{"id":"https://openalex.org/W4400214422","doi":"https://doi.org/10.1158/2159-8290.26134858","title":"Figure S3 from Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy","display_name":"Figure S3 from Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4400214422","doi":"https://doi.org/10.1158/2159-8290.26134858"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.26134858","doi":"https://doi.org/10.1158/2159-8290.26134858","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.26134858","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.26134858","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085217090","display_name":"Matheus Henrique Dias","orcid":"https://orcid.org/0000-0002-2961-1142","observed_orcids":["https://orcid.org/0000-0002-2961-1142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matheus Henrique Dias","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2961-1142","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090302884","display_name":"Anoek Friskes","orcid":"https://orcid.org/0000-0002-9845-3715","observed_orcids":["https://orcid.org/0000-0002-9845-3715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anoek Friskes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9845-3715","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009783386","display_name":"Siying Wang","orcid":"https://orcid.org/0000-0003-0810-8828","observed_orcids":["https://orcid.org/0000-0003-0810-8828","https://orcid.org/0009-0002-3746-176X","https://orcid.org/0009-0003-1438-6354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siying Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0810-8828","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079694182","display_name":"Jo\u00e3o M. Fernandes Neto","orcid":"https://orcid.org/0000-0002-0549-8835","observed_orcids":["https://orcid.org/0000-0002-0549-8835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joao M. Fernandes Neto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0549-8835","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102915373","display_name":"Frank P. A. van Gemert","orcid":"https://orcid.org/0009-0000-6076-9469","observed_orcids":["https://orcid.org/0009-0000-6076-9469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank van Gemert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-6076-9469","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056948757","display_name":"Soufiane M. C. Mourragui","orcid":"https://orcid.org/0000-0001-6920-2696","observed_orcids":["https://orcid.org/0000-0001-6920-2696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soufiane Mourragui","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6920-2696","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061571526","display_name":"Chrysa Papagianni","orcid":"https://orcid.org/0009-0002-0513-0763","observed_orcids":["https://orcid.org/0009-0002-0513-0763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chrysa Papagianni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-0513-0763","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049897931","display_name":"Hendrik J. Kuiken","orcid":"https://orcid.org/0000-0002-1015-4607","observed_orcids":["https://orcid.org/0000-0002-1015-4607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hendrik J. Kuiken","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1015-4607","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005545073","display_name":"Sara Mainardi","orcid":"https://orcid.org/0000-0001-7255-6153","observed_orcids":["https://orcid.org/0000-0001-7255-6153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Mainardi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7255-6153","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076778474","display_name":"Daniel Alvarez Villanueva","orcid":"https://orcid.org/0000-0003-2585-622X","observed_orcids":["https://orcid.org/0000-0003-2585-622X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Alvarez-Villanueva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2585-622X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084927840","display_name":"Cor Lieftink","orcid":"https://orcid.org/0000-0002-2754-4150","observed_orcids":["https://orcid.org/0000-0002-2754-4150"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cor Lieftink","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2754-4150","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044639892","display_name":"Ben Morris","orcid":"https://orcid.org/0000-0002-9850-6071","observed_orcids":["https://orcid.org/0000-0002-9850-6071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben Morris","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9850-6071","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051328586","display_name":"Anna Dekker","orcid":"https://orcid.org/0000-0002-1000-3788","observed_orcids":["https://orcid.org/0000-0002-1000-3788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Dekker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1000-3788","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043411351","display_name":"Emma van Dijk","orcid":"https://orcid.org/0009-0004-1595-2327","observed_orcids":["https://orcid.org/0009-0004-1595-2327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma van Dijk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-1595-2327","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023532676","display_name":"Lieke H.S. Wilms","orcid":"https://orcid.org/0009-0000-1795-6752","observed_orcids":["https://orcid.org/0009-0000-1795-6752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lieke H.S. Wilms","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-1795-6752","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044344396","display_name":"Marcelo S. da Silva","orcid":"https://orcid.org/0000-0003-4203-9299","observed_orcids":["https://orcid.org/0000-0003-4203-9299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcelo S. da