{"id":"https://openalex.org/W4400430684","doi":"https://doi.org/10.3389/fimmu.2024.1398153","title":"An early regulatory mechanism of hyperinflammation by restricting monocyte contribution","display_name":"An early regulatory mechanism of hyperinflammation by restricting monocyte contribution","publication_year":2024,"publication_date":"2024-07-08","ids":{"openalex":"https://openalex.org/W4400430684","doi":"https://doi.org/10.3389/fimmu.2024.1398153","pmid":"https://pubmed.ncbi.nlm.nih.gov/39040105","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11260625"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2024.1398153","doi":"https://doi.org/10.3389/fimmu.2024.1398153","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2024.1398153","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2024.1398153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008792449","display_name":"Megumi Akiyama","orcid":"https://orcid.org/0000-0002-8308-382X","observed_orcids":["https://orcid.org/0000-0002-8308-382X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Megumi Akiyama","raw_affiliation_strings":["Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","Department of Hematology, Graduate School of Medical and Dental Sciences, TMDU, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, TMDU, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082657971","display_name":"Masashi Kanayama","orcid":"https://orcid.org/0000-0001-8366-5275","observed_orcids":["https://orcid.org/0000-0001-8366-5275"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Kanayama","raw_affiliation_strings":["Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002230786","display_name":"Yoshihiro Umezawa","orcid":"https://orcid.org/0000-0003-1027-1552","observed_orcids":["https://orcid.org/0000-0003-1027-1552"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Umezawa","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, TMDU, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, TMDU, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071276592","display_name":"Toshikage Nagao","orcid":"https://orcid.org/0000-0002-1766-3842","observed_orcids":["https://orcid.org/0000-0002-1766-3842"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshikage Nagao","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, TMDU, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, TMDU, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064783343","display_name":"Yuta Izumi","orcid":"https://orcid.org/0000-0001-5816-3257","observed_orcids":["https://orcid.org/0000-0001-5816-3257"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Izumi","raw_affiliation_strings":["Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087127498","display_name":"Masahide Yamamoto","orcid":"https://orcid.org/0000-0002-3142-8806","observed_orcids":["https://orcid.org/0000-0002-3142-8806"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahide Yamamoto","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, TMDU, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, TMDU, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075597870","display_name":"Toshiaki Ohteki","orcid":"https://orcid.org/0000-0002-8088-5165","observed_orcids":["https://orcid.org/0000-0002-8088-5165"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshiaki Ohteki","raw_affiliation_strings":["Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075597870"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.7721,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.66617022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":null,"first_page":"1398153","last_page":"1398153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.392300009727478,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.392300009727478,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.27709999680519104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0925000011920929,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monocyte-apoptosis","display_name":"monocyte apoptosis","score":0.574999988079071},{"id":"https://openalex.org/keywords/hyperinflammation","display_name":"hyperinflammation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.8299999833106995},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.5529999732971191},{"id":"https://openalex.org/keywords/host-survival","display_name":"host survival","score":0.5}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.8314498662948608},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.786583423614502},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6491564512252808},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6476913690567017},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5972223281860352},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5532490611076355},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.46790632605552673},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.45484837889671326},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4404250681400299},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4317830801010132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3415336012840271}],"mesh":[{"descriptor_ui":"D000080424","descriptor_name":"Cytokine Release Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000080424","descriptor_name":"Cytokine Release Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2024.1398153","doi":"https://doi.org/10.3389/fimmu.2024.1398153","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2024.1398153","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11260625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11260625","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11260625/pdf/fimmu-15-1398153.