{"id":"https://openalex.org/W4400297635","doi":"https://doi.org/10.1093/humrep/deae108.937","title":"P-605 Effectiveness of follitropin delta in patients with potential poor response: A post hoc analysis from the ESTHER-1 trial","display_name":"P-605 Effectiveness of follitropin delta in patients with potential poor response: A post hoc analysis from the ESTHER-1 trial","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4400297635","doi":"https://doi.org/10.1093/humrep/deae108.937"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/deae108.937","doi":"https://doi.org/10.1093/humrep/deae108.937","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/deae108.937","pdf_url":"https://academic.oup.com/humrep/article-pdf/39/Supplement_1/deae108.937/58509277/deae108.937.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/humrep/article-pdf/39/Supplement_1/deae108.937/58509277/deae108.937.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101448504","display_name":"Rita Lobo","orcid":"https://orcid.org/0009-0004-1578-9793","observed_orcids":["https://orcid.org/0009-0004-1578-9793"]},"institutions":[{"id":"https://openalex.org/I4210128638","display_name":"Ferring Pharmaceuticals (Denmark)","ror":"https://ror.org/03m7mhz19","country_code":"DK","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4210128638"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"R Lobo","raw_affiliation_strings":["Ferring Pharmaceuticals, Clinical and Translational Sciences Global Department , Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring Pharmaceuticals, Clinical and Translational Sciences Global Department , Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210128638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074966913","display_name":"Ida Engberg Jepsen","orcid":"https://orcid.org/0000-0002-4632-4292","observed_orcids":["https://orcid.org/0000-0002-4632-4292"]},"institutions":[{"id":"https://openalex.org/I4210128638","display_name":"Ferring Pharmaceuticals (Denmark)","ror":"https://ror.org/03m7mhz19","country_code":"DK","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4210128638"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"I \u00a0E Jepsen","raw_affiliation_strings":["Ferring Pharmaceuticals, Clinical and Translational Sciences Global Department , Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring Pharmaceuticals, Clinical and Translational Sciences Global Department , Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210128638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109094661","display_name":"Ali Falahati","orcid":"https://orcid.org/0009-0001-5836-5593","observed_orcids":["https://orcid.org/0009-0001-5836-5593"]},"institutions":[{"id":"https://openalex.org/I4210128638","display_name":"Ferring Pharmaceuticals (Denmark)","ror":"https://ror.org/03m7mhz19","country_code":"DK","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4210128638"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"A Falahati","raw_affiliation_strings":["Ferring Pharmaceuticals, Global Biometrics , Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring Pharmaceuticals, Global Biometrics , Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210128638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088090311","display_name":"Nikolaos P. Polyzos","orcid":"https://orcid.org/0000-0001-6161-0011","observed_orcids":["https://orcid.org/0000-0001-6161-0011"]},"institutions":[{"id":"https://openalex.org/I4210096255","display_name":"Hospital Universitario Dexeus","ror":"https://ror.org/00scfzf83","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096255"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"N \u00a0P Polyzos","raw_affiliation_strings":["Dexeus University Hospital, Department of Obstetrics- Gynecology and Reproductive Medicine , Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dexeus University Hospital, Department of Obstetrics- Gynecology and Reproductive Medicine , Barcelona, Spain","institution_ids":["https://openalex.org/I4210096255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054849352","display_name":"Juan Antonio Garc\u00eda-Velasco","orcid":"https://orcid.org/0000-0003-1005-8727","observed_orcids":["https://orcid.org/0000-0003-1005-8727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J \u00a0A Garc\u00eda-Velasco","raw_affiliation_strings":["IVI/RMA Madrid, IVI/RMA Madrid , Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IVI/RMA Madrid, IVI/RMA Madrid , Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085234723","display_name":"Anja Bisgaard Pinborg","orcid":"https://orcid.org/0000-0002-8340-104X","observed_orcids":["https://orcid.org/0000-0002-8340-104X"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"A Pinborg","raw_affiliation_strings":["Rigshospitalet- Copenhagen University