{"id":"https://openalex.org/W4399998555","doi":"https://doi.org/10.1016/j.phrs.2024.107286","title":"Progress in the development of modulators targeting Frizzleds","display_name":"Progress in the development of modulators targeting Frizzleds","publication_year":2024,"publication_date":"2024-06-25","ids":{"openalex":"https://openalex.org/W4399998555","doi":"https://doi.org/10.1016/j.phrs.2024.107286","pmid":"https://pubmed.ncbi.nlm.nih.gov/38936522"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2024.107286","doi":"https://doi.org/10.1016/j.phrs.2024.107286","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2024.107286","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.phrs.2024.107286","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045393147","display_name":"Junlan Chuan","orcid":"https://orcid.org/0000-0002-5663-8068","observed_orcids":["https://orcid.org/0000-0002-5663-8068","https://orcid.org/0000-0003-0009-6420"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junlan Chuan","raw_affiliation_strings":["Sichuan Provincial Key Laboratory for Human Disease Gene Study and Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Provincial Key Laboratory for Human Disease Gene Study and Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences,\u00a0No. 9, Section 4, Renmin South Road,\u00a0Chengdu 610041,\u00a0China; The University of Chinese Academy of Sciences,\u00a0380 Huaibeizhuang, Huairou District,\u00a0Beijing 101408,\u00a0China","Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences,\u00a0No. 9, Section 4, Renmin South Road,\u00a0Chengdu 610041,\u00a0China","The University of Chinese Academy of Sciences,\u00a0380 Huaibeizhuang, Huairou District,\u00a0Beijing 101408,\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences,\u00a0No. 9, Section 4, Renmin South Road,\u00a0Chengdu 610041,\u00a0China; The University of Chinese Academy of Sciences,\u00a0380 Huaibeizhuang, Huairou District,\u00a0Beijing 101408,\u00a0China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences,\u00a0No. 9, Section 4, Renmin South Road,\u00a0Chengdu 610041,\u00a0China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]},{"raw_affiliation_string":"The University of Chinese Academy of Sciences,\u00a0380 Huaibeizhuang, Huairou District,\u00a0Beijing 101408,\u00a0China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041899699","display_name":"Shengliu Pan","orcid":"https://orcid.org/0009-0003-7757-4141","observed_orcids":["https://orcid.org/0009-0003-7757-4141"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengliu Pan","raw_affiliation_strings":["Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences,\u00a0No. 9, Section 4, Renmin South Road,\u00a0Chengdu 610041,\u00a0China; The University of Chinese Academy of Sciences,\u00a0380 Huaibeizhuang, Huairou District,\u00a0Beijing 101408,\u00a0China","Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences,\u00a0No. 9, Section 4, Renmin South Road,\u00a0Chengdu 610041,\u00a0China","The University of Chinese Academy of Sciences,\u00a0380 Huaibeizhuang, Huairou District,\u00a0Beijing 101408,\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences,\u00a0No. 9, Section 4, Renmin South Road,\u00a0Chengdu 610041,\u00a0China; The University of Chinese Academy of Sciences,\u00a0380 Huaibeizhuang, Huairou District,\u00a0Beijing 101408,\u00a0China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences,\u00a0No. 9, Section 4, Renmin South Road,\u00a0Chengdu 610041,\u00a0China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]},{"raw_affiliation_string":"The University of Chinese Academy of Sciences,\u00a0380 Huaibeizhuang, Huairou District,\u00a0Beijing 101408,\u00a0China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030672669","display_name":"Zhongliang Jiang","orcid":"https://orcid.org/0000-0001-7822-4520","observed_orcids":["https://orcid.org/0000-0001-7822-4520"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongliang Jiang","raw_affiliation_strings":["Hematology Department, Miller School of Medicine, University of Miami,\u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Miller School of Medicine, University of Miami,\u00a0USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008617015","display_name":"Jianyou Shi","orcid":"https://orcid.org/0000-0002-1026-0282","observed_orcids":["https://orcid.org/0000-0002-1026-0282"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianyou Shi","raw_affiliation_strings":["Sichuan Provincial Key Laboratory for Human Disease Gene Study and Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: shijianyoude@126.com","Sichuan Provincial Key Laboratory for Human Disease Gene Study and Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Provincial Key Laboratory for Human Disease Gene Study and Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: shijianyoude@126.com","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]},{"raw_affiliation_string":"Sichuan Provincial Key Laboratory for Human Disease Gene Study and Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080583583","display_name":"Zhenglin Yang","orcid":"https://orcid.org/0000-0003-4617-1422","observed_orcids":["https://orcid.org/0000-0003-4617-1422"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenglin Yang","raw_affiliation_strings":["Research Unit for Blindness Prevention, Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; Jinfeng Laboratory, Chongqing, China. Electronic address: yangzhenglin@cashq.ac.cn","Jinfeng Laboratory, Chongqing, China","Research Unit for Blindness Prevention, Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit for Blindness Prevention, Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; Jinfeng Laboratory, Chongqing, China. Electronic address: yangzhenglin@cashq.ac.cn","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210118397","https://openalex.org/I4405260818"]},{"raw_affiliation_string":"Jinfeng Laboratory, Chongqing, China","institution_ids":["https://openalex.org/I4405260818"]},{"raw_affiliation_string":"Research Unit for Blindness Prevention, Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210118397"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5008617015","https://openalex.org/A5080583583"],"corresponding_institution_ids":["https://openalex.org/I150229711","https://openalex.org/I200296433","https://openalex.org/I4210118397","https://openalex.org/I4405260818"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":{"value":3740,"currency":"USD","value_usd":3740},"fwci":0.2295,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.20971132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"206","issue":null,"first_page":"107286","last_page":"107286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frizzled-receptors","display_name":"Frizzled receptors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cysteine-rich-domain","display_name":"cysteine-rich domain","score":0.9539999961853027},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.843999981880188},{"id":"https://openalex.org/keywords/purmorphamine","display_name":"purmorphamine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bivalent-antibody","display_name":"bivalent antibody","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5460000038146973},{"id":"https://openalex.org/keywords/degenerative-diseases","display_name":"degenerative diseases","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7911560535430908},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.6649147868156433},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6147168278694153},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5390177965164185},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5149696469306946},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5061125159263611},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4981882572174072},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4978320598602295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.480684369802475},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43227052688598633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3621984124183655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23324552178382874}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.phrs.2024.107286","doi":"https://doi.org/10.1016/j.phrs.2024.107286","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2024.107286","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:38936522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38936522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9d4ce56d3b30477ebe5ceb7c145b0f84","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9d4ce56d3b30477ebe5ceb7c145b0f84","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacological Research, Vol 206, Iss , Pp 107286- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.phrs.2024.107286","doi":"https://doi.org/10.1016/j.phrs.2024.107286","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2024.107286","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2606321635","display_name":null,"funder_award_id":"2021YFS0369","funder_id":"https://openalex.org/F4320333335","funder_display_name":"Sichuan Province Science and Technology Support Program"},{"id":"https://openalex.org/G3113929375","display_name":null,"funder_award_id":"82101163","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4404450559","display_name":null,"funder_award_id":"82330030","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5865890565","display_name":null,"funder_award_id":"12M-5\\u2013032","funder_id":"https://openalex.org/F4320321849","funder_display_name":"Chinese Academy of Meteorological Sciences"},{"id":"https://openalex.org/G6627021358","display_name":null,"funder_award_id":"24ZDYF0552","funder_id":"https://openalex.org/F4320333335","funder_display_name":"Sichuan Province Science and Technology Support Program"},{"id":"https://openalex.org/G728059352","display_name":null,"funder_award_id":"82121003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7835890344","display_name":null,"funder_award_id":"2019-12M-5-032","funder_id":"https://openalex.org/F4320336738","funder_display_name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321849","display_name":"Chinese Academy of Meteorological Sciences","ror":"https://ror.org/034b53w38"},{"id":"https://openalex.org/F4320333335","display_name":"Sichuan Province Science and Technology Support