{"id":"https://openalex.org/W4400107562","doi":"https://doi.org/10.35516/jjps.v17i2.1702","title":"Chitosan/ Alginate/ Gelucire in-situ Gelling System for Oral Sustained Delivery of Paracetamol for Dysphagic Patients","display_name":"Chitosan/ Alginate/ Gelucire in-situ Gelling System for Oral Sustained Delivery of Paracetamol for Dysphagic Patients","publication_year":2024,"publication_date":"2024-06-25","ids":{"openalex":"https://openalex.org/W4400107562","doi":"https://doi.org/10.35516/jjps.v17i2.1702"},"language":"en","primary_location":{"id":"doi:10.35516/jjps.v17i2.1702","doi":"https://doi.org/10.35516/jjps.v17i2.1702","is_oa":true,"landing_page_url":"https://doi.org/10.35516/jjps.v17i2.1702","pdf_url":"https://jjournals.ju.edu.jo/index.php/jjps/article/download/1702/704","source":{"id":"https://openalex.org/S2765017797","display_name":"Jordan Journal of Pharmaceutical Sciences","issn_l":"1995-7157","issn":["1995-7157","2707-6253"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4324277456","host_organization_name":"TechKnowledge General Trading","host_organization_lineage":["https://openalex.org/P4324277456"],"host_organization_lineage_names":["TechKnowledge General Trading"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jordan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jjournals.ju.edu.jo/index.php/jjps/article/download/1702/704","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074355295","display_name":"Inam Al-Naji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Inam Al-Naji","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010993631","display_name":"Faisal Al\u2010Akayleh","orcid":"https://orcid.org/0000-0002-7225-0936","observed_orcids":["https://orcid.org/0000-0002-7225-0936","https://orcid.org/0000-0002-3311-5555"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Faisal Al-akayleh","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099633595","display_name":"Ruaa Al-Ajeeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Ruaa Al-Ajeeli","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009839170","display_name":"Nidal Adel Qinna","orcid":"https://orcid.org/0000-0002-9628-6036","observed_orcids":["https://orcid.org/0000-0002-9628-6036"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Nidal A. Qinna","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058969151","display_name":"Mayyas M. Al-Remawi","orcid":"https://orcid.org/0000-0002-5927-1468","observed_orcids":["https://orcid.org/0000-0002-5927-1468"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Mayyas Al-Remawi","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Petra University, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069455797","display_name":"Mai Subhi Khanfar","orcid":"https://orcid.org/0000-0002-6544-0475","observed_orcids":["https://orcid.org/0000-0002-6544-0475"]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Mai Khanfar","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan","institution_ids":["https://openalex.org/I156983542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002816436","display_name":"Ahmed S.A. Ali Agha","orcid":"https://orcid.org/0009-0000-8516-2313","observed_orcids":["https://orcid.org/0009-0000-8516-2313"]},"institutions":[{"id":"https://openalex.org/I114972647","display_name":"University of Jordan","ror":"https://ror.org/05k89ew48","country_code":"JO","type":"education","lineage":["https://openalex.org/I114972647"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Ahmed S.A. Ali Agha","raw_affiliation_strings":["Faculty of Pharmacy, Department of Pharmaceutical Sciences. The University of Jordan. Amman 11942, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Department of Pharmaceutical Sciences. The University of Jordan. Amman 11942, Jordan","institution_ids":["https://openalex.org/I114972647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055647868","display_name":"Al-Sayed Sallam","orcid":"https://orcid.org/0000-0002-7872-2084","observed_orcids":["https://orcid.org/0000-0002-7872-2084"]},"institutions":[{"id":"https://openalex.org/I4210111034","display_name":"TQ Pharma (Jordan)","ror":"https://ror.org/024t3b967","country_code":"JO","type":"company","lineage":["https://openalex.org/I4210111034"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Al-Sayed Sallam","raw_affiliation_strings":["Al Taqaddom Pharmaceutical Industries Co., Muwaqar, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Al Taqaddom Pharmaceutical Industries Co., Muwaqar, Jordan","institution_ids":["https://openalex.org/I4210111034"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6329,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.56785295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"17","issue":"2","first_page":"292","last_page":"306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-situ-gel","display_name":"in situ gel","score":0.8109999895095825},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.847000002861023},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dysphagia","display_name":"dysphagia","score":0.8309999704360962},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.8270000219345093},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sodium-alginate","display_name":"sodium alginate","score":1.0},{"id":"https://openalex.org/keywords/ph-responsive-gels","display_name":"pH-responsive gels","score":0.40299999713897705},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8659999966621399},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7099999785423279},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.8565207719802856},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.8551455736160278},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6794695258140564},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5930931568145752},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5466204285621643},{"id":"https://openalex.org/C2992618853","wikidata":"https://www.wikidata.org/wiki/Q422092","display_name":"Sodium