"],"corresponding_institution_ids":["https://openalex.org/I200777214"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":null,"first_page":"1338497","last_page":"1338497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colistin","display_name":"colistin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.48399999737739563},{"id":"https://openalex.org/keywords/toxicity-biomarkers","display_name":"biomarkers of toxicity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/liver-metabolome","display_name":"liver metabolome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/renal-dopamine","display_name":"renal dopamine","score":0.7739999890327454},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/xanthine","display_name":"xanthine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acetylcholine-degradation","display_name":"acetylcholine degradation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.8736738562583923},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.8060420751571655},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6107010841369629},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5828558206558228},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5572411417961121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4702172577381134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4138379991054535},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.40630653500556946},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.37283140420913696},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.33085620403289795},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.28002017736434937},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2506694793701172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2091338336467743}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmolb.2024.1338497","doi":"https://doi.org/10.3389/fmolb.2024.1338497","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2024.1338497","pdf_url":null,"source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11266156","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11266156","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11266156/pdf/fmolb-11-1338497.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Mol Biosci","raw_type":"Text"},{"id":"pmid:39050734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39050734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in molecular biosciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c39bd5b2392e4945a8221a124b47b216","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c39bd5b2392e4945a8221a124b47b216","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Molecular Biosciences, Vol 11 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmolb.2024.1338497","doi":"https://doi.org/10.3389/fmolb.2024.1338497","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2024.1338497","pdf_url":null,"source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400512648.pdf","grobid_xml":"https://content.openalex.org/works/W4400512648.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1526193826","https://openalex.org/W1571446334","https://openalex.org/W1965230827","https://openalex.org/W1970383581","https://openalex.org/W1989299822","https://openalex.org/W2003356106","https://openalex.org/W2028516891","https://openalex.org/W2038055340","https://openalex.org/W2056089395","https://openalex.org/W2067642768","https://openalex.org/W2114447339","https://openalex.org/W2117795567","https://openalex.org/W2118734761","https://openalex.org/W2120266293","https://openalex.org/W2168502103","https://openalex.org/W2171632431","https://openalex.org/W2289921214","https://openalex.org/W2290466312","https://openalex.org/W2325106992","https://openalex.org/W2409556733","https://openalex.org/W2488493198","https://openalex.org/W2576159096","https://openalex.org/W2619583382","https://openalex.org/W2766360997","https://openalex.org/W2767683865","https://openalex.org/W2772634790","https://openalex.org/W2802026713","https://openalex.org/W2886738588","https://openalex.org/W2898408013","https://openalex.org/W2913414414","https://openalex.org/W2949112913","https://openalex.org/W3006350968","https://openalex.org/W3120208712","https://openalex.org/W3126098334","https://openalex.org/W3154501132","https://openalex.org/W3159995035","https://openalex.org/W3196876619","https://openalex.org/W3215015981","https://openalex.org/W3217557260","https://openalex.org/W4200399026","https://openalex.org/W4212782342","https://openalex.org/W4221024918","https://openalex.org/W4225346161