{"id":"https://openalex.org/W4400132425","doi":"https://doi.org/10.1016/j.tox.2024.153875","title":"Involvement of multiple epigenetic mechanisms by altered DNA methylation from the early stage of renal carcinogenesis before proliferative lesion formation upon repeated administration of ochratoxin A","display_name":"Involvement of multiple epigenetic mechanisms by altered DNA methylation from the early stage of renal carcinogenesis before proliferative lesion formation upon repeated administration of ochratoxin A","publication_year":2024,"publication_date":"2024-06-28","ids":{"openalex":"https://openalex.org/W4400132425","doi":"https://doi.org/10.1016/j.tox.2024.153875","pmid":"https://pubmed.ncbi.nlm.nih.gov/38945198"},"language":"en","primary_location":{"id":"doi:10.1016/j.tox.2024.153875","doi":"https://doi.org/10.1016/j.tox.2024.153875","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tox.2024.153875","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.tox.2024.153875","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002376938","display_name":"Shunsuke Ozawa","orcid":"https://orcid.org/0000-0003-1102-5871","observed_orcids":["https://orcid.org/0000-0003-1102-5871"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Ozawa","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: s213387q@st.go.tuat.ac.jp","Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: s213387q@st.go.tuat.ac.jp","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050660374","display_name":"Ryota Ojiro","orcid":"https://orcid.org/0000-0002-4480-5252","observed_orcids":["https://orcid.org/0000-0002-4480-5252"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryota Ojiro","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: ojiro@ono-pharma.com","Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: ojiro@ono-pharma.com","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101547261","display_name":"Qian Tang","orcid":"https://orcid.org/0000-0002-3882-6516","observed_orcids":["https://orcid.org/0000-0002-3882-6516"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Qian Tang","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: tangqian@tri-apex.com","Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: tangqian@tri-apex.com","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040573161","display_name":"Xinyu Zou","orcid":"https://orcid.org/0000-0001-8551-9319","observed_orcids":["https://orcid.org/0000-0001-8551-9319"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Xinyu Zou","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: s213605v@st.go.tuat.ac.jp","Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: s213605v@st.go.tuat.ac.jp","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110815407","display_name":"Meilan Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meilan Jin","raw_affiliation_strings":["Laboratory of Veterinary Pathology, College of Veterinary Medicine, Southwest University,\u00a0No. 2 Tiansheng Road, BeiBei District,\u00a0Chongqing 400715,\u00a0PR China. Electronic address: meilan0622@swu.edu.cn","Laboratory of Veterinary Pathology, College of Veterinary Medicine, Southwest University,\u00a0No. 2 Tiansheng Road, BeiBei District,\u00a0Chongqing 400715,\u00a0PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, College of Veterinary Medicine, Southwest University,\u00a0No. 2 Tiansheng Road, BeiBei District,\u00a0Chongqing 400715,\u00a0PR China. Electronic address: meilan0622@swu.edu.cn","institution_ids":["https://openalex.org/I142108993"]},{"raw_affiliation_string":"Laboratory of Veterinary Pathology, College of Veterinary Medicine, Southwest University,\u00a0No. 2 Tiansheng Road, BeiBei District,\u00a0Chongqing 400715,\u00a0PR China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055943723","display_name":"Toshinori Yoshida","orcid":"https://orcid.org/0000-0003-2476-7794","observed_orcids":["https://orcid.org/0000-0003-2476-7794"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshinori Yoshida","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: yoshida7@cc.tuat.ac.jp","Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: yoshida7@cc.tuat.ac.jp","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062202170","display_name":"Makoto Shibutani","orcid":"https://orcid.org/0000-0003-3417-9697","observed_orcids":["https://orcid.org/0000-0003-3417-9697"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Makoto Shibutani","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: mshibuta@cc.tuat.ac.jp","Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan. Electronic address: mshibuta@cc.tuat.ac.jp","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology,\u00a03-5-8 Saiwai-cho, Fuchu-shi,\u00a0Tokyo 183-8509,\u00a0Japan","institution_ids":["https://openalex.org/I92614990"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062202170"],"corresponding_institution_ids":["https://openalex.org/I92614990"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":1.2446,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75912844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"506","issue":null,"first_page":"153875","last_page":"153875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.30570000410079956,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ochratoxin-a","display_name":"ochratoxin A","score":1.0},{"id":"https://openalex.org/keywords/renal-carcinogenesis","display_name":"renal carcinogenesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/epigenetic-mechanisms","display_name":"epigenetic mechanisms","score":0.8309999704360962},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/karyomegaly","display_name":"karyomegaly","score":0.9070000052452087},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9319999814033508},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9139999747276306},{"id":"https://openalex.org/keywords/gen1","display_name":"GEN1","score":0.796999990940094},{"id":"https://openalex.org/keywords/anxa3","display_name":"ANXA3","score":0.8759999871253967},{"id":"https://openalex.org/keywords/osm","display_name":"OSM","score":0.8209999799728394},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9819999933242798},{"id":"https://openalex.org/keywords/3-chloro-1-2-propanediol","display_name":"3-chloro-1,2-propanediol","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8083958029747009},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7189614176750183},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6178364753723145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5516411662101746},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5374916195869446},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.48613354563713074},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4576226472854614},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44750604033470154},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4349588453769684},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3921847343444824},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3718331456184387},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33605289459228516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17920881509780884},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1727665364742279}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009793","descriptor_name":"Ochratoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011042","descriptor_name":"Poisons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tox.2024.153875","doi":"https://doi.org/10.1016/j.tox.2024.153875","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tox.2024.153875","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:38945198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38945198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.tox.2024.153875","doi":"https://doi.org/10.1016/j.tox.2024.153875","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tox.2024.153875","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1254977003","https://openalex.org/W1536396357","https://openalex.org/W1601755300","https://openalex.org/W1972755859","https://openalex.org/W1981515049","https://openalex.org/W1993454508","https://openalex.org/W1993657855","https://openalex.org/W2005219717","https://openalex.org/W2005576653","https://openalex.org/W2013816626","https://openalex.org/W2017046792","https://openalex.org/W2020120430","https://openalex.org/W2037207156","https://openalex.org/W2040487132","https://openalex.org/W2045547872","https://openalex.org/W2047138715","https://openalex.org/W2050967181","https://openalex.org/W2065677017","https://openalex.org/W2083797876","https://openalex.org/W2106551077","https://openalex.org/W2107277218","https://openalex.org/W2121213878","https://openalex.org/W2123312139","https://openalex.org/W2130878263","https://openalex.org/W2148409401","https://openalex.org/W2148676049","https://openalex.org/W2163176