{"id":"https://openalex.org/W4400430397","doi":"https://doi.org/10.25258/ijpqa.15.2.52","title":"Psidium guajava Linn Leaves Extracts: A Potential Digestive Enzyme Inhibitor in the Treatment of Obesity","display_name":"Psidium guajava Linn Leaves Extracts: A Potential Digestive Enzyme Inhibitor in the Treatment of Obesity","publication_year":2024,"publication_date":"2024-06-25","ids":{"openalex":"https://openalex.org/W4400430397","doi":"https://doi.org/10.25258/ijpqa.15.2.52"},"language":"en","primary_location":{"id":"doi:10.25258/ijpqa.15.2.52","doi":"https://doi.org/10.25258/ijpqa.15.2.52","is_oa":true,"landing_page_url":"https://doi.org/10.25258/ijpqa.15.2.52","pdf_url":"https://doi.org/10.25258/ijpqa.15.2.52","source":{"id":"https://openalex.org/S4210219243","display_name":"International Journal of Pharmaceutical Quality Assurance","issn_l":"0975-9506","issn":["0975-9506","2961-6093"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.25258/ijpqa.15.2.52","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049376332","display_name":"Shubhangi A. Patil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shubhangi A Patil","raw_affiliation_strings":["Department of Pharmacology , KIMS , KVV Deemed to be University , Karad , Maharashtra , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , KIMS , KVV Deemed to be University , Karad , Maharashtra , India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048229457","display_name":"Pratibha Satish Salve","orcid":"https://orcid.org/0000-0001-9050-5288","observed_orcids":["https://orcid.org/0000-0001-9050-5288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pratibha S Salve","raw_affiliation_strings":["Department of Pharmacology , KIMS , KVV Deemed to be University , Karad , Maharashtra , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , KIMS , KVV Deemed to be University , Karad , Maharashtra , India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038918596","display_name":"Jyotiram  Arjun Sawale","orcid":"https://orcid.org/0000-0002-8383-7249","observed_orcids":["https://orcid.org/0000-0002-8383-7249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jyotiram A Sawale","raw_affiliation_strings":["Department of Pharmacognosy , Krishna Institute of Pharmacy , KVV Deemed to be University , Karad , Maharashtra , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy , Krishna Institute of Pharmacy , KVV Deemed to be University , Karad , Maharashtra , India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083886994","display_name":"Niranjan Dattatray Chivate","orcid":"https://orcid.org/0000-0001-8859-1877","observed_orcids":["https://orcid.org/0000-0001-8859-1877"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niranjan D Chivate","raw_affiliation_strings":["Department of Pharmaceutics , KCT'S Krishna College of Pharmacy , Karad , Maharashtra , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics , KCT'S Krishna College of Pharmacy , Karad , Maharashtra , India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2368,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.39462157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":"02","first_page":"875","last_page":"879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14360","display_name":"Psidium guajava Extracts and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14360","display_name":"Psidium guajava Extracts and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guava","display_name":"guava","score":0.9990000128746033},{"id":"https://openalex.org/keywords/guava-leaf-extract","display_name":"guava leaf extract","score":0.925000011920929},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5730000138282776},{"id":"https://openalex.org/keywords/digestive-enzyme-inhibition","display_name":"digestive enzyme inhibition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/alpha-amylase-inhibition","display_name":"\u03b1-amylase inhibition","score":0.8870000243186951},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-lipase-inhibition","display_name":"pancreatic lipase inhibition","score":1.0},{"id":"https://openalex.org/keywords/hypolipidemic-activity","display_name":"hypolipidemic activity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.8700000047683716},{"id":"https://openalex.org/keywords/aqueous-and-methanolic-extracts","display_name":"aqueous and methanolic