Hospital, Fertility Department , Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigshospitalet- Copenhagen University Hospital, Fertility Department , Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061705724","display_name":"Enrica Gravotta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Gravotta","raw_affiliation_strings":["Ferring Pharmaceuticals, Global Medical Affairs , Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring Pharmaceuticals, Global Medical Affairs , Milan, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4302,"currency":"EUR","value_usd":4656},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follitropin-delta","display_name":"follitropin delta","score":0.9789999723434448},{"id":"https://openalex.org/keywords/follitropin-alfa","display_name":"follitropin alfa","score":0.9810000061988831},{"id":"https://openalex.org/keywords/poor-ovarian-response","display_name":"poor ovarian response","score":0.8190000057220459},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.6790000200271606},{"id":"https://openalex.org/keywords/anti-mullerian-hormone","display_name":"anti-M\u00fcllerian hormone","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ovarian-reserve","display_name":"ovarian reserve","score":0.5960000157356262},{"id":"https://openalex.org/keywords/controlled-ovarian-stimulation","display_name":"controlled ovarian stimulation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/ivf-icsi","display_name":"IVF/ICSI","score":0.7940000295639038},{"id":"https://openalex.org/keywords/gnrh-antagonist-protocol","display_name":"GnRH antagonist protocol","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ovarian-hyperstimulation-syndrome","display_name":"ovarian hyperstimulation syndrome","score":0.8360000252723694},{"id":"https://openalex.org/keywords/oocyte-retrieval","display_name":"oocyte retrieval","score":0.7960000038146973},{"id":"https://openalex.org/keywords/blastocyst-quality","display_name":"blastocyst quality","score":0.8489999771118164},{"id":"https://openalex.org/keywords/live-birth-rate","display_name":"live birth rate","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ongoing-pregnancy-rate","display_name":"ongoing pregnancy rate","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.8327555656433105},{"id":"https://openalex.org/C2992886853","wikidata":"https://www.wikidata.org/wiki/Q18381816","display_name":"Post hoc","level":2,"score":0.6967723965644836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4900125563144684},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.41993623971939087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3863641023635864},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32068461179733276}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/humrep/deae108.937","doi":"https://doi.org/10.1093/humrep/deae108.937","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/deae108.937","pdf_url":"https://academic.oup.com/humrep/article-pdf/39/Supplement_1/deae108.937/58509277/deae108.937.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/humrep/deae108.937","doi":"https://doi.org/10.1093/humrep/deae108.937","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/deae108.937","pdf_url":"https://academic.oup.com/humrep/article-pdf/39/Supplement_1/deae108.937/58509277/deae108.937.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400297635.pdf","grobid_xml":"https://content.openalex.org/works/W4400297635.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4283749146","https://openalex.org/W2558449694","https://openalex.org/W3175498007","https://openalex.org/W4412131000","https://openalex.org/W3194993700","https://openalex.org/W7162413482","https://openalex.org/W4301396533","https://openalex.org/W3093430872","https://openalex.org/W4411728241","https://openalex.org/W2906022573"],"abstract_inverted_index":{"Abstract":[0],"Study":[1,157,288],"question":[2],"What":[3,54],"is":[4,41,55,527,535],"the":[5,82,106,118,139,145,172,185,201,315,326,343,363,389,435,463,502,513,525,533,547,553,556,561,567,578],"effectiveness":[6,568],"of":[7,78,84,95,120,141,147,164,189,217,233,292,297,317,321,325,335,370,376,383,407,417,438,496,524,542,546,560,569,577],"individualised":[8,103,114],"follitropin":[9,15,30,45,79,115,136,142,192,211,349,356,387,398,425,432,455,460,477,484,503,514,570],"delta":[10,31,80,116,143,193,350,426,456,478,504,571],"dosing":[11,17,32,76,195,202],"compared":[12,133],"to":[13,61,134,278,491],"conventional":[14,135],"alfa":[16,46,212,399,433,461,485,515],"in":[18,47,68,144,249,342,403,501,512],"patients":[19,48,148,166,205,323,473],"with":[20,49,130,149,167,206,220,256,348,355,366,397,424,431,445,454,459,476,483],"potential":[21,50,111,150,168,221,557],"poor":[22,51,151,169,492],"response":[23,60,86,152,170],"undergoing":[24,244],"ovarian":[25,52,59,63,85,96,121