{"id":"https://openalex.org/W4400155451","doi":"https://doi.org/10.1007/978-981-99-3746-2_7","title":"Application of CRISPR in Cancer Research and Treatment","display_name":"Application of CRISPR in Cancer Research and Treatment","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4400155451","doi":"https://doi.org/10.1007/978-981-99-3746-2_7"},"language":"en","primary_location":{"id":"doi:10.1007/978-981-99-3746-2_7","doi":"https://doi.org/10.1007/978-981-99-3746-2_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-981-99-3746-2_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomarkers for Cancer Diagnosis and Therapy","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4400154156","display_name":"Molecular Biomarkers for Cancer Diagnosis and Therapy"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078008510","display_name":"Abhay Kumar Singh","orcid":"https://orcid.org/0000-0003-4686-3795","observed_orcids":["https://orcid.org/0000-0003-4686-3795"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhay Kumar Singh","raw_affiliation_strings":["Department of Radiation Oncology, School of Medicine, Washington University, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, School of Medicine, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025492711","display_name":"Vaishali Kapoor","orcid":"https://orcid.org/0000-0002-7581-1487","observed_orcids":["https://orcid.org/0000-0002-7581-1487"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4390039355","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299725459","https://openalex.org/I1328499231","https://openalex.org/I4390039355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaishali Kapoor","raw_affiliation_strings":["Department of Radiation Oncology, School of Medicine, Washington University, St. Louis, MO, USA","Siteman Cancer Center, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, School of Medicine, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4390039355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082419850","display_name":"Ravi Kr. Gupta","orcid":"https://orcid.org/0000-0002-1230-8382","observed_orcids":["https://orcid.org/0000-0002-1230-8382"]},"institutions":[{"id":"https://openalex.org/I143247161","display_name":"Babasaheb Bhimrao Ambedkar University","ror":"https://ror.org/04x7ccp17","country_code":"IN","type":"education","lineage":["https://openalex.org/I143247161"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ravi Kr. Gupta","raw_affiliation_strings":["Department of Environmental Microbiology, Babasaheb Bhimrao Ambedkar University, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Microbiology, Babasaheb Bhimrao Ambedkar University, Lucknow, India","institution_ids":["https://openalex.org/I143247161"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20891299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"101","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cancer-research","display_name":"cancer research","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7390000224113464},{"id":"https://openalex.org/keywords/genetic-screen","display_name":"genetic screen","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/animal-models-of-cancer","display_name":"animal models of cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cell-engineering","display_name":"cell engineering","score":0.7590000033378601},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/epigenome","display_name":"epigenome","score":0.6959999799728394},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.7915568351745605},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47229865193367004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40006548166275024},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33747386932373047},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21221160888671875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04857119917869568}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-981-99-3746-2_7","doi":"https://doi.org/10.1007/978-981-99-3746-2_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-981-99-3746-2_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomarkers for Cancer Diagnosis and Therapy","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.49000000953674316}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1564857146","https://openalex.org/W1594078235","https://openalex.org/W1635615463","https://openalex.org/W1692777765","https://openalex.org/W1863795766","https://openalex.org/W1934704664","https://openalex.org/W1973260880","https://openalex.org/W2104091091","https://openalex.org/W2127749855","https://openalex.org/W2154283358","https://openalex.org/W2178681339","https://openalex.org/W2180291937","https://openalex.org/W2320341074","https://openalex.org/W2396078929","https://openalex.org/W2409671300","https://openalex.org/W2504729294","https://openalex.org/W2505703250","https://openalex.org/W2522085729","https://openalex.org/W2548694234","https://openalex.org/W2565920990","https://openalex.org/W2584719393","https://openalex.org/W2588571054","https://openalex.org/W2589417329","https://openalex.org/W2601913258","https://openalex.org/W2604130415","https://openalex.org/W2604982880","https://openalex.org/W2606915822","https://openalex.org/W2612339358","https://openalex.org/W2625817416","https://openalex.org/W2750148951","https://openalex.org/W2750741474","https://openalex.org/W2752478005","https://openalex.org/W2785904295","https://openalex.org/W2791923357","https://openalex.org/W2800905921","https://openalex.org/W2802994786","https://openalex.org/W2894490018","https://openalex.org/W2901478468","https://openalex.org/W2910070214","https://openalex.org/W2921526118","https://openalex.org/W2985370419","https://openalex.org/W2998345757","https://openalex.org/W3003839508","https://openalex.org/W3012061988","https://openalex.org/W3019413961","https://openalex.org/W3162164072","https://openalex.org/W4213164504"],"related_works":["https://openalex.org/W4320855945","https://openalex.org/W2563770935","https://openalex.org/W7134121347","https://openalex.org/W3204655553","https://openalex.org/W3159588171","https://openalex.org/W4391952511","https://openalex.org/W2803039783","https://openalex.org/W2786018128","https://openalex.org/W7102519871","https://openalex.org/W2302263272"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-06-30T00:00:00"}
