{"id":"https://openalex.org/W4400108860","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.3572","title":"Negative hyperselection and mechanisms of acquired resistance to first-line chemotherapy plus anti-EGFR in patients (pts) with pMMR RAS/BRAF wild-type (wt) metastatic colorectal cancer (mCRC): A translational analysis of the TRIPLETE trial.","display_name":"Negative hyperselection and mechanisms of acquired resistance to first-line chemotherapy plus anti-EGFR in patients (pts) with pMMR RAS/BRAF wild-type (wt) metastatic colorectal cancer (mCRC): A translational analysis of the TRIPLETE trial.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4400108860","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.3572"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.3572","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.3572","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.3572","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004626743","display_name":"Veronica Conca","orcid":"https://orcid.org/0000-0001-7713-4005","observed_orcids":["https://orcid.org/0000-0001-7713-4005"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Veronica Conca","raw_affiliation_strings":["Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071611045","display_name":"Martina Carullo","orcid":"https://orcid.org/0000-0003-2846-2517","observed_orcids":["https://orcid.org/0000-0003-2846-2517"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Carullo","raw_affiliation_strings":["Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021003402","display_name":"Paola Vignali","orcid":"https://orcid.org/0009-0001-4181-4903","observed_orcids":["https://orcid.org/0009-0001-4181-4903"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Vignali","raw_affiliation_strings":["Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072503801","display_name":"Daniele Rossini","orcid":"https://orcid.org/0009-0000-3777-8471","observed_orcids":["https://orcid.org/0009-0000-3777-8471"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Rossini","raw_affiliation_strings":["Division of Clinical Pharmacology and Oncology, Department of Health Sciences, School of Psychology, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Oncology, Department of Health Sciences, School of Psychology, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005516545","display_name":"Marco Maria Germani","orcid":"https://orcid.org/0000-0002-1036-5869","observed_orcids":["https://orcid.org/0000-0002-1036-5869"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Maria Germani","raw_affiliation_strings":["Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028325185","display_name":"Francesca Bergamo","orcid":"https://orcid.org/0000-0002-8795-4653","observed_orcids":["https://orcid.org/0000-0002-8795-4653"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Bergamo","raw_affiliation_strings":["Oncology Unit 1, Veneto Institute of Oncology - IRCCS, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit 1, Veneto Institute of Oncology - IRCCS, Padua, Italy","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079437223","display_name":"Filippo Pietrantonio","orcid":"https://orcid.org/0000-0002-8530-8420","observed_orcids":["https://orcid.org/0000-0002-8530-8420"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Pietrantonio","raw_affiliation_strings":["Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066696741","display_name":"Beatrice Borelli","orcid":"https://orcid.org/0000-0002-9739-408X","observed_orcids":["https://orcid.org/0000-0002-9739-408X"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Borelli","raw_affiliation_strings":["Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026460566","display_name":"Federica Marmorino","orcid":"https://orcid.org/0000-0001-7725-3434","observed_orcids":["https://orcid.org/0000-0001-7725-3434"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Marmorino","raw_affiliation_strings":["Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017086518","display_name":"Mirella Giordano","orcid":"https://orcid.org/0009-0003-0445-4501","observed_orcids":["https://orcid.org/0009-0003-0445-4501"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mirella Giordano","raw_affiliation_strings":["Cell Therapy and Transfusion Medicine Unit, Careggi University Hospital, Florence and Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy and Transfusion Medicine Unit, Careggi University Hospital, Florence and Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Florence, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065746326","display_name":"Giovanni Randon","orcid":"https://orcid.org/0000-0003-0244-445X","observed_orcids":["https://orcid.org/0000-0003-0244-445X"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Randon","raw_affiliation_strings":["Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093406748","display_name":"Ada Taravella","orcid":"https://orcid.org/0009-0000-2153-3867","observed_orcids":["https://orcid.org/0009-0000-2153-3867"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ada Taravella","raw_affiliation_strings":["Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa & Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa & Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010620444","display_name":"Riccardo