{"id":"https://openalex.org/W4400511633","doi":"https://doi.org/10.1038/s41467-024-50142-1","title":"Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis","display_name":"Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis","publication_year":2024,"publication_date":"2024-07-10","ids":{"openalex":"https://openalex.org/W4400511633","doi":"https://doi.org/10.1038/s41467-024-50142-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/38987535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11236979"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-50142-1","doi":"https://doi.org/10.1038/s41467-024-50142-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-50142-1","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41467-024-50142-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yu Zheng","orcid":"https://orcid.org/0000-0002-1297-8933","observed_orcids":["https://orcid.org/0000-0002-1297-8933"]},"institutions":[{"id":"https://openalex.org/I4210100240","display_name":"RIKEN Center for Sustainable Resource Science","ror":"https://ror.org/010rf2m76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Zheng","raw_affiliation_strings":["Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1297-8933","affiliations":[{"raw_affiliation_string":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan","institution_ids":["https://openalex.org/I4210100240"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Katsuyuki Sakai","orcid":"https://orcid.org/0000-0001-9210-6176","observed_orcids":["https://orcid.org/0000-0001-9210-6176"]},"institutions":[{"id":"https://openalex.org/I4210100240","display_name":"RIKEN Center for Sustainable Resource Science","ror":"https://ror.org/010rf2m76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyuki Sakai","raw_affiliation_strings":["Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9210-6176","affiliations":[{"raw_affiliation_string":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan","institution_ids":["https://openalex.org/I4210100240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031755129","display_name":"Kohei Watanabe","orcid":"https://orcid.org/0000-0002-3146-5439","observed_orcids":["https://orcid.org/0000-0002-3146-5439"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Watanabe","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101745399","display_name":"Hiroshi Takagi","orcid":"https://orcid.org/0000-0003-3954-792X","observed_orcids":["https://orcid.org/0000-0003-3954-792X"]},"institutions":[{"id":"https://openalex.org/I4210100240","display_name":"RIKEN Center for Sustainable Resource Science","ror":"https://ror.org/010rf2m76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Takagi","raw_affiliation_strings":["Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan","institution_ids":["https://openalex.org/I4210100240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004540211","display_name":"Yumi Shiozaki-Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100240","display_name":"RIKEN Center for Sustainable Resource Science","ror":"https://ror.org/010rf2m76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumi Sato-Shiozaki","raw_affiliation_strings":["Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan","institution_ids":["https://openalex.org/I4210100240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008468320","display_name":"Yuko Misumi","orcid":"https://orcid.org/0000-0003-3434-6678","observed_orcids":["https://orcid.org/0000-0003-3434-6678"]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Misumi","raw_affiliation_strings":["Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056734050","display_name":"Yohei Miyanoiri","orcid":"https://orcid.org/0000-0001-6889-5160","observed_orcids":["https://orcid.org/0000-0001-6889-5160"]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohei Miyanoiri","raw_affiliation_strings":["Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022765206","display_name":"Genji Kurisu","orcid":"https://orcid.org/0000-0002-5354-0807","observed_orcids":["https://orcid.org/0000-0002-5354-0807"]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Genji Kurisu","raw_affiliation_strings":["Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5354-0807","affiliations":[{"raw_affiliation_string":"Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063551924","display_name":"Toshihiko Nogawa","orcid":"https://orcid.org/0000-0003-1270-5270","observed_orcids":["https://orcid.org/0000-0003-1270-5270"]},"institutions":[{"id":"https://openalex.org/I4210100240","display_name":"RIKEN Center for Sustainable Resource Science","ror":"https://ror.org/010rf2m76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Nogawa","raw_affiliation_strings":["Molecular Structure Characterization Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Structure Characterization Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan","institution_ids":["https://openalex.org/I4210100240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039662933","display_name":"Ryo Takita","orcid":"https://orcid.org/0000-0003-4104-9890","observed_orcids":["https://orcid.org/0000-0003-4104-9890"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Takita","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan","Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4104-9890","affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021597347","display_name":"Shunji Takahashi","orcid":"https://orcid.org/0000-0003-1684-9298","observed_orcids":["https://orcid.org/0000-0003-1684-9298"]},"institutions":[{"id":"https://openalex.org/I4210100240","display_name":"RIKEN