{"id":"https://openalex.org/W4400257883","doi":"https://doi.org/10.1038/s41598-024-62910-6","title":"Myricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson\u2019s disease","display_name":"Myricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson\u2019s disease","publication_year":2024,"publication_date":"2024-07-02","ids":{"openalex":"https://openalex.org/W4400257883","doi":"https://doi.org/10.1038/s41598-024-62910-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/38956066","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11219851"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-024-62910-6","doi":"https://doi.org/10.1038/s41598-024-62910-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-62910-6","pdf_url":"https://www.nature.com/articles/s41598-024-62910-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-024-62910-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113798695","display_name":"Si\u2010Chun Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210101984","display_name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/016yezh07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Chun Gu","raw_affiliation_strings":["Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhi-Guo Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210101984","display_name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/016yezh07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Guo Xie","raw_affiliation_strings":["Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102604933","display_name":"Min\u2010Jue Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210101984","display_name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/016yezh07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min-Jue Gu","raw_affiliation_strings":["Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091395756","display_name":"Changde Wang","orcid":"https://orcid.org/0000-0002-2132-2944","observed_orcids":["https://orcid.org/0000-0002-2132-2944"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210133418","display_name":"Yueyang Hospital","ror":"https://ror.org/03yd12021","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-De Wang","raw_affiliation_strings":["Department of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210133418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064872181","display_name":"Limin Xu","orcid":"https://orcid.org/0000-0002-6788-5355","observed_orcids":["https://orcid.org/0000-0002-6788-5355"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210101984","display_name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/016yezh07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Min Xu","raw_affiliation_strings":["Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741096","display_name":"Chen Gao","orcid":"https://orcid.org/0000-0001-9372-8014","observed_orcids":["https://orcid.org/0000-0001-9372-8014","https://orcid.org/0000-0003-0832-5144"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210101984","display_name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/016yezh07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Gao","raw_affiliation_strings":["Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076492373","display_name":"Xiaolei Yuan","orcid":"https://orcid.org/0000-0003-4038-2886","observed_orcids":["https://orcid.org/0000-0003-4038-2886"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210101984","display_name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/016yezh07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Lei Yuan","raw_affiliation_strings":["Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103171181","display_name":"You Wu","orcid":"https://orcid.org/0000-0001-6592-777X","observed_orcids":["https://orcid.org/0000-0001-6592-777X","https://orcid.org/0000-0003-1533-5551"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210101984","display_name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/016yezh07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"You Wu","raw_affiliation_strings":["Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042393602","display_name":"Yuqing Hu","orcid":"https://orcid.org/0000-0002-6282-6436","observed_orcids":["https://orcid.org/0000-0002-6282-6436"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210101984","display_name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/016yezh07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Qing Hu","raw_affiliation_strings":["Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102727923","display_name":"Yang Cao","orcid":"https://orcid.org/0000-0002-6625-7605","observed_orcids":["https://orcid.org/0000-0002-6625-7605"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210133418","display_name":"Yueyang Hospital","ror":"https://ror.org/03yd12021","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133418"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Cao","raw_affiliation_strings":["Department of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China. cindy8813966@126.com","Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, 230 Baoding Road, Shanghai, 200082, China. cindy8813966@126.com","Department of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China. cindy8813966@126.com","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210133418"]},{"raw_affiliation_string":"Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, 230 Baoding Road, Shanghai, 200082, China. cindy8813966@126.com","institution_ids":["https://openalex.org/I4210098460"]},{"raw_affiliation_string":"Department of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210133418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064392146","display_name":"Qing Ye","orcid":"https://orcid.org/0009-0002-4453-6360","observed_orcids":["https://orcid.org/0009-0002-4453-6360","https://orcid.org/0000-0001-8587-5022"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210101984","display_name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/016yezh07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101984"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Ye","raw_affiliation_strings":["Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China. 