{"id":"https://openalex.org/W4400034883","doi":"https://doi.org/10.17615/m6mq-tz16","title":"Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics","display_name":"Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4400034883","doi":"https://doi.org/10.17615/m6mq-tz16"},"language":"en","primary_location":{"id":"pmh:cdr.lib.unc.edu:tt44pz53q","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/m6mq-tz16","pdf_url":"https://doi.org/10.17615/m6mq-tz16","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 82(7)","raw_type":"Article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/m6mq-tz16","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049857586","display_name":"Huihui Fan","orcid":"https://orcid.org/0000-0003-4233-5389","observed_orcids":["https://orcid.org/0000-0003-4233-5389"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan, C","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068226921","display_name":"William Richard McCombie","orcid":"https://orcid.org/0000-0003-1899-0682","observed_orcids":["https://orcid.org/0000-0003-1899-0682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"McCombie, W.R","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058085525","display_name":"Jonathan B. Preall","orcid":"https://orcid.org/0000-0002-7772-2437","observed_orcids":["https://orcid.org/0000-0002-7772-2437"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Preall, J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Arun, G","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arun, G","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078760490","display_name":"Melissa Kramer","orcid":"https://orcid.org/0000-0001-9669-3611","observed_orcids":["https://orcid.org/0000-0001-9669-3611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kramer, M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087844192","display_name":"Karen M. Kostroff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kostroff, K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ha, T","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ha, T","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024461025","display_name":"Katie Brophy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brophy, K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Russo, S","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russo, S","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072185005","display_name":"David Arthur Tuveson","orcid":"https://orcid.org/0000-0002-8017-2712","observed_orcids":["https://orcid.org/0000-0002-8017-2712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tuveson, D.A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067754981","display_name":"Dennis Plenker","orcid":"https://orcid.org/0000-0003-3895-4064","observed_orcids":["https://orcid.org/0000-0003-3895-4064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Plenker, D","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029202750","display_name":"John Erby Wilkinson","orcid":"https://orcid.org/0000-0001-9174-8556","observed_orcids":["https://orcid.org/0000-0001-9174-8556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilkinson, J.E","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062498736","display_name":"Charles M. Perou","orcid":"https://orcid.org/0000-0001-9827-2247","observed_orcids":["https://orcid.org/0000-0001-9827-2247"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Perou, C.M","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrews, P","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrews, P","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bhatia, S","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhatia, S","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079751903","display_name":"David L. Spector","orcid":"https://orcid.org/0000-0003-3614-4965","observed_orcids":["https://orcid.org/0000-0003-3614-4965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Spector, D.L","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083419860","display_name":"Pooja Naik","orcid":"https://orcid.org/0000-0002-2753-7129","observed_orcids":["https://orcid.org/0000-0002-2753-7129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naik, P","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029185095","display_name":"Arvind Rishi","orcid":"https://orcid.org/0000-0002-0968-7617","observed_orcids":["https://orcid.org/0000-0002-0968-7617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rishi, A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12758105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.19779999554157257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":1.0},{"id":"https://openalex.org/keywords/patient-derived-organoids","display_name":"patient-derived organoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/organoid-biobank","display_name":"organoid biobank","score":0.8790000081062317},{"id":"https://openalex.org/keywords/long-term-organoid-culture","display_name":"long-term organoid culture","score":0.8529999852180481},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8960000276565552},{"id":"https://openalex.org/keywords/myc-signaling","display_name":"MYC signaling","score":0.925000011920929},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.546999990940094},{"id":"https://openalex.org/keywords/single-cell-profiling","display_name":"single-cell profiling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5009999871253967},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.784138560295105},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.7229868173599243},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6197162866592407},{"id":"https://openalex.org/C2986637895","wikidata":"https://www.wikidata.org/wiki/Q953865","display_name":"Breast