{"id":"https://openalex.org/W4400205379","doi":"https://doi.org/10.6060/ivkkt.20246707.7029","title":"SYNTHESIS AND STUDY OF ANTINOCICEPTIVE ACTIVITY OF SUBSTITUTED 2-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YLAMINO)-4-OXOBUT-2-ENOATES","display_name":"SYNTHESIS AND STUDY OF ANTINOCICEPTIVE ACTIVITY OF SUBSTITUTED 2-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YLAMINO)-4-OXOBUT-2-ENOATES","publication_year":2024,"publication_date":"2024-05-30","ids":{"openalex":"https://openalex.org/W4400205379","doi":"https://doi.org/10.6060/ivkkt.20246707.7029"},"language":"en","primary_location":{"id":"doi:10.6060/ivkkt.20246707.7029","doi":"https://doi.org/10.6060/ivkkt.20246707.7029","is_oa":true,"landing_page_url":"http://doi.org/10.6060/ivkkt.20246707.7029","pdf_url":null,"source":{"id":"https://openalex.org/S4210215561","display_name":"IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA","issn_l":"0579-2991","issn":["0579-2991","2500-3070"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I3276886","host_organization_name":"Ivanovo State University of Chemistry and Technology","host_organization_lineage":["https://openalex.org/I3276886"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemChemTech","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://doi.org/10.6060/ivkkt.20246707.7029","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093455502","display_name":"Yulia O. Sharavyeva","orcid":"https://orcid.org/0000-0001-5240-569X","observed_orcids":["https://orcid.org/0000-0001-5240-569X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yulia O. Sharavyeva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062967931","display_name":"\u0420\u0430\u043c\u0438\u0437 \u0420\u0430\u0433\u0438\u0431\u043e\u0432\u0438\u0447 \u041c\u0430\u0445\u043c\u0443\u0434\u043e\u0432","orcid":"https://orcid.org/0000-0002-2326-3976","observed_orcids":["https://orcid.org/0000-0002-2326-3976"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramiz R. Makhmudov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059795023","display_name":"Daria A. Shipilovskikh","orcid":"https://orcid.org/0000-0001-6086-4300","observed_orcids":["https://orcid.org/0000-0001-6086-4300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daria A. Shipilovskikh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081123794","display_name":"P. S. Silaichev","orcid":"https://orcid.org/0000-0002-2840-6809","observed_orcids":["https://orcid.org/0000-0002-2840-6809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pavel S. Silaichev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006715496","display_name":"Irina A. Gorbunova","orcid":"https://orcid.org/0000-0003-3028-7914","observed_orcids":["https://orcid.org/0000-0003-3028-7914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irina A. Gorbunova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2748,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.32029473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"67","issue":"7","first_page":"19","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13876","display_name":"Chemical synthesis and pharmacological studies","score":0.42750000953674316,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13876","display_name":"Chemical synthesis and pharmacological studies","score":0.42750000953674316,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.3458999991416931,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.17910000681877136,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intramolecular-cyclization","display_name":"intramolecular cyclization","score":0.9010000228881836},{"id":"https://openalex.org/keywords/decyclization","display_name":"decyclization","score":0.7870000004768372},{"id":"https://openalex.org/keywords/propionic-anhydride","display_name":"propionic anhydride","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.7400000095367432},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/analgesics","display_name":"analgesics","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5638967752456665},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4394024610519409},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.4200224280357361},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.045695990324020386},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.03586563467979431}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6060/ivkkt.20246707.7029","doi":"https://doi.org/10.6060/ivkkt.20246707.7029","is_oa":true,"landing_page_url":"http://doi.org/10.6060/ivkkt.20246707.7029","pdf_url":null,"source":{"id":"https://openalex.org/S4210215561","display_name":"IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA","issn_l":"0579-2991","issn":["0579-2991","2500-3070"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I3276886","host_organization_name":"Ivanovo State University of Chemistry and