Cerantola","orcid":"https://orcid.org/0000-0001-8004-3542","observed_orcids":["https://orcid.org/0000-0001-8004-3542"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Cerantola","raw_affiliation_strings":["Department of Surgery, Oncology and Gastroenterology, University of Padua and Oncology Unit 1 Veneto Institute of Oncology - IRCCS, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Oncology and Gastroenterology, University of Padua and Oncology Unit 1 Veneto Institute of Oncology - IRCCS, Padua, Italy","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088550918","display_name":"Alessandro Cappetta","orcid":"https://orcid.org/0000-0002-2147-2790","observed_orcids":["https://orcid.org/0000-0002-2147-2790"]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Cappetta","raw_affiliation_strings":["Department of Oncology, San Bortolo General Hospital, AULSS8 Berica, Vicenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, San Bortolo General Hospital, AULSS8 Berica, Vicenza, Italy","institution_ids":["https://openalex.org/I4210152245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058657353","display_name":"Angela Buonadonna","orcid":"https://orcid.org/0000-0002-1930-0308","observed_orcids":["https://orcid.org/0000-0002-1930-0308"]},"institutions":[{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Buonadonna","raw_affiliation_strings":["Department of Medical Oncology, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045260424","display_name":"Alberto Zaniboni","orcid":"https://orcid.org/0000-0002-2140-7040","observed_orcids":["https://orcid.org/0000-0002-2140-7040","https://orcid.org/0000-0002-0817-4633"]},"institutions":[{"id":"https://openalex.org/I4210148231","display_name":"Fondazione Poliambulanza Istituto Ospedaliero","ror":"https://ror.org/03kt3v622","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210148231"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Zaniboni","raw_affiliation_strings":["Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Italy","institution_ids":["https://openalex.org/I4210148231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002745641","display_name":"Lorenzo Antonuzzo","orcid":"https://orcid.org/0000-0003-3349-5604","observed_orcids":["https://orcid.org/0000-0003-3349-5604"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Antonuzzo","raw_affiliation_strings":["Clinical Oncology Unit, Department of Experimental and Clinical Medicine - Careggi University Hospital, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology Unit, Department of Experimental and Clinical Medicine - Careggi University Hospital, Florence, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058514609","display_name":"Gianluca Masi","orcid":"https://orcid.org/0000-0001-8329-8989","observed_orcids":["https://orcid.org/0000-0001-8329-8989"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Masi","raw_affiliation_strings":["Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008698979","display_name":"Clara Ugolini","orcid":"https://orcid.org/0000-0002-3489-8280","observed_orcids":["https://orcid.org/0000-0002-3489-8280"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Clara Ugolini","raw_affiliation_strings":["Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081985776","display_name":"Chiara Cremolini","orcid":"https://orcid.org/0000-0002-0520-4841","observed_orcids":["https://orcid.org/0000-0002-0520-4841"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Cremolini","raw_affiliation_strings":["Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana and Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"3572","last_page":"3572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/ras-braf-wild-type","display_name":"RAS/BRAF wild-type","score":0.8799999952316284},{"id":"https://openalex.org/keywords/proficient-mismatch-repair","display_name":"proficient mismatch repair","score":0.7929999828338623},{"id":"https://openalex.org/keywords/anti-egfr-resistance","display_name":"anti-EGFR resistance","score":0.8230000138282776},{"id":"https://openalex.org/keywords/panitumumab","display_name":"panitumumab","score":0.9449999928474426},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.7440000176429749},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/folfox","display_name":"FOLFOX","score":0.5550000071525574},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.5429999828338623},{"id":"https://openalex.org/keywords/her2-amplification","display_name":"HER2 amplification","score":0.6549999713897705},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.6209999918937683},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9208757877349854},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7516882419586182},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.575251579284668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5331021547317505},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5307873487472534},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49397116899490356},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.48417288064956665},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.4628213346004486},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45186901092529297}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.3572","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.3572","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.3572","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326084","display_name":"Regione