{"id":"https://openalex.org/W4400103510","doi":"https://doi.org/10.1159/000539971","title":"Poly(Lactic-Co-Glycolic Acid) Microparticles for the Delivery of Model Drug Compounds for Applications in Vascular Tissue Engineering","display_name":"Poly(Lactic-Co-Glycolic Acid) Microparticles for the Delivery of Model Drug Compounds for Applications in Vascular Tissue Engineering","publication_year":2024,"publication_date":"2024-06-22","ids":{"openalex":"https://openalex.org/W4400103510","doi":"https://doi.org/10.1159/000539971","pmid":"https://pubmed.ncbi.nlm.nih.gov/38934132","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11631679"},"language":"en","primary_location":{"id":"doi:10.1159/000539971","doi":"https://doi.org/10.1159/000539971","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000539971","pdf_url":null,"source":{"id":"https://openalex.org/S4394735558","display_name":"Cells Tissues Organs","issn_l":"1422-6405","issn":["1422-6405","1422-6421"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells Tissues Organs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11631679/pdf/nihms-2006039.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014719383","display_name":"Jordyn M. Wyse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordyn M. Wyse","raw_affiliation_strings":["Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","The University of Texas at San Antonio - University of Texas Health Science Center at San Antonio Joint Graduate Program in Biomedical Engineering, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"The University of Texas at San Antonio - University of Texas Health Science Center at San Antonio Joint Graduate Program in Biomedical Engineering, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109739076","display_name":"Bryan A Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan A. Sullivan","raw_affiliation_strings":["Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","The University of Texas at San Antonio - University of Texas Health Science Center at San Antonio Joint Graduate Program in Biomedical Engineering, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"The University of Texas at San Antonio - University of Texas Health Science Center at San Antonio Joint Graduate Program in Biomedical Engineering, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066541782","display_name":"Priscilla Lopez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priscilla Lopez","raw_affiliation_strings":["Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003317806","display_name":"Teja Guda","orcid":"https://orcid.org/0000-0002-3218-2916","observed_orcids":["https://orcid.org/0000-0002-3218-2916"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teja Guda","raw_affiliation_strings":["Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","Institute of Regenerative Medicine, The University of Texas at San Antonio, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"Institute of Regenerative Medicine, The University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044052070","display_name":"Christopher R. Rathbone","orcid":"https://orcid.org/0000-0002-6937-4030","observed_orcids":["https://orcid.org/0000-0002-6937-4030"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R. Rathbone","raw_affiliation_strings":["Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","Institute of Regenerative Medicine, The University of Texas at San Antonio, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"Institute of Regenerative Medicine, The University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033170988","display_name":"Marissa E. Wechsler","orcid":"https://orcid.org/0000-0003-4298-2594","observed_orcids":["https://orcid.org/0000-0003-4298-2594"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marissa E. Wechsler","raw_affiliation_strings":["Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","Institute of Regenerative Medicine, The University of Texas at San Antonio, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"Institute of Regenerative Medicine, The University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033170988"],"corresponding_institution_ids":["https://openalex.org/I45438204"],"apc_list":null,"apc_paid":null,"fwci":0.6893,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.60555605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"213","issue":"6","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.20090000331401825,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.061900001019239426,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-tissue-engineering","display_name":"vascular tissue engineering","score":0.746999979019165},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7760000228881836},{"id":"https://openalex.org/keywords/fibrin-scaffold","display_name":"fibrin scaffold","score":0.8169999718666077},{"id":"https://openalex.org/keywords/microrna-delivery","display_name":"microRNA delivery","score":0.875},{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.8989999890327454},{"id":"https://openalex.org/keywords/protein-delivery","display_name":"protein delivery","score":0.9179999828338623},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8579999804496765},{"id":"https://openalex.org/keywords/revascularization","display_name":"revascularization","score":0.7950000166893005},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.7904195785522461},{"id":"https://openalex.org/C2780472526","wikidata":"https://www.wikidata.org/wiki/Q409373","display_name":"Glycolic acid","level":4,"score":0.7903419733047485},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7553611397743225},{"id":"https://openalex.org/C2777521759","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microparticle","level":2,"score":0.7502535581588745},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6837756633758545},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5535979270935059},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5043193101882935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49276426434516907},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4807848334312439},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4673771262168884},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.4510476291179657},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4432127773761749},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39861857891082764},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3582203984260559},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23444175720214844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14839890599250793},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.08402621746063232},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08118799328804016},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06114727258682251},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06004375219345093},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000539971","doi":"https://doi.org/10.1159/000539971","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000539971","pdf_url":null,"source":{"id":"https://openalex.org/S4394735558","display_name":"Cells Tissues Organs","issn_l":"1422-6405","issn":["1422-6405","1422-6421"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells Tissues Organs","raw_type":"journal-article"},{"id":"pmid:38934132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38934132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells, tissues, organs","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11631679","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11631679","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11631679/pdf/nihms-2006039.