{"id":"https://openalex.org/W4400367342","doi":"https://doi.org/10.1002/jmv.29783","title":"Attenuated replication and damaging effects of SARS\u2010CoV\u20102 Omicron variants in an intestinal epithelial barrier model","display_name":"Attenuated replication and damaging effects of SARS\u2010CoV\u20102 Omicron variants in an intestinal epithelial barrier model","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4400367342","doi":"https://doi.org/10.1002/jmv.29783","pmid":"https://pubmed.ncbi.nlm.nih.gov/38965890"},"language":"en","primary_location":{"id":"doi:10.1002/jmv.29783","doi":"https://doi.org/10.1002/jmv.29783","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmv.29783","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.29783","source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.29783","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026282881","display_name":"Meta Vol\u010di\u010d","orcid":"https://orcid.org/0000-0001-6406-7683","observed_orcids":["https://orcid.org/0000-0001-6406-7683"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Meta Volcic","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6406-7683","affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011102619","display_name":"Rayhane Nchioua","orcid":"https://orcid.org/0009-0001-1436-1232","observed_orcids":["https://orcid.org/0009-0001-1436-1232"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rayhane Nchioua","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042275453","display_name":"Chiara Pastorio","orcid":"https://orcid.org/0000-0002-4745-3678","observed_orcids":["https://orcid.org/0000-0002-4745-3678"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Chiara Pastorio","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025948942","display_name":"Fabian Zech","orcid":"https://orcid.org/0000-0002-1668-8060","observed_orcids":["https://orcid.org/0000-0002-1668-8060"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Zech","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092087292","display_name":"Isabell Hau\u00dfmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Isabell Hau\u00dfmann","raw_affiliation_strings":["Institute for Medical Virology and Epidemiology of Viral Diseases University Hospital T\u00fcbingen T\u00fcbingen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Virology and Epidemiology of Viral Diseases University Hospital T\u00fcbingen T\u00fcbingen Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel Sauter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Sauter","raw_affiliation_strings":["Institute for Medical Virology and Epidemiology of Viral Diseases University Hospital T\u00fcbingen T\u00fcbingen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Virology and Epidemiology of Viral Diseases University Hospital T\u00fcbingen T\u00fcbingen Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084193924","display_name":"Clarissa Read","orcid":"https://orcid.org/0000-0002-4632-2684","observed_orcids":["https://orcid.org/0000-0002-4632-2684"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clarissa Read","raw_affiliation_strings":["Central Facility for Electron Microscopy, Ulm University, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Facility for Electron Microscopy, Ulm University, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022410156","display_name":"Paul Walther","orcid":"https://orcid.org/0000-0002-4080-5685","observed_orcids":["https://orcid.org/0000-0002-4080-5685"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paul Walther","raw_affiliation_strings":["Central Facility for Electron Microscopy, Ulm University, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Facility for Electron Microscopy, Ulm University, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075006919","display_name":"Frank Kirchhoff","orcid":"https://orcid.org/0000-0002-7052-2360","observed_orcids":["https://orcid.org/0000-0002-7052-2360"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank Kirchhoff","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7052-2360","affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026282881","https://openalex.org/A5075006919"],"corresponding_institution_ids":["https://openalex.org/I4210155144"],"apc_list":{"value":4420,"currency":"USD","value_usd":4420},"apc_paid":{"value":4420,"currency":"USD","value_usd":4420},"fwci":2.8411,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.90921663,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"96","issue":"7","first_page":"e29783","last_page":"e29783"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omicron-variant","display_name":"Omicron variant","score":0.9350000023841858},{"id":"https://openalex.org/keywords/intestinal-epithelial-barrier","display_name":"intestinal epithelial