","https://openalex.org/W4283753319","https://openalex.org/W4287500177","https://openalex.org/W4295123530","https://openalex.org/W4298108804","https://openalex.org/W4307544182","https://openalex.org/W4308577347","https://openalex.org/W4321597930","https://openalex.org/W4388946675","https://openalex.org/W4392716625"],"related_works":["https://openalex.org/W4212782342","https://openalex.org/W2289921214","https://openalex.org/W7131369448","https://openalex.org/W2097173594","https://openalex.org/W4410249944","https://openalex.org/W2108428442","https://openalex.org/W4282922605","https://openalex.org/W7119522274","https://openalex.org/W2782101170","https://openalex.org/W2124512516"],"abstract_inverted_index":{"Introduction:":[0],"Colistin":[1],"(CMS)":[2],"is":[3,15,35,57,86],"used":[4,48],"for":[5,245,323],"the":[6,33,42,61,83,87,121,135,143,149,153,166,169,184,246,273,289,294,312,324,328],"curation":[7],"of":[8,63,66,77,82,91,97,131,146,158,168,186,205,217,262,278,288,296,299,315],"infections":[9],"caused":[10],"by":[11,17,156],"multidrug-resistant":[12],"bacteria.":[13],"CMS":[14,98,147,174,206,329,333],"constrained":[16],"toxicity,":[18],"particularly":[19],"in":[20,43,88,117,199,268],"kidney":[21],"and":[22,32,108,113,123,151,176,182,215,220,231,240,265,302,332],"neuronal":[23],"cells.":[24],"The":[25,80,111,138,161,198,250],"recommended":[26],"human":[27,54,72,125,136],"doses":[28,49,99,204],"are":[29,69],"2.5\u20135":[30],"mg/kg/day,":[31],"toxicity":[34,45,194],"linked":[36,283],"to":[37,59,71,74,120,284,311],"higher":[38,52],"doses.":[39,55],"So":[40],"far,":[41],"vivo":[44,89,200],"studies":[46],"have":[47,101],"even":[50],"10-fold":[51],"than":[53],"It":[56],"essential":[58],"investigate":[60],"impact":[62,93,145],"metabolic":[64],"response":[65],"doses,":[67,73,126],"that":[68,100,189,305,337],"comparable":[70],"identify":[75],"biomarkers":[76],"latent":[78],"toxicity.":[79],"innovation":[81],"current":[84],"study":[85,139,274],"stimulation":[90],"CMS's":[92],"using":[94],"a":[95,208,225,281,320],"range":[96],"never":[102],"been":[103],"investigated":[104],"before,":[105],"i.e.,":[106],"1":[107,112],"1.5":[109,114],"mg/kg.":[110],"mg/kg,":[115],"administered":[116],"mice,":[118],"correspond":[119],"therapeutic":[122],"toxic":[124],"based":[127],"on":[128,142,148,152],"previous":[129],"expertise":[130],"our":[132],"team,":[133],"regarding":[134],"exposure.":[137],"mainly":[140],"focused":[141],"biochemical":[144,170],"metabolome,":[150],"alterations":[154],"provoked":[155],"50%-fold":[157],"dose":[159,180],"increase.":[160],"main":[162],"objectives":[163],"were":[164,222,243],"i)":[165],"comprehension":[167],"changes":[171],"resulting":[172],"after":[173],"administration":[175],"ii)":[177],"from":[178],"its":[179],"increase;":[181],"iii)":[183],"determination":[185],"dose-related":[187],"metabolites":[188,256],"could":[190],"be":[191,339],"considered":[192],"as":[193,307],"monitoring":[195],"biomarkers.":[196],"Methods:":[197],"experiment":[201],"employed":[202],"two":[203],"versus":[207],"control":[209],"group":[210],"treated":[211],"with":[212,224],"normal":[213],"saline,":[214],"samples":[216],"plasma,":[218],"kidney,":[219],"liver":[221,279],"analysed":[223],"UPLC-MS-based":[226],"metabolomics":[227],"protocol.":[228],"Both":[229],"univariate":[230],"multivariate":[232],"statistical":[233],"approaches":[234],"(PCA,":[235],"OPLS-DA,":[236],"PLS":[237],"regression,":[238],"ROC)":[239],"pathway":[241],"analysis":[242],"combined":[244],"data":[247],"interpretation.":[248],"Results:":[249],"results":[251],"pointed":[252],"out":[253],"six":[254],"dose-responding":[255],"(PAA,":[257],"DA4S,":[258],"2,8-DHA,":[259],"etc.),":[260],"dysregulation":[261],"renal":[263,269,300],"dopamine,":[264],"extended":[266],"perturbations":[267],"purine":[270],"metabolism.":[271],"Also,":[272],"determined":[275],"altered":[276],"levels":[277,298],"suberylglycine,":[280],"metabolite":[282],"hepatic":[285],"steatosis.":[286],"One":[287],"most":[290],"intriguing":[291],"findings":[292],"was":[293],"detection":[295],"elevated":[297],"xanthine":[301],"uric":[303],"acid,":[304],"act":[306],"AChE":[308],"activators,":[309],"leading":[310],"rapid":[313],"degradation":[314],"acetylcholine.":[316],"This":[317],"evidence":[318],"provides":[319],"na\u00efve":[321],"hypothesis,":[322],"potential":[325],"association":[326],"between":[327],"induced":[330,334],"nephrotoxicity":[331],"39":[335],"neurotoxicity,":[336],"should":[338],"further":[340],"investigated.":[341]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-11T00:00:00"}