1273313618@qq.com","Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China. 1273313618@qq.com","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]},{"raw_affiliation_string":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064392146","https://openalex.org/A5102727923"],"corresponding_institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210101984","https://openalex.org/I4210133418"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":7.5164,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.9826434,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"15107","last_page":"15107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myricetin","display_name":"myricetin","score":1.0},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dopaminergic-neuron-death","display_name":"dopaminergic neuron death","score":0.953000009059906},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.7129999995231628},{"id":"https://openalex.org/keywords/mpp","display_name":"MPP+","score":0.972000002861023},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.6690000295639038},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.7710000276565552},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9580000042915344},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7310000061988831},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.7979999780654907},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.6520000100135803},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7864987850189209},{"id":"https://openalex.org/C2777601987","wikidata":"https://www.wikidata.org/wiki/Q5283581","display_name":"Disturbance (geology)","level":2,"score":0.5380380153656006},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5266211628913879},{"id":"https://openalex.org/C2778173338","wikidata":"https://www.wikidata.org/wiki/Q951449","display_name":"Myricetin","level":5,"score":0.505420446395874},{"id":"https://openalex.org/C3018987647","wikidata":"https://www.wikidata.org/wiki/Q3221083","display_name":"Motor symptoms","level":4,"score":0.4650586247444153},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4253385663032532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3174368143081665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2635011076927185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09046569466590881},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07791724801063538},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.06213614344596863},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015632","descriptor_name":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-024-62910-6","doi":"https://doi.org/10.1038/s41598-024-62910-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-62910-6","pdf_url":"https://www.nature.com/articles/s41598-024-62910-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11219851","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11219851","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11219851/pdf/41598_2024_Article_62910.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:38956066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38956066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:567dadeeddc8448591074dfab12253a0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/567dadeeddc8448591074dfab12253a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-024-62910-6","doi":"https://doi.org/10.1038/s41598-024-62910-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-62910-6","pdf_url":"https://www.nature.com/articles/s41598-024-62910-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3602224998","display_name":null,"funder_award_id":"82074355","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G4831500700","display_name":null,"funder_award_id":"82074355","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5120769860","display_name":null,"funder_award_id":"SHDC2023CRD005","funder_id":"https://openalex.org/F4320326252","funder_display_name":"Shanghai Shen Kang Hospital Development Center"},{"id":"https://openalex.org/G5344065029","display_name":null,"funder_award_id":"21Y31920300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6174500403","display_name":null,"funder_award_id":"2020PJD066","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6182319813","display_name":null,"funder_award_id":"20204Y0168","funder_id":"https://openalex.org/F4320317789","funder_display_name":"Shanghai Municipal Health Commission"},{"id":"https://openalex.org/G6845688758","display_name":null,"funder_award_id":"21Y31920300","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G8228234173","display_name":null,"funder_award_id":"2020PJD066","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"}],"funders":[{"id":"https://openalex.org/F4320317789","display_name":"Shanghai Municipal Health Commission","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320326252","display_name":"Shanghai Shen Kang Hospital Development Center","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400257883.pdf","grobid_xml":"https://content.openalex.org/works/W4400257883.