Toscana","ror":"https://ror.org/02r6c6d62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400143543","https://openalex.org/W4280552598","https://openalex.org/W4282914981","https://openalex.org/W4402558624","https://openalex.org/W7162578617","https://openalex.org/W4317863051","https://openalex.org/W4415939901","https://openalex.org/W4411669999","https://openalex.org/W4387816965","https://openalex.org/W4409201911"],"abstract_inverted_index":{"3572":[0],"Background:":[1],"Anti-EGFRs":[2],"plus":[3,373],"doublets":[4],"are":[5],"the":[6,91,109,153,159,379,411],"standard":[7],"first-line":[8,82,371],"treatment":[9],"for":[10,387],"patients":[11,264],"with":[12,68,94,142,210,297,311,345,370,418],"left-sided":[13],"RAS/BRAFwt":[14,23],"mCRC.":[15],"Anti-EGFR":[16],"sensitivity":[17],"seems":[18],"restricted":[19],"to":[20,26,43,53,80,309,357,398],"negatively":[21],"hyperselected":[22],"cases,":[24,335],"according":[25],"PRESSING1/2":[27],"panels.":[28],"Analysing":[29],"circulating":[30],"tumor":[31,277],"DNA":[32],"in":[33,47,90,158,186,202,220,238,267,285,293,333,408],"liquid":[34],"instead":[35],"of":[36,56,111,136,155,206,269,275,324,378,405,413],"tissue":[37,100,118,179,352,391],"biopsies":[38],"is":[39,60,383],"a":[40,61,304,359,384],"promising":[41],"strategy":[42],"optimize":[44],"upfront":[45],"therapy":[46],"RAS/BRAF":[48,70,211],"wt":[49,71,212,313,366],"mCRC":[50,77,367],"pts":[51,67,165,208,287,368],"and":[52,101,106,125,129,176,194,213,248,256,262,289,353,392],"identify":[54],"mechanisms":[55],"acquired":[57,325],"resistance.":[58],"TRIPLETE":[59,92],"phase":[62],"III":[63],"trial":[64,93],"where":[65],"435":[66],"untreated":[69],"\u2013":[72],"per":[73],"local":[74],"assessment":[75],"-":[76],"were":[78,115,120,132,145,218,236,252,265,283,329],"randomized":[79],"receive":[81],"FOLFOX/panitumumab":[83],"(pan)":[84],"or":[85,149,272],"mFOLFOXIRI/pan.":[86],"Methods:":[87],"Patients":[88,141,296],"enrolled":[89],"available":[95,167],"formaline-fixed":[96],"paraffin":[97],"embedded":[98],"(FFPE)":[99],"plasma":[102,107,130,354,393],"at":[103,108,301,331,395,410],"baseline":[104,396],"(BP),":[105],"time":[110,412],"disease":[112],"progression":[113],"(PDP)":[114],"included.":[116],"FFPE":[117,173,178,223,390],"samples":[119,131],"profiled":[121],"using":[122],"FoundationOne":[123],"CDx":[124],"Oncomine":[126,137],"Focus":[127],"Assay,":[128],"analyzed":[133],"by":[134],"means":[135],"Pan-Cancer":[138],"Cell-Free":[139],"Assay.":[140],"pMMR":[143,214,363],"tumors":[144],"grouped":[146],"as":[147],"PRESSING-positive":[148,261],"negative":[150,263,348],"based":[151],"on":[152],"detection":[154],"alterations":[156,217,251],"included":[157],"PRESSING":[160,216,339],"panel.":[161],"Results:":[162],"134":[163],"(31%)":[164],"had":[166],"next-generation":[168],"sequencing":[169],"(NGS)":[170],"data":[171],"from":[172],"tissue,":[174],"BP":[175,204],"PDP.":[177],"analysis":[180,355],"revealed":[181],"locally":[182],"unknown":[183],"RAS":[184,192,198,281,298,312,406],"mutations":[185,407],"6":[187],"(4%)":[188],"cases.":[189,295],"After":[190],"excluding":[191],"mutated":[193,201,299],"dMMR/unknown":[195],"cases":[196,224],"(N=26),":[197],"was":[199,341,415],"found":[200,219,253,330],"2":[203,249,294,334],"out":[205],"102":[207],"(2%)":[209],"tumors.":[215],"15":[221],"(15%)":[222],"(":[225,240,254],"HER2ampl:":[226],"9,":[227],"HER2mut:":[228],"3,":[229],"AKT1mut:":[230],"1,":[231],"PIK3CAex20:":[232],"2).":[233],"Matching":[234],"results":[235],"achieved":[237],"8":[239],"HER2":[241,244],"ampl:":[242],"6;":[243],"mut:":[245],"2)":[246],"BP,":[247],"additional":[250,322],"AKT1mut":[255],"PTENmut).":[257],"No":[258],"differences":[259],"between":[260],"reported":[266],"terms":[268],"ORR,":[270],"PFS":[271],"OS,":[273],"regardless":[274],"primary":[276],"location.":[278],"In":[279],"PDP,":[280],"mut":[282,291,328],"detected":[284],"9":[286],"(9%),":[288],"BRAFV600E":[290],"co-occurred":[292],"ctDNA":[300,314,409],"PDP":[302],"showed":[303],"significative":[305],"shorter":[306],"OS":[307],"compared":[308],"those":[310],"[HR":[315],"0.3":[316],"95%":[317],"CI":[318],"0.13-0.9,":[319],"p=.03].":[320],"As":[321],"mechanism":[323],"resistance,":[326],"MAP2K1":[327],"PD":[332,414],"while":[336],"no":[337],"other":[338],"alteration":[340],"found.":[342],"Conclusions:":[343],"Inconsistently":[344],"previous":[346],"data,":[347],"hyperselection":[349],"both":[350],"through":[351],"failed":[356,397],"demonstrate":[358],"prognostic":[360],"role":[361],"among":[362],"RAS/":[364],"BRAF":[365],"treated":[369],"chemotherapy":[372,381],"pan.":[374],"The":[375,403],"confounding":[376],"effect":[377],"associated":[380],"backbone":[382],"potential":[385],"explanation":[386],"this":[388],"finding.":[389],"analyses":[394],"provide":[399],"fully":[400],"concordant":[401],"results.":[402],"occurrence":[404],"significantly":[416],"correlated":[417],"worse":[419],"post-progression":[420],"survival.":[421]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-06-29T00:00:00"}
