{"id":"https://openalex.org/W4400495809","doi":"https://doi.org/10.7554/elife.97987.1.sa4","title":"eLife Assessment: Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence","display_name":"eLife Assessment: Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence","publication_year":2024,"publication_date":"2024-07-10","ids":{"openalex":"https://openalex.org/W4400495809","doi":"https://doi.org/10.7554/elife.97987.1.sa4"},"language":"en","primary_location":{"id":"doi:10.7554/elife.97987.1.sa4","doi":"https://doi.org/10.7554/elife.97987.1.sa4","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.97987.1.sa4","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.97987.1.sa4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034963668","display_name":"Charles L. Sawyers","orcid":"https://orcid.org/0000-0003-4955-6475","observed_orcids":["https://orcid.org/0000-0003-4955-6475"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles L Sawyers","raw_affiliation_strings":["Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034963668"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1344073410"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/prostate-cancer-recurrence","display_name":"prostate cancer recurrence","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.7870000004768372},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.658033013343811},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5644354224205017},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.5477676391601562},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5472965240478516},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5360589027404785},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5150456428527832},{"id":"https://openalex.org/C2779256933","wikidata":"https://www.wikidata.org/wiki/Q58929","display_name":"Castration","level":3,"score":0.48639896512031555},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.47047072649002075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4685322642326355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4256255328655243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3979203701019287},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3680764436721802},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3068152070045471},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.24986529350280762},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.24640795588493347}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.97987.1.sa4","doi":"https://doi.org/10.7554/elife.97987.1.sa4","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.97987.1.sa4","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.97987.1.sa4","doi":"https://doi.org/10.7554/elife.97987.1.sa4","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.97987.1.sa4","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W82309289","https://openalex.org/W1684904284","https://openalex.org/W1959696062","https://openalex.org/W1969057487","https://openalex.org/W1973200020","https://openalex.org/W1982813442","https://openalex.org/W1999574084","https://openalex.org/W2009735641","https://openalex.org/W2017728303","https://openalex.org/W2033230341","https://openalex.org/W2033737664","https://openalex.org/W2045292016","https://openalex.org/W2045696380","https://openalex.org/W2046234516","https://openalex.org/W2047496509","https://openalex.org/W2052853635","https://openalex.org/W2056587454","https://openalex.org/W2057477877","https://openalex.org/W2065006553","https://openalex.org/W2075137329","https://openalex.org/W2086158679","https://openalex.org/W2090754742","https://openalex.org/W2099703259","https://openalex.org/W2103017472","https://openalex.org/W2105491262","https://openalex.org/W2108426942","https://openalex.org/W2108955823","https://openalex.org/W2127310510","https://openalex.org/W2129781547","https://openalex.org/W2137526110","https://openalex.org/W2146512944","https://openalex.org/W2156854438","https://openalex.org/W2161784528","https://openalex.org/W2163035374","https://openalex.org/W2166554521","https://openalex.org/W2169456326","https://openalex.org/W2241673155","https://openalex.org/W2373606074","https://openalex.org/W2406250479","https://openalex.org/W2569090251","https://openalex.org/W2626892910","https://openalex.org/W2791769121","https://openalex.org/W2961102588","https://openalex.org/W2989747508","https://openalex.org/W2989807288","https://openalex.org/W2998936402","https://openalex.org/W3006817681","https://openalex.org/W3113132600","https://openalex.org/W3198512485","https://openalex.org/W3206191004","https://openalex.org/W3209605673","https://openalex.org/W3212685049","https://openalex.org/W4251063368","https://openalex.org/W4285088269","https://openalex.org/W4288097016","https://openalex.org/W4311724082","https://openalex.org/W4324346858","https://openalex.org/W4387494986"],"related_works":["https://openalex.org/W4400495678","https://openalex.org/W2954137333","https://openalex.org/W3206191004","https://openalex.org/W4311724082","https://openalex.org/W2062941473","https://openalex.org/W2289198755","https://openalex.org/W2912360271","https://openalex.org/W2117395680","https://openalex.org/W2887517163","https://openalex.org/W4249689730"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2024-07-11T00:00:00"}