{"id":"https://openalex.org/W4400295102","doi":"https://doi.org/10.1093/humrep/deae108.853","title":"P-513 Non-invasive PGT (niPGT) of vitrified blastocysts cultured for 24 hours after thawing","display_name":"P-513 Non-invasive PGT (niPGT) of vitrified blastocysts cultured for 24 hours after thawing","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4400295102","doi":"https://doi.org/10.1093/humrep/deae108.853"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/deae108.853","doi":"https://doi.org/10.1093/humrep/deae108.853","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/deae108.853","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Takeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255912","display_name":"Asada Ladies Clinic","ror":"https://ror.org/03jdf4784","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255912"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Takeda","raw_affiliation_strings":["Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan","institution_ids":["https://openalex.org/I4405255912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110711355","display_name":"H. Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255912","display_name":"Asada Ladies Clinic","ror":"https://ror.org/03jdf4784","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255912"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Watanabe","raw_affiliation_strings":["Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan","institution_ids":["https://openalex.org/I4405255912"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y Kida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255912","display_name":"Asada Ladies Clinic","ror":"https://ror.org/03jdf4784","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255912"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Kida","raw_affiliation_strings":["Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan","institution_ids":["https://openalex.org/I4405255912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109166022","display_name":"F Kondo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255912","display_name":"Asada Ladies Clinic","ror":"https://ror.org/03jdf4784","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255912"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"F Kondo","raw_affiliation_strings":["Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan","institution_ids":["https://openalex.org/I4405255912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087208064","display_name":"Hiroya Kitasaka","orcid":"https://orcid.org/0000-0001-5850-2773","observed_orcids":["https://orcid.org/0000-0001-5850-2773"]},"institutions":[{"id":"https://openalex.org/I4405255912","display_name":"Asada Ladies Clinic","ror":"https://ror.org/03jdf4784","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255912"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Kitasaka","raw_affiliation_strings":["Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan","institution_ids":["https://openalex.org/I4405255912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111803097","display_name":"Naoto Fukunaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255912","display_name":"Asada Ladies Clinic","ror":"https://ror.org/03jdf4784","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255912"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Fukunaga","raw_affiliation_strings":["Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan","institution_ids":["https://openalex.org/I4405255912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110513534","display_name":"Y. Asada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255912","display_name":"Asada Ladies Clinic","ror":"https://ror.org/03jdf4784","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255912"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Asada","raw_affiliation_strings":["Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asada Ladies Clinic, Asada Institute for Reproductive Medicine , Aichi, Japan","institution_ids":["https://openalex.org/I4405255912"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405255912"],"apc_list":{"value":4302,"currency":"EUR","value_usd":4656},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitrified-blastocysts","display_name":"vitrified blastocysts","score":0.9110000133514404},{"id":"https://openalex.org/keywords/spent-culture-medium","display_name":"spent culture medium","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.6930000185966492},{"id":"https://openalex.org/keywords/embryo-ploidy","display_name":"embryo ploidy","score":0.6690000295639038},{"id":"https://openalex.org/keywords/aneuploidy-detection","display_name":"aneuploidy detection","score":0.7820000052452087},{"id":"https://openalex.org/keywords/preimplantation-genetic-diagnosis","display_name":"preimplantation genetic