{"id":"https://openalex.org/W4400344904","doi":"https://doi.org/10.1016/j.stemcr.2026.102933","title":"Chromosome X dosage modulates development of aneuploidy in genetically diverse mouse embryonic stem cells","display_name":"Chromosome X dosage modulates development of aneuploidy in genetically diverse mouse embryonic stem cells","publication_year":2026,"publication_date":"2026-06-09","ids":{"openalex":"https://openalex.org/W4400344904","doi":"https://doi.org/10.1016/j.stemcr.2026.102933","pmid":"https://pubmed.ncbi.nlm.nih.gov/42263679","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13385727"},"language":"en","primary_location":{"id":"doi:10.1016/j.stemcr.2026.102933","doi":"https://doi.org/10.1016/j.stemcr.2026.102933","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2026.102933","pdf_url":null,"source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.stemcr.2026.102933","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000694007","display_name":"Alexander R. Stanton","orcid":"https://orcid.org/0000-0003-0139-979X","observed_orcids":["https://orcid.org/0000-0003-0139-979X"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Stanton","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA; Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 021111, USA","The Jackson Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA; Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 021111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017451446","display_name":"Selcan Aydin","orcid":"https://orcid.org/0000-0002-0457-9641","observed_orcids":["https://orcid.org/0000-0002-0457-9641"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selcan Aydin","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA","The Jackson Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041831032","display_name":"Daniel A. Skelly","orcid":"https://orcid.org/0000-0002-2329-2216","observed_orcids":["https://orcid.org/0000-0002-2329-2216"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Skelly","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA","The Jackson Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tracy McGarr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Tracy McGarr","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA","University of Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031800936","display_name":"Dylan Stavish","orcid":"https://orcid.org/0000-0002-1441-2028","observed_orcids":["https://orcid.org/0000-0002-1441-2028"]},"institutions":[{"id":"https://openalex.org/I1313839066","display_name":"WiCell","ror":"https://ror.org/032ycrz75","country_code":"US","type":"facility","lineage":["https://openalex.org/I1313839066"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Dylan Stavish","raw_affiliation_strings":["Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK","WiCell Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"WiCell Research Institute","institution_ids":["https://openalex.org/I1313839066"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kim Leonhard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313839066","display_name":"WiCell","ror":"https://ror.org/032ycrz75","country_code":"US","type":"facility","lineage":["https://openalex.org/I1313839066"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Leonhard","raw_affiliation_strings":["WiCell, Madison, WI 53719, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WiCell, Madison, WI 53719, USA","institution_ids":["https://openalex.org/I1313839066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054220851","display_name":"Seth M. Taapken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313839066","display_name":"WiCell","ror":"https://ror.org/032ycrz75","country_code":"US","type":"facility","lineage":["https://openalex.org/I1313839066"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth Taapken","raw_affiliation_strings":["WiCell, Madison, WI 53719, USA","Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WiCell, Madison, WI 53719, USA","institution_ids":["https://openalex.org/I1313839066"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111584920","display_name":"Tenneille E. Ludwig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313839066","display_name":"WiCell","ror":"https://ror.org/032ycrz75","country_code":"US","type":"facility","lineage":["https://openalex.org/I1313839066"]},{"id":"https://openalex.org/I4210146973","display_name":"Predictive Biology (United States)","ror":"https://ror.org/04zttqy84","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tenneille Ludwig","raw_affiliation_strings":["WiCell, Madison, WI 53719, USA","Predictive Biology Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WiCell, Madison, WI 53719, USA","institution_ids":["https://openalex.org/I1313839066"]},{"raw_affiliation_string":"Predictive Biology