{"id":"https://openalex.org/W4400102277","doi":"https://doi.org/10.1016/j.heliyon.2024.e33707","title":"Manuka combinations with nigella sativa and hydroxyurea in treating iron overload of pediatric \u03b2-thalassemia major, randomized clinical trial","display_name":"Manuka combinations with nigella sativa and hydroxyurea in treating iron overload of pediatric \u03b2-thalassemia major, randomized clinical trial","publication_year":2024,"publication_date":"2024-06-26","ids":{"openalex":"https://openalex.org/W4400102277","doi":"https://doi.org/10.1016/j.heliyon.2024.e33707","pmid":"https://pubmed.ncbi.nlm.nih.gov/39044986","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11263651"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2024.e33707","doi":"https://doi.org/10.1016/j.heliyon.2024.e33707","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e33707","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.heliyon.2024.e33707","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005031589","display_name":"Mohamed Medhat Abdelwahab Gamaleldin","orcid":"https://orcid.org/0000-0002-5188-637X","observed_orcids":["https://orcid.org/0000-0002-5188-637X"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4405259154","display_name":"Fakeeh College for Medical Sciences","ror":"https://ror.org/01tynvf67","country_code":"SA","type":"education","lineage":["https://openalex.org/I4405259154"]}],"countries":["EG","SA","US"],"is_corresponding":true,"raw_author_name":"Mohamed M. Gamaleldin","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt","Department of Pharmaceutical Sciences (Pharm-D Program), Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia","Department of Pharmacy Practice & Science, R. K. Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA"],"raw_orcid":"https://orcid.org/0000-0002-5188-637X","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt","institution_ids":["https://openalex.org/I113643904"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences (Pharm-D Program), Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I4405259154"]},{"raw_affiliation_string":"Department of Pharmacy Practice & Science, R. K. Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108727792","display_name":"Ivo L Abraham","orcid":"https://orcid.org/0000-0003-0490-4421","observed_orcids":["https://orcid.org/0000-0003-0490-4421"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ivo L. Abraham","raw_affiliation_strings":["Clinical Translational Sciences, University of Arizona Health Sciences, Arizona, USA","Department of Family and Community Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA","Department of Pharmacy Practice & Science, R. K. Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Translational Sciences, University of Arizona Health Sciences, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Family and Community Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Pharmacy Practice & Science, R. K. Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085921543","display_name":"Mohamed Meabed","orcid":"https://orcid.org/0000-0002-9535-4084","observed_orcids":["https://orcid.org/0000-0002-9535-4084"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mohamed Hussein Meabed","raw_affiliation_strings":["Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt","institution_ids":["https://openalex.org/I113643904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086832009","display_name":"Ahmed Abdullah Elberry","orcid":"https://orcid.org/0000-0002-0073-3066","observed_orcids":["https://orcid.org/0000-0002-0073-3066"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]},{"id":"https://openalex.org/I4400600919","display_name":"Batterjee Medical College","ror":"https://ror.org/00dqry546","country_code":"SA","type":"education","lineage":["https://openalex.org/I4400600919"]}],"countries":["EG","SA"],"is_corresponding":true,"raw_author_name":"Ahmed A. Elberry","raw_affiliation_strings":["Department of Clinical Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt","Department of Pharmacy Practice, Pharmacy Program, Batterjee Medical College, Jeddah, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt","institution_ids":["https://openalex.org/I113643904"]},{"raw_affiliation_string":"Department of Pharmacy Practice, Pharmacy Program, Batterjee Medical College, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I4400600919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024816586","display_name":"Shaimaa Mahmoud Nashat Sayed Abdelhalim","orcid":"https://orcid.org/0000-0001-5372-5337","observed_orcids":["https://orcid.org/0000-0001-5372-5337"]},"institutions":[{"id":"https://openalex.org/I4405259154","display_name":"Fakeeh College for Medical Sciences","ror":"https://ror.org/01tynvf67","country_code":"SA","type":"education","lineage":["https://openalex.org/I4405259154"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Shaimaa M. Abdelhalim","raw_affiliation_strings":["Department of Pharmaceutical Sciences (Pharm-D Program), Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences (Pharm-D Program), Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I4405259154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104337897","display_name":"Ahmed