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:39040105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39040105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:58dce29f44d34dada377f630ef1cf21c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/58dce29f44d34dada377f630ef1cf21c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2024.1398153","doi":"https://doi.org/10.3389/fimmu.2024.1398153","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2024.1398153","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8014203529","display_name":null,"funder_award_id":"JPMXP1323015483","funder_id":"https://openalex.org/F4320324799","funder_display_name":"Tokyo Medical and Dental University"}],"funders":[{"id":"https://openalex.org/F4320323514","display_name":"Daiichi Sankyo Foundation of Life Science","ror":"https://ror.org/05j492n53"},{"id":"https://openalex.org/F4320324799","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31"},{"id":"https://openalex.org/F4320325449","display_name":"Kanae Foundation for the Promotion of Medical Science","ror":null},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400430684.pdf","grobid_xml":"https://content.openalex.org/works/W4400430684.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W748993927","https://openalex.org/W1570257210","https://openalex.org/W1965616728","https://openalex.org/W1980109110","https://openalex.org/W1981127449","https://openalex.org/W2006380937","https://openalex.org/W2019749991","https://openalex.org/W2031084334","https://openalex.org/W2034915619","https://openalex.org/W2056411965","https://openalex.org/W2067290870","https://openalex.org/W2085099489","https://openalex.org/W2092885353","https://openalex.org/W2093981626","https://openalex.org/W2102790338","https://openalex.org/W2109357160","https://openalex.org/W2129261650","https://openalex.org/W2135703618","https://openalex.org/W2139366327","https://openalex.org/W2148994065","https://openalex.org/W2150781849","https://openalex.org/W2159197936","https://openalex.org/W2166819626","https://openalex.org/W2282724676","https://openalex.org/W2599353531","https://openalex.org/W2607819139","https://openalex.org/W2727765604","https://openalex.org/W2756071038","https://openalex.org/W2793787928","https://openalex.org/W2804159084","https://openalex.org/W2895707612","https://openalex.org/W2897945399","https://openalex.org/W2910046601","https://openalex.org/W2959092261","https://openalex.org/W2964500472","https://openalex.org/W2979807405","https://openalex.org/W2998853022","https://openalex.org/W3009885589","https://openalex.org/W3090648670","https://openalex.org/W3094121937","https://openalex.org/W3094957507","https://openalex.org/W3105908160","https://openalex.org/W3113375820","https://openalex.org/W3127051356","https://openalex.org/W3129461204","https://openalex.org/W3131897555","https://openalex.org/W4236842068","https://openalex.org/W4283013111","https://openalex.org/W4291021430","https://openalex.org/W4298616625","https://openalex.org/W4306408058","https://openalex.org/W4311201794","https://openalex.org/W4318670722","https://openalex.org/W4322603980","https://openalex.org/W4367040782","https://openalex.org/W4389935431"],"related_works":["https://openalex.org/W1972921777","https://openalex.org/W1999650493","https://openalex.org/W1481381887","https://openalex.org/W2162373031","https://openalex.org/W1971514874","https://openalex.org/W4245038898","https://openalex.org/W4400422878","https://openalex.org/W2034587781","https://openalex.org/W2070903118","https://openalex.org/W3203794898"],"abstract_inverted_index":{"Innate":[0],"immune":[1],"cells":[2],"play":[3],"a":[4,10,134,149,166,185],"key":[5],"role":[6],"in":[7,85,100,131,140],"inflammation":[8,22,152,175],"as":[9,165],"source":[11],"of":[12,38,43,53,61,67,91,108,115,123,136],"pro-inflammatory":[13,109,129],"cytokines.":[14],"However,":[15],"it":[16],"remains":[17],"unclear":[18],"how":[19],"innate":[20],"immunity-mediated":[21],"is":[23,55],"fine-tuned":[24],"to":[25,105,169],"minimize":[26],"tissue":[27,171],"damage":[28,172],"and":[29,79,111,176],"assure":[30],"the":[31,35,51,59,64,80,86,101,112,121,141],"host\u2019s":[32],"survival":[33],"at":[34],"early":[36],"phase":[37,66],"systemic":[39,118,151],"inflammation.":[40,62,119],"The":[41],"results":[42],"this":[44],"study":[45],"with":[46],"mouse":[47],"models":[48],"demonstrate":[49],"that":[50,189],"supply":[52,125],"monocytes":[54,82,137,163],"restricted":[56],"depending":[57],"on":[58,128],"magnitude":[60],"During":[63],"acute":[65],"severe":[68],"inflammation,":[69],"monocytes,":[70],"but":[71,96],"not":[72,191],"neutrophils,":[73],"were":[74,83],"substantially":[75],"reduced":[76],"by":[77,154,174,194],"apoptosis":[78,95],"remaining":[81],"dysfunctional":[84],"bone":[87,102],"marrow.":[88],"Monocyte-specific":[89],"ablation":[90],"Casp3/7":[92],"prevented":[93],"monocyte":[94,98,124],"promoted":[97],"necrosis":[99],"marrow,":[103],"leading":[104],"elevated":[106],"levels":[107],"cytokines":[110,130],"increased":[113],"mortality":[114],"mice":[116],"during":[117,144],"Importantly,":[120],"limitation":[122],"was":[126,138],"dependent":[127],"vivo.":[132],"Consistently,":[133],"reduction":[135],"observed":[139],"peripheral":[142],"blood":[143],"cytokine-release":[145],"syndrome":[146],"(CRS)":[147],"patients,":[148],"pathogen-unrelated":[150],"induced":[153],"chimeric":[155],"antigen":[156],"receptor-T":[157],"cell":[158],"(CAR-T":[159],"cell)":[160],"therapy.":[161],"Thus,":[162],"act":[164],"safety":[167],"valve":[168],"alleviate":[170],"caused":[173],"ensure":[177],"host":[178],"survival,":[179],"which":[180],"may":[181],"be":[182],"responsible":[183],"for":[184],"primitive":[186],"immune-control":[187],"mechanism":[188],"does":[190],"require":[192],"intervention":[193],"acquired":[195],"immunity.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-07-09T00:00:00"}