Inc","institution_ids":["https://openalex.org/I4210146973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036429896","display_name":"Erik M. McIntire","orcid":"https://orcid.org/0000-0001-6495-8670","observed_orcids":["https://orcid.org/0000-0001-6495-8670"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik McIntire","raw_affiliation_strings":["Department of Human Genetics, the University of Chicago, Chicago, IL 60637, USA","JAX: The Jackson Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, the University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"JAX: The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079425444","display_name":"Matthew T Pankratz","orcid":"https://orcid.org/0000-0002-7397-6755","observed_orcids":["https://orcid.org/0000-0002-7397-6755"]},"institutions":[{"id":"https://openalex.org/I1313839066","display_name":"WiCell","ror":"https://ror.org/032ycrz75","country_code":"US","type":"facility","lineage":["https://openalex.org/I1313839066"]},{"id":"https://openalex.org/I4210146973","display_name":"Predictive Biology (United States)","ror":"https://ror.org/04zttqy84","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Pankratz","raw_affiliation_strings":["Predictive Biology Inc, Carlsbad, CA 92010, USA","WiCell Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Predictive Biology Inc, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I4210146973"]},{"raw_affiliation_string":"WiCell Research Institute","institution_ids":["https://openalex.org/I1313839066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080894389","display_name":"Anne Czechanski","orcid":"https://orcid.org/0000-0003-3210-4210","observed_orcids":["https://orcid.org/0000-0003-3210-4210"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I4210146973","display_name":"Predictive Biology (United States)","ror":"https://ror.org/04zttqy84","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Czechanski","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA","Predictive Bio Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Predictive Bio Inc","institution_ids":["https://openalex.org/I4210146973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109258884","display_name":"Ted Choi","orcid":"https://orcid.org/0009-0009-3274-4200","observed_orcids":["https://orcid.org/0009-0009-3274-4200"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210146973","display_name":"Predictive Biology (United States)","ror":"https://ror.org/04zttqy84","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ted Choi","raw_affiliation_strings":["Predictive Biology Inc, Carlsbad, CA 92010, USA","Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Predictive Biology Inc, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I4210146973"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079793809","display_name":"Steven P. Gygi","orcid":"https://orcid.org/0000-0001-7626-0034","observed_orcids":["https://orcid.org/0000-0001-7626-0034"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Steven P. Gygi","raw_affiliation_strings":["Harvard Medical School, Boston, MA 02115, USA","The University of Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"The University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079234046","display_name":"Ivana Barbaric","orcid":"https://orcid.org/0000-0003-3120-9563","observed_orcids":["https://orcid.org/0000-0003-3120-9563"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Ivana Barbaric","raw_affiliation_strings":["Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK","The Jackson Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025727935","display_name":"Thomas Vierbuchen","orcid":"https://orcid.org/0000-0002-5690-5680","observed_orcids":["https://orcid.org/0000-0002-5690-5680"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Vierbuchen","raw_affiliation_strings":["Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering CancerCenter, New York, NY 10065, USA; Center for Stem Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","The Jackson Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering CancerCenter, New York, NY 10065, USA; Center for Stem Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067281001","display_name":"Steven C. Munger","orcid":"https://orcid.org/0000-0002-8458-1871","observed_orcids":["https://orcid.org/0000-0002-8458-1871"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Munger","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA; Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 021111, USA","THE JACKSON LABORATORY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA; Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 021111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210115256"]},{"raw_affiliation_string":"THE JACKSON LABORATORY","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018279869","display_name":"Laura