{"id":"https://openalex.org/W4400242518","doi":"https://doi.org/10.1128/jb.00175-24","title":"Clostridioides difficile superoxide reductase mitigates oxygen sensitivity","display_name":"Clostridioides difficile superoxide reductase mitigates oxygen sensitivity","publication_year":2024,"publication_date":"2024-07-02","ids":{"openalex":"https://openalex.org/W4400242518","doi":"https://doi.org/10.1128/jb.00175-24","pmid":"https://pubmed.ncbi.nlm.nih.gov/38953644","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11270899"},"language":"en","primary_location":{"id":"doi:10.1128/jb.00175-24","doi":"https://doi.org/10.1128/jb.00175-24","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.00175-24","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11270899/pdf/jb.00175-24.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086504760","display_name":"Rebecca Kochanowsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Kochanowsky","raw_affiliation_strings":["School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012472911","display_name":"Katelyn E. Carothers","orcid":"https://orcid.org/0000-0001-7013-5355","observed_orcids":["https://orcid.org/0000-0001-7013-5355"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Carothers","raw_affiliation_strings":["School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA"],"raw_orcid":"https://orcid.org/0000-0001-7013-5355","affiliations":[{"raw_affiliation_string":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008871897","display_name":"Bryan P. Roxas","orcid":"https://orcid.org/0000-0002-0139-2232","observed_orcids":["https://orcid.org/0000-0002-0139-2232"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Angelo P. Roxas","raw_affiliation_strings":["School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000174637","display_name":"Farhan Anwar","orcid":"https://orcid.org/0000-0002-1671-9939","observed_orcids":["https://orcid.org/0000-0002-1671-9939"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farhan Anwar","raw_affiliation_strings":["School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019164833","display_name":"V. K. Viswanathan","orcid":"https://orcid.org/0000-0002-9258-9865","observed_orcids":["https://orcid.org/0000-0002-9258-9865"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4388891792","display_name":"BIO5 Institute","ror":"https://ror.org/023drta67","country_code":"US","type":"facility","lineage":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. K. Viswanathan","raw_affiliation_strings":["BIO5 Institute for Collaborative Research, The University of Arizona, Tucson, Arizona, USA","School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA"],"raw_orcid":"https://orcid.org/0000-0002-9258-9865","affiliations":[{"raw_affiliation_string":"BIO5 Institute for Collaborative Research, The University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]},{"raw_affiliation_string":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017921517","display_name":"Gayatri Vedantam","orcid":"https://orcid.org/0000-0002-3144-0610","observed_orcids":["https://orcid.org/0000-0002-3144-0610"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4210098770","display_name":"Southern Arizona VA Health Care System","ror":"https://ror.org/00xb4cb83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210098770","https://openalex.org/I4210138663"]},{"id":"https://openalex.org/I4388891792","display_name":"BIO5 Institute","ror":"https://ror.org/023drta67","country_code":"US","type":"facility","lineage":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayatri Vedantam","raw_affiliation_strings":["BIO5 Institute for Collaborative Research, The University of Arizona, Tucson, Arizona, USA","School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA","Southern Arizona VA Healthcare System, Tucson, Arizona, USA"],"raw_orcid":"https://orcid.org/0000-0002-3144-0610","affiliations":[{"raw_affiliation_string":"BIO5 Institute for Collaborative Research, The University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]},{"raw_affiliation_string":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Southern Arizona VA Healthcare System, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I4210098770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0919,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.91795719,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"206","issue":"7","first_page":"e0017524","last_page":"e0017524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridioides-difficile","display_name":"Clostridium difficile","score":1.0},{"id":"https://openalex.org/keywords/superoxide-reductase","display_name":"superoxide