{"id":"https://openalex.org/W4400320259","doi":"https://doi.org/10.1111/liv.16025","title":"AI \u2010based digital pathology provides newer insights into lifestyle intervention\u2010induced fibrosis regression in MASLD : An exploratory study","display_name":"AI \u2010based digital pathology provides newer insights into lifestyle intervention\u2010induced fibrosis regression in MASLD : An exploratory study","publication_year":2024,"publication_date":"2024-07-04","ids":{"openalex":"https://openalex.org/W4400320259","doi":"https://doi.org/10.1111/liv.16025","pmid":"https://pubmed.ncbi.nlm.nih.gov/38963299"},"language":"en","primary_location":{"id":"doi:10.1111/liv.16025","doi":"https://doi.org/10.1111/liv.16025","is_oa":true,"landing_page_url":"https://doi.org/10.1111/liv.16025","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.16025","source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.16025","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014947962","display_name":"Hai\u2010Yang Yuan","orcid":"https://orcid.org/0009-0009-8648-7625","observed_orcids":["https://orcid.org/0009-0009-8648-7625"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai\u2010Yang Yuan","raw_affiliation_strings":["MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109730294","display_name":"Xiaofei Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao\u2010Fei Tong","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020772043","display_name":"Yayun Ren","orcid":"https://orcid.org/0000-0002-8613-5728","observed_orcids":["https://orcid.org/0000-0002-8613-5728"]},"institutions":[{"id":"https://openalex.org/I4210154055","display_name":"Histoindex (Singapore)","ror":"https://ror.org/04hwc4q95","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210154055"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ya\u2010Yun Ren","raw_affiliation_strings":["HistoIndex Pte Ltd  Singapore Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoIndex Pte Ltd  Singapore Singapore","institution_ids":["https://openalex.org/I4210154055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356508","display_name":"Yangyang Li","orcid":"https://orcid.org/0000-0002-5791-9443","observed_orcids":["https://orcid.org/0000-0002-5791-9443","https://orcid.org/0000-0001-7864-6600"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang\u2010Yang Li","raw_affiliation_strings":["Department of Pathology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100722139","display_name":"Xinlei Wang","orcid":"https://orcid.org/0000-0001-8658-223X","observed_orcids":["https://orcid.org/0000-0001-8658-223X"]},"institutions":[{"id":"https://openalex.org/I4210154055","display_name":"Histoindex (Singapore)","ror":"https://ror.org/04hwc4q95","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210154055"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xin\u2010Lei Wang","raw_affiliation_strings":["HistoIndex Pte Ltd  Singapore Singapore","Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province  Wenzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoIndex Pte Ltd  Singapore Singapore","institution_ids":["https://openalex.org/I4210154055"]},{"raw_affiliation_string":"Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province  Wenzhou China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349889","display_name":"Lili Chen","orcid":"https://orcid.org/0000-0002-1800-4662","observed_orcids":["https://orcid.org/0000-0002-1800-4662"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li\u2010Li Chen","raw_affiliation_strings":["MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012098217","display_name":"Sui\u2010Dan Chen","orcid":"https://orcid.org/0000-0002-5226-8573","observed_orcids":["https://orcid.org/0000-0002-5226-8573"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sui\u2010Dan Chen","raw_affiliation_strings":["Department of Pathology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063853140","display_name":"Xiaozhi Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao\u2010Zhi Jin","raw_affiliation_strings":["MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao\u2010Dong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154055","display_name":"Histoindex (Singapore)","ror":"https://ror.org/04hwc4q95","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210154055"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xiao\u2010Dong Wang","raw_affiliation_strings":["HistoIndex Pte Ltd  Singapore Singapore","Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province  Wenzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoIndex Pte Ltd  Singapore Singapore","institution_ids":["https://openalex.org/I4210154055"]},{"raw_affiliation_string":"Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province  Wenzhou China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071075382","display_name":"Giovanni