Silva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4203-9299","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000562650","display_name":"Robin A. Jansen","orcid":"https://orcid.org/0009-0001-7272-234X","observed_orcids":["https://orcid.org/0009-0001-7272-234X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin A. Jansen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-7272-234X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047045246","display_name":"Antonio Mulero\u2010S\u00e1nchez","orcid":"https://orcid.org/0000-0003-1668-7022","observed_orcids":["https://orcid.org/0000-0003-1668-7022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Mulero-S\u00e1nchez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1668-7022","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055213329","display_name":"Elke Malzer","orcid":"https://orcid.org/0000-0002-8529-8234","observed_orcids":["https://orcid.org/0000-0002-8529-8234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elke Malzer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8529-8234","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003826728","display_name":"August Vidal","orcid":"https://orcid.org/0000-0001-5727-2099","observed_orcids":["https://orcid.org/0000-0001-5727-2099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"August Vidal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5727-2099","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060569859","display_name":"Cristina Santos","orcid":"https://orcid.org/0000-0002-9854-5097","observed_orcids":["https://orcid.org/0000-0002-9854-5097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Santos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9854-5097","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035175323","display_name":"Ram\u00f3n Salazar","orcid":"https://orcid.org/0000-0001-9419-6232","observed_orcids":["https://orcid.org/0000-0001-9419-6232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ram\u00f3n Salazar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9419-6232","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037639617","display_name":"Rosangela A.M. Wailemann","orcid":"https://orcid.org/0000-0003-4909-9657","observed_orcids":["https://orcid.org/0000-0003-4909-9657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosangela A.M. Wailemann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4909-9657","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028091390","display_name":"Thompson E.P. Torres","orcid":"https://orcid.org/0000-0003-1425-9358","observed_orcids":["https://orcid.org/0000-0003-1425-9358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thompson E.P. Torres","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1425-9358","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035090455","display_name":"Giulia De Conti","orcid":"https://orcid.org/0000-0002-2647-228X","observed_orcids":["https://orcid.org/0000-0002-2647-228X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulia De Conti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2647-228X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022915602","display_name":"Jonne A. Raaijmakers","orcid":"https://orcid.org/0000-0003-1759-8347","observed_orcids":["https://orcid.org/0000-0003-1759-8347"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonne A. Raaijmakers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1759-8347","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087708892","display_name":"P\u00e9tur Sn\u00e6bj\u00f6rnsson","orcid":"https://orcid.org/0000-0002-1086-8108","observed_orcids":["https://orcid.org/0000-0002-1086-8108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petur Snaebjornsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1086-8108","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022374609","display_name":"Shengxian Yuan","orcid":"https://orcid.org/0000-0002-4883-0156","observed_orcids":["https://orcid.org/0000-0002-4883-0156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shengxian Yuan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4883-0156","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030429117","display_name":"Wenxin Qin","orcid":"https://orcid.org/0000-0002-1989-3027","observed_orcids":["https://orcid.org/0000-0002-1989-3027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenxin Qin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1989-3027","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112006097","display_name":"John S. Kovach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John S. Kovach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072122806","display_name":"Hugo A. Armelin","orcid":"https://orcid.org/0000-0001-9557-0804","observed_orcids":["https://orcid.org/0000-0001-9557-0804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hugo A. Armelin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9557-0804","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002551113","display_name":"Hein te Riele","orcid":"https://orcid.org/0000-0003-0255-4042","observed_orcids":["https://orcid.org/0000-0003-0255-4042"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hein te Riele","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0255-4042","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035202405","display_name":"Alexander van Oudenaarden","orcid":"https://orcid.org/0000-0002-9442-3551","observed_orcids":["https://orcid.org/0000-0002-9442-3551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander van Oudenaarden","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9442-3551","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010924102","display_name":"Haojie Jin","orcid":"https://orcid.org/0000-0001-9295-1951","observed_orcids":["https://orcid.org/0000-0001-9295-1951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haojie Jin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9295-1951","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058317809","display_name":"Roderick