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1762178123","https://openalex.org/W1799409770","https://openalex.org/W1883534697","https://openalex.org/W1913653254","https://openalex.org/W1964046231","https://openalex.org/W1965514945","https://openalex.org/W1977817124","https://openalex.org/W1985613988","https://openalex.org/W1985842394","https://openalex.org/W2006696253","https://openalex.org/W2024820040","https://openalex.org/W2031054443","https://openalex.org/W2046638138","https://openalex.org/W2052548407","https://openalex.org/W2074533002","https://openalex.org/W2080330212","https://openalex.org/W2087804982","https://openalex.org/W2123621258","https://openalex.org/W2134724878","https://openalex.org/W2134886133","https://openalex.org/W2142430469","https://openalex.org/W2144102286","https://openalex.org/W2294172555","https://openalex.org/W2343663109","https://openalex.org/W2530157596","https://openalex.org/W2531872507","https://openalex.org/W2604448831","https://openalex.org/W2765542802","https://openalex.org/W2775124792","https://openalex.org/W2784858783","https://openalex.org/W2793998823","https://openalex.org/W2909817598","https://openalex.org/W2922901810","https://openalex.org/W2963301415","https://openalex.org/W2969573657","https://openalex.org/W2977524116","https://openalex.org/W3044551997","https://openalex.org/W3046632500","https://openalex.org/W3047082133","https://openalex.org/W3121101545","https://openalex.org/W3204268733","https://openalex.org/W4200597081","https://openalex.org/W4210631328","https://openalex.org/W4213149094","https://openalex.org/W4214598871","https://openalex.org/W4214725121","https://openalex.org/W4223612729","https://openalex.org/W4284969610","https://openalex.org/W4293769844","https://openalex.org/W4294663982","https://openalex.org/W4307757262","https://openalex.org/W4315648122","https://openalex.org/W4323349858","https://openalex.org/W4323566734","https://openalex.org/W4377041429","https://openalex.org/W4380628458","https://openalex.org/W4380685507","https://openalex.org/W4386152052"],"related_works":["https://openalex.org/W4294663982","https://openalex.org/W4324133462","https://openalex.org/W4414286697","https://openalex.org/W4311047384","https://openalex.org/W4380355022","https://openalex.org/W3155975001","https://openalex.org/W4408031682","https://openalex.org/W3114257724","https://openalex.org/W4323046307","https://openalex.org/W7163743908"],"abstract_inverted_index":{"Abstract":[0],"Ferroptosis":[1,84],"is":[2],"an":[3],"iron-dependent":[4],"cell":[5,170,178],"death":[6,38,57,225],"form":[7],"characterized":[8],"by":[9,66,74,87,129,159,226],"reactive":[10],"oxygen":[11],"species":[12],"(ROS)":[13],"overgeneration":[14],"and":[15,34,73,98,115,137,139,149,172,192],"lipid":[16],"peroxidation.":[17],"Myricetin,":[18],"a":[19,161,218],"flavonoid":[20],"that":[21,31,104,214],"exists":[22],"in":[23,119,144,151,199,229],"numerous":[24],"plants,":[25],"exhibits":[26],"potent":[27],"antioxidant":[28],"capacity.":[29],"Given":[30],"iron":[32],"accumulation":[33,118],"ROS-provoked":[35],"dopaminergic":[36,223],"neuron":[37,224],"are":[39],"the":[40,89,145],"two":[41,205],"main":[42],"pathological":[43],"hallmarks":[44],"of":[45,91,132,142,185,208],"Parkinson\u2019s":[46],"disease":[47],"(PD),":[48],"we":[49],"aimed":[50],"to":[51],"investigate":[52],"whether":[53],"myricetin":[54,105,166,181,215],"decreases":[55],"neuronal":[56,113],"through":[58],"suppressing":[59],"ferroptosis.":[60,179,209],"The":[61,101],"PD":[62,120,152],"models":[63],"were":[64,157],"established":[65],"intraperitoneally":[67],"injecting":[68],"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine":[69],"(MPTP)":[70],"into":[71],"rats":[72],"treating":[75],"SH-SY5Y":[76,169,177,203],"cells":[77],"with":[78],"1-methyl-4-phenylpyridinium":[79],"(MPP":[80],"+":[81,175,201],"),":[82],"respectively.":[83],"was":[85],"identified":[86],"assessing":[88],"levels":[90,131,141],"Fe":[92,133],"2+":[93,134],",":[94,135],"ROS,":[95,136],"malondialdehyde":[96],"(MDA),":[97],"glutathione":[99,194],"(GSH).":[100],"results":[102],"demonstrated":[103],"treatment":[106,167],"effectively":[107],"mitigated":[108],"MPTP-triggered":[109],"motor":[110],"impairment,":[111],"dopamine":[112],"death,":[114],"\u03b1-synuclein":[116],"(\u03b1-Syn)":[117],"models.":[121,153],"Myricetin":[122],"also":[123],"alleviated":[124,173],"MPTP-induced":[125],"ferroptosis,":[126],"as":[127],"evidenced":[128],"decreased":[130],"MDA":[138],"increased":[140],"GSH":[143],"substantia":[146],"nigra":[147],"(SN)":[148],"serum":[150],"All":[154],"these":[155,211],"changes":[156],"reversed":[158],"erastin,":[160],"ferroptosis":[162,228],"activator.":[163],"In":[164],"vitro,":[165],"restored":[168],"viability":[171],"MPP":[174,200],"-induced":[176],"Mechanistically,":[180],"accelerated":[182],"nuclear":[183,186],"translocation":[184],"factor":[187,189],"E2-related":[188],"2":[190],"(Nrf2)":[191],"subsequent":[193],"peroxidase":[195],"4":[196],"(Gpx4)":[197],"expression":[198],"-treated":[202],"cells,":[204],"critical":[206],"inhibitors":[207],"Collectively,":[210],"data":[212],"demonstrate":[213],"may":[216],"be":[217],"potential":[219],"agent":[220],"for":[221],"decreasing":[222],"inhibiting":[227],"PD.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-07-03T00:00:00"}