{"id":"https://openalex.org/W4400412290","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e17540","title":"Multiomic analysis in ovarian clear cell carcinoma to gain insight into biology and therapeutic opportunities.","display_name":"Multiomic analysis in ovarian clear cell carcinoma to gain insight into biology and therapeutic opportunities.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4400412290","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e17540"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.e17540","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e17540","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e17540","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054914416","display_name":"Ben L. Kong","orcid":"https://orcid.org/0000-0002-9019-6961","observed_orcids":["https://orcid.org/0000-0002-9019-6961"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Kong","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077154295","display_name":"Jayne M. Stommel","orcid":"https://orcid.org/0000-0003-2485-7992","observed_orcids":["https://orcid.org/0000-0003-2485-7992"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayne Stommel","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083096762","display_name":"Jenna B Emerson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna Emerson","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006264852","display_name":"Elizabeth G. Munro","orcid":"https://orcid.org/0000-0002-3553-3013","observed_orcids":["https://orcid.org/0000-0002-3553-3013"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth G. Munro","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026593581","display_name":"Christopher L. Corless","orcid":"https://orcid.org/0000-0003-4871-8364","observed_orcids":["https://orcid.org/0000-0003-4871-8364"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Corless","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069625939","display_name":"Tanja B. Pejovic","orcid":"https://orcid.org/0000-0001-8537-1086","observed_orcids":["https://orcid.org/0000-0001-8537-1086"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanja Pejovic","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"e17540","last_page":"e17540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-clear-cell-carcinoma","display_name":"ovarian clear cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/her2-expression","display_name":"HER2 expression","score":0.8550000190734863},{"id":"https://openalex.org/keywords/her2-amplification","display_name":"HER2 amplification","score":0.9869999885559082},{"id":"https://openalex.org/keywords/trastuzumab-deruxtecan","display_name":"trastuzumab deruxtecan","score":0.9779999852180481},{"id":"https://openalex.org/keywords/her2-antibody-drug-conjugate","display_name":"HER2 antibody-drug conjugate","score":0.8989999890327454},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6909999847412109},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.6420000195503235},{"id":"https://openalex.org/keywords/arid1a-mutation","display_name":"ARID1A mutation","score":0.753000020980835},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.843999981880188},{"id":"https://openalex.org/keywords/chromosome-loss","display_name":"chromosome loss","score":0.5839999914169312},{"id":"https://openalex.org/keywords/metastatic-ovarian-cancer","display_name":"metastatic ovarian cancer","score":0.578000009059906},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.4309999942779541},{"id":"https://openalex.org/keywords/nanostring-geomx","display_name":"NanoString GeoMx","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6739673018455505},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.5686609745025635},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5457704067230225},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4965699315071106},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4533391296863556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4134577512741089},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3201013207435608},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2359321117401123}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.e17540","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e17540","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e17540","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7160273099","https://openalex.org/W4312139746","https://openalex.org/W3172828713","https://openalex.org/W4386506157","https://openalex.org/W2096389012","https://openalex.org/W4379768006","https://openalex.org/W4400412146","https://openalex.org/W2966545163","https://openalex.org/W3025681141","https://openalex.org/W7219615692"],"abstract_inverted_index":{"e17540":[0],"Background:":[1],"Ovarian":[2],"clear":[3],"cell":[4],"carcinoma":[5],"(OCCC)":[6],"is":[7,39,311],"a":[8,81,164],"rare":[9],"subtype":[10],"with":[11,23,128,224,229,269,279,294],"distinct":[12],"histologic":[13],"and":[14,28,48,78,106,114,155,158,213,215,320,331],"molecular":[15],"features.":[16],"The":[17,264],"prognosis":[18],"of":[19,25,109,132,300,317,326,335],"advanced/recurrent":[20],"OCCC":[21,273,329],"treated":[22,228,293],"standard":[24],"care":[26],"surgery":[27],"platinum-based":[29],"chemotherapy":[30],"remains":[31],"poor":[32],"due":[33],"to":[34,43,52,59,163,191,313],"inherent":[35],"chemoresistance.":[36],"Therefore,":[37],"there":[38],"an":[40,129,250],"urgent":[41],"need":[42],"identify":[44],"novel":[45],"biological":[46],"insights":[47],"personalized":[49],"treatment":[50],"approaches":[51],"improve":[53],"outcomes.":[54],"Methods:":[55],"Participants":[56],"were":[57,126,227],"referred":[58],"the":[60,64,117,174,315,324,332],"SMMART":[61],"Program":[62],"at":[63],"OHSU":[65],"Knight":[66],"Cancer":[67],"Institute.":[68],"Archival":[69],"or":[70,235,280],"fresh":[71],"tissue":[72],"was":[73,267],"obtained":[74],"from":[75],"metastatic":[76],"sites":[77],"processed":[79],"through":[80],"multiomics":[82],"platform":[83],"that":[84],"included":[85,140],"immunohistochemistry":[86],"(Ki67,":[87],"HER2,":[88],"CD4,":[89],"CD8,":[90],"PD-L1),":[91],"fluorescent":[92],"in-situ":[93],"hybridization,":[94],"targeted":[95],"next-generation":[96],"sequencing":[97],"panel":[98],"(225":[99],"genes),":[100],"whole":[101],"transcriptomic":[102],"sequencing,":[103],"chromosomal":[104,207],"microarray,":[105],"multiplexed":[107],"analysis":[108],"67":[110],"key":[111],"cancer":[112,166],"proteins":[113],"phosphoproteins":[115],"on":[116,328],"Nanostring":[118],"GeoMx":[119],"Digital":[120],"Spatial":[121],"Profiler.":[122],"Results:":[123],"5":[124],"participants":[125,223,288],"enrolled":[127],"average":[130],"age":[131],"62":[133],"years":[134],"(range":[135],"52-72).":[136],"Therapeutically":[137],"relevant":[138],"findings":[139,178],"detectable":[141],"HER2":[142,150,157,171,225,277,301,318,327,337],"expression":[143,161,226,278],"by":[144,152],"IHC":[145],"(2+,":[146],"N=2;":[147],"3+,":[148,246],"N=2),":[149],"amplification":[151,283,321],"FISH":[153,247,259],"(N=2),":[154],"high":[156],"phospho-HER2":[159],"protein":[160],"compared":[162],"breast":[165],"cohort":[167,274],"(phospho-HER2":[168],"supports":[169],"active":[170],"signaling":[172],"in":[173,219,284,305,322,338],"tumor":[175],"cells).":[176],"Additional":[177],"include":[179],"TMB":[180],"<10":[181],"muts/Mb":[182],"(N=5),":[183,186],"microsatellite":[184],"stable":[185,262],"Ki67":[187],"40-60%":[188],"(N=4),":[189,197,206],"mild":[190],"moderate":[192],"CD4":[193],"and/or":[194],"CD8":[195],"infiltration":[196],"PD-L1":[198],">1%":[199],"(N=3),":[200],"low":[201],"homologous":[202],"recombination":[203],"deficiency":[204],"score":[205],"losses":[208],"including":[209],"ATM,":[210],"SMAD4,":[211],"RB1,":[212],"TP53,":[214],"single":[216],"nucleotide":[217],"variations":[218],"ARID1A":[220],"(N=4).":[221],"Two":[222,287],"off-label":[230],"trastuzumab":[231,295],"deruxtecan":[232],"for":[233],"6":[234],"7":[236],"cycles":[237],"yielding":[238],"significant":[239],"clinical":[240,290],"benefit.":[241],"Participant":[242,254],"A":[243],"(HER2":[244,256],"=":[245,257],"negative)":[248],"had":[249,261],"exceptional":[251],"response":[252],"while":[253],"B":[255],"2+,":[258],"amplified)":[260],"disease.":[263,308],"toxicity":[265],"profile":[266],"consistent":[268],"literature.":[270],"Conclusions:":[271],"Our":[272],"revealed":[275],"elevated":[276],"without":[281],"genomic":[282],"4/5":[285],"cases.":[286],"experienced":[289],"benefit":[291,334],"when":[292],"deruxtecan,":[296],"supporting":[297],"further":[298],"exploration":[299],"antibody":[302],"drug":[303],"conjugates":[304],"this":[306,339],"aggressive":[307],"More":[309],"study":[310],"needed":[312],"determine":[314],"frequency":[316],"overexpression":[319],"OCCC,":[323],"importance":[325],"pathophysiology,":[330],"therapeutic":[333],"targeting":[336],"population.":[340]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2024-07-09T00:00:00"}