alginate","level":3,"score":0.5416709184646606},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5376362204551697},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45717576146125793},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4540785253047943},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.4464164674282074},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.43856281042099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17230737209320068},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11044004559516907},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.09754279255867004},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07206815481185913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06155446171760559}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.35516/jjps.v17i2.1702","doi":"https://doi.org/10.35516/jjps.v17i2.1702","is_oa":true,"landing_page_url":"https://doi.org/10.35516/jjps.v17i2.1702","pdf_url":"https://jjournals.ju.edu.jo/index.php/jjps/article/download/1702/704","source":{"id":"https://openalex.org/S2765017797","display_name":"Jordan Journal of Pharmaceutical Sciences","issn_l":"1995-7157","issn":["1995-7157","2707-6253"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4324277456","host_organization_name":"TechKnowledge General Trading","host_organization_lineage":["https://openalex.org/P4324277456"],"host_organization_lineage_names":["TechKnowledge General Trading"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jordan Journal of Pharmaceutical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.35516/jjps.v17i2.1702","doi":"https://doi.org/10.35516/jjps.v17i2.1702","is_oa":true,"landing_page_url":"https://doi.org/10.35516/jjps.v17i2.1702","pdf_url":"https://jjournals.ju.edu.jo/index.php/jjps/article/download/1702/704","source":{"id":"https://openalex.org/S2765017797","display_name":"Jordan Journal of Pharmaceutical Sciences","issn_l":"1995-7157","issn":["1995-7157","2707-6253"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4324277456","host_organization_name":"TechKnowledge General Trading","host_organization_lineage":["https://openalex.org/P4324277456"],"host_organization_lineage_names":["TechKnowledge General Trading"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jordan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319684","display_name":"University of Petra","ror":"https://ror.org/039d9es10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400107562.pdf","grobid_xml":"https://content.openalex.org/works/W4400107562.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1497651483","https://openalex.org/W1503144949","https://openalex.org/W1975491341","https://openalex.org/W1980535921","https://openalex.org/W1992441860","https://openalex.org/W1992789135","https://openalex.org/W2001311709","https://openalex.org/W2005114943","https://openalex.org/W2006053978","https://openalex.org/W2007388331","https://openalex.org/W2019671614","https://openalex.org/W2045053498","https://openalex.org/W2052295083","https://openalex.org/W2058791176","https://openalex.org/W2065523400","https://openalex.org/W2079141522","https://openalex.org/W2089907998","https://openalex.org/W2099148994","https://openalex.org/W2131945662","https://openalex.org/W2153454511","https://openalex.org/W2157936924","https://openalex.org/W2302279438","https://openalex.org/W2519688722","https://openalex.org/W2520203262","https://openalex.org/W2563446221","https://openalex.org/W2769003476","https://openalex.org/W2800338457","https://openalex.org/W2944950683","https://openalex.org/W3091360862","https://openalex.org/W3126703894","https://openalex.org/W3133038783","https://openalex.org/W3151213628","https://openalex.org/W3182552383","https://openalex.org/W4200386398","https://openalex.org/W4206219065","https://openalex.org/W4280635701","https://openalex.org/W4283394074","https://openalex.org/W4291115151","https://openalex.org/W4293206967","https://openalex.org/W4313202658","https://openalex.org/W4385198136","https://openalex.org/W4385741711","https://openalex.org/W4390400008","https://openalex.org/W4390989658"],"related_works":["https://openalex.org/W2001311709","https://openalex.org/W2944950683","https://openalex.org/W2157936924","https://openalex.org/W2014092243","https://openalex.org/W2132485548","https://openalex.org/W2153454511","https://openalex.org/W2099148994","https://openalex.org/W2000353865","https://openalex.org/W1992789135","https://openalex.org/W4415358045"],"abstract_inverted_index":{"The":[0,47,88,145],"study":[1],"aims":[2],"to":[3,28,121,142],"formulate":[4],"an":[5,105],"oral":[6],"in-situ":[7,48],"gel":[8,49],"for":[9,169],"sustained":[10,158],"paracetamol":[11,63,91],"delivery,":[12],"targeting":[13],"pediatric":[14],"and":[15,24,37,70,125,136,153,174],"geriatric":[16],"patients.":[17],"A":[18],"blend":[19,148],"of":[20,62,75,101,110,149,160],"sodium":[21,76,79,96,151],"alginate,":[22,152],"chitosan,":[23,150],"Gelucires":[25],"was":[26],"used":[27],"create":[29],"the":[30,60,139,175],"gel.":[31],"Characterization":[32],"techniques,":[33],"such":[34],"as":[35],"rheology":[36],"in":[38,55,92,115],"vivo":[39],"bioavailability":[40],"tests":[41],"on":[42],"rat":[43],"models,":[44],"were":[45],"employed.":[46],"transitioned":[50],"into":[51],"a":[52,93,118,157,164],"gel-matrix":[53],"system":[54,168],"0.1N":[56],"HCl,":[57],"effectively":[58],"controlling":[59],"release":[61,84,108,159],"at":[64,85],"different":[65],"pH":[66,86],"levels":[67],"(1.2,":[68],"5.4,":[69],"6.8).":[71],"Gels":[72],"made":[73],"solely":[74],"alginate":[77,97],"or":[78],"alginate-chitosan":[80],"exhibited":[81],"rapid":[82],"drug":[83,107,166],"6.8.":[87],"formulation":[89],"containing":[90],"Gelucire":[94,154],"(G33/01):3-3%":[95],"-":[98],"chitosan":[99],"ratio":[100],"1:1:4":[102],"w/w":[103],"showed":[104],"extended":[106],"time":[109,120,134],"over":[111],"8":[112],"hours.":[113],"Bioavailability":[114],"rats":[116],"revealed":[117],"higher":[119],"maximum":[122],"concentration":[123,128],"(Tmax)":[124],"lower":[126],"peak":[127],"(Cmax)":[129],"but":[130],"comparable":[131],"mean":[132],"residence":[133],"(MRT)":[135],"area":[137],"under":[138],"curve":[140],"(AUC0-\u221e)":[141],"commercial":[143],"formulations.":[144],"gel's":[146],"synergistic":[147],"G33/01":[155],"ensures":[156],"paracetamol,":[161],"making":[162],"it":[163],"promising":[165],"delivery":[167],"vulnerable":[170],"populations":[171],"like":[172],"children":[173],"elderly.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-06-29T00:00:00"}