{"id":"https://openalex.org/W4400512387","doi":"https://doi.org/10.2139/ssrn.4889585","title":"Investigation of Genomic Mimicry and Multimorbidity in Multiple Sclerosis Using Exome Sequencing","display_name":"Investigation of Genomic Mimicry and Multimorbidity in Multiple Sclerosis Using Exome Sequencing","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4400512387","doi":"https://doi.org/10.2139/ssrn.4889585"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.4889585","doi":"https://doi.org/10.2139/ssrn.4889585","is_oa":true,"landing_page_url":"http://doi.org/10.2139/ssrn.4889585","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://doi.org/10.2139/ssrn.4889585","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023504989","display_name":"Nicholas B. Blackburn","orcid":"https://orcid.org/0000-0002-9774-1539","observed_orcids":["https://orcid.org/0000-0002-9774-1539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas  B. Blackburn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007057287","display_name":"Bennet J. McComish","orcid":"https://orcid.org/0000-0003-1940-0007","observed_orcids":["https://orcid.org/0000-0003-1940-0007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bennet  J. McComish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079169818","display_name":"Allan Motyer","orcid":"https://orcid.org/0000-0002-5552-2469","observed_orcids":["https://orcid.org/0000-0002-5552-2469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan Motyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102043786","display_name":"James C. Slimmer","orcid":"https://orcid.org/0009-0003-5717-4984","observed_orcids":["https://orcid.org/0009-0003-5717-4984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James  C. Slimmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057439502","display_name":"Stephen Leslie","orcid":"https://orcid.org/0000-0003-3511-3470","observed_orcids":["https://orcid.org/0000-0003-3511-3470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Leslie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050636465","display_name":"Simon Broadley","orcid":"https://orcid.org/0000-0002-9429-4307","observed_orcids":["https://orcid.org/0000-0002-9429-4307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon  A. Broadley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088611035","display_name":"Vilija Jokubaitis","orcid":"https://orcid.org/0000-0002-3942-4340","observed_orcids":["https://orcid.org/0000-0002-3942-4340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vilija G. Jokubaitis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042431509","display_name":"Anneke van der Walt","orcid":"https://orcid.org/0000-0002-4278-7003","observed_orcids":["https://orcid.org/0000-0002-4278-7003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anneke van der Walt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022332929","display_name":"Allan G. Kermode","orcid":"https://orcid.org/0000-0002-4476-4016","observed_orcids":["https://orcid.org/0000-0002-4476-4016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan Kermode","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014375641","display_name":"Jeannette Lechner\u2010Scott","orcid":"https://orcid.org/0000-0002-3850-447X","observed_orcids":["https://orcid.org/0000-0002-3850-447X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeannette Lechner-Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025305464","display_name":"Grant Peter Parnell","orcid":"https://orcid.org/0000-0002-2898-0253","observed_orcids":["https://orcid.org/0000-0002-2898-0253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grant  P. Parnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058252357","display_name":"Marzena J. Fabis\u2010Pedrini","orcid":"https://orcid.org/0000-0002-2614-8607","observed_orcids":["https://orcid.org/0000-0002-2614-8607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marzena  J. Fabis-Pedrini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Rodney Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodney Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103856111","display_name":"Stacey Jackson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stacey Jackson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059129245","display_name":"Vicki E. Maltby","orcid":"https://orcid.org/0000-0002-3785-4742","observed_orcids":["https://orcid.org/0000-0002-3785-4742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vicki  E. Maltby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091688246","display_name":"Jac Charlesworth","orcid":"https://orcid.org/0000-0001-6201-3518","observed_orcids":["https://orcid.org/0000-0001-6201-3518"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jac Charlesworth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049531649","display_name":"Kathryn P. Burdon","orcid":"https://orcid.org/0000-0001-8217-1249","observed_orcids":["https://orcid.org/0000-0001-8217-1249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn Burdon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067070663","display_name":"Bruce V. Taylor","orcid":"https://orcid.org/0000-0003-2807-0070","observed_orcids":["https://orcid.org/0000-0003-2807-0070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080712147","display_name":"Trevor John Kilpatrick","orcid":"https://orcid.org/0000-0003-3999-085X","observed_orcids":["https://orcid.org/0000-0003-3999-085X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trevor  J. Kilpatrick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061300992","display_name":"Justin P. Rubio","orcid":"https://orcid.org/0000-0003-3750-917X","observed_orcids":["https://orcid.org/0000-0003-3750-917X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin  P. Rubio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/multimorbidity","display_name":"multimorbidity","score":0.9769999980926514},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.8169999718666077},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.41999998688697815},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C7863114","wikidata":"https://www.wikidata.org/wiki/Q192627","display_name":"Mimicry","level":2,"score":0.8315863013267517},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.7221025228500366},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5548650026321411},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.5434976816177368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4537730813026428},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4249807596206665},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41109010577201843},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3251287043094635},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.1468522846698761},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.13724061846733093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1274501383304596},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08509901165962219}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.4889585","doi":"https://doi.org/10.2139/ssrn.4889585","is_oa":true,"landing_page_url":"http://doi.org/10.2139/ssrn.4889585","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.4889585","doi":"https://doi.org/10.2139/ssrn.4889585","is_oa":true,"landing_page_url":"http://doi.org/10.2139/ssrn.4889585","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W837666906","https://openalex.org/W1971211819","https://openalex.org/W1994981945","https://openalex.org/W2020427316","https://openalex.org/W2023235195","https://openalex.org/W2056665586","https://openalex.org/W2059787342","https://openalex.org/W2094205468","https://openalex.org/W2132325919","https://openalex.org/W2150352214","https://openalex.org/W2152740112","https://openalex.org/W2168462034","https://openalex.org/W2566502421","https://openalex.org/W2581679870","https://openalex.org/W2583347849","https://openalex.org/W2620900381","https://openalex.org/W2734418154","https://openalex.org/W2777074421","https://openalex.org/W2808094593","https://openalex.org/W2911408542","https://openalex.org/W2937167333","https://openalex.org/W2984251519","https://openalex.org/W3034589602","https://openalex.org/W3082363863","https://openalex.org/W3162800482","https://openalex.org/W4281258964","https://openalex.org/W4284693543","https://openalex.org/W4287447537","https://openalex.org/W4385064560"],"related_works":["https://openalex.org/W2983766859","https://openalex.org/W2604143540","https://openalex.org/W7216661059","https://openalex.org/W2949761825","https://openalex.org/W2410072875","https://openalex.org/W2467911696","https://openalex.org/W2772716407","https://openalex.org/W2523345525","https://openalex.org/W4402346591","https://openalex.org/W2205868118"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-07-11T00:00:00"}