981","https://openalex.org/W2171216120","https://openalex.org/W2189200355","https://openalex.org/W2211610211","https://openalex.org/W2238022740","https://openalex.org/W2321413400","https://openalex.org/W2343052553","https://openalex.org/W2343562240","https://openalex.org/W2566141085","https://openalex.org/W2593951400","https://openalex.org/W2765803730","https://openalex.org/W2785550069","https://openalex.org/W2792783567","https://openalex.org/W2811323898","https://openalex.org/W2895646618","https://openalex.org/W3014471563","https://openalex.org/W3084505752","https://openalex.org/W3102637951","https://openalex.org/W3146579363","https://openalex.org/W3183356903","https://openalex.org/W3205815008","https://openalex.org/W4220699429","https://openalex.org/W4289545008","https://openalex.org/W4293776632","https://openalex.org/W4376121182","https://openalex.org/W4391429739"],"related_works":["https://openalex.org/W4376121182","https://openalex.org/W4391429739","https://openalex.org/W2035892698","https://openalex.org/W2170422290","https://openalex.org/W4250428536","https://openalex.org/W2102775130","https://openalex.org/W2057494515","https://openalex.org/W2148409401","https://openalex.org/W2046507938","https://openalex.org/W1992180600"],"abstract_inverted_index":{"Ochratoxin":[0],"A":[1],"(OTA)":[2],"is":[3,158],"a":[4,62,180,189,196],"rat":[5],"renal":[6,63,119,123,259,268],"carcinogen":[7,64],"that":[8,151,229],"induces":[9],"karyomegaly":[10],"and":[11,30,81,84,89,99,107,132,204,236,245],"micronuclei":[12],"in":[13,27,33,110,164],"proximal":[14],"tubular":[15],"epithelial":[16],"cells":[17],"(PTECs).":[18],"We":[19],"previously":[20],"performed":[21],"comprehensive":[22],"gene":[23,31,45,105],"profiling":[24],"of":[25,35,113,134,154,171,179,188,198,207,243,257],"alterations":[26],"promoter-region":[28],"methylation":[29],"expression":[32,53,106],"PTECs":[34,112,137,157,200,209],"rats":[36,114],"treated":[37,115],"with":[38,60,116,140,146,174],"OTA":[39,175,193,218,265],"for":[40,125,223],"13":[41,128],"weeks.":[42,129],"The":[43,169],"OTA-specific":[44,94],"profile":[46],"was":[47],"obtained":[48],"by":[49],"excluding":[50],"genes":[51,75,92,98,173],"showing":[52,93],"changes":[54],"similar":[55],"to":[56,104,160],"those":[57],"upon":[58],"treatment":[59],"3-chloro-1,2-propanediol,":[61],"not":[65],"inducing":[66],"karyomegaly.":[67],"In":[68],"this":[69],"study,":[70],"we":[71],"validated":[72],"the":[73,111,143,152,177,186,225,241,250,254],"candidate":[74],"using":[76],"methylated":[77],"DNA":[78,226],"enrichment":[79],"PCR":[80],"real-time":[82],"RT-PCR,":[83],"identified":[85],"Gen1,":[86],"Anxa3,":[87],"Cdkn1a,":[88],"Osm":[90,216],"as":[91,213,215],"epigenetic":[95,272],"changes.":[96],"These":[97],"related":[100],"molecules":[101],"were":[102,138],"subjected":[103],"immunohistochemical":[108],"analyses":[109],"OTA,":[117,141],"other":[118],"carcinogens,":[120],"or":[121,127],"non-carcinogenic":[122],"toxicants":[124],"4":[126],"Cdkn1a":[130],"upregulation":[131,170,242],"increase":[133,153,206],"p21WAF1/CIP1+":[135,155],"karyomegalic":[136,156],"observed":[139],"matching":[142],"findings":[144],"associated":[145],"micronucleus-inducing":[147],"carcinogens.":[148],"This":[149,247],"suggested":[150],"linked":[159],"micronucleus":[161],"formation,":[162],"which":[163,184],"turn":[165],"accelerates":[166],"chromosomal":[167,251],"instability.":[168],"Cdkn1a-related":[172],"suggests":[176],"acquisition":[178],"senescence-associated":[181],"secretory":[182],"phenotype,":[183],"promotes":[185],"establishment":[187],"carcinogenic":[190],"environment.":[191],"Meanwhile,":[192],"specifically":[194],"caused":[195],"decrease":[197],"GEN1+":[199],"reflecting":[201,210],"Gen1":[202,234],"downregulation":[203],"an":[205],"ANXA3+":[208],"Anxa3":[211,244],"upregulation,":[212],"well":[214],"upregulation.":[217],"may":[219,248,266],"efficiently":[220],"disrupt":[221],"pathways":[222],"repairing":[224],"double-strand":[227],"breaks":[228],"it":[230],"itself":[231],"causes,":[232],"via":[233],"downregulation,":[235],"enhance":[237],"cell":[238],"proliferation":[239],"through":[240],"Osm.":[246],"exacerbate":[249],"instability":[252],"from":[253],"early":[255],"stage":[256],"OTA-induced":[258],"carcinogenesis":[260,269],"before":[261],"proliferative":[262],"lesions":[263],"form.":[264],"cause":[267],"involving":[270],"multiple":[271],"mechanisms.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-06-29T00:00:00"}