Targher","orcid":"https://orcid.org/0000-0002-4325-3900","observed_orcids":["https://orcid.org/0000-0002-4325-3900"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]},{"id":"https://openalex.org/I4210101944","display_name":"Ospedale Sacro Cuore Don Calabria","ror":"https://ror.org/010hq5p48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210101944"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Targher","raw_affiliation_strings":["Department of Medicine University of Verona  Verona Italy","Metabolic Diseases Research Unit IRCCS Sacro Cuore\u2014Don Calabria Hospital, Negrar di Valpolicella  Verona Italy"],"raw_orcid":"https://orcid.org/0000-0002-4325-3900","affiliations":[{"raw_affiliation_string":"Department of Medicine University of Verona  Verona Italy","institution_ids":["https://openalex.org/I119439378"]},{"raw_affiliation_string":"Metabolic Diseases Research Unit IRCCS Sacro Cuore\u2014Don Calabria Hospital, Negrar di Valpolicella  Verona Italy","institution_ids":["https://openalex.org/I4210101944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090673306","display_name":"Christopher D. Byrne","orcid":"https://orcid.org/0000-0001-6322-7753","observed_orcids":["https://orcid.org/0000-0001-6322-7753","https://orcid.org/0000-0002-9602-8694","https://orcid.org/0000-0003-1250-5172"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210118229","display_name":"NIHR Southampton Biomedical Research Centre","ror":"https://ror.org/01qqpzg67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2802965805","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher D. Byrne","raw_affiliation_strings":["Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southampton and University of Southampton, Southampton General Hospital  Southampton UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southampton and University of Southampton, Southampton General Hospital  Southampton UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I2802965805","https://openalex.org/I4210118229","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019237114","display_name":"Lai Wei","orcid":"https://orcid.org/0000-0001-7519-627X","observed_orcids":["https://orcid.org/0000-0001-7519-627X"]},"institutions":[{"id":"https://openalex.org/I4210153550","display_name":"Beijing Tsinghua Chang Gung Hospital","ror":"https://ror.org/050nfgr37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153550"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lai Wei","raw_affiliation_strings":["Hepatopancreatobiliary Center Beijing Tsinghua Changgung Hospital, Tsinghua University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatopancreatobiliary Center Beijing Tsinghua Changgung Hospital, Tsinghua University  Beijing China","institution_ids":["https://openalex.org/I4210153550","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101716089","display_name":"Vincent Wai\u2010Sun Wong","orcid":"https://orcid.org/0000-0003-2215-9410","observed_orcids":["https://orcid.org/0000-0003-2215-9410"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Vincent W.\u2010S Wong","raw_affiliation_strings":["Department of Medicine and Therapeutics Chinese University of Hong Kong, Hong Kong Special Administrative Region  China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics Chinese University of Hong Kong, Hong Kong Special Administrative Region  China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077241004","display_name":"Dean Tai","orcid":"https://orcid.org/0000-0002-6166-5618","observed_orcids":["https://orcid.org/0000-0002-6166-5618"]},"institutions":[{"id":"https://openalex.org/I4210154055","display_name":"Histoindex (Singapore)","ror":"https://ror.org/04hwc4q95","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210154055"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Dean Tai","raw_affiliation_strings":["HistoIndex Pte Ltd  Singapore Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoIndex Pte Ltd  Singapore Singapore","institution_ids":["https://openalex.org/I4210154055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070639714","display_name":"Arun Jayant Sanyal","orcid":"https://orcid.org/0000-0001-8682-5748","observed_orcids":["https://orcid.org/0000-0001-8682-5748"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arun J. Sanyal","raw_affiliation_strings":["Stravitz\u2010Sanyal Institute for Liver Disease and Metabolic Health Virginia Commonwealth University School of Medicine  Richmond Virginia USA"],"raw_orcid":"https://orcid.org/0000-0001-8682-5748","affiliations":[{"raw_affiliation_string":"Stravitz\u2010Sanyal Institute for Liver Disease and Metabolic Health Virginia Commonwealth University School of Medicine  Richmond Virginia USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066330334","display_name":"Hong You","orcid":"https://orcid.org/0000-0001-9409-1158","observed_orcids":["https://orcid.org/0000-0001-9409-1158"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong You","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China"],"raw_orcid":"https://orcid.org/0000-0001-9409-1158","affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Capital Medical University  Beijing China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030038857","display_name":"Ming\u2010Hua Zheng","orcid":"https://orcid.org/0000-0003-4984-2631","observed_orcids":["https://orcid.org/0000-0003-4984-2631"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming\u2010Hua Zheng","raw_affiliation_strings":["Institute of Hepatology Wenzhou Medical University  Wenzhou China","Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province  Wenzhou China","MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"],"raw_orcid":"https://orcid.org/0000-0003-4984-2631","affiliations":[{"raw_affiliation_string":"Institute of Hepatology Wenzhou Medical University  Wenzhou China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province  Wenzhou China","institution_ids":[]},{"raw_affiliation_string":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China","institution_ids":["https://openalex.org/I2801769982"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5030038857","https://openalex.org/A5066330334","https://openalex.org/A5070639714"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I184840846","https://openalex.org/I27781120","https://openalex.org/I2801769982","https://openalex.org/I4210089514","https://openalex.org/I4210147433"],"apc_list":{"value":4740,"currency":"USD","value_usd":4740},"apc_paid":null,"fwci":3.6377,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.93935641,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"44","issue":"10","first_page":"2572","last_page":"2582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.8989999890327454},{"id":"https://openalex.org/keywords/liver-fibrosis-regression","display_name":"liver fibrosis regression","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lifestyle-intervention","display_name":"lifestyle intervention","score":0.9869999885559082},{"id":"https://openalex.org/keywords/placebo-response","display_name":"placebo response","score":0.7089999914169312},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"digital pathology","score":0.7300000190734863},{"id":"https://openalex.org/keywords/second-harmonic-generation-microscopy","display_name":"second harmonic generation microscopy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/two-photon-fluorescence","display_name":"two-photon fluorescence","score":0.9350000023841858},{"id":"https://openalex.org/keywords/periportal-fibrosis","display_name":"periportal fibrosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/fibrosis-quantification","display_name":"fibrosis quantification","score":0.6890000104904175},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.7528636455535889},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7035512328147888},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.5173177719116211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5128195881843567},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5057570934295654},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.4363013803958893},{"id":"https://openalex.org/C2909954168","wikidata":"https://www.wikidata.org/wiki/Q860755","display_name":"Digital image analysis","level":2,"score":0.4186832308769226},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4182121157646179},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3912642002105713},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38757240772247314},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.2889097034931183},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20357823371887207},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/liv.16025","doi":"https://doi.org/10.1111/liv.16025","is_oa":true,"landing_page_url":"https://doi.org/10.1111/liv.16025","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.16025","source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},{"id":"pmid:38963299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38963299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver international : official journal of the International Association for the Study of the Liver","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:491664","doi":null,"is_oa":true,"landing_page_url":"https://eprints.soton.ac.uk/id/eprint/491664/1/draft_20240608.docx","pdf_url":"https://eprints.soton.ac.uk/491664/3/Figure_2.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1111/liv.16025","doi":"https://doi.org/10.1111/liv.16025","is_oa":true,"landing_page_url":"https://doi.org/10.1111/liv.16025","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.16025","source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400320259.pdf","grobid_xml":"https://content.openalex.org/works/W4400320259.