extracts","score":0.8159999847412109},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2778130027","wikidata":"https://www.wikidata.org/wiki/Q320179","display_name":"Psidium","level":2,"score":0.9020200967788696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6213676929473877},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.545546293258667},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.49598702788352966},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.42727023363113403},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35952028632164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3362865746021271},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.33553346991539},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3163183331489563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2615266740322113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21976923942565918},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06851533055305481}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25258/ijpqa.15.2.52","doi":"https://doi.org/10.25258/ijpqa.15.2.52","is_oa":true,"landing_page_url":"https://doi.org/10.25258/ijpqa.15.2.52","pdf_url":"https://doi.org/10.25258/ijpqa.15.2.52","source":{"id":"https://openalex.org/S4210219243","display_name":"International Journal of Pharmaceutical Quality Assurance","issn_l":"0975-9506","issn":["0975-9506","2961-6093"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.25258/ijpqa.15.2.52","doi":"https://doi.org/10.25258/ijpqa.15.2.52","is_oa":true,"landing_page_url":"https://doi.org/10.25258/ijpqa.15.2.52","pdf_url":"https://doi.org/10.25258/ijpqa.15.2.52","source":{"id":"https://openalex.org/S4210219243","display_name":"International Journal of Pharmaceutical Quality Assurance","issn_l":"0975-9506","issn":["0975-9506","2961-6093"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400430397.pdf","grobid_xml":"https://content.openalex.org/works/W4400430397.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2731596337","https://openalex.org/W4411288184","https://openalex.org/W4409385423","https://openalex.org/W7120656217","https://openalex.org/W3166169018","https://openalex.org/W7169649210","https://openalex.org/W2612427989","https://openalex.org/W4404048435","https://openalex.org/W4308543316","https://openalex.org/W4382793003"],"abstract_inverted_index":{"Obesity":[0],"is":[1,7],"a":[2],"major":[3],"worldwide":[4],"problem":[5],"and":[6,14,31,37,39,78,138,159],"associated":[8,100],"with":[9,23,49,101],"metabolic":[10],"disorders,":[11],"including":[12],"hyperglycemia":[13],"hyperlipidemia.":[15],"Many":[16],"researchers":[17],"focus":[18],"on":[19,63],"herbal":[20],"plants":[21],"rich":[22],"polyphenols":[24],"are":[25],"potent":[26],"inhibitors":[27],"of":[28,52,56,89],"digestive":[29,64],"enzymes":[30,99],"could":[32],"be":[33],"used":[34],"as":[35],"antihyperlipidemic":[36],"antihyperglycemic":[38],"hence":[40],"useful":[41],"in":[42],"obesity":[43,102],"treatment.":[44],"The":[45,86,104,176],"present":[46],"work":[47],"deals":[48],"the":[50,53,117,127,139,149,160],"determination":[51],"inhibitory":[54,177],"effect":[55],"Psidium":[57],"guajava":[58,91],"Linn":[59],"(Guava)":[60],"leaves":[61],"extract":[62,106,119,129,141,151,162],"enzymes.":[65,185],"Our":[66],"findings":[67],"confirmed":[68],"that":[69],"guava":[70],"leaf":[71,87],"extracts":[72,88],"inhibit":[73],"two":[74],"primary":[75],"enzymes,":[76],"\u03b1-amylase":[77,131],"\u03b1-glucosidase.":[79],"Similarly,":[80],"investigated":[81],"pancreatic":[82,108],"lipase":[83,109],"inhibition":[84,110,121,132,143,154,164],"potential.":[85],"P.":[90],"demonstrated":[92,152],"significant":[93],"anti-obesity":[94],"properties":[95],"by":[96],"inhibiting":[97],"key":[98],"development.":[103],"aqueous":[105,128,150],"exhibited":[107],"ranging":[111,133,165],"from":[112,134,166],"19.25":[113],"to":[114,124,136,146,157,168,172],"38.51%,":[115],"while":[116],"methanolic":[118,140,161],"showed":[120,142],"between":[122,144,155],"22.96":[123],"46.66%.":[125],"Additionally,":[126],"displayed":[130,163],"43.10":[135],"62.06%,":[137],"48.27":[145],"62.06%.":[147],"Moreover,":[148],"\u03b1-glucosidase":[153],"13.11":[156],"49.18%,":[158],"29.50":[167],"60.65%":[169],"for":[170,182],"200":[171],"1000":[173],"\u03bcg/mL":[174],"concentrations.":[175],"activity":[178],"observed":[179],"was":[180],"dosedependent":[181],"all":[183],"three":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-09T00:00:00"}