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cells Tissues Organs","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11631679","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11631679","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11631679/pdf/nihms-2006039.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cells Tissues Organs","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.550000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3627460516","display_name":"Elucidating Skeletal Muscle Satellite Cell:Microvessel Interactions in Diabetic Muscle","funder_award_id":"SC1DK122578","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3930808375","display_name":null,"funder_award_id":"R21 DE032179","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5002332524","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"2137423","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7860510944","display_name":"Sacrificial templated grafts to encourage bone healing through mechanotransduction","funder_award_id":"1r21de032179-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310677","display_name":"University of Texas at San Antonio","ror":"https://ror.org/01kd65564"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400103510.pdf","grobid_xml":"https://content.openalex.org/works/W4400103510.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1591691911","https://openalex.org/W1966070581","https://openalex.org/W2010201046","https://openalex.org/W2028174136","https://openalex.org/W2045556067","https://openalex.org/W2080963472","https://openalex.org/W2082511674","https://openalex.org/W2084121938","https://openalex.org/W2088607224","https://openalex.org/W2110101054","https://openalex.org/W2153317779","https://openalex.org/W2163127813","https://openalex.org/W2163753130","https://openalex.org/W2171311487","https://openalex.org/W2280289381","https://openalex.org/W2406453816","https://openalex.org/W2552730765","https://openalex.org/W2564386018","https://openalex.org/W2609170124","https://openalex.org/W2895397573","https://openalex.org/W2943940643","https://openalex.org/W3088820536","https://openalex.org/W3092455672","https://openalex.org/W3166747195","https://openalex.org/W3172446261","https://openalex.org/W3200244304","https://openalex.org/W4210641545","https://openalex.org/W4214633948","https://openalex.org/W4226290813","https://openalex.org/W4283837731"],"related_works":["https://openalex.org/W2088607224","https://openalex.org/W2278911947","https://openalex.org/W4318777818","https://openalex.org/W2114816415","https://openalex.org/W2064089516","https://openalex.org/W1965907530","https://openalex.org/W2156547324","https://openalex.org/W1995889155","https://openalex.org/W3120672343","https://openalex.org/W3035239408"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Localized":[1],"delivery":[2,32,65,68,110,208],"of":[3,21,38,111,143,146,155,163,170,190,196,217,251],"angiogenesis-promoting":[4],"factors":[5],"such":[6,34],"as":[7,35],"small":[8,117],"molecules,":[9,114],"nucleic":[10,119],"acids,":[11],"peptides,":[12],"and":[13,19,49,74,105,109,121,141,235],"proteins":[14],"to":[15,42,55,77,193,227,255],"promote":[16],"the":[17,44,57,79,83,106,161,164,167,197,215,220,252],"repair":[18],"regeneration":[20],"damaged":[22],"tissues":[23],"remains":[24],"a":[25,63,116,156,249,256],"challenge":[26],"in":[27,125,150,174,181,241,245,248,258],"vascular":[28],"tissue":[29],"engineering.":[30],"Current":[31],"methods":[33],"direct":[36,89,228],"administration":[37],"therapeutics":[39],"can":[40,69],"fail":[41],"maintain":[43],"necessary":[45],"sustained":[46,73],"release":[47,76,175],"profile":[48],"often":[50],"rely":[51],"on":[52],"supraphysiologic":[53],"doses":[54],"achieve":[56],"desired":[58],"therapeutic":[59,90,199,239],"effect.":[60],"By":[61],"implementing":[62],"microparticle":[64,222],"system,":[66],"localized":[67],"be":[70],"coupled":[71],"with":[72,82,201,237],"controlled":[75],"mitigate":[78],"risks":[80],"involved":[81],"high":[84],"dosages":[85],"currently":[86],"required":[87,159],"from":[88,177],"administration.":[91,229],"METHODS:":[92],"For":[93],"this":[94],"purpose,":[95],"poly(lactic-co-glycolic":[96],"acid)":[97],"(PLGA)":[98],"microparticles":[99,191],"were":[100,123],"fabricated":[101],"via":[102],"anti-solvent":[103],"microencapsulation":[104,133],"loading,":[107],"release,":[108],"model":[112,144,171,198,238,250],"angiogenic":[113],"specifically":[115],"molecule,":[118],"acid,":[120],"protein,":[122],"assessed":[124],"vitro":[126,182],"using":[127,184,219],"microvascular":[128],"fragments":[129],"(MVFs).":[130],"RESULTS:":[131],"The":[132,153],"approach":[134],"utilized":[135],"enabled":[136],"rapid":[137],"spherical":[138],"particle":[139],"formation":[140],"encapsulation":[142],"drugs":[145,172],"different":[147],"sizes,":[148],"all":[149],"one":[151,242],"method.":[152],"addition":[154],"fibrin":[157],"scaffold,":[158],"for":[160,206],"culture":[162],"MVFs,":[165,202],"reduced":[166],"initial":[168],"burst":[169],"observed":[173],"profiles":[176],"PLGA":[178,232],"alone.":[179],"Lastly,":[180],"studies":[183],"MVFs":[185],"demonstrated":[186],"that":[187,214],"higher":[188],"concentrations":[189],"led":[192],"greater":[194],"co-localization":[195],"(miRNA)":[200],"which":[203],"is":[204],"vital":[205],"targeted":[207],"methods.":[209],"It":[210],"was":[211,224],"also":[212],"found":[213],"biodistribution":[216,247],"miRNA":[218],"delivered":[221],"system":[223],"enhanced":[225],"compared":[226],"CONCLUSION:":[230],"Overall,":[231],"microparticles,":[233],"formulated":[234],"loaded":[236],"compounds":[240],"step,":[243],"resulted":[244],"improved":[246],"vasculature":[253],"leading":[254],"future":[257],"translational":[259],"revascularization.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-06-28T00:00:00"}