diagnosis","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6615345478057861},{"id":"https://openalex.org/C2778022349","wikidata":"https://www.wikidata.org/wiki/Q1072553","display_name":"Vitrification","level":2,"score":0.5330772399902344},{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.47762244939804077},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4472014307975769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37371936440467834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.354450523853302},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.234386146068573},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09209305047988892}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/humrep/deae108.853","doi":"https://doi.org/10.1093/humrep/deae108.853","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/deae108.853","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4381683376","https://openalex.org/W4400295873","https://openalex.org/W4400297618","https://openalex.org/W4307392841","https://openalex.org/W4411748779","https://openalex.org/W4401058724","https://openalex.org/W7172278498","https://openalex.org/W4387396380","https://openalex.org/W4407843321","https://openalex.org/W7146622775"],"abstract_inverted_index":{"Abstract":[0],"Study":[1,134],"question":[2],"Is":[3],"niPGT":[4,18,63,104,253],"on":[5,107,123,259],"culture":[6,21,72,111,185,208,389,410,423],"medium":[7,22,73,112,128,186,209,236,424,461],"exposed":[8],"for":[9,27,153,168,199,232,292,308,313,328,335,341,346,378,383,428],"24":[10,200],"hours":[11],"to":[12,80,87,140,243,392,450,472],"vitrified-thawed":[13],"blastocysts":[14,25,192,269],"useful?":[15],"Summary":[16],"answer":[17],"using":[19,64],"a":[20,32,220,228,429,463,469],"from":[23,69,130,148,161,255,406],"vitrified":[24,144,191,268,459],"cultured":[26,167,197,218],"24hours":[28],"after":[29,265],"thawing":[30,266],"showed":[31],"high":[33],"concordance":[34,303,317,327,334,360,365],"rate":[35,304,323],"with":[36,90,151,271],"the":[37,51,108,131,183,204,250,256,275,280,321,325,332,354,358,363,399,407,413,420,434,447,451],"PGTa":[38,272],"results.":[39],"What":[40],"is":[41,47],"known":[42],"already":[43],"Conventional":[44],"PGTa,":[45],"which":[46,404],"widely":[48],"practiced":[49],"around":[50],"world,":[52],"requires":[53],"specialized":[54],"techniques":[55],"and":[56,83,158,160,182,196,202,206,227,239,264,279,296,310,331,343,362,371,426,467],"involves":[57],"embryonic":[58],"trophectoderm":[59],"(TE)":[60],"biopsy.":[61],"Recently,":[62],"cell":[65],"free":[66],"DNA":[67],"released":[68],"embryos":[70,147,173,205,240,258],"into":[71],"has":[74,84],"been":[75,85,100,116],"reported":[76],"as":[77,320],"an":[78],"alternative":[79,471],"conventional":[81,473],"PGT,":[82],"found":[86],"correlate":[88],"well":[89],"TE-biopsy":[91],"analysis":[92,245,273,456],"results":[93,251,278,289,437],"(Carmen.":[94],"Rubio,":[95],"2020).":[96],"Although":[97],"there":[98,114],"have":[99,115],"numerous":[101],"reports":[102],"of":[103,110,119,127,252,267,274,282,324,396,398,415,433,441,457],"accuracy":[105,121,440],"based":[106,122],"timing":[109,414],"collection,":[113],"few":[117],"comparisons":[118],"its":[120],"different":[124],"time":[125],"points":[126],"collection":[129,417],"same":[132,257],"embryo.":[133],"design,":[135],"size,":[136],"duration":[137],"From":[138],"March":[139],"April":[141],"2023,":[142],"128":[143],"pronuclear":[145],"stage":[146],"33":[149],"patients":[150],"consent":[152],"research":[154],"use,":[155],"were":[156,165,180,193,211,217,241,290,351],"thawed":[157,195,458],"cultured,":[159],"Day":[162,178,225],"4,":[163],"they":[164],"individually":[166,198],"over":[169],"40":[170],"hours.":[171],"60":[172],"that":[174,427,439,455],"reached":[175],"blastocyst":[176,460],"by":[177,246],"6":[179,262],"vitrified,":[181],"spent":[184,207],"(SCM1)":[187,263],"was":[188,237,305,338,376,390,444],"collected.":[189,212],"The":[190,301,315,436],"later":[194],"hours,":[201],"then":[203],"(SCM2)":[210],"Participants/materials,":[213],"setting,":[214],"methods":[215],"Embryos":[216],"in":[219,353,446],"30":[221],"\u03bcl":[222,230],"droplet":[223,231],"until":[224],"4":[226],"10":[229],"individual":[233],"culture.":[234],"Culture":[235],"collected":[238],"subjected":[242],"chromosomal":[244],"NGS.":[247],"We":[248],"compared":[249,449],"taken":[254],"days":[260],"4-":[261],"(SCM2),":[270],"embryos.":[276],"Main":[277],"role":[281],"chance":[283],"Among":[284],"all":[285,329],"media":[286],"samples":[287],"analyzed,":[288],"obtained":[291],"80.0%":[293],"(48/60)":[294],"SCM1":[295,309,342,370,452],"96.7%":[297],"(58/60)":[298],"SCM2":[299,347,448],"samples.":[300],"ploidy":[302,359,442],"81.3%":[306],"(39/48)":[307],"98.3%":[311],"(57/58)":[312],"SCM2.":[314,372],"overall":[316,364],"rate,":[318,357,361],"defined":[319],"combined":[322],"total":[326],"chromosomes":[330,337],"partial":[333],"some":[336],"72.9%":[339],"(35/48)":[340],"94.8%":[344],"(55/58)":[345],"respectively.":[348],"Significant":[349],"differences":[350],"identified":[352],"informative":[355],"sample":[356,416,425],"rate(p":[366],"<":[367],"0.05)":[368],"between":[369,419],"Fisher\u2019s":[373],"exact":[374],"test":[375],"used":[377],"statistical":[379],"analysis.":[380],"Limitations,":[381],"reasons":[382],"caution":[384],"In":[385],"this":[386],"study,":[387],"embryo":[388,400],"continued":[391],"day":[393,402,421],"6,":[394],"regardless":[395],"morphology":[397],"at":[401],"5,":[403],"differs":[405],"usual":[408],"clinical":[409],"process.":[411],"Additionally,":[412],"differed":[418],"4-6":[422],"blastocyst.":[430],"Wider":[431],"implications":[432],"findings":[435],"demonstrated":[438],"status":[443],"higher":[445],"sample,":[453],"suggesting":[454],"maybe":[462],"more":[464],"precise":[465],"predictor":[466],"therefore":[468],"non-invasive":[470],"PGTa.":[474],"Trial":[475],"registration":[476],"number":[477],"not":[478],"applicable":[479]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-07-05T00:00:00"}
