{"id":"https://openalex.org/W4400465263","doi":"https://doi.org/10.1186/s12866-024-03392-4","title":"Green synthesis of zinc oxide nanoparticles (ZnO-NPs) by Streptomyces baarnensis and its active metabolite (Ka): a promising combination against multidrug-resistant ESKAPE pathogens and cytotoxicity","display_name":"Green synthesis of zinc oxide nanoparticles (ZnO-NPs) by Streptomyces baarnensis and its active metabolite (Ka): a promising combination against multidrug-resistant ESKAPE pathogens and cytotoxicity","publication_year":2024,"publication_date":"2024-07-09","ids":{"openalex":"https://openalex.org/W4400465263","doi":"https://doi.org/10.1186/s12866-024-03392-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/38982372","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11232237"},"language":"en","primary_location":{"id":"doi:10.1186/s12866-024-03392-4","doi":"https://doi.org/10.1186/s12866-024-03392-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12866-024-03392-4","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/s12866-024-03392-4","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/s12866-024-03392-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030175009","display_name":"Mohamed H. Kalaba","orcid":"https://orcid.org/0000-0002-1984-8103","observed_orcids":["https://orcid.org/0000-0002-1984-8103"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed H. Kalaba","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079225574","display_name":"Gamal M. El-Sherbiny","orcid":"https://orcid.org/0000-0003-3968-0536","observed_orcids":["https://orcid.org/0000-0003-3968-0536"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Gamal M. El-Sherbiny","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt. gamalelsherbiny1970@azhar.edu.eg","Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt. gamalelsherbiny1970@azhar.edu.eg","institution_ids":["https://openalex.org/I184834183"]},{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076671538","display_name":"Emad A. Ewais","orcid":"https://orcid.org/0000-0003-2075-6764","observed_orcids":["https://orcid.org/0000-0003-2075-6764"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Emad A. Ewais","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071579714","display_name":"Osama M. Darwesh","orcid":"https://orcid.org/0000-0002-7742-4982","observed_orcids":["https://orcid.org/0000-0002-7742-4982"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Osama M. Darwesh","raw_affiliation_strings":["Agricultural Microbiology Department, National Research Centre, Dokki, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural Microbiology Department, National Research Centre, Dokki, Cairo, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086982041","display_name":"Saad A. M. Moghannem","orcid":"https://orcid.org/0000-0002-6686-5520","observed_orcids":["https://orcid.org/0000-0002-6686-5520"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Saad A. Moghannem","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt","institution_ids":["https://openalex.org/I184834183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079225574"],"corresponding_institution_ids":["https://openalex.org/I184834183"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":6.4738,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.98619657,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"24","issue":"1","first_page":"254","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10090","display_name":"ZnO doping and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-oxide-nanoparticles","display_name":"zinc oxide nanoparticles","score":0.9629999995231628},{"id":"https://openalex.org/keywords/green-synthesis","display_name":"green synthesis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.6430000066757202},{"id":"https://openalex.org/keywords/eskape-pathogens","display_name":"ESKAPE pathogens","score":0.972000002861023},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9779999852180481},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/antibiotic-synergy","display_name":"antibiotic