,574],"stimulation?":[26],"Summary":[27],"answer":[28],"Individualised":[29],"provides":[33],"a":[34,66,214,250,367,373,380,538],"favourable":[35],"efficacy":[36,132],"and":[37,40,98,110,228,262,295,303,309,314,339,351,379,396,410,427,434,457,462,469,479,506,555],"safety":[38],"balance":[39],"as":[42,44,198],"good":[43,298],"response.":[53,493],"known":[56],"already":[57],"Poor":[58],"controlled":[62],"stimulation":[64,225],"constitutes":[65],"challenge":[67],"in-vitro":[69],"fertilisation/intracytoplasmic":[70],"sperm":[71],"injection":[72],"(IVF/ICSI)":[73],"treatment.":[74],"The":[75,414,448,521],"algorithm":[77,203],"incorporates":[81],"prediction":[83],"based":[87,536],"on":[88,268,537],"anti-M\u00fcllerian":[89],"hormone":[90],"(AMH),":[91],"an":[92,102],"accurate":[93],"marker":[94],"reserve,":[97],"body":[99],"weight,":[100],"for":[101,128,204,519,566],"dosing.":[104],"In":[105],"general":[107],"IVF/ICSI":[108,247,260],"population":[109],"high":[112],"responders,":[113],"reduces":[117],"risk":[119],"hyperstimulation":[122],"syndrome":[123],"(OHSS)":[124],"and/or":[125],"preventive":[126],"interventions":[127],"OHSS,":[129],"sustained":[131],"alfa.":[137,357],"However,":[138],"performance":[140],"subpopulation":[146],"has":[153],"not":[154],"been":[155],"evaluated.":[156],"design,":[158],"size,":[159],"duration":[160],"Post":[161],"hoc":[162,530],"analysis":[163],"332":[165,322],"from":[171,224],"ESTHER-1":[173,328,562],"trial":[174],"(determined":[175],"by":[176,200],"AMH":[177,207,332,375],"level":[178],"at":[179,213,333],"screening":[180,334],"<9":[181],"pmol/L).":[182],"Patients":[183],"received":[184],"maximum":[186],"daily":[187,231,391],"dose":[188,216,222,232,392],"12":[190],"\u00b5g":[191,395,409],"(fixed":[194],"throughout":[196],"stimulation)":[197],"stipulated":[199],"<15":[208],"pmol/l,":[209],"or":[210,264],"starting":[215],"150":[218],"IU,":[219],"adjustments":[223],"day":[226],"6":[227],"onwards":[229],"(maximum":[230],"450":[234],"IU).":[235],"Participants/materials,":[236],"setting,":[237],"methods":[238],"Participants":[239],"were":[240,284,340,346,353,360,467,510],"women,":[241],"18\u201340":[242],"years,":[243,372],"their":[245,487],"first":[246],"cycle":[248,307],"GnRH":[251],"antagonist":[252],"protocol,":[253],"including":[254],"triggering":[255],"human":[257],"chorionic":[258],"gonadotrophin,":[259],"insemination,":[261],"single":[263],"double":[265],"blastocyst":[266],"transfer":[267,277],"Day":[269],"5.":[270],"Ultrasound":[271],"was":[272,393,420,441,452,499],"performed":[273],"10\u201311":[274],"weeks":[275],"after":[276],"confirm":[279],"ongoing":[280,301,449],"pregnancy.":[281],"All":[282],"pregnancies":[283],"followed":[285],"until":[286],"birth.":[287],"outcomes":[289],"include":[290],"number":[291,296,416,437,541,583],"oocytes":[293,418],"retrieved":[294,419],"quality":[299],"blastocysts,":[300],"pregnancy":[302,450],"live":[304,464],"birth":[305,465],"rates,":[306],"cancellation":[308],"OHSS":[310,497],"rates.":[311],"Main":[312],"results":[313],"role":[316],"chance":[318],"A":[319],"total":[320,405],"(25.0%":[324],"overall":[327],"population)":[329],"had":[330,486],"serum":[331],"<":[336],"9":[337],"pmol/l":[338,378],"included":[341],"analysis:":[344],"168":[345],"treated":[347,354,475,482],"164":[352],"Baseline":[358],"characteristics":[359],"similar":[361],"between":[362],"treatment":[364],"groups,":[365],"mean":[368,381,390,404,415,436],"age":[369],"34.8":[371],"median":[374],"5.7":[377],"weight":[382],"64.5":[384],"kg.":[385],"With":[386],"delta,":[388],"12.0":[394],"12.4":[400],"\u00b5g,":[401,412],"resulting":[402],"doses":[406],"104.6":[408],"112.3":[411],"respectively.":[413,471],"5.8":[421],"\u00b1":[422,429,443],"3.5":[423],"5.5":[428],"3.6":[430],"good-quality":[439],"blastocysts":[440],"1.2":[442],"1.4":[444],"both":[446],"treatments.":[447],"rate":[451],"29.8%":[453],"29.3%":[458],"rates":[466],"29.2%":[468],"28.7%,":[470],"Thirteen":[472],"(7.7%)":[474],"14":[480],"(8.5%)":[481],"cycles":[488],"cancelled":[489],"due":[490],"One":[494],"case":[495],"(0.6%)":[498],"observed":[500,511],"group,":[505],"3":[507],"cases":[508],"(1.8%)":[509],"group.":[516],"Limitations,":[517],"reasons":[518],"caution":[520],"main":[522],"limitation":[523],"study":[526,534],"its":[528],"post":[529],"nature.":[531],"Furthermore,":[532],"relatively":[539],"small":[540],"patients.":[543],"Wider":[544],"implications":[545],"findings":[548],"This":[549],"subgroup":[550,559],"analysis,":[551],"alongside":[552],"normoresponder":[554],"hyperresponder":[558],"trial,":[563],"adds":[564],"evidence":[565],"across":[572],"all":[573],"reserve":[575],"subgroups":[576],"infertile":[579],"population.":[580],"Trial":[581],"registration":[582],"NCT01956110":[584]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-07-05T00:00:00"}