reductase","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5389999747276306},{"id":"https://openalex.org/keywords/oxygen-tolerance","display_name":"oxygen tolerance","score":0.7559999823570251},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.9190000295639038},{"id":"https://openalex.org/keywords/superoxide-radical-scavenging","display_name":"superoxide radical scavenging","score":0.9520000219345093},{"id":"https://openalex.org/keywords/proteomic-changes","display_name":"proteome changes","score":0.5740000009536743},{"id":"https://openalex.org/keywords/gastrointestinal-colonization","display_name":"intestinal colonization","score":0.5690000057220459},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.628000020980835},{"id":"https://openalex.org/keywords/clostridium-difficile-infection","display_name":"Clostridium difficile infection","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.7258374691009521},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7105745673179626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6951578259468079},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6048610210418701},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5187766551971436},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4814035892486572},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4639069437980652},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.43543845415115356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28808772563934326},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23963162302970886}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jb.00175-24","doi":"https://doi.org/10.1128/jb.00175-24","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.00175-24","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11270899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11270899","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11270899/pdf/jb.00175-24.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:38953644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38953644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11270899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11270899","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11270899/pdf/jb.00175-24.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2790059148","display_name":null,"funder_award_id":"I01BX001183","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G2887603861","display_name":null,"funder_award_id":"IK6 BX003789","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3243798062","display_name":"Redox stress responses in Clostridium difficile: mechanisms and implications","funder_award_id":"R21AI119478","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8859400237","display_name":null,"funder_award_id":"IK6BX003789, I01BX001183","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400242518.pdf","grobid_xml":"https://content.openalex.org/works/W4400242518.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1492422940","https://openalex.org/W1509038183","https://openalex.org/W1536864250","https://openalex.org/W1836564745","https://openalex.org/W1969374802","https://openalex.org/W1975677298","https://openalex.org/W1975920595","https://openalex.org/W1978513706","https://openalex.org/W1992035719","https://openalex.org/W1993018668","https://openalex.org/W1995199032","https://openalex.org/W1996241686","https://openalex.org/W1997267262","https://openalex.org/W2008058166","https://openalex.org/W2011299520","https://openalex.org/W2011747966","https://openalex.org/W2022708180","https://openalex.org/W2026856365","https://openalex.org/W2032894712","https://openalex.org/W2034538188","https://openalex.org/W2041633947","https://openalex.org/W2043667854","https://openalex.org/W2047821263","https://openalex.org/W2049085828","https://openalex.org/W2049355215","https://openalex.org/W2065956804","https://openalex.org/W2068491817","https://openalex.org/W2069192355","https://openalex.org/W2069480047","https://openalex.org/W2071825506","https://openalex.org/W2076243547","https://openalex.org/W2077265746","https://openalex.org/W2079183971","https://openalex.org/W2091290075","https://openalex.org/W2091846570","https://openalex.org/W2101422765","https://openalex.org/W2106635583","https://openalex.org/W2121149847","https://openalex.org/W2143366126","https://openalex.org/W2150064568","https://openalex.org/W2152161931","https://openalex.org/W2155162875","https://openalex.org/W2160454557","https://openalex.org/W2162133321","https://openalex.org/W2165289645","https://openalex.org/W2168546011","https://openalex.org/W2338773685","https://openalex.org/W2534434987","https