tumor","level":4,"score":0.5295459032058716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3934360146522522},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35944604873657227},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3492574095726013},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3353589177131653},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3233490586280823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30259430408477783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2902137339115143},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2764075994491577}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:cdr.lib.unc.edu:tt44pz53q","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/m6mq-tz16","pdf_url":"https://doi.org/10.17615/m6mq-tz16","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 82(7)","raw_type":"Article"},{"id":"doi:10.17615/m6mq-tz16","doi":"https://doi.org/10.17615/m6mq-tz16","is_oa":true,"landing_page_url":"https://doi.org/10.17615/m6mq-tz16","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:tt44pz53q","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/m6mq-tz16","pdf_url":"https://doi.org/10.17615/m6mq-tz16","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 82(7)","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1413283406","display_name":null,"funder_award_id":"U01CA238475","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G167093600","display_name":null,"funder_award_id":"5P01CA 013106","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2407663899","display_name":null,"funder_award_id":"CA-58223","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2417796342","display_name":"Graphical Processing Units and a Large-Memory Compute Node for Applications in Genomics, Neuroscience, and Structural Biology","funder_award_id":"1s10od028632-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3061762448","display_name":null,"funder_award_id":"HHSN26100008","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4758132551","display_name":null,"funder_award_id":"2P3OCA45508","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4960772654","display_name":null,"funder_award_id":"5P01CA013106-Project 3","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5613785615","display_name":null,"funder_award_id":"HHSN26100008","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5638354291","display_name":null,"funder_award_id":"Project 3","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G870117454","display_name":null,"funder_award_id":"P50 CA 58223","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000073604","display_name":null,"funder_award_id":"P50 CA58223","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000136654","display_name":null,"funder_award_id":"5P01CA013106","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000182874","display_name":null,"funder_award_id":"CA58223","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000247932","display_name":null,"funder_award_id":"U01CA238475-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G975991007","display_name":null,"funder_award_id":"NCI 2P3OCA45508","funder_id":"https://openalex.org/F4320314202","funder_display_name":"Cold Spring Harbor Laboratory"}],"funders":[{"id":"https://openalex.org/F4320314202","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764"},{"id":"https://openalex.org/F4320315952","display_name":"Leidos","ror":"https://ror.org/012cvds63"},{"id":"https://openalex.org/F4320318877","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400034883.pdf","grobid_xml":"https://content.openalex.org/works/W4400034883.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W4386439204","https://openalex.org/W3033121461","https://openalex.org/W3094248195","https://openalex.org/W3047600752","https://openalex.org/W3047590429","https://openalex.org/W4307092668","https://openalex.org/W3048825385","https://openalex.org/W2811397904","https://openalex.org/W4388777186"],"abstract_inverted_index":{"Triple-negative":[0],"breast":[1,9,39,94,133],"cancer":[2,10,40,83,134],"(TNBC)":[3],"is":[4],"an":[5],"aggressive":[6,91],"form":[7],"of":[8,36,58,70,82,90,100,117,152,155,164],"with":[11,44,79],"poor":[12],"patient":[13,51],"outcomes,":[14],"highlighting":[15],"the":[16,139,167],"unmet":[17],"clinical":[18],"need":[19],"for":[20,63,131,141],"targeted":[21],"therapies":[22],"and":[23,30,38,55,75,96,114,119,136,144,162],"better":[24],"model":[25],"systems.":[26],"Here,":[27],"we":[28],"developed":[29],"comprehensively":[31],"characterized":[32],"a":[33,45,56],"diverse":[34],"biobank":[35],"normal":[37,112],"patient-derived":[41,153],"organoids":[42,87,154],"(PDO)":[43],"focus":[46],"on":[47],"TNBCs.":[48],"PDOs":[49,59,71,127],"recapitulated":[50],"tumor":[52],"intrinsic":[53],"properties":[54],"subset":[57],"can":[60],"be":[61],"propagated":[62],"long-term":[64],"culture":[65],"(LT-TNBC).":[66],"Single":[67],"cell":[68,73],"profiling":[69],"identified":[72],"types":[74],"gene":[76],"candidates":[77],"affiliated":[78],"different":[80],"aspects":[81],"progression.":[84],"The":[85,105],"LT-TNBC":[86],"exhibit":[88,115],"signatures":[89],"MYC-driven,":[92],"basal-like":[93],"cancers":[95],"are":[97,109],"largely":[98],"comprised":[99],"luminal":[101],"progenitor":[102],"(LP)-like":[103],"cells.":[104],"TNBC":[106,126,156],"LP-like":[107],"cells":[108],"distinct":[110],"from":[111],"LPs":[113],"hyperactivation":[116],"NOTCH":[118],"MYC":[120],"signaling.":[121],"Overall,":[122],"this":[123],"study":[124],"validates":[125],"as":[128],"robust":[129],"models":[130],"understanding":[132],"biology":[135],"progression,":[137],"paving":[138],"way":[140],"personalized":[142],"medicine":[143],"tailored":[145],"treatment":[146],"options.":[147],"Significance:":[148],"A":[149],"comprehensive":[150],"analysis":[151],"provides":[157],"insights":[158],"into":[159],"cellular":[160],"heterogeneity":[161],"mechanisms":[163],"tumorigenesis":[165],"at":[166],"single-cell":[168],"level.":[169]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-06-27T00:00:00"}