{"id":"https://openalex.org/W4400414892","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e16179","title":"Liquid biopsy-based prediction of clinical benefit from immune checkpoint inhibitors in advanced biliary tract cancer.","display_name":"Liquid biopsy-based prediction of clinical benefit from immune checkpoint inhibitors in advanced biliary tract cancer.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4400414892","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e16179"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.e16179","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e16179","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.e16179","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.16_suppl.e16179","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.16_suppl.e16179","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030995808","display_name":"Nan Zhang","orcid":"https://orcid.org/0009-0007-5445-5771","observed_orcids":["https://orcid.org/0009-0007-5445-5771"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Zhang","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yunchao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunchao Wang","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048783249","display_name":"Mingming Yuan","orcid":"https://orcid.org/0000-0001-5475-7736","observed_orcids":["https://orcid.org/0000-0001-5475-7736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingming Yuan","raw_affiliation_strings":["Geneplus-Beijing, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geneplus-Beijing, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102006926","display_name":"Jing Shao","orcid":"https://orcid.org/0000-0002-2500-2366","observed_orcids":["https://orcid.org/0000-0002-2500-2366"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Shao","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734556","display_name":"Rongrong Chen","orcid":"https://orcid.org/0000-0002-4489-4179","observed_orcids":["https://orcid.org/0000-0002-4489-4179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rongrong Chen","raw_affiliation_strings":["Geneplus-Beijing, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geneplus-Beijing, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102939707","display_name":"Mingjian Piao","orcid":"https://orcid.org/0009-0005-4981-5942","observed_orcids":["https://orcid.org/0009-0005-4981-5942"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingjian Piao","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114188494","display_name":"Jiongyuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiongyuan Li","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026752395","display_name":"Chengjie Li","orcid":"https://orcid.org/0000-0001-5602-6566","observed_orcids":["https://orcid.org/0000-0001-5602-6566","https://orcid.org/0000-0002-7739-1367","https://orcid.org/0009-0005-6833-7579"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengjie Li","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425554","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-3617-2627","observed_orcids":["https://orcid.org/0000-0002-3617-2627","https://orcid.org/0000-0003-2756-2620","https://orcid.org/0009-0001-8129-4308"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longhao Zhang","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059650831","display_name":"Jingnan Xue","orcid":"https://orcid.org/0000-0003-0548-1862","observed_orcids":["https://orcid.org/0000-0003-0548-1862"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingnan Xue","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780541","display_name":"Yanyu Wang","orcid":"https://orcid.org/0000-0003-3365-3262","observed_orcids":["https://orcid.org/0000-0003-3365-3262"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyu Wang","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061600552","display_name":"Ziyu Xun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyu Xun","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406237","display_name":"Shanshan Wang","orcid":"https://orcid.org/0000-0002-0575-6523","observed_orcids":["https://orcid.org/0000-0002-0575-6523"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Wang","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427550","display_name":"Yiran Li","orcid":"https://orcid.org/0000-0002-4704-8728","observed_orcids":["https://orcid.org/0000-0002-4704-8728"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiran Li","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104020381","display_name":"Huishan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huishan Sun","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018965590","display_name":"Hanping Wang","orcid":"https://orcid.org/0000-0003-3540-2280","observed_orcids":["https://orcid.org/0000-0003-3540-2280"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanping Wang","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, State Key Laboratory of Severe and Rare Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, State Key Laboratory of Severe and Rare Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085589805","display_name":"Haitao Zhao","orcid":"https://orcid.org/0000-0002-3444-8044","observed_orcids":["https://orcid.org/0000-0002-3444-8044"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Tao Zhao","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"e16179","last_page":"e16179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-biliary-tract-cancer","display_name":"advanced biliary tract cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.796999990940094},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.7450000047683716},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/leukocyte-transcriptome","display_name":"leukocyte transcriptome","score":0.7720000147819519},{"id":"https://openalex.org/keywords/immune-cell-deconvolution","display_name":"immune cell deconvolution","score":0.9210000038146973},{"id":"https://openalex.org/keywords/progression-free-survival-prediction","display_name":"progression-free survival prediction","score":0.7490000128746033},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8560000061988831},{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/first-line-immunotherapy","display_name":"first-line