{"id":"https://openalex.org/W4400229405","doi":"https://doi.org/10.1038/s41467-026-78673-9","title":"Aging-related cellular and molecular changes reveal a role for Bglap3+ neurons in MEC spatial cognition","display_name":"Aging-related cellular and molecular changes reveal a role for Bglap3+ neurons in MEC spatial cognition","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W4400229405","doi":"https://doi.org/10.1038/s41467-026-78673-9"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-78673-9","doi":"https://doi.org/10.1038/s41467-026-78673-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78673-9","pdf_url":"https://www.nature.com/articles/s41467-026-78673-9_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-78673-9_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058507980","display_name":"Qichen Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qichen Cao","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160650608","display_name":"Guge Suri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guge Suri","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","Peking University\u2013Tsinghua University\u2013National Institute of Biological Sciences Joint Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking University\u2013Tsinghua University\u2013National Institute of Biological Sciences Joint Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I99065089"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104340965","display_name":"Sihui Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sihui Cheng","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210160507"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034100857","display_name":"Yuanjing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanjing Liu","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210160507"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009744072","display_name":"Jiangyuan Liu","orcid":"https://orcid.org/0000-0002-6739-6674","observed_orcids":["https://orcid.org/0000-0002-6739-6674"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangyuan Liu","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210160507"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114185730","display_name":"Shidan Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shidan Wen","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156672182","display_name":"Meng Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Zhong","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101348454","display_name":"Jun Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Hao","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024702715","display_name":"Shuyang Yao","orcid":"https://orcid.org/0009-0005-7250-1490","observed_orcids":["https://orcid.org/0009-0005-7250-1490"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuyang Yao","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0005-7250-1490","affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043943801","display_name":"Yikai Yang","orcid":"https://orcid.org/0000-0001-8110-3359","observed_orcids":["https://orcid.org/0000-0001-8110-3359"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yikai Yang","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026859056","display_name":"Shuai Xu","orcid":"https://orcid.org/0000-0002-6502-7138","observed_orcids":["https://orcid.org/0000-0002-6502-7138","https://orcid.org/0009-0005-5442-2975"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Xu","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-6502-7138","affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210160507"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156465579","display_name":"Hong Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Jin","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113350326","display_name":"Xinyu Yan","orcid":"https://orcid.org/0009-0004-6882-6789","observed_orcids":["https://orcid.org/0009-0004-6882-6789"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Yan","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081099972","display_name":"Weixiang Guo","orcid":"https://orcid.org/0000-0001-9303-6595","observed_orcids":["https://orcid.org/0000-0001-9303-6595"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixiang Guo","raw_affiliation_strings":["State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-9303-6595","affiliations":[{"raw_affiliation_string":"State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042049166","display_name":"Chenglin Miao","orcid":"https://orcid.org/0000-0002-0607-5180","observed_orcids":["https://orcid.org/0000-0002-0607-5180"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenglin Miao","raw_affiliation_strings":["PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, China","Peking University\u2013Tsinghua University\u2013National Institute of Biological Sciences Joint Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-0607-5180","affiliations":[{"raw_affiliation_string":"PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking University\u2013Tsinghua University\u2013National Institute of Biological Sciences Joint Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I99065089"]},{"raw_affiliation_string":"Peking\u2013Tsinghua Center for Life Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210160507"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768054"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5042049166","https://openalex.org/A5160650608"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I4391768054","https://openalex.org/I99065089"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00198249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11904","display_name":"Spatial Cognition and Navigation","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2203","display_name":"Automotive Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medial-entorhinal-cortex","display_name":"medial entorhinal cortex","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.7689999938011169},{"id":"https://openalex.org/keywords/grid-cells","display_name":"grid cells","score":0.7459999918937683},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.6330000162124634},{"id":"https://openalex.org/keywords/spatial-learning","display_name":"spatial learning","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.5740000009536743},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6190000176429749},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.46299999952316284},{"id":"https://openalex.org/keywords/spatial-tuning","display_name":"spatial tuning","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2986811735","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Cognitive aging","level":3,"score":0.7549728155136108},{"id":"https://openalex.org/C2993665655","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Brain