F. Mahmoud Hussein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ahmed F. Mahmoud Hussein","raw_affiliation_strings":["Beni-Suef Health Insurance Hospital, Beni-Suef, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beni-Suef Health Insurance Hospital, Beni-Suef, Egypt","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054496901","display_name":"Raghda R. S. Hussein","orcid":"https://orcid.org/0000-0002-0503-685X","observed_orcids":["https://orcid.org/0000-0002-0503-685X"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Raghda R.S. Hussein","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt","institution_ids":["https://openalex.org/I113643904"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005031589","https://openalex.org/A5024816586","https://openalex.org/A5054496901","https://openalex.org/A5085921543","https://openalex.org/A5086832009","https://openalex.org/A5104337897","https://openalex.org/A5108727792"],"corresponding_institution_ids":["https://openalex.org/I113643904","https://openalex.org/I138006243","https://openalex.org/I4400600919","https://openalex.org/I4405259154"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.3541,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52088248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"10","issue":"13","first_page":"e33707","last_page":"e33707"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":0.05660000070929527,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-thalassemia-major","display_name":"beta-thalassemia major","score":0.9629999995231628},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9950000047683716},{"id":"https://openalex.org/keywords/manuka-honey","display_name":"manuka honey","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nigella-sativa","display_name":"Nigella sativa","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.9259999990463257},{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":0.7760000228881836},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6000000238418579},{"id":"https://openalex.org/keywords/serum-ferritin","display_name":"serum ferritin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/transferrin-saturation","display_name":"transferrin saturation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.7829999923706055},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.3330000042915344},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6967798471450806},{"id":"https://openalex.org/C2910659018","wikidata":"https://www.wikidata.org/wiki/Q953395","display_name":"Manuka Honey","level":2,"score":0.6375234723091125},{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.6204707026481628},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.574110746383667},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.49895691871643066},{"id":"https://openalex.org/C2779679107","wikidata":"https://www.wikidata.org/wiki/Q412474","display_name":"Aspartate transaminase","level":4,"score":0.43374067544937134},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.43162792921066284},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.4304863512516022},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.423380970954895},{"id":"https://openalex.org/C2776877979","wikidata":"https://www.wikidata.org/wiki/Q424288","display_name":"Transaminase","level":3,"score":0.4157804846763611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40492355823516846},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4017001986503601},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.38297876715660095},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3517799973487854},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32737553119659424},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.1897699534893036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1670072078704834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14175936579704285},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.heliyon.2024.e33707","doi":"https://doi.org/10.1016/j.heliyon.2024.e33707","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e33707","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11263651","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11263651","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11263651/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmid:39044986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39044986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d5805860bff945ac8ab67a570c4c167c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d5805860bff945ac8ab67a570c4c167c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 10, Iss 13, Pp e33707- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2024.e33707","doi":"https://doi.org/10.1016/j.heliyon.2024.e33707","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e33707","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G3307452271","display_name":null,"funder_award_id":"NCT04292314","funder_id":"https://openalex.org/F4320317165","funder_display_name":"Beni-Suef University"},{"id":"https://openalex.org/G5423188181","display_name":null,"funder_award_id":"HAPO-02-K-012-2020-02-359","funder_id":"https://openalex.org/F4320317165","funder_display_name":"Beni-Suef University"}],"funders":[{"id":"https://openalex.org/F4320317165","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400102277.pdf","grobid_xml":"https://content.openalex.org/works/W4400102277.