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1561196873","https://openalex.org/W2808779488","https://openalex.org/W2821544409","https://openalex.org/W2888552653","https://openalex.org/W2922248347","https://openalex.org/W2945803471","https://openalex.org/W2957317165","https://openalex.org/W2958296451","https://openalex.org/W2977362851","https://openalex.org/W2978365020","https://openalex.org/W2984524859","https://openalex.org/W2991974053","https://openalex.org/W2993083975","https://openalex.org/W3009945933","https://openalex.org/W3013169226","https://openalex.org/W3031010405","https://openalex.org/W3103790217","https://openalex.org/W3120912424","https://openalex.org/W3154727812","https://openalex.org/W3154897461","https://openalex.org/W3177390597","https://openalex.org/W3182732609","https://openalex.org/W3183536970","https://openalex.org/W3215901809","https://openalex.org/W3217341309","https://openalex.org/W4200440801","https://openalex.org/W4206216291","https://openalex.org/W4206799234","https://openalex.org/W4221005344","https://openalex.org/W4280636329","https://openalex.org/W4281567922","https://openalex.org/W4281698011","https://openalex.org/W4283791928","https://openalex.org/W4284705169","https://openalex.org/W4310786400","https://openalex.org/W4321609378","https://openalex.org/W4377090407","https://openalex.org/W4381681857","https://openalex.org/W4381893710","https://openalex.org/W4383186679","https://openalex.org/W4387302098","https://openalex.org/W4387375398","https://openalex.org/W4387910358","https://openalex.org/W4392303931","https://openalex.org/W4394893998","https://openalex.org/W6786063168"],"related_works":["https://openalex.org/W4410017266","https://openalex.org/W4402374278","https://openalex.org/W4410170745","https://openalex.org/W4384946601","https://openalex.org/W4404813840","https://openalex.org/W4412894944","https://openalex.org/W4283791928","https://openalex.org/W7056850360","https://openalex.org/W7167814061","https://openalex.org/W4410199011"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Lifestyle":[3],"intervention":[4,111,119],"is":[5,18,249],"the":[6,37,81,131,154,179,189,208,217,228,232],"mainstay":[7],"of":[8,22,39,60,83,148],"therapy":[9],"for":[10],"metabolic":[11],"dysfunction-associated":[12],"steatohepatitis":[13],"(MASH),":[14],"and":[15,100,137,145,156,172,224,245],"liver":[16,97,126,183],"fibrosis":[17,61,86,127,151,161,184,202,214,243],"a":[19,33,64,199],"key":[20],"consequence":[21],"MASH":[23,40,103,233],"that":[24],"predicts":[25],"adverse":[26],"clinical":[27,41,234],"outcomes.":[28],"The":[29],"placebo":[30,229,246],"response":[31],"plays":[32],"pivotal":[34],"role":[35],"in":[36,88,130,153,178,188,207,213,216,227,231],"outcome":[38],"trials.":[42],"Second":[43],"harmonic":[44],"generation/two-photon":[45],"excitation":[46],"fluorescence":[47],"(SHG/TPEF)":[48],"microscopy":[49],"with":[50,128,204],"artificial":[51],"intelligence":[52],"analyses":[53],"can":[54],"provide":[55],"an":[56],"automated":[57],"quantitative":[58],"assessment":[59],"features":[62],"on":[63],"continuous":[65],"scale":[66],"called":[67],"qFibrosis.":[68],"In":[69],"this":[70,75,173],"exploratory":[71],"study,":[72],"we":[73,196,220],"used":[74],"approach":[76],"to":[77],"gain":[78],"insight":[79,240],"into":[80,241],"effect":[82],"lifestyle":[84,110,118,170],"intervention-induced":[85],"changes":[87,212],"MASH.":[89],"METHODS:":[90],"We":[91,124],"examined":[92],"unstained":[93],"sections":[94],"from":[95,102],"paired":[96],"biopsies":[98],"(baseline":[99],"end-of-intervention)":[101],"individuals":[104],"who":[105],"had":[106,150],"received":[107],"either":[108],"routine":[109],"(RLI)":[112],"(n":[113,121],"=":[114,122],"35)":[115],"or":[116,166],"strengthened":[117],"(SLI)":[120],"17).":[123],"quantified":[125],"qFibrosis":[129],"portal":[132],"tract,":[133],"periportal,":[134],"transitional,":[135],"pericentral,":[136],"central":[138],"vein":[139],"regions.":[140],"RESULTS:":[141],"About":[142],"20%":[143],"(7/35)":[144],"65%":[146],"(11/17)":[147],"patients":[149,226],"regression":[152,167,185,203,244],"RLI":[155,223],"SLI":[157,180,225],"groups,":[158],"respectively.":[159],"Liver":[160],"tended":[162],"towards":[163],"no":[164],"change":[165],"after":[168],"each":[169],"intervention,":[171],"phenomenon":[174],"was":[175,186],"more":[176,200],"prominent":[177],"group.":[181],"SLI-induced":[182],"concentrated":[187],"periportal":[190,209,218],"region.":[191,210],"CONCLUSION:":[192],"Using":[193],"digital":[194],"pathology,":[195],"could":[197,221],"detect":[198],"pronounced":[201],"SLI,":[205],"mainly":[206],"With":[211],"area":[215],"region,":[219],"differentiate":[222],"group":[230],"trial.":[235],"Digital":[236],"pathology":[237],"provides":[238],"new":[239],"lifestyle-induced":[242],"responses,":[247],"which":[248],"not":[250],"captured":[251],"by":[252],"conventional":[253],"histological":[254],"staging.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-06T00:00:00"}