aging","level":3,"score":0.5609637498855591},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5499070882797241},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5417793989181519},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4736265540122986},{"id":"https://openalex.org/C2779695026","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Aging brain","level":3,"score":0.4610402584075928},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.44139575958251953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2656536400318146},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.18698608875274658},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12623539566993713},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1153249740600586}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41467-026-78673-9","doi":"https://doi.org/10.1038/s41467-026-78673-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78673-9","pdf_url":"https://www.nature.com/articles/s41467-026-78673-9_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2024.06.27.600930","doi":"https://doi.org/10.1101/2024.06.27.600930","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.06.27.600930","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-78673-9","doi":"https://doi.org/10.1038/s41467-026-78673-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78673-9","pdf_url":"https://www.nature.com/articles/s41467-026-78673-9_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400229405.pdf","grobid_xml":"https://content.openalex.org/works/W4400229405.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W1501304874","https://openalex.org/W1512234833","https://openalex.org/W1523904580","https://openalex.org/W1586895509","https://openalex.org/W1630370318","https://openalex.org/W1725969320","https://openalex.org/W1752420865","https://openalex.org/W1888004466","https://openalex.org/W1891932798","https://openalex.org/W1966788003","https://openalex.org/W1970792572","https://openalex.org/W1973311433","https://openalex.org/W1981694662","https://openalex.org/W1992842030","https://openalex.org/W1998802149","https://openalex.org/W1999856091","https://openalex.org/W2003765916","https://openalex.org/W2008579006","https://openalex.org/W2009359439","https://openalex.org/W2013651116","https://openalex.org/W2014792483","https://openalex.org/W2019035443","https://openalex.org/W2023521517","https://openalex.org/W2023768217","https://openalex.org/W2030015211","https://openalex.org/W2034786388","https://openalex.org/W2035025978","https://openalex.org/W2036615793","https://openalex.org/W2037343688","https://openalex.org/W2037628926","https://openalex.org/W2042132483","https://openalex.org/W2052515926","https://openalex.org/W2052884971","https://openalex.org/W2070770741","https://openalex.org/W2074358376","https://openalex.org/W2075657688","https://openalex.org/W2082605281","https://openalex.org/W2084588382","https://openalex.org/W2088358452","https://openalex.org/W2092580449","https://openalex.org/W2099901929","https://openalex.org/W2102212449","https://openalex.org/W2103861118","https://openalex.org/W2114104545","https://openalex.org/W2120127728","https://openalex.org/W2120313194","https://openalex.org/W2120778579","https://openalex.org/W2126079698","https://openalex.org/W2128340731","https://openalex.org/W2131271579","https://openalex.org/W2131938193","https://openalex.org/W2137435206","https://openalex.org/W2142449474","https://openalex.org/W2143454347","https://openalex.org/W2147414198","https://openalex.org/W2165269820","https://openalex.org/W2165400927","https://openalex.org/W2166846124","https://openalex.org/W2168154867","https://openalex.org/W2169456326","https://openalex.org/W2171625211","https://openalex.org/W2174794163","https://openalex.org/W2179438025","https://openalex.org/W2201923684","https://openalex.org/W2231058499","https://openalex.org/W2464751873","https://openalex.org/W2469581795","https://openalex.org/W2471536144","https://openalex.org/W2482918638","https://openalex.org/W2520498925","https://openalex.org/W2576056287","https://openalex.org/W2577983519","https://openalex.org/W2595012769","https://openalex.org/W2610604817","https://openalex.org/W2616981115","https://openalex.org/W2712068521","https://openalex.org/W2751705769","https://openalex.org/W2759621709","https://openalex.org/W2765445094","https://openalex.org/W2774672285","https://openalex.org/W2782274120","https://openalex.org/W2793584781","https://openalex.org/W2794229082","https://openalex.org/W2800417008","https://openalex.org/W2806530968","https://openalex.org/W2887114371","https://openalex.org/W2892282934","https://openalex.org/W2915848182","https://openalex.org/W2928665623","https://openalex.org/W2975507539","https://openalex.org/W2984472267","https://openalex.org/W2991414673","https://openalex.org/W3002043570","https://openalex.org/W3162218953","https://openalex.org/W3164692211","https://openalex.org/W3212895337","https://openalex.org/W4220671829","https://openalex.org/W4229033508","https://openalex.org/W4241650885","https://openalex.org/W4313312704"],"related_works":["https://openalex.org/W4414777478","https://openalex.org/W4391948270","https://openalex.org/W1988407393","https://openalex.org/W7098620206","https://openalex.org/W4383906744","https://openalex.org/W2188187772","https://openalex.org/W7126357637","https://openalex.org/W3021320887","https://openalex.org/W3204634535","https://openalex.org/W4383956063"],"abstract_inverted_index":{"Abstract":[0],"Aging-related":[1],"cognitive":[2],"decline,":[3],"including":[4],"impairments":[5],"in":[6,94,103,139],"spatial":[7,51,107,136],"orientation":[8],"and":[9,19,27,49,70,117,125],"memory,":[10],"has":[11],"been":[12],"linked":[13],"to":[14,121],"dysfunction":[15,124],"within":[16],"the":[17,25,56,128],"hippocampus":[18],"medial":[20],"entorhinal":[21],"cortex":[22],"(MEC).":[23],"However,":[24],"cellular":[26,116],"molecular":[28,118],"alterations":[29],"underlying":[30],"MEC":[31,57,110,123],"aging":[32],"remain":[33],"poorly":[34],"understood.":[35],"Here":[36],"we":[37],"show":[38],"that":[39,89,127],"old":[40,71],"mice":[41,105],"exhibit":[42],"a":[43,79,83],"reduced":[44],"proportion":[45],"of":[46,55,85,99,109,130],"grid":[47],"cells":[48],"decreased":[50],"stability.":[52],"Transcriptomic":[53],"profiling":[54],"using":[58],"10x":[59],"Genomics":[60],"Visium":[61],"technology":[62],"reveals":[63],"1664":[64],"differentially":[65],"expressed":[66],"genes":[67],"between":[68],"young":[69,104],"mice.":[72],"Among":[73],"these,":[74],"Bglap3":[75,100,131],"is":[76],"identified":[77],"as":[78],"marker":[80],"gene":[81],"for":[82],"subpopulation":[84],"Layer":[86],"III":[87],"neurons":[88,102,133],"showed":[90],"an":[91],"age-associated":[92],"reduction":[93],"cell":[95],"number.":[96],"Chemogenetic":[97],"silencing":[98],"+":[101,132],"impairs":[106],"tuning":[108],"neurons.":[111],"Together,":[112],"these":[113],"findings":[114],"elucidate":[115],"mechanisms":[119],"contributing":[120],"age-related":[122],"suggest":[126],"loss":[129],"may":[134],"underlie":[135],"coding":[137],"deficits":[138],"aging.":[140]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-07-03T00:00:00"}