Center for Sustainable Resource Science","ror":"https://ror.org/010rf2m76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shunji Takahashi","raw_affiliation_strings":["Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan. shunjitaka@riken.jp","Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1684-9298","affiliations":[{"raw_affiliation_string":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan. shunjitaka@riken.jp","institution_ids":["https://openalex.org/I4210100240"]},{"raw_affiliation_string":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, 351-0198, Japan","institution_ids":["https://openalex.org/I4210100240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5021597347"],"corresponding_institution_ids":["https://openalex.org/I4210100240"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":6790,"currency":"USD","value_usd":6790},"fwci":0.9498,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6426799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"15","issue":"1","first_page":"5779","last_page":"5779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.326200008392334,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.326200008392334,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.29789999127388,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12893","display_name":"Organic Chemistry Cycloaddition Reactions","score":0.11959999799728394,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intramolecular-diels-alder-reaction","display_name":"intramolecular Diels-Alder reaction","score":0.8980000019073486},{"id":"https://openalex.org/keywords/diels-alder-reaction","display_name":"Diels-Alder reaction","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ferredoxin","display_name":"ferredoxin","score":0.7599999904632568},{"id":"https://openalex.org/keywords/iron-sulfur-proteins","display_name":"iron-sulfur proteins","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lewis-acid-catalysis","display_name":"Lewis acid catalysis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gallium-substitution","display_name":"gallium substitution","score":0.7120000123977661},{"id":"https://openalex.org/keywords/michael-addition","display_name":"Michael addition","score":0.8930000066757202},{"id":"https://openalex.org/keywords/natural-product-biosynthesis","display_name":"natural product biosynthesis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/enzyme-catalysis","display_name":"enzyme catalysis","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2779664164","wikidata":"https://www.wikidata.org/wiki/Q898648","display_name":"Cycloaddition","level":3,"score":0.9475904107093811},{"id":"https://openalex.org/C163638829","wikidata":"https://www.wikidata.org/wiki/Q900337","display_name":"Lewis acids and bases","level":3,"score":0.8336914777755737},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.8212352991104126},{"id":"https://openalex.org/C134621786","wikidata":"https://www.wikidata.org/wiki/Q415215","display_name":"Ferredoxin","level":3,"score":0.6981320977210999},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6686879992485046},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5610431432723999},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5056095123291016},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.475288987159729},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.4597179889678955},{"id":"https://openalex.org/C19927201","wikidata":"https://www.wikidata.org/wiki/Q6537198","display_name":"Lewis acid catalysis","level":4,"score":0.42996641993522644},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32637059688568115},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.313758909702301},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.25544053316116333},{"id":"https://openalex.org/C65024703","wikidata":"https://www.wikidata.org/wiki/Q373406","display_name":"Reaction mechanism","level":3,"score":0.2145766317844391}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007506","descriptor_name":"Iron-Sulfur Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007506","descriptor_name":"Iron-Sulfur Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058116","descriptor_name":"Lewis Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058116","descriptor_name":"Lewis Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D061565","descriptor_name":"Cycloaddition Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-024-50142-1","doi":"https://doi.org/10.1038/s41467-024-50142-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-50142-1","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11236979","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11236979","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11236979/pdf/41467_2024_Article_50142.