Technology","host_organization_lineage":["https://openalex.org/I3276886"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemChemTech","raw_type":"journal-article"},{"id":"pmh:https://cyberleninka.ru/article/n/synthesis-and-study-of-antinociceptive-activity-of-substituted-2-3-cyano4-5-6-7-tetrahydrobenzo-b-thiophen-2-ylamino-4-oxobut-2","doi":null,"is_oa":false,"landing_page_url":"https://cyberleninka.ru/article/n/synthesis-and-study-of-antinociceptive-activity-of-substituted-2-3-cyano4-5-6-7-tetrahydrobenzo-b-thiophen-2-ylamino-4-oxobut-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"doi:10.6060/ivkkt.20246707.7029","doi":"https://doi.org/10.6060/ivkkt.20246707.7029","is_oa":true,"landing_page_url":"http://doi.org/10.6060/ivkkt.20246707.7029","pdf_url":null,"source":{"id":"https://openalex.org/S4210215561","display_name":"IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA","issn_l":"0579-2991","issn":["0579-2991","2500-3070"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I3276886","host_organization_name":"Ivanovo State University of Chemistry and Technology","host_organization_lineage":["https://openalex.org/I3276886"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemChemTech","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7746999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4308545019","https://openalex.org/W4386450382","https://openalex.org/W4405500385","https://openalex.org/W4399890139","https://openalex.org/W4224635318","https://openalex.org/W3036101622","https://openalex.org/W4386450368","https://openalex.org/W4400650467","https://openalex.org/W4406317973","https://openalex.org/W4387062608"],"abstract_inverted_index":{"In":[0],"the":[1,7,21,25,29,45,108,120,124,134,139,147,160,192,205,211,222,227,230,239,249,268],"current":[2],"work,":[3],"we":[4],"present":[5],"results":[6,228],"study":[8,42,278,307],"of":[9,12,24,31,36,39,47,61,71,76,103,110,119,126,133,141,146,188,213,221,241,252,259,308,311],"synthetic":[10],"transformations":[11],"substituted":[13,87,136,270,312],"3-thienylimino-3H-furan-2-one":[14],"derivatives":[15],"containing":[16],"a":[17,74,93,234,272],"nitrile":[18],"substituent":[19],"in":[20,51,168,184,262,279],"third":[22],"position":[23],"thiophene":[26],"ring":[27],"under":[28,123,138],"action":[30,125,140],"nucleophilic":[32],"reagents.":[33],"This":[34],"class":[35,251,275],"compounds":[37,105,150,165,232,289],"is":[38],"great":[40],"for":[41,84,215,276,283],"due":[43],"to":[44,58,170,204,226,248,281],"presence":[46],"several":[48],"reaction":[49,109],"centers":[50],"its":[52],"structure,":[53],"which":[54,89],"makes":[55],"it":[56],"possible":[57],"obtain":[59],"products":[60,122],"various":[62],"structures,":[63],"while":[64],"retaining":[65],"important":[66],"pharmacophore":[67],"groups":[68],"-":[69],"fragments":[70],"2-aminothiophene":[72],"and":[73,82,106,155,159,172,177,238,284,306],"fragment":[75],"2,4-dioxobutanoic":[77],"acid.":[78],"We":[79],"have":[80,233],"synthesized":[81],"studied":[83,183,202],"biological":[85,175],"activity":[86,176,181,261,310],"2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enoates,":[88],"were":[90,166],"obtained":[91],"by":[92,116,153,191],"multistep":[94],"synthesis":[95],"method.":[96],"The":[97,144,163,256],"proposed":[98],"method":[99],"provides":[100],"high":[101,257],"yields":[102],"target":[104],"includes":[107],"4-aryl-2-hydroxy-4-oxobutanoic":[111],"acids":[112],"with":[113,196,264,290],"2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile,":[114],"followed":[115],"intramolecular":[117],"cyclization":[118],"resulting":[121,135,164],"propionic":[127],"anhydride,":[128],"as":[129,131],"well":[130],"decyclization":[132],"3-thienylimino-3H-furan-2-ones":[137],"primary":[142],"alcohols.":[143],"structure":[145],"finally":[148],"isolated":[149],"was":[151,182,201],"confirmed":[152],"1H":[154],"13C":[156],"NMR":[157],"spectroscopy":[158],"elemental":[161],"analysis.":[162],"screened":[167],"vivo":[169],"detect":[171],"evaluate":[173],"their":[174],"acute":[178,242],"toxicity.":[179],"Antinociceptive":[180],"white":[185],"outbred":[186],"mice":[187,214],"both":[189],"sexes":[190],"hot":[193],"plate":[194],"test":[195,223],"intraperitoneal":[197,219],"injection.":[198],"Acute":[199],"toxicity":[200,243,266],"according":[203],"Pershin":[206],"method,":[207],"based":[208],"on":[209],"monitoring":[210],"condition":[212],"10":[216],"days":[217],"after":[218],"injection":[220],"compounds.":[224],"According":[225],"obtained,":[229],"tested":[231],"pronounced":[235],"antinociceptive":[236,260,309],"activity,":[237],"assessment":[240],"indicates":[244],"that":[245],"they":[246],"belong":[247],"V":[250],"practically":[253],"non-toxic":[254],"drugs.":[255],"values":[258],"combination":[263],"low":[265],"make":[267],"considered":[269],"2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enoates":[271],"highly":[273],"promising":[274],"further":[277],"order":[280],"search":[282],"develop":[285],"new":[286],"biologically":[287],"active":[288],"analgesic":[291],"effect.":[292],"For":[293],"citation:":[294],"Sharavyeva":[295],"Yu.O.,":[296],"Makhmudov":[297],"R.R.,":[298],"Shipilovskikh":[299],"D.A.,":[300],"Silaichev":[301],"P.S.,":[302],"Gorbunova":[303],"I.A.":[304],"Synthesis":[305],"2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enoates.":[313],"ChemChemTech":[314],"[Izv.":[315],"Vyssh.":[316],"Uchebn.":[317],"Zaved.":[318],"Khim.":[319,320],"Tekhnol.].":[321],"2024.":[322],"V.":[323],"67.":[324],"N":[325],"7.":[326],"P.":[327],"19-27.":[328],"DOI:":[329],"10.6060/ivkkt.20246707.7029.":[330]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-07-02T00:00:00"}