L. Beijersbergen","orcid":"https://orcid.org/0000-0003-0116-4130","observed_orcids":["https://orcid.org/0000-0003-0116-4130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roderick L. Beijersbergen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0116-4130","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004386682","display_name":"Alberto Villanueva","orcid":"https://orcid.org/0000-0001-5164-0006","observed_orcids":["https://orcid.org/0000-0001-5164-0006"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto Villanueva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5164-0006","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074565662","display_name":"Ren\u00e9 H. Medema","orcid":"https://orcid.org/0000-0002-6754-0381","observed_orcids":["https://orcid.org/0000-0002-6754-0381","https://orcid.org/0009-0004-3701-7751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rene H. Medema","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6754-0381","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028266055","display_name":"Ren\u00e9 Bernards","orcid":"https://orcid.org/0000-0001-8677-3423","observed_orcids":["https://orcid.org/0000-0001-8677-3423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rene Bernards","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8677-3423","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.39649999141693115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.39649999141693115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.09589999914169312,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.06629999727010727,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lb-100","display_name":"LB-100","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.8140000104904175},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ppp2r1a","display_name":"PPP2R1A","score":0.9039999842643738},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.8090000152587891},{"id":"https://openalex.org/keywords/wee1-inhibition","display_name":"WEE1 inhibition","score":0.8980000019073486},{"id":"https://openalex.org/keywords/adavosertib","display_name":"adavosertib","score":0.9710000157356262},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7829999923706055},{"id":"https://openalex.org/keywords/calyculin-a","display_name":"calyculin A","score":0.8489999771118164},{"id":"https://openalex.org/keywords/okadaic-acid","display_name":"okadaic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.5839999914169312},{"id":"https://openalex.org/keywords/drug-sensitization","display_name":"drug sensitization","score":0.7110000252723694},{"id":"https://openalex.org/keywords/isogenic-cell-models","display_name":"isogenic cell models","score":0.4429999887943268},{"id":"https://openalex.org/keywords/molecular-signatures","display_name":"molecular signatures","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6242078542709351},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.467338889837265},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33269035816192627},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3233684301376343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3031288981437683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1889325976371765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2159-8290.26134858","doi":"https://doi.org/10.1158/2159-8290.26134858","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.26134858","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.26134858","doi":"https://doi.org/10.1158/2159-8290.26134858","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.26134858","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400213798","https://openalex.org/W4400214421","https://openalex.org/W4400214420","https://openalex.org/W4400213803","https://openalex.org/W7164986808","https://openalex.org/W4283364952","https://openalex.org/W4408083459","https://openalex.org/W2901292274","https://openalex.org/W6911480750","https://openalex.org/W2503850107"],"abstract_inverted_index":{"Figure":[0],"S3:":[1],"High":[2],"N-Myc":[3,23],"levels":[4,24],"sensitize":[5],"neuroblastoma":[6,27,47],"cells":[7,15,57,163],"to":[8,16,100],"LB-100,":[9],"and":[10,55,66,78,106,140,161],"PP2A":[11],"knockdown":[12,73,98],"sensitizes":[13],"CRC":[14],"WEE1":[17],"inhibition":[18],"(A)":[19],"Western":[20,69],"blots":[21,70],"comparing":[22],"in":[25,76,104,119,159],"isogenic":[26],"models.":[28,48],"GAPDH":[29,81],"was":[30,50,82,111],"used":[31,83],"as":[32,84],"a":[33,85,101],"loading":[34,86],"control.":[35,87,127],"(B)":[36],"long-term":[37],"viability":[38,110],"assays":[39,90],"compares":[40],"the":[41,56,72,92,120,123],"toxicity":[42],"of":[43,74,94,122],"LB-100":[44,49,147],"across":[45],"these":[46],"refreshed":[51],"every":[52],"2-3":[53],"days,":[54],"were":[58],"grown":[59],"for":[60],"10":[61],"days":[62,118],"before":[63],"fixing,":[64],"staining,":[65],"imaging.":[67],"(C)":[68],"show":[71,91],"PPP2R1A":[75,97],"HT-29":[77,105,160],"SW-480":[79,107,162],"cells.":[80,108],"(D)":[88],"Dose-response":[89],"effect":[93],"Adavosertib":[95],"after":[96,116,164],"compared":[99],"control":[102],"shRNA":[103],"Cell":[109],"estimated":[112],"by":[113,146],"resazurin":[114],"fluorescence":[115],"5":[117],"presence":[121],"drug":[124],"or":[125,154],"DMSO":[126],"The":[128,134],"normalized":[129],"values":[130],"are":[131],"plotted.":[132],"(E)":[133],"heat":[135],"map":[136],"shows":[137],"all":[138],"\u201cHallmarks\u201d":[139],"\u201cKEGG\u201d":[141],"molecular":[142],"signatures":[143],"significantly":[144],"enriched":[145],"(4":[148],"\u00b5M),":[149],"calyculin":[150],"A":[151],"(5":[152],"nM),":[153],"okadaic":[155],"acid":[156],"(10":[157],"nM)":[158],"8":[165],"hours.":[166],"Asterisks":[167],"indicate":[168],"significance":[169],"level":[170],"(*":[171],"p-value":[172,175,178],"<0.05,":[173],"**":[174],"<0.01,":[176],"***":[177],"<0.001).":[179]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-07-02T00:00:00"}
