{"id":"https://openalex.org/W4399985353","doi":"https://doi.org/10.1186/s13148-024-01698-8","title":"Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception","display_name":"Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception","publication_year":2024,"publication_date":"2024-06-24","ids":{"openalex":"https://openalex.org/W4399985353","doi":"https://doi.org/10.1186/s13148-024-01698-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/38915093","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11197381"},"language":"en","primary_location":{"id":"doi:10.1186/s13148-024-01698-8","doi":"https://doi.org/10.1186/s13148-024-01698-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-024-01698-8","pdf_url":null,"source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13148-024-01698-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034761450","display_name":"Jorge Enrique Tovar Perez","orcid":"https://orcid.org/0009-0000-4004-8736","observed_orcids":["https://orcid.org/0009-0000-4004-8736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Enrique Tovar Perez","raw_affiliation_strings":["Center for Epigenetics and Disease Prevention, Texas A&M Health, Houston, TX, 77030, USA"],"raw_orcid":"https://orcid.org/0009-0000-4004-8736","affiliations":[{"raw_affiliation_string":"Center for Epigenetics and Disease Prevention, Texas A&M Health, Houston, TX, 77030, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053796573","display_name":"Shilan Zhang","orcid":"https://orcid.org/0009-0000-7240-976X","observed_orcids":["https://orcid.org/0009-0000-7240-976X"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shilan Zhang","raw_affiliation_strings":["Department of Cardiovascular Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200070, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099442733","display_name":"William Hodgeman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Hodgeman","raw_affiliation_strings":["Wolfson Medical School, The University of Glasgow, Glasgow, G12 8QQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wolfson Medical School, The University of Glasgow, Glasgow, G12 8QQ, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020639999","display_name":"Sabeeta Kapoor","orcid":"https://orcid.org/0000-0001-7906-3343","observed_orcids":["https://orcid.org/0000-0001-7906-3343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabeeta Kapoor","raw_affiliation_strings":["Center for Epigenetics and Disease Prevention, Texas A&M Health, Houston, TX, 77030, USA"],"raw_orcid":"https://orcid.org/0000-0001-7906-3343","affiliations":[{"raw_affiliation_string":"Center for Epigenetics and Disease Prevention, Texas A&M Health, Houston, TX, 77030, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077577650","display_name":"Praveen Rajendran","orcid":"https://orcid.org/0000-0002-6221-7366","observed_orcids":["https://orcid.org/0000-0002-6221-7366"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Praveen Rajendran","raw_affiliation_strings":["Center for Epigenetics and Disease Prevention, Texas A&M Health, Houston, TX, 77030, USA","Department of Translational Medical Sciences, and Antibody & Biopharmaceuticals Core, Texas A&M Medicine, Houston, TX, 77030, USA"],"raw_orcid":"https://orcid.org/0000-0002-6221-7366","affiliations":[{"raw_affiliation_string":"Center for Epigenetics and Disease Prevention, Texas A&M Health, Houston, TX, 77030, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Translational Medical Sciences, and Antibody & Biopharmaceuticals Core, Texas A&M Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019493882","display_name":"Koichi S. Kobayashi","orcid":"https://orcid.org/0000-0003-2930-0114","observed_orcids":["https://orcid.org/0000-0003-2930-0114"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405287186","display_name":"Institute for Vaccine Research and Development, Hokkaido University","ror":"https://ror.org/04bst9757","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405287186"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi S. Kobayashi","raw_affiliation_strings":["Department of Immunology, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638, Japan","Department of Microbial Pathogenesis and Immunology, Texas A&M Health, Bryan, TX, 77087, USA","Hokkaido University Institute for Vaccine Research and Development, Sapporo, 060-8638, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Department of Microbial Pathogenesis and Immunology, Texas A&M Health, Bryan, TX, 77087, USA","institution_ids":[]},{"raw_affiliation_string":"Hokkaido University Institute for Vaccine Research and Development, Sapporo, 060-8638, Japan","institution_ids":["https://openalex.org/I4405287186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082820494","display_name":"Roderick H. Dashwood","orcid":"https://orcid.org/0000-0003-0351-4034","observed_orcids":["https://orcid.org/0000-0003-0351-4034"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roderick H. Dashwood","raw_affiliation_strings":["Center for Epigenetics and Disease Prevention, Texas A&M Health, Houston, TX, 77030, USA. rdashwood@tamu.edu","Department of Translational Medical Sciences, and Antibody & Biopharmaceuticals Core, Texas A&M Medicine, Houston, TX, 77030, USA. rdashwood@tamu.edu","Department of Translational Medical Sciences, and Antibody & Biopharmaceuticals Core, Texas A&M Medicine, Houston, TX, 77030, USA"],"raw_orcid":"https://orcid.org/0000-0003-0351-4034","affiliations":[{"raw_affiliation_string":"Center for Epigenetics and Disease Prevention, Texas A&M Health, Houston, TX, 77030, USA. rdashwood@tamu.