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:38987535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38987535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50142-1","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-50142-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7ac52a8fadf64ebc863ac3670f2ebd36","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7ac52a8fadf64ebc863ac3670f2ebd36","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-50142-1","doi":"https://doi.org/10.1038/s41467-024-50142-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-50142-1","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2592785493","display_name":"Establishment of platform for creation of novel bioactive natural products by expression of latent functions of microorganisms","funder_award_id":"22KK0080","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4755445851","display_name":"Molecular design for lipid science","funder_award_id":"24K02151","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5232553611","display_name":"Elucidation of molecular basis of biosynthesis with the aim of expanding the diversity of natural products","funder_award_id":"20H00416","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6973993131","display_name":null,"funder_award_id":"20H00416","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7426584540","display_name":null,"funder_award_id":"23H04564","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320324670","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400511633.pdf","grobid_xml":"https://content.openalex.org/works/W4400511633.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1602014877","https://openalex.org/W1623951421","https://openalex.org/W1845424422","https://openalex.org/W1848034425","https://openalex.org/W1968132781","https://openalex.org/W1969881511","https://openalex.org/W1972588250","https://openalex.org/W1984978561","https://openalex.org/W1985672936","https://openalex.org/W1989611539","https://openalex.org/W1992173555","https://openalex.org/W2000270075","https://openalex.org/W2000547662","https://openalex.org/W2003843231","https://openalex.org/W2008844584","https://openalex.org/W2011202597","https://openalex.org/W2014045288","https://openalex.org/W2015723183","https://openalex.org/W2027642444","https://openalex.org/W2035946051","https://openalex.org/W2036341105","https://openalex.org/W2039559098","https://openalex.org/W2049996223","https://openalex.org/W2050466511","https://openalex.org/W2053423439","https://openalex.org/W2053700413","https://openalex.org/W2055468061","https://openalex.org/W2058848030","https://openalex.org/W2060939270","https://openalex.org/W2064224876","https://openalex.org/W2065304507","https://openalex.org/W2072977687","https://openalex.org/W2075888213","https://openalex.org/W2076972711","https://openalex.org/W2079620571","https://openalex.org/W2084447564","https://openalex.org/W2086416477","https://openalex.org/W2090449991","https://openalex.org/W2090780245","https://openalex.org/W2133544158","https://openalex.org/W2150697053","https://openalex.org/W2153445710","https://openalex.org/W2161747039","https://openalex.org/W2266627069","https://openalex.org/W2558779755","https://openalex.org/W2588160927","https://openalex.org/W2792597665","https://openalex.org/W2805464884","https://openalex.org/W2811245482","https://openalex.org/W2888208256","https://openalex.org/W2894479533","https://openalex.org/W2951309525","https://openalex.org/W2952734876","https://openalex.org/W2982045146","https://openalex.org/W2998266408","https://openalex.org/W3000537710","https://openalex.org/W3017252460","https://openalex.org/W3100324984","https://openalex.org/W3113356217","https://openalex.org/W3128831519","https://openalex.org/W3171810102","https://openalex.org/W3177828909","https://openalex.org/W3205584884","https://openalex.org/W3208036300","https://openalex.org/W3217267830","https://openalex.org/W4205131056","https://openalex.org/W4213019664"],"related_works":["https://openalex.org/W2501895227","https://openalex.org/W2494002388","https://openalex.org/W1985672936","https://openalex.org/W2769574917","https://openalex.org/W3026072135","https://openalex.org/W4200369459","https://openalex.org/W2222894040","https://openalex.org/W4411747411","https://openalex.org/W2962086870","https://openalex.org/W2582041499"],"abstract_inverted_index":{"To":[0],"the":[1,48,82,93,118,128],"best":[2],"of":[3,37,61,131],"our":[4,123],"knowledge,":[5],"enzymes":[6,24],"that":[7,47,81],"catalyse":[8],"intramolecular":[9,49],"Diels-Alder":[10],"([4+2]":[11],"cycloaddition)":[12],"reactions":[13,100],"are":[14],"frequently":[15],"reported":[16],"in":[17],"natural":[18],"product":[19],"biosynthesis;":[20],"however,":[21],"no":[22],"native":[23],"utilising":[25],"Lewis":[26,71,89,136],"acid":[27,90,137],"catalysis":[28],"have":[29],"been":[30],"reported.":[31],"Verticilactam":[32],"is":[33],"a":[34,59,134],"representative":[35],"member":[36],"polycyclic":[38],"macrolactams,":[39],"presumably":[40],"produced":[41],"by":[42,56,70,101],"spontaneous":[43],"cycloaddition.":[44],"We":[45],"report":[46],"[4+2]":[50,95,140],"cycloadditions":[51],"can":[52],"be":[53],"significantly":[54],"accelerated":[55],"ferredoxins":[57],"(Fds),":[58],"class":[60],"small":[62],"iron-sulphur":[63],"(Fe-S)":[64],"proteins.":[65],"Through":[66],"iron":[67,75],"atom":[68],"substitution":[69],"acidic":[72],"gallium":[73],"(Ga)":[74],"and":[76,97],"computational":[77],"calculations,":[78],"we":[79],"confirm":[80],"ubiquitous":[83,119],"Fe-S":[84,120],"cluster":[85],"efficiently":[86],"functions":[87],"as":[88,133],"to":[91,112],"accelerate":[92],"tandem":[94],"cycloaddition":[96,141],"Michael":[98],"addition":[99],"lowering":[102],"free":[103],"energy":[104],"barriers.":[105],"Our":[106],"work":[107],"highlights":[108],"Nature's":[109],"ingenious":[110],"strategy":[111],"generate":[113],"complex":[114],"molecule":[115],"structures":[116],"using":[117],"protein.":[121],"Furthermore,":[122],"study":[124],"sheds":[125],"light":[126],"on":[127],"future":[129],"design":[130],"Fd":[132],"versatile":[135],"catalyst":[138],"for":[139],"reactions.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-11T00:00:00"}