G. Reinholdt","orcid":"https://orcid.org/0000-0003-4054-4048","observed_orcids":["https://orcid.org/0000-0003-4054-4048"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura G. Reinholdt","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA; Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 021111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA; Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 021111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085891063","display_name":"Mart\u00edn F. Pera","orcid":"https://orcid.org/0000-0001-6239-0428","observed_orcids":["https://orcid.org/0000-0001-6239-0428"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin F. Pera","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA; Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 021111, USA. Electronic address: martin.pera@jax.org"],"raw_orcid":"https://orcid.org/0000-0001-6239-0428","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA; Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 021111, USA. Electronic address: martin.pera@jax.org","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5085891063"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210115256"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":2.9209,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.87011778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"7","first_page":"102933","last_page":"102933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/x-chromosome-dosage","display_name":"X chromosome dosage","score":0.9100000262260437},{"id":"https://openalex.org/keywords/diversity-outbred-mice","display_name":"Diversity Outbred mice","score":0.8159999847412109},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9990000128746033},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6660000085830688},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7473399639129639},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.649006187915802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5986756682395935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5136022567749023},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5053296685218811},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.49927449226379395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37403345108032227},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1772173047065735}],"mesh":[{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014960","descriptor_name":"X Chromosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.stemcr.2026.102933","doi":"https://doi.org/10.1016/j.stemcr.2026.102933","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2026.102933","pdf_url":null,"source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2024.06.29.601344","doi":"https://doi.org/10.1101/2024.06.29.601344","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.06.29.601344","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/07/03/2024.06.29.601344.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13385727","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13385727/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13385727/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"Text"},{"id":"pmid:42263679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42263679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.stemcr.2026.102933","doi":"https://doi.org/10.1016/j.stemcr.2026.102933","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2026.102933","pdf_url":null,"source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332648","display_name":"Tufts University School of Medicine","ror":"https://ror.org/05wvpxv85"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400344904.pdf","grobid_xml":"https://content.openalex.org/works/W4400344904.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W68735071","https://openalex.org/W1967467247","https://openalex.org/W1970726947","https://openalex.org/W1976501240","https://openalex.org/W1983257493","https://openalex.org/W1984802615","https://openalex.org/W1987583896","https://openalex.org/W2003935383","https://openalex.org/W2005434435","https://openalex.org/W2006756331","https://openalex.org/W2008675991","https://openalex.org/W2034117897","https://openalex.org/W2034772886","https://openalex.org/W2034923684","https://openalex.org/W2037338370","https://openalex.org/W2044877927","https://openalex.org/W2045899482","https://openalex.org/W2049171639","https://openalex.org/W2049358079","https://openalex.org/W2053361209","https://openalex.org/W2062220093","https://openalex.org/W2065796189","https://openalex.org/W2066413879","https://openalex.org/W2075682647","https://openalex.org/W2078663366","https://openalex.org/W2093176183","https://openalex.org/W2099914822","https://openalex.org/W2115105022","https://openalex.org/W2138088258","https://openalex.org/W2148272837","https://openalex.org/W2171756746","https://openalex.org/W2185465661","https://openalex.org/W2268260867","https://openalex.org/W2268687088","https://openalex.org/W2335787821","https://openalex.org/W2434017435","https://openalex.org/W2469297379","https://openalex.org/W2478088043","https://openalex.org/W2517125215","https://openalex.org/W2551032364","https://openalex.org/W2561883112","https://openalex.org/W2622798239","https://openalex.org/W2738015524","https://openalex.org/W2757319828","https://openalex.org/W2793847699","https://openalex.org/W2802963454","https://openalex.org/W2810745552","https://openalex.org/W2910960849","https://openalex.org/W2926334753","https://openalex.org/W2950395494","https://openalex.org/W2951068818","https://openalex.org/W2951506174","https://openalex.org/W2999417355","https://openalex.org/W3004539220","https://openalex.org/W3048813231","https://openalex.org/W3048837873","https://openalex.org/W3089222593","https://openalex.org/W3091103931","https://openalex.org/W3152850638","https://openalex.org/W4221116780","https://openalex.org/W4223519419","https://openalex.org/W4281567315","https://openalex.org/W4288489029","https://openalex.org/W4310297807","https://openalex.org/W4310786388","https://openalex.org/W4312129115","https://openalex.org/W4360612923","https://openalex.org/W4381930196","https://openalex.org/W4384937972","https://openalex.org/W4391543778","https://openalex.org/W4400281382"],"related_works":["https://openalex.org/W4409457397","https://openalex.org/W6963376240","https://openalex.org/W7162532403","https://openalex.org/W1979963706","https://openalex.org/W2910960849","https://openalex.org/W2775641585","https://openalex.org/W2517125215","https://openalex.org/W2106121484","https://openalex.org/W2087858590","https://openalex.org/W2049171639"],"abstract_inverted_index":{"SUMMARY":[0],"The":[1],"genetic":[2,37,191,214,247],"integrity":[3,52,192],"of":[4,25,46,69,93,108,163,182,190,193,201,216,281,290],"pluripotent":[5,221,241,268],"stem":[6,72,222,232,242,259,269,274],"cells":[7,233,260,270,282],"(PSC)":[8],"is":[9,20,41],"critical":[10],"to":[11,114,218,254,262],"their":[12],"applications":[13],"in":[14,50,149,220,228,239,256,266,283],"research":[15],"and":[16,63,90,137,195,261,287],"therapy,":[17],"but":[18,39],"it":[19],"compromised":[21],"by":[22],"frequent":[23],"development":[24],"structural":[26],"chromosome":[27,165],"variants":[28],"associated":[29,187,206,294],"with":[30,86,173,188,207,236,295],"malignancy.":[31],"Many":[32],"cell":[33,73,223,243,275],"lines":[34,75,85,96,110,172,244,276],"exhibit":[35],"remarkable":[36],"stability,":[38],"little":[40],"known":[42,48],"about":[43],"the":[44,47,171,208],"basis":[45],"variation":[49],"genomic":[51],"amongst":[53],"different":[54],"PSC":[55],"isolates.":[56],"Here":[57],"we":[58],"identify":[59,156],"aneuploidies":[60],"using":[61],"RNA-seq":[62,121],"proteomics":[64],"data":[65,122],"from":[66,77],"a":[67,91,104,138,179,185,263,278],"panel":[68],"mouse":[70,230,257,272],"embryonic":[71,231,258,273],"(mESC)":[74],"derived":[76],"170":[78],"Diversity":[79],"Outbred":[80],"mice.":[81],"We":[82,155],"found":[83],"62":[84],"detectable":[87],"aneuploid":[88,126,147,229],"subpopulations":[89],"subset":[92],"originally":[94],"XX":[95,109,153,271],"that":[97,125,142,170,196],"lost":[98],"one":[99],"Chromosome":[100,133],"X":[101,134,164,176],"(XO).":[102],"Strikingly,":[103],"much":[105],"lower":[106,132],"proportion":[107,181,280],"were":[111],"aneuploid,":[112],"compared":[113],"XY":[115,127,143],"or":[116],"XO":[117],"lines.":[118,154],"Two":[119],"single-cell":[120],"sets":[123],"demonstrated":[124],"DO":[128],"mESC":[129,144],"also":[130],"show":[131,198,277],"gene":[135],"expression,":[136],"prospective":[139],"study":[140],"confirmed":[141],"accumulate":[145],"higher":[146,180,279,288],"proportions":[148],"culture":[150],"than":[151],"isogenic":[152],"potential":[157],"mechanisms":[158],"for":[159],"this":[160],"protective":[161],"effect":[162],"dosage,":[166],"including":[167],"our":[168],"findings":[169],"two":[174],"active":[175],"Chromosomes":[177],"have":[178],"2-cell-like":[183],"cells,":[184],"state":[186,286],"maintenance":[189],"mESC,":[194],"they":[197],"differential":[199],"expression":[200,289],"X-linked":[202],"tumor":[203,291],"suppressor":[204,292],"genes":[205,293],"DNA":[209,296],"damage":[210,297],"response.":[211],"Highlights":[212],"First":[213],"analysis":[215],"predisposition":[217],"aneuploidy":[219,255],"cultures":[224],"Chromosomal":[225],"regions":[226,237],"duplicated":[227],"are":[234],"syntenic":[235],"overrepresented":[238],"human":[240,267],"bearing":[245],"recurrent":[246],"abnormalities":[248],"X-Chromosome":[249],"dosage":[250],"strongly":[251],"influences":[252],"susceptibility":[253],"lesser":[264],"degree":[265],"2":[284],"cell-like":[285],"response":[298]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-07-06T00:00:00"}
