{"id":"https://openalex.org/W4400105792","doi":"https://doi.org/10.1016/j.lungcan.2024.107859","title":"Integrated analysis of older adults and patients with renal dysfunction in the IMpower130 and IMpower132 randomized controlled trials for advanced non-squamous non-small cell lung cancer","display_name":"Integrated analysis of older adults and patients with renal dysfunction in the IMpower130 and IMpower132 randomized controlled trials for advanced non-squamous non-small cell lung cancer","publication_year":2024,"publication_date":"2024-06-28","ids":{"openalex":"https://openalex.org/W4400105792","doi":"https://doi.org/10.1016/j.lungcan.2024.107859","pmid":"https://pubmed.ncbi.nlm.nih.gov/39127586"},"language":"en","primary_location":{"id":"doi:10.1016/j.lungcan.2024.107859","doi":"https://doi.org/10.1016/j.lungcan.2024.107859","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lungcan.2024.107859","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078287634","display_name":"Makoto Nishio","orcid":"https://orcid.org/0000-0003-4969-4165","observed_orcids":["https://orcid.org/0000-0003-4969-4165"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Makoto Nishio","raw_affiliation_strings":["Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan. Electronic address: mnishio@jfcr.or.jp"],"raw_orcid":"https://orcid.org/0000-0003-4969-4165","affiliations":[{"raw_affiliation_string":"Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan. Electronic address: mnishio@jfcr.or.jp","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006885419","display_name":"Satoshi Watanabe","orcid":"https://orcid.org/0000-0003-0041-6981","observed_orcids":["https://orcid.org/0000-0003-0041-6981"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Watanabe","raw_affiliation_strings":["Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. Electronic address: satoshi7@med.niigata-u.ac.jp"],"raw_orcid":"https://orcid.org/0000-0003-0041-6981","affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. Electronic address: satoshi7@med.niigata-u.ac.jp","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016585769","display_name":"Hibiki Udagawa","orcid":"https://orcid.org/0000-0001-8822-2684","observed_orcids":["https://orcid.org/0000-0001-8822-2684"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hibiki Udagawa","raw_affiliation_strings":["Department of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-shi, Chiba 277-8577, Japan. Electronic address: hudagawa@east.ncc.go.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-shi, Chiba 277-8577, Japan. Electronic address: hudagawa@east.ncc.go.jp","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039185381","display_name":"Naoko Sueoka\u2010Aragane","orcid":"https://orcid.org/0000-0002-7428-9068","observed_orcids":["https://orcid.org/0000-0002-7428-9068"]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Aragane","raw_affiliation_strings":["Department of Internal Medicine, Division of Haematology, Respiratory Medicine and Oncology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Electronic address: sueokan@cc.saga-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Haematology, Respiratory Medicine and Oncology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Electronic address: sueokan@cc.saga-u.ac.jp","institution_ids":["https://openalex.org/I177136067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075157545","display_name":"Yuki Nakagawa","orcid":"https://orcid.org/0000-0003-4103-2423","observed_orcids":["https://orcid.org/0000-0003-4103-2423"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Nakagawa","raw_affiliation_strings":["Chugai Pharmaceutical Co, Ltd, 2-1-1 Nihonbashi-Muromachi, Chuo-ku, Tokyo 103-8324, Japan. Electronic address: nakagawa.yuki99@chugai-pharm.co.jp"],"raw_orcid":"https://orcid.org/0000-0003-4103-2423","affiliations":[{"raw_affiliation_string":"Chugai Pharmaceutical Co, Ltd, 2-1-1 Nihonbashi-Muromachi, Chuo-ku, Tokyo 103-8324, Japan. Electronic address: nakagawa.yuki99@chugai-pharm.co.jp","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113970581","display_name":"Yuki Kobayashi","orcid":"https://orcid.org/0009-0006-9510-0849","observed_orcids":["https://orcid.org/0009-0006-9510-0849"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Kobayashi","raw_affiliation_strings":["Chugai Pharmaceutical Co, Ltd, 2-1-1 Nihonbashi-Muromachi, Chuo-ku, Tokyo 103-8324, Japan. Electronic address: kobayashi.yuki38@chugai-pharm.co.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chugai Pharmaceutical Co, Ltd, 2-1-1 Nihonbashi-Muromachi, Chuo-ku, Tokyo 103-8324, Japan. Electronic address: kobayashi.yuki38@chugai-pharm.co.jp","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036440015","display_name":"Haruhiro Saito","orcid":"https://orcid.org/0000-0002-8541-8339","observed_orcids":["https://orcid.org/0000-0002-8541-8339"]},"institutions":[{"id":"https://openalex.org/I4387152949","display_name":"Kanagawa Cancer Center","ror":"https://ror.org/00aapa202","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152949"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruhiro Saito","raw_affiliation_strings":["Department of Thoracic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa 241-8515, Japan. Electronic address: saito-h@kcch.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa 241-8515, Japan. Electronic address: saito-h@kcch.jp","institution_ids":["https://openalex.org/I4387152949"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5078287634"],"corresponding_institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"196","issue":null,"first_page":"107859","last_page":"107859"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.15870000422000885,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.9890000224113464},{"id":"https://openalex.org/keywords/non-squamous-non-small-cell-lung-cancer","display_name":"non-squamous non-small cell lung cancer","score":0.9350000023841858},{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.7229999899864197},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5740000009536743},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.9049999713897705},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.878000020980835},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7269999980926514},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9950000047683716},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.7170000076293945},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9682736396789551},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7251206636428833},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6422418355941772},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6325552463531494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6269484758377075},{"id":"https://openalex.org/C3019814559","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Squamous cell cancer","level":3,"score":0.5155436992645264},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4311481714248657}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lungcan.2024.107859","doi":"https://doi.org/10.1016/j.lungcan.2024.107859","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lungcan.2024.107859","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},{"id":"pmid:39127586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39127586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung cancer (Amsterdam, Netherlands)","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1990691414","https://openalex.org/W2024360503","https://openalex.org/W2088464819","https://openalex.org/W2099725888","https://openalex.org/W2160924853","https://openalex.org/W2892640821","https://openalex.org/W2893960509","https://openalex.org/W2943671268","https://openalex.org/W2946386783","https://openalex.org/W3008898135","https://openalex.org/W3012136773","https://openalex.org/W3017322331","https://openalex.org/W3110814768","https://openalex.org/W3125795216","https://openalex.org/W3128646645","https://openalex.org/W3216993465","https://openalex.org/W4255131969","https://openalex.org/W4316810205","https://openalex.org/W4320858009","https://openalex.org/W4322503686"],"related_works":["https://openalex.org/W4389280175","https://openalex.org/W7161282041","https://openalex.org/W4410805375","https://openalex.org/W4417501004","https://openalex.org/W3125795216","https://openalex.org/W7202347038","https://openalex.org/W4409577147","https://openalex.org/W4400036647","https://openalex.org/W4294218861","https://openalex.org/W4383314577"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2024-06-29T00:00:00"}