synergy","score":0.5320000052452087},{"id":"https://openalex.org/keywords/nanoemulsions","display_name":"nanoemulsions","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/fractional-inhibitory-concentration-index","display_name":"fractional inhibitory concentration index","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.6238570213317871},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5128040909767151},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.5102417469024658},{"id":"https://openalex.org/C2777347573","wikidata":"https://www.wikidata.org/wiki/Q522244","display_name":"Secondary metabolite","level":3,"score":0.4980344772338867},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.49064770340919495},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.48724642395973206},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.4750780463218689},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.4510471522808075},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4264594614505768},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.41388148069381714},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3589089512825012},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3568803668022156},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.27147176861763},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.25229084491729736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2512558698654175},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.21705394983291626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16745159029960632},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1556520164012909},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015034","descriptor_name":"Zinc Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015034","descriptor_name":"Zinc Oxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055772","descriptor_name":"Green Chemistry Technology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12866-024-03392-4","doi":"https://doi.org/10.1186/s12866-024-03392-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12866-024-03392-4","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/s12866-024-03392-4","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11232237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11232237","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11232237/pdf/12866_2024_Article_3392.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiol","raw_type":"Text"},{"id":"pmid:38982372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38982372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e2e5936e99c74fb3a36b2b4684a7c3c4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e2e5936e99c74fb3a36b2b4684a7c3c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Microbiology, Vol 24, Iss 1, Pp 1-18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12866-024-03392-4","doi":"https://doi.org/10.1186/s12866-024-03392-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12866-024-03392-4","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/s12866-024-03392-4","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321655","display_name":"Science and Technology Development Fund","ror":"https://ror.org/044vr6g03"},{"id":"https://openalex.org/F4320330007","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400465263.pdf","grobid_xml":"https://content.openalex.org/works/W4400465263.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1499823044","https://openalex.org/W1505747354","https://openalex.org/W1968185740","https://openalex.org/W1969200326","https://openalex.org/W1970818029","https://openalex.org/W1989750245","https://openalex.org/W2007124437","https://openalex.org/W2021511547","https://openalex.org/W2042315618","https://openalex.org/W2056917379","https://openalex.org/W2059603082","https://openalex.org/W2060692013","https://openalex.org/W2065650825","https://openalex.org/W2067869089","https://openalex.org/W2089829277","https://openalex.org/W2093627406","https://openalex.org/W2097053833","https://openalex.org/W2102331921","https://openalex.org/W2112047872","https://openalex.org/W2121304440","https://openalex.org/W2127567906","https://openalex.org/W2128245530","https://openalex.org/W2134877726","https://openalex.org/W2151823004","https://openalex.org/W2169353222","https://openalex.org/W2188361993","https://openalex.org/W2300661077","https://openalex.org/W2336232418","https://openalex.org/W2399234890","https://openalex.org/W2407628067","https://openalex.org/W2430706935","https://openalex.org/W2461840561","https://openalex.org/W2469436474","https://openalex.org/W2494633142","https://openalex.org/W2527026626","https://openalex.org/W2552713898","https://openalex.org/W2610453110","https://openalex.org/W2618546654","https://openalex.org/W2762513057","https://openalex.org/W2800992270","https://openalex.org/W2839447588","https://openalex.org/W2938514331","https://openalex.org/W2954797532","https://openalex.org/W2959360417","https://openalex.org/W2969724824","https://openalex.org/W2974855124","https://openalex.org/W2982472703","https://openalex.org/W2995297793","https://openalex.org/W2998104881","https://openalex.org/W3002947119","https://openalex.org/W3004227146","https://openalex.org/W3004841967","https://openalex.org/W3036339137","https://openalex.org/W3087929048","https://openalex.org/W3095916298","https://openalex.org/W3102211966","https://openalex.org/W3119194360","https://openalex.org/W3129897365","https://openalex.org/W3164694342","https://openalex.org/W3171493832","https://openalex.org/W3208985294","https://openalex.org/W4200373660","https://openalex.org/W4210954575","https://openalex.org/W4214666678","https://openalex.org/W4224238193","https://openalex.org/W4283161129","https://openalex.org/W4285492682","https://openalex.org/W4285494655","https://openalex.org/W4300817458","https://openalex.org/W4303696588","https://openalex.org/W4306770702","https://openalex.org/W4323318424","https://openalex.org/W4376492123","https://openalex.org/W4377023903","https://openalex.org/W4380372173","https://openalex.org/W4389117776","https://openalex.org/W4391655672","https://openalex.org/W4398774573","https://openalex.org/W6814360748"],"related_works":["https://openalex.org/W7213307482","https://openalex.org/W2552713898","https://openalex.org/W4406771804","https://openalex.org/W7164208840","https://openalex.org/W2892076029","https://openalex.org/W4200464601","https://openalex.org/W4388658517","https://openalex.org/W3214800167","https://openalex.org/W2909342098","https://openalex.org/W4402071338"],"abstract_inverted_index":{"Abstract":[0],"Various":[1],"eco-friendly":[2],"techniques":[3],"are":[4],"being":[5],"researched":[6],"for":[7,11,440,488,514],"synthesizing":[8],"ZnO-NPs,":[9],"known":[10],"their":[12,25,34,255],"bioactivity.":[13],"This":[14],"study":[15,462],"aimed":[16],"at":[17,357,377,383],"biosynthesizing":[18],"ZnO-NPs":[19,66,99,128,146,161],"using":[20,153],"Streptomyces":[21,62,68],"baarnensis":[22,63,69],"MH-133,":[23],"characterizing":[24],"physicochemical":[26,88],"properties,":[27],"investigating":[28],"antibacterial":[29,523],"activity,":[30],"and":[31,72,85,133,150,160,181,193,232,239,257,277,302,322,341,391,398,425,525],"enhancement":[32],"of":[33,54,61,98,114,158,199,206,219,237,262,280,299,307,316,386,394,415,431,477,517],"efficacy":[35,346],"by":[36,87,164,286],"combining":[37],"them":[38],"with":[39,145,197,216,226,235,269,326,344,372],"a":[40,46,51,81,250,270,303,420,437,511],"water-insoluble":[41],"active":[42],"compound":[43,53,141],"(Ka)":[44,142],"in":[45,330,347,467,496],"nanoemulsion":[47,251,264,293,333,348,370,411,468,508],"form.":[48,334,349],"Ka":[49,159],"is":[50],"pure":[52,140],"9-Ethyl-1,4,6,9,10-pentahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione":[55],"obtained":[56,163],"previously":[57,374],"from":[58,189],"our":[59],"strain":[60],"MH-133.":[64],"Biosynthesized":[65],"employing":[67],"MH-133":[70],"filtrate":[71],"zinc":[73],"sulfate":[74],"(ZnSO":[75],"4":[76],".7H":[77],"2":[78],"O)":[79],"as":[80],"precursor":[82],"were":[83,247],"purified":[84],"characterized":[86],"investigation.":[89],"High-resolution-transmission":[90],"electron":[91],"microscopy":[92],"(HR-TEM)":[93],"verified":[94],"the":[95,204,263,314,373,413,416,444,456,460,465,471,478,515],"effective":[96],"biosynthesis":[97],"(size":[100],"<":[101],"12":[102,390],"nm),