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1533552696","https://openalex.org/W1551781691","https://openalex.org/W1966497743","https://openalex.org/W1989031118","https://openalex.org/W2005360883","https://openalex.org/W2015235051","https://openalex.org/W2026288205","https://openalex.org/W2039615288","https://openalex.org/W2048366988","https://openalex.org/W2072500831","https://openalex.org/W2132381451","https://openalex.org/W2144138306","https://openalex.org/W2145420110","https://openalex.org/W2152670967","https://openalex.org/W2154853392","https://openalex.org/W2172029200","https://openalex.org/W2209943919","https://openalex.org/W2516679218","https://openalex.org/W2549062637","https://openalex.org/W2734149616","https://openalex.org/W2780023007","https://openalex.org/W2784913868","https://openalex.org/W2901534482","https://openalex.org/W2942787986","https://openalex.org/W2947183183","https://openalex.org/W2954515500","https://openalex.org/W2990622018","https://openalex.org/W2999849162","https://openalex.org/W3001693016","https://openalex.org/W3003582320","https://openalex.org/W3035032230","https://openalex.org/W3035824239","https://openalex.org/W3087441452","https://openalex.org/W3156173205","https://openalex.org/W3186675110","https://openalex.org/W3196832642","https://openalex.org/W3205959706","https://openalex.org/W3215658413","https://openalex.org/W3216772807","https://openalex.org/W4206529552","https://openalex.org/W4206944222","https://openalex.org/W4211119300","https://openalex.org/W4225081563","https://openalex.org/W4281869799","https://openalex.org/W4283209680","https://openalex.org/W4289530080","https://openalex.org/W4293207200"],"related_works":["https://openalex.org/W4384626744","https://openalex.org/W2901534482","https://openalex.org/W2025207248","https://openalex.org/W4407290685","https://openalex.org/W2014869363","https://openalex.org/W2034530762","https://openalex.org/W3199979928","https://openalex.org/W962759412","https://openalex.org/W2571070159","https://openalex.org/W2510866156"],"abstract_inverted_index":{"Background:":[0],"\u03b2-thalassemia":[1,97,250],"major":[2,98,251],"is":[3,32,39],"microcytic":[4],"hypochromic":[5],"anemia":[6],"disorder":[7],"inherited":[8],"from":[9,12],"parents,":[10],"resulting":[11],"a":[13,20,22],"mutation":[14],"in":[15,30,49,95,106,181,212,245],"the":[16,67,81,143,182,192,213,222,241],"\u03b2-globin":[17],"locus.":[18],"As":[19,34],"result,":[21],"quantitative":[23],"defective":[24],"hemoglobin":[25],"synthesis":[26],"and":[27,60,72,91,162,169,176,206],"relative":[28],"excess":[29],"\u03b1-globin":[31],"occurred.":[33],"such,":[35],"frequent":[36],"blood":[37,86],"transfusion":[38],"required,":[40],"that":[41,228],"leads":[42],"to":[43,80],"iron":[44,93,157,177,247],"overload.":[45],"Iron":[46],"overload":[47,94,248],"results":[48],"several":[50],"pathological":[51],"complications,":[52],"including":[53],"cell":[54],"death,":[55],"tissue":[56],"injury,":[57],"organ":[58],"dysfunction,":[59],"liver":[61],"fibrosis.":[62],"The":[63,115,201],"present":[64],"study":[65],"examined":[66],"effectiveness":[68],"of":[69,203,249],"nigella":[70,127,183,214,229],"Sativa":[71],"manuka":[73,77,132,139,186,217,232,238],"honey":[74,78,133,140,187,218,233],"combination":[75],"or":[76,138,240],"alone":[79,141,239,244],"conventional":[82,144,242],"therapy":[83,145],"(Deferasirox":[84],"+":[85,185],"transfusion)":[87],"used":[88],"for":[89,146],"preventing":[90],"managing":[92,246],"pediatric":[96],"patients.":[99,252],"Methods:":[100],"One":[101],"hundred":[102],"sixty-five":[103],"patients":[104,116],"participated":[105],"this":[107],"randomized,":[108],"double-blind,":[109],"standard":[110],"therapy-controlled,":[111],"parallel-design":[112],"multisite":[113],"trial.":[114],"were":[117,165,178,198,209],"randomly":[118],"allocated":[119],"into":[120],"three":[121],"groups,":[122],"receiving":[123],"either":[124],"500":[125],"mg":[126],"sativa":[128,184,215,230],"oil":[129],"combined":[130],"with":[131,191,221],"lozenge":[134],"(344":[135],"mg)":[136],"daily":[137],"plus":[142,216,231],"ten":[147],"treatment":[148,243],"months.":[149],"Ferritin":[150],"level,":[151],"serum":[152,174],"iron,":[153],"transferrin":[154],"saturation,":[155],"total":[156],"binding":[158],"capacity,":[159],"alanine":[160,204],"transaminase,":[161],"aspartate":[163,207],"transaminase":[164,205,208],"determined":[166],"at":[167],"baseline":[168],"month":[170],"10.":[171],"Results:":[172],"Eventually,":[173],"ferritin":[175],"decreased":[179,211],"significantly":[180,199,210],"group":[188,219],"as":[189],"compared":[190,220],"control":[193,223],"group.":[194,224],"Other":[195],"clinical":[196],"parameters":[197],"impacted.":[200],"level":[202],"Conclusion:":[225],"Results":[226],"showed":[227],"was":[234],"more":[235],"effective":[236],"than":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-06-28T00:00:00"}