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Translational Medical Sciences, and Antibody & Biopharmaceuticals Core, Texas A&M Medicine, Houston, TX, 77030, USA. rdashwood@tamu.edu","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Translational Medical Sciences, and Antibody & Biopharmaceuticals Core, Texas A&M Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5082820494"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.6294,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.5500838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"16","issue":"1","first_page":"83","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.16590000689029694,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.9309999942779541},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mhc-downregulation","display_name":"MHC downregulation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.75},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.8339999914169312},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.8140000104904175},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8499026894569397},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.7153869271278381},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6022251844406128},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5883321166038513},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5291222333908081},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4896462559700012},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4631962180137634},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4291064739227295},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4223012924194336},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4167257249355316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.366787314414978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14924365282058716},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1310940980911255}],"mesh":[{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13148-024-01698-8","doi":"https://doi.org/10.1186/s13148-024-01698-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-024-01698-8","pdf_url":null,"source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11197381","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11197381","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11197381/pdf/13148_2024_Article_1698.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Epigenetics","raw_type":"Text"},{"id":"pmid:38915093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38915093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical epigenetics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0e8b189a61454d52aa2a22e919c30eda","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0e8b189a61454d52aa2a22e919c30eda","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Epigenetics, Vol 16, Iss 1, Pp 1-17 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13148-024-01698-8","doi":"https://doi.org/10.1186/s13148-024-01698-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-024-01698-8","pdf_url":null,"source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[{"id":"https://openalex.org/G4270383038","display_name":"Roles of bacterial flora in endotoxin shock mediated vi*","funder_award_id":"R03TW006833","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G6939488478","display_name":"Nod2-mediated regulation of intestinal homeostasis","funder_award_id":"R01DK074738","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7305589455","display_name":"CCAR2 as a Target for Prevention of Colorectal Cancer.","funder_award_id":"R01CA122959","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000884908","display_name":"Immunoepigenetic targeting of MHC regulators in FAP","funder_award_id":"R01CA257559","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309422","display_name":"John S. Dunn Foundation","ror":"https://ror.org/03yhprz62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399985353.pdf","grobid_xml":"https://content.openalex.org/works/W4399985353.grobid-xml"},"referenced_works_count":115,"referenced_works":["https://openalex.org/W1157613785","https://openalex.org/W1488814076","https://openalex.org/W1526222764","https://openalex.org/W1528845830","https://openalex.org/W1536422556","https://openalex.org/W1556364911","https://openalex.org/W1629239351","https://openalex.org/W1669971307","https://openalex.org/W1742190155","https://openalex.org/W1823992529","https://openalex.org/W1939365747","https://openalex.org/W1942735513","https://openalex.org/W1952767463","https://openalex.org/W1956285448","https://openalex.org/W1960849084","https://openalex.org/W1966682269","https://openalex.org/W1971272503","https://openalex.org/W1976180152","https://openalex.org/W1976195988","https://openalex.org/W1985115694","https://openalex.org/W1985219178","https://openalex.org/W1993786192","https://openalex.org/W1997559803","https://openalex.org/W1999341606","https://openalex.org/W2000070744","https://openalex.org/W2001761736","https://openalex.org/W2004010971","https://openalex.org/W2004333515","https://openalex.org/W2010936391","https://openalex.org/W2011664887","https://openalex.org/W2012326746","https://openalex.org/W2012425092","https://openalex.org/