barrier","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.6520000100135803},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/claudin-1","display_name":"claudin-1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/raji-cells","display_name":"Raji cells","score":0.7879999876022339},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6480000019073486},{"id":"https://openalex.org/keywords/long-covid","display_name":"long COVID","score":0.6209999918937683},{"id":"https://openalex.org/keywords/gastrointestinal-symptoms","display_name":"gastrointestinal symptoms","score":0.9419999718666077},{"id":"https://openalex.org/keywords/remdesivir","display_name":"remdesivir","score":0.8820000290870667},{"id":"https://openalex.org/keywords/camostat","display_name":"camostat","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cathepsin-inhibitors","display_name":"cathepsin inhibitors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/delta-variant","display_name":"Delta variant","score":0.6899999976158142},{"id":"https://openalex.org/keywords/viral-pathogenesis","display_name":"viral pathogenesis","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.8257042169570923},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.8244684338569641},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.8192283511161804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6410568356513977},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5116460919380188},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.4989166259765625},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.4452376663684845},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.44105035066604614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4340302050113678},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4282432198524475},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4265408515930176},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.4130759537220001},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2638525366783142},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.1773267686367035},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.118929922580719},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0795125961303711},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D062793","descriptor_name":"Occludin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062793","descriptor_name":"Occludin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/jmv.29783","doi":"https://doi.org/10.1002/jmv.29783","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmv.29783","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.29783","source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"doi:10.1101/2024.02.28.582510","doi":"https://doi.org/10.1101/2024.02.28.582510","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.02.28.582510","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38965890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38965890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Journal Article"},{"id":"pmh:oai:oparu.uni-ulm.de:123456789/58618","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-58618-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400353","display_name":"OPen Access Repositorium der Universit\u00e4t Ulm (OPARU) (Ulm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I196349391","host_organization_name":"Universit\u00e4t Ulm","host_organization_lineage":["https://openalex.org/I196349391"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:article"}],"best_oa_location":{"id":"doi:10.1002/jmv.29783","doi":"https://doi.org/10.1002/jmv.29783","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmv.29783","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.29783","source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1195029094","display_name":null,"funder_award_id":"CRC-1279","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1861563813","display_name":null,"funder_award_id":"CRC 1279","funder_id":"https://openalex.org/F4320325530","funder_display_name":"Universit\u00e4t Ulm"},{"id":"https://openalex.org/G4920106867","display_name":null,"funder_award_id":"SA 2676/3\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320324900","display_name":"Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn","ror":"https://ror.org/041nas322"},{"id":"https://openalex.org/F4320325530","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400367342.pdf","grobid_xml":"https://content.openalex.org/works/W4400367342.