Program","ror":null},{"id":"https://openalex.org/F4320336738","display_name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W1607958791","https://openalex.org/W1956332901","https://openalex.org/W1967056471","https://openalex.org/W1971108880","https://openalex.org/W1973897761","https://openalex.org/W1974094726","https://openalex.org/W1978047924","https://openalex.org/W1983612298","https://openalex.org/W1986724654","https://openalex.org/W1990567821","https://openalex.org/W1991231767","https://openalex.org/W1994029539","https://openalex.org/W1994399278","https://openalex.org/W2018448892","https://openalex.org/W2018758095","https://openalex.org/W2031522329","https://openalex.org/W2033984390","https://openalex.org/W2036833206","https://openalex.org/W2040942754","https://openalex.org/W2041935553","https://openalex.org/W2047224295","https://openalex.org/W2069750786","https://openalex.org/W2083571191","https://openalex.org/W2090455515","https://openalex.org/W2091258025","https://openalex.org/W2096171021","https://openalex.org/W2096879794","https://openalex.org/W2100701799","https://openalex.org/W2114185268","https://openalex.org/W2120488402","https://openalex.org/W2131631752","https://openalex.org/W2135914580","https://openalex.org/W2152418590","https://openalex.org/W2155769759","https://openalex.org/W2157907012","https://openalex.org/W2157973267","https://openalex.org/W2158021558","https://openalex.org/W2158079348","https://openalex.org/W2163171072","https://openalex.org/W2164964874","https://openalex.org/W2200010353","https://openalex.org/W2255131494","https://openalex.org/W2287193949","https://openalex.org/W2558801358","https://openalex.org/W2604323597","https://openalex.org/W2610869016","https://openalex.org/W2618986294","https://openalex.org/W2751008973","https://openalex.org/W2752245937","https://openalex.org/W2754574141","https://openalex.org/W2782108097","https://openalex.org/W2801533813","https://openalex.org/W2887239058","https://openalex.org/W2888170117","https://openalex.org/W2888670324","https://openalex.org/W2891096931","https://openalex.org/W2901994783","https://openalex.org/W2914135414","https://openalex.org/W2919427816","https://openalex.org/W2922723892","https://openalex.org/W2930419027","https://openalex.org/W2937472469","https://openalex.org/W2942724704","https://openalex.org/W2945287782","https://openalex.org/W2963099735","https://openalex.org/W2970175551","https://openalex.org/W2983689600","https://openalex.org/W3000881576","https://openalex.org/W3006360975","https://openalex.org/W3006744839","https://openalex.org/W3013678053","https://openalex.org/W3015428855","https://openalex.org/W3015997291","https://openalex.org/W3025609656","https://openalex.org/W3034098816","https://openalex.org/W3048320307","https://openalex.org/W3061588182","https://openalex.org/W3094360637","https://openalex.org/W3128641191","https://openalex.org/W3129522259","https://openalex.org/W3158539122","https://openalex.org/W3168347719","https://openalex.org/W3180740192","https://openalex.org/W3196804523","https://openalex.org/W3208832662","https://openalex.org/W4210880258","https://openalex.org/W4224214492","https://openalex.org/W4282838893","https://openalex.org/W4285391272","https://openalex.org/W4311227953","https://openalex.org/W4313557491","https://openalex.org/W4318947307","https://openalex.org/W4365518190","https://openalex.org/W4379197309","https://openalex.org/W4380869898","https://openalex.org/W4386453121","https://openalex.org/W4388290428","https://openalex.org/W4390619424","https://openalex.org/W6857608670"],"related_works":["https://openalex.org/W4394883055","https://openalex.org/W2804103434","https://openalex.org/W7203864502","https://openalex.org/W4396935839","https://openalex.org/W2114355635","https://openalex.org/W2973973763","https://openalex.org/W2751008973","https://openalex.org/W4394575265","https://openalex.org/W7151268553","https://openalex.org/W2108981830"],"abstract_inverted_index":{"The":[0],"Frizzleds":[1],"(FZDs)":[2],"receptors":[3,16,22],"on":[4],"the":[5,10,20,28,38,52,73,79,88,104,119,124,138,144,159,171,179,185,194,199,209],"cell":[6],"surface":[7],"belong":[8],"to":[9,78,103,118],"class":[11],"F":[12],"of":[13,23,56,63,75,81,87,108,127,149,198,212],"G":[14],"protein-coupled":[15],"(GPCRs)":[17],"which":[18,157],"are":[19,152],"major":[21],"WNT":[24,30,99,160],"protein":[25,96],"that":[26],"mediates":[27],"classical":[29],"signaling":[31,100,161],"pathway":[32],"and":[33,48,54,67,83,135,184,189,206],"other":[34],"non-classical":[35],"pathways.":[36],"Besides,":[37],"FZDs":[39,57,64,89,114,139,150,172],"also":[40],"play":[41],"a":[42,61],"core":[43],"role":[44],"in":[45,175],"tissue":[46],"regeneration":[47],"tumor":[49],"occurrence.":[50],"With":[51],"structure":[53],"mechanism":[55],"activation":[58,115],"becoming":[59],"clearer,":[60],"series":[62],"modulators":[65,173,201],"(inhibitors":[66],"agonists)":[68],"have":[69],"been":[70],"developed,":[71],"with":[72,143],"hope":[74],"bringing":[76],"benefits":[77],"treatment":[80],"cancer":[82],"degenerative":[84],"diseases.":[85],"Most":[86],"inhibitors":[90],"(small":[91],"molecules,":[92],"antibodies":[93,156],"or":[94,123,154],"designed":[95],"inhibitors)":[97],"block":[98],"through":[101,140],"binding":[102],"cysteine-rich":[105],"domain":[106,122,126],"(CRD)":[107],"FZDs.":[109,128],"Several":[110],"small":[111,131],"molecules":[112,132],"impede":[113],"by":[116],"targeting":[117],"third":[120],"intracellular":[121],"transmembrane":[125,145],"However,":[129],"three":[130],"(FZM1.8,":[133],"SAG1.3":[134],"purmorphamine)":[136],"activate":[137,158],"direct":[141],"interaction":[142],"domain.":[146],"Another":[147],"type":[148],"agonists":[151],"bivalent":[153],"tetravalent":[155],"via":[162],"inducing":[163],"FZD-LRP5/6":[164],"heterodimerization.":[165],"In":[166],"this":[167],"article,":[168],"we":[169],"reviewed":[170],"reported":[174],"recent":[176],"years,":[177],"summarized":[178],"critical":[180],"molecules'":[181],"discovery":[182],"processes":[183],"elucidated":[186],"relevant":[187,200],"structural":[188],"pharmacological":[190],"mechanisms.":[191],"We":[192],"believe":[193],"summaried":[195],"molecular":[196],"mechanisms":[197],"could":[202],"provide":[203],"important":[204],"guidance":[205],"reference":[207],"for":[208],"future":[210],"development":[211],"FZD":[213],"modulators.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-06-26T00:00:00"}