":[103],"whereas":[104],"dynamic":[105],"light":[106],"scattering":[107],"(DLS)":[108],"analysis":[109,261,288],"showed":[110,223,336,380,436],"an":[111,296],"average":[112,297],"size":[113,298],"17.5":[115],"nm.":[116],"X-ray":[117],"diffraction":[118,122],"(XRD)":[119],"exhibited":[120,244],"characteristic":[121],"patterns":[123],"that":[124,243,291,353,464],"confirmed":[125,285],"crystalline":[126],"structure.":[127],"efficiently":[129],"inhibited":[130,167],"both":[131],"Gram-positive":[132],"Gram-negative":[134],"bacteria":[135,445,520],"(MICs:":[136],"31.25\u2013125":[137],"\u00b5g/ml).":[138],"The":[139,221,241,259,309,350,433,485],"was":[143,284,492,499],"combined":[144],"to":[147,253,404,418,447,522],"improve":[148,254],"effectiveness":[149],"reduce":[151],"dose":[152],"checkerboard":[154,165],"microdilution.":[155],"Niteen":[156],"treatments":[157,215,225],"combinations":[162,172,187,212,242,328,338,376,417],"matrix":[166],"Klebsiella":[168],"pneumonia":[169,324,362,400,427],".":[170],"Eleven":[171],"had":[173],"fractional":[174],"inhibitory":[175],"concentration":[176,340,385],"index":[177,305],"(FICi)":[178],"between":[179],"1.03":[180],"2,":[182],"meaning":[183],"indifferent,":[184],"another":[185],"five":[186],"resulted":[188],"additive":[190,230],"FICi":[191,198,236],"(0.625\u20131)":[192],"only":[194],"one":[195],"combination":[196,388,435,466],"0.5,":[200],"indicating":[201],"synergy.":[202],"In":[203,504],"case":[205],"methicillin-resistant":[207,317],"S.":[208],"aureus":[209,319],"(MRSA),":[210],"Ka-ZnO-NPs":[211,292,327,337,354,387,489,507],"yielded":[213],"23":[214],"varying":[217],"degrees":[218],"interaction.":[220],"results":[222],"eleven":[224],"indifferent":[227],"interaction,":[228],"eight":[229],"interactions,":[231],"two":[233],"synergies":[234],"0.5":[238],"0.375.":[240],"synergy":[245],"action":[246],"transformed":[248],"into":[249],"form":[252,469],"solubility":[256],"bioavailability.":[258],"HR-TEM":[260],"revealed":[265,463],"spherical":[266],"oil":[267],"particles":[268],"granulated":[271],"core":[272],"smaller":[273],"than":[274],"200":[275],"nm":[276,301],"no":[278],"signs":[279],"aggregation.":[281],"Effective":[282],"dispersion":[283],"DLS":[287],"which":[289],"indicated":[290,352],"droplets":[294],"have":[295],"53.1":[300],"polydispersity":[304],"(PI)":[306],"0.523.":[308],"killing":[310],"kinetic":[311],"assay":[312],"assessed":[313],"viability":[315],"Staphylococcus":[318],"(":[320],"MRSA)":[321],"K.":[323,361,399,426],"post-treatment":[325],"either":[329],"non-formulated":[331,490],"or":[332],"Results":[335],"show":[339],"time-dependent":[342],"manner,":[343],"higher":[345],"findings":[351],"without":[355],"formulation":[356],"MIC":[358,378,384,409],"values":[359],"killed":[360],"after":[363,389,428],"24":[364,429],"h":[365,393,430,442],"but":[366,495],"not":[367],"MRSA.":[368],"Our":[369],"loaded":[371],"mentioned":[375],"value":[379],"bactericidal":[381],"effect":[382,422],"18":[392],"incubation":[395],"against":[396,473],"MRSA":[397,424],",":[401],"respectively,":[402],"compared":[403],"free":[405,434],"combinations.":[406],"At":[407],"half":[408],"value,":[410],"increased":[412],"activity":[414,524],"cause":[419],"bacteriostatic":[421,438],"on":[423],"incubation.":[432],"impact":[439],"6":[441],"before":[443],"regrew":[446],"increase":[448],"log":[449],"10":[450],"colony":[451],"forming":[452],"unit":[453],"(CFU)/ml":[454],"over":[455],"initial":[457],"level.":[458],"Similarly,":[459],"cytotoxicity":[461,472],"decreased":[470],"kidney":[474],"epithelial":[475],"cells":[476],"African":[479],"green":[480],"monkey":[481],"(VERO)":[482],"cell":[483],"line.":[484],"IC":[486],"50":[487],"treatment":[491],"8.17/1.69":[493],"(\u00b5g/\u00b5g)/ml,":[494],"nano-emulsion,":[497],"it":[498],"22.94":[500],"+":[501],"4.77":[502],"(\u00b5g/\u00b5g)/mL.":[503],"conclusion,":[505],"efficient":[506],"may":[509],"be":[510],"promising":[512],"solution":[513],"fighting":[516],"ESKAPE":[518],"pathogenic":[519],"according":[521],"low":[526],"toxicity.":[527]},"counts_by_year":[{"year":2026,"cited_by_count":39},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-07-10T00:00:00"}