immunotherapy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cell-free-dna-sequencing","display_name":"cell-free DNA sequencing","score":0.7839999794960022},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.856226921081543},{"id":"https://openalex.org/C3017919176","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Biliary tract cancer","level":4,"score":0.739905595779419},{"id":"https://openalex.org/C2775982439","wikidata":"https://www.wikidata.org/wiki/Q3562150","display_name":"Biliary tract","level":2,"score":0.5746796131134033},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5229295492172241},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.4831530451774597},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4426164925098419},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4200056791305542},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41786524653434753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41567811369895935},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33772552013397217},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2815074622631073},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23557040095329285},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.12261271476745605}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.e16179","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e16179","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.e16179","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.16_suppl.e16179","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.e16179","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e16179","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.e16179","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.16_suppl.e16179","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400414892.pdf","grobid_xml":"https://content.openalex.org/works/W4400414892.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4283724763","https://openalex.org/W7162630322","https://openalex.org/W4393087079","https://openalex.org/W3128409629","https://openalex.org/W3048388428","https://openalex.org/W4388423150","https://openalex.org/W4410814306","https://openalex.org/W3133754393","https://openalex.org/W7162309345","https://openalex.org/W4379333518"],"abstract_inverted_index":{"e16179":[0],"Background:":[1],"Immune":[2],"checkpoint":[3],"inhibitors":[4],"(ICIs)":[5],"show":[6],"promising":[7],"efficacy":[8],"as":[9,43],"first-line":[10,45],"therapy":[11,42],"for":[12,220],"advanced":[13],"biliary":[14],"tract":[15],"cancer":[16],"(aBTC),":[17],"but":[18],"validated":[19],"predictive":[20],"biomarkers":[21,29],"are":[22,319],"lacking.":[23],"Here,":[24],"we":[25],"identified":[26],"liquid":[27,293],"biopsy-based":[28,294],"and":[30,61,92,137,152,164,184,232,310,316],"developed":[31],"a":[32,212,217,225,243,270],"prediction":[33],"model.":[34],"Methods:":[35],"aBTC":[36],"patients":[37,170,187],"who":[38],"received":[39],"ICIs-based":[40],"combination":[41],"the":[44,59,83,89,104,115,130,138,160,201,288],"treatment":[46],"were":[47,56,156,171,188,209,239],"prospectively":[48],"enrolled":[49],"in":[50,144,304],"this":[51,292,312],"study":[52],"(NCT06074029).":[53],"Plasma":[54],"samples":[55],"collected":[57],"before":[58],"first":[60],"second":[62],"immunotherapy":[63],"infusion":[64],"to":[65,128,158,198,241,247,297],"perform":[66],"cell-free":[67],"DNA":[68,76],"(cfDNA)":[69],"sequencing":[70],"of":[71,141,186,261,281,291],"1021":[72],"genes.":[73],"Circulating":[74],"tumor":[75],"(ctDNA)":[77],"concentration":[78,91,102],"was":[79,96,112,121,146,181,193],"calculated":[80,97],"by":[81,88,98,103],"multiplying":[82],"mean":[84],"variant":[85],"allele":[86],"frequency":[87],"cfDNA":[90,116],"ctDNA":[93,101,106,227],"fold":[94,228],"change":[95],"dividing":[99],"on-treatment":[100],"pre-treatment":[105],"concentration.":[107,117],"Tumor":[108],"mutation":[109],"burden":[110],"(TMB)":[111],"normalized":[113],"using":[114,133,148,216],"In":[118],"addition,":[119],"RNA":[120],"extracted":[122],"from":[123,251,302],"peripheral":[124],"blood":[125],"mononuclear":[126],"cells":[127,143],"profile":[129],"leukocyte":[131],"transcriptome":[132,135],"whole":[134],"sequencing,":[136],"relative":[139],"proportions":[140],"immune":[142],"leukocytes":[145],"deconvoluted":[147],"CIBERSORT":[149],"algorithm.":[150],"Log-rank":[151],"univariate":[153],"Cox":[154,214],"regression":[155,215,245],"used":[157,240],"evaluate":[159],"relationship":[161],"between":[162],"features":[163],"progression-free":[165],"survival":[166],"(PFS).":[167],"Results:":[168],"37":[169],"enrolled,":[172],"with":[173,200,273,314],"62.2%":[174],"having":[175],"intrahepatic":[176],"cholangiocarcinoma.":[177],"The":[178,190,253],"median":[179,191],"age":[180],"61":[182],"years":[183],"54.1%":[185],"females.":[189],"PFS":[192,199,257],"4.4":[194],"months.":[195],"Variables":[196],"related":[197],"log-rank":[202],"p":[203],"value":[204],"smaller":[205],"than":[206],"0.05":[207],"(Table)":[208],"entered":[210],"into":[211],"multivariate":[213],"stepwise":[218],"approach":[219],"final":[221],"variable":[222],"selection.":[223],"As":[224],"result,":[226],"change,":[229],"KRAS":[230],"mutation,":[231],"resting":[233],"memory":[234],"CD4":[235],"T":[236],"cell":[237],"level":[238],"construct":[242],"COX":[244],"model":[246,254,296,313],"predict":[248,299],"clinical":[249],"benefit":[250,301],"ICIs.":[252],"predicting":[255],"6-month":[256],"demonstrated":[258],"an":[259,277],"AUC":[260,279],"0.909":[262],"(95%":[263],"CI,":[264],"0.795-1.024).":[265],"Internal":[266],"validation,":[267],"performed":[268],"through":[269],"bootstrap":[271],"analysis":[272],"100":[274],"iterations,":[275],"yielded":[276],"optimism-adjusted":[278],"estimate":[280],"0.859.":[282],"Conclusions:":[283],"Our":[284],"preliminary":[285],"results":[286],"support":[287],"excellent":[289],"performance":[290],"multivariable":[295],"early":[298],"durable":[300],"ICIs":[303],"aBTC.":[305],"A":[306],"large":[307],"sample":[308],"size":[309],"verifying":[311],"internal":[315],"external":[317],"data":[318],"warranted.":[320],"Clinical":[321],"trial":[322],"information:":[323],"NCT06074029":[324],".":[325],"[Table:":[326],"see":[327],"text]":[328]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2024-07-09T00:00:00"}