://openalex.org/W2588370254","https://openalex.org/W2767203214","https://openalex.org/W2786774014","https://openalex.org/W2792562616","https://openalex.org/W2804335534","https://openalex.org/W2805380469","https://openalex.org/W2806529338","https://openalex.org/W2809697921","https://openalex.org/W2912030928","https://openalex.org/W2986841338","https://openalex.org/W3015060289","https://openalex.org/W3032575120","https://openalex.org/W3084125378","https://openalex.org/W3087072225","https://openalex.org/W3095839267","https://openalex.org/W3135842290","https://openalex.org/W3175883958","https://openalex.org/W4200140897","https://openalex.org/W4200319570","https://openalex.org/W4249109700","https://openalex.org/W4288080907","https://openalex.org/W4387742420","https://openalex.org/W4389879815","https://openalex.org/W4391640650"],"related_works":["https://openalex.org/W4312017936","https://openalex.org/W4408669868","https://openalex.org/W4407023813","https://openalex.org/W2805380469","https://openalex.org/W4402617121","https://openalex.org/W7033830821","https://openalex.org/W4403894701","https://openalex.org/W4401913736","https://openalex.org/W4200319570","https://openalex.org/W4200140897"],"abstract_inverted_index":{"ABSTRACT":[0],"Clostridioides":[1,204],"difficile":[2,29,35,60,70,108,118,132,156,181,199,205,231,252,290,300],"causes":[3],"a":[4,10,18,77,154,224,255,304],"serious":[5],"diarrheal":[6,220],"disease":[7],"and":[8,41,58,101,144,191,215,302],"is":[9,36,53,83,206,275],"common":[11],"healthcare-associated":[12],"bacterial":[13],"pathogen.":[14],"Although":[15],"it":[16],"has":[17,232],"major":[19],"impact":[20],"on":[21,196],"human":[22],"health,":[23],"the":[24,50,145,169,176,197,242,250,271,276],"mechanistic":[25],"details":[26],"of":[27,56,92,114,179,217,239,263,270,278,284,298],"C.":[28,34,59,69,107,117,131,155,180,198,230,251,289,299],"intestinal":[30],"colonization":[31],"remain":[32],"undefined.":[33],"highly":[37],"sensitive":[38,120],"to":[39,87,96,121,127,168,235],"oxygen":[40,110,164,240],"requires":[42],"anaerobic":[43],"conditions":[44],"for":[45,308],"in":[46,65,105,135,186,227,241,266,287],"vitro":[47,228],"growth.":[48],"However,":[49],"mammalian":[51,243],"gut":[52],"not":[54],"devoid":[55],"oxygen,":[57],"tolerates":[61],"moderate":[62],"oxidative":[63,189,292],"stress":[64,165],"vivo":[66],".":[67],"The":[68,90,268],"genome":[71,253],"encodes":[72,254],"several":[73],"antioxidant":[74,128,248,264],"proteins,":[75,249],"including":[76,282],"predicted":[78,256],"superoxide":[79,150,257],"reductase":[80,258],"(SOR)":[81],"that":[82,124],"upregulated":[84],"upon":[85],"exposure":[86],"antimicrobial":[88],"peptides.":[89],"goal":[91],"this":[93],"study":[94],"was":[95],"establish":[97,175],"SOR":[98,125,157],"enzymatic":[99,177,280],"activity":[100,178],"assess":[102],"its":[103,184,285],"role":[104,185,286],"protecting":[106,288],"against":[109,140,188,291],"exposure.":[111],"Insertional":[112],"inactivation":[113],"sor":[115,133],"rendered":[116],"more":[119],"superoxide,":[122],"indicating":[123],"contributes":[126],"defense.":[129],"Heterologous":[130],"expression":[134],"Escherichia":[136],"coli":[137],"conferred":[138],"protection":[139,187],"superoxide-dependent":[141],"growth":[142],"inhibition,":[143],"corresponding":[146],"cell":[147,201],"lysates":[148],"showed":[149],"scavenging":[151],"activity.":[152],"Finally,":[153],"mutant":[158],"exhibited":[159],"global":[160],"proteome":[161],"changes":[162],"under":[163],"when":[166],"compared":[167],"parent":[170],"strain.":[171],"Collectively,":[172],"our":[173,296],"data":[174],"SOR,":[182],"confirm":[183],"stress,":[190],"demonstrate":[192],"SOR\u2019s":[193,279],"broader":[194],"impacts":[195],"vegetative":[200],"proteome.":[202],"IMPORTANCE":[203],"an":[207,260],"important":[208],"pathogen":[209],"strongly":[210],"associated":[211],"with":[212],"healthcare":[213],"settings":[214],"capable":[216],"causing":[218],"severe":[219],"disease.":[221],"While":[222],"considered":[223],"strict":[225],"anaerobe":[226],",":[229],"been":[233],"shown":[234],"tolerate":[236],"low":[237],"levels":[238],"host.":[244],"Among":[245],"other":[246],"well-characterized":[247],"(SOR),":[259],"understudied":[261],"component":[262],"defense":[265],"pathogens.":[267],"significance":[269],"research":[272],"reported":[273],"herein":[274],"characterization":[277],"activity,":[281],"confirmation":[283],"stress.":[293],"This":[294],"furthers":[295],"understanding":[297],"pathogenesis":[301],"presents":[303],"potential":[305],"new":[306],"avenue":[307],"targeted":[309],"therapies.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-03T00:00:00"}