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1965082410","https://openalex.org/W1989543512","https://openalex.org/W2004051909","https://openalex.org/W2020337923","https://openalex.org/W2029101220","https://openalex.org/W2053117473","https://openalex.org/W2085248976","https://openalex.org/W2085355903","https://openalex.org/W2091369121","https://openalex.org/W2095871783","https://openalex.org/W2120950548","https://openalex.org/W2563634412","https://openalex.org/W2766325864","https://openalex.org/W3008636104","https://openalex.org/W3009912996","https://openalex.org/W3015554176","https://openalex.org/W3023334190","https://openalex.org/W3024312732","https://openalex.org/W3045925312","https://openalex.org/W3046021561","https://openalex.org/W3081842677","https://openalex.org/W3095430612","https://openalex.org/W3095861979","https://openalex.org/W3096967708","https://openalex.org/W3100328380","https://openalex.org/W3111190823","https://openalex.org/W3118681094","https://openalex.org/W3132877309","https://openalex.org/W3133812656","https://openalex.org/W3136739124","https://openalex.org/W3137882953","https://openalex.org/W3151076337","https://openalex.org/W3157249971","https://openalex.org/W3160137998","https://openalex.org/W3163104912","https://openalex.org/W3183430591","https://openalex.org/W3184810728","https://openalex.org/W3197084797","https://openalex.org/W3205365352","https://openalex.org/W3205686334","https://openalex.org/W4210360899","https://openalex.org/W4210665241","https://openalex.org/W4211165282","https://openalex.org/W4213308264","https://openalex.org/W4214725635","https://openalex.org/W4214849431","https://openalex.org/W4220953727","https://openalex.org/W4221107345","https://openalex.org/W4223453653","https://openalex.org/W4223603433","https://openalex.org/W4225117868","https://openalex.org/W4225297238","https://openalex.org/W4225699259","https://openalex.org/W4280575933","https://openalex.org/W4295777530","https://openalex.org/W4297540272","https://openalex.org/W4307836382","https://openalex.org/W4307985186","https://openalex.org/W4309306496","https://openalex.org/W4313890541","https://openalex.org/W4323043940","https://openalex.org/W4323359837","https://openalex.org/W4324376274","https://openalex.org/W4328109460","https://openalex.org/W4361029841","https://openalex.org/W4366680015","https://openalex.org/W4376872235","https://openalex.org/W4380480194","https://openalex.org/W4387952733","https://openalex.org/W4390660454"],"related_works":["https://openalex.org/W4225117868","https://openalex.org/W4387704627","https://openalex.org/W4225297238","https://openalex.org/W3096835549","https://openalex.org/W4328109460","https://openalex.org/W3110108935","https://openalex.org/W4307773589","https://openalex.org/W3131517051","https://openalex.org/W4392858262","https://openalex.org/W4200625712"],"abstract_inverted_index":{"Many":[0],"COVID-19":[1],"patients":[2],"suffer":[3],"from":[4,119],"gastrointestinal":[5],"symptoms":[6],"and":[7,57,78,89,101,110,130,138,149],"impaired":[8],"intestinal":[9,36,47,75,167],"barrier":[10,48,76,99,131,152,168],"function":[11,169],"is":[12,38,79],"thought":[13],"to":[14,82],"play":[15],"a":[16],"key":[17],"role":[18],"in":[19],"Long":[20],"COVID.":[21],"Despite":[22],"its":[23],"importance,":[24],"the":[25,90,134,139,155],"impact":[26],"of":[27,67,87],"severe":[28],"acute":[29],"respiratory":[30],"syndrome":[31],"coronavirus":[32],"2":[33,143],"(SARS-CoV-2)":[34],"on":[35,127],"epithelia":[37],"poorly":[39],"understood.":[40],"To":[41],"address":[42],"this,":[43],"we":[44],"established":[45],"an":[46],"model":[49,63],"integrating":[50],"epithelial":[51,62,151],"Caco-2":[52,68],"cells,":[53,72],"mucus-secreting":[54],"HT29":[55],"cells":[56,69],"Raji":[58],"cells.":[59],"This":[60],"gut":[61],"allows":[64],"efficient":[65],"differentiation":[66],"into":[70],"microfold-like":[71],"faithfully":[73],"mimics":[74],"function,":[77,100],"highly":[80],"permissive":[81],"SARS-CoV-2":[83,88,147,165],"infection.":[84],"Early":[85],"strains":[86],"Delta":[91],"variant":[92],"replicated":[93],"with":[94],"high":[95],"efficiency,":[96],"severely":[97],"disrupted":[98],"depleted":[102,117],"tight":[103,120],"junction":[104],"proteins,":[105],"such":[106],"as":[107],"claudin-1,":[108],"occludin,":[109],"ZO-1.":[111],"In":[112],"comparison,":[113],"Omicron":[114,175],"subvariants":[115],"also":[116],"ZO-1":[118],"junctions":[121],"but":[122,170],"had":[123],"fewer":[124],"damaging":[125,179],"effects":[126],"mucosal":[128],"integrity":[129],"function.":[132],"Remdesivir,":[133],"fusion":[135],"inhibitor":[136,144,157],"EK1":[137],"transmembrane":[140],"serine":[141],"protease":[142],"Camostat":[145],"inhibited":[146],"replication":[148],"thus":[150],"damage,":[153],"while":[154],"Cathepsin":[156],"E64d":[158],"was":[159],"ineffective.":[160],"Our":[161],"results":[162],"support":[163],"that":[164,173],"disrupts":[166],"further":[171],"suggest":[172],"circulating":[174],"variants":[176],"are":[177],"less":[178],"than":[180],"earlier":[181],"viral":[182],"strains.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-06T00:00:00"}