W2013584312","https://openalex.org/W2017075227","https://openalex.org/W2018185988","https://openalex.org/W2019661764","https://openalex.org/W2028691831","https://openalex.org/W2031087599","https://openalex.org/W2031248889","https://openalex.org/W2040882330","https://openalex.org/W2043817901","https://openalex.org/W2051607934","https://openalex.org/W2052668971","https://openalex.org/W2057023729","https://openalex.org/W2068320971","https://openalex.org/W2069932218","https://openalex.org/W2071115015","https://openalex.org/W2073258270","https://openalex.org/W2079712794","https://openalex.org/W2082389503","https://openalex.org/W2084292672","https://openalex.org/W2088474515","https://openalex.org/W2093188241","https://openalex.org/W2097056602","https://openalex.org/W2102238765","https://openalex.org/W2108886247","https://openalex.org/W2112963706","https://openalex.org/W2116650389","https://openalex.org/W2117247812","https://openalex.org/W2117691193","https://openalex.org/W2122413073","https://openalex.org/W2122823330","https://openalex.org/W2126004433","https://openalex.org/W2128627050","https://openalex.org/W2141661046","https://openalex.org/W2155752130","https://openalex.org/W2161588387","https://openalex.org/W2164772840","https://openalex.org/W2168963367","https://openalex.org/W2169432835","https://openalex.org/W2170069789","https://openalex.org/W2257932041","https://openalex.org/W2276873235","https://openalex.org/W2285093314","https://openalex.org/W2291548946","https://openalex.org/W2308472440","https://openalex.org/W2337401980","https://openalex.org/W2415257785","https://openalex.org/W2479346408","https://openalex.org/W2512467713","https://openalex.org/W2592370523","https://openalex.org/W2593831845","https://openalex.org/W2724336500","https://openalex.org/W2738462696","https://openalex.org/W2774471682","https://openalex.org/W2780166051","https://openalex.org/W2797515810","https://openalex.org/W2808020079","https://openalex.org/W2890153998","https://openalex.org/W2901219667","https://openalex.org/W2902532424","https://openalex.org/W2909103067","https://openalex.org/W2912466575","https://openalex.org/W2940062333","https://openalex.org/W2970548174","https://openalex.org/W2971764330","https://openalex.org/W2974503966","https://openalex.org/W2976711511","https://openalex.org/W3122102740","https://openalex.org/W3130189452","https://openalex.org/W3131183594","https://openalex.org/W3134746059","https://openalex.org/W3136229160","https://openalex.org/W3154367087","https://openalex.org/W3207210287","https://openalex.org/W4210920145","https://openalex.org/W4213222090","https://openalex.org/W4220671728","https://openalex.org/W4220672788","https://openalex.org/W4224228275","https://openalex.org/W4281669451","https://openalex.org/W4283375792","https://openalex.org/W4306938729","https://openalex.org/W4393102654","https://openalex.org/W4396928917"],"related_works":["https://openalex.org/W2057608553","https://openalex.org/W7203581481","https://openalex.org/W4413317731","https://openalex.org/W4401844580","https://openalex.org/W3046867901","https://openalex.org/W7139946068","https://openalex.org/W4400259367","https://openalex.org/W1964219687","https://openalex.org/W3156253900","https://openalex.org/W7168226840"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gastrointestinal":[1],"malignancies":[2,150],"encompass":[3],"a":[4,22,153],"diverse":[5],"group":[6],"of":[7,33,44,115,128,134],"cancers":[8],"that":[9,68,97],"pose":[10],"significant":[11],"challenges":[12],"to":[13,50,99,120],"global":[14],"health.":[15],"The":[16,132],"major":[17],"histocompatibility":[18],"complex":[19],"(MHC)":[20],"plays":[21],"pivotal":[23],"role":[24],"in":[25,102,146],"immune":[26,38,80],"surveillance,":[27],"orchestrating":[28],"the":[29,37,41,65,76,91,126],"recognition":[30],"and":[31,58,84,107,124,151,159],"elimination":[32],"tumor":[34,82],"cells":[35],"by":[36],"system.":[39],"However,":[40],"intricate":[42],"regulation":[43],"MHC":[45,70,100,122],"gene":[46],"expression":[47,123],"is":[48],"susceptible":[49],"dynamic":[51],"epigenetic":[52,66,95,118],"modification,":[53],"which":[54],"can":[55],"influence":[56],"functionality":[57],"pathological":[59],"outcomes.":[60],"MAIN":[61],"BODY:":[62],"By":[63],"understanding":[64],"alterations":[67],"drive":[69],"downregulation,":[71],"insights":[72],"are":[73,113],"gained":[74],"into":[75],"molecular":[77],"mechanisms":[78,96],"underlying":[79],"escape,":[81],"progression,":[83],"immunotherapy":[85],"resistance.":[86],"This":[87],"systematic":[88],"review":[89],"examines":[90],"current":[92],"literature":[93],"on":[94],"contribute":[98],"deregulation":[101],"esophageal,":[103],"gastric,":[104],"pancreatic,":[105],"hepatic":[106],"colorectal":[108],"malignancies.":[109],"Potential":[110],"clinical":[111,144],"implications":[112],"discussed":[114],"targeting":[116],"aberrant":[117],"modifications":[119],"restore":[121],"0":[125],"effectiveness":[127],"immunotherapeutic":[129],"interventions.":[130],"CONCLUSION:":[131],"integration":[133],"epigenetic-targeted":[135],"therapies":[136],"with":[137,148],"immunotherapies":[138],"holds":[139],"great":[140],"potential":[141],"for":[142,156],"improving":[143],"outcomes":[145],"patients":[147],"gastrointestinal":[149],"represents":[152],"compelling":[154],"avenue":[155],"future":[157],"research":[158],"therapeutic":[160],"development.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-06-25T00:00:00"}
