{"id":"https://openalex.org/W4399879820","doi":"https://doi.org/10.1097/qad.0000000000003965","title":"Efficacy and safety of tesamorelin in people with HIV on integrase inhibitors","display_name":"Efficacy and safety of tesamorelin in people with HIV on integrase inhibitors","publication_year":2024,"publication_date":"2024-06-20","ids":{"openalex":"https://openalex.org/W4399879820","doi":"https://doi.org/10.1097/qad.0000000000003965","pmid":"https://pubmed.ncbi.nlm.nih.gov/38905488","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11365754"},"language":"en","primary_location":{"id":"doi:10.1097/qad.0000000000003965","doi":"https://doi.org/10.1097/qad.0000000000003965","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0000000000003965","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11365754/pdf/nihms-2003686.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007158012","display_name":"Samuel C Russo","orcid":"https://orcid.org/0000-0002-1443-7735","observed_orcids":["https://orcid.org/0000-0002-1443-7735"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel C. Russo","raw_affiliation_strings":["Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069374568","display_name":"Mollie W Ockene","orcid":"https://orcid.org/0000-0003-0600-6617","observed_orcids":["https://orcid.org/0000-0003-0600-6617"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mollie W. Ockene","raw_affiliation_strings":["Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098955414","display_name":"Allison K Arpante","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison K. Arpante","raw_affiliation_strings":["Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109735911","display_name":"Julia E Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia E. Johnson","raw_affiliation_strings":["Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101909011","display_name":"Hang Lee","orcid":"https://orcid.org/0000-0002-3498-236X","observed_orcids":["https://orcid.org/0000-0002-3498-236X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hang Lee","raw_affiliation_strings":["MGH Biostatistics Center, Massachusetts General Hospital, Boston, MA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH Biostatistics Center, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014118695","display_name":"Mabel P. Toribio","orcid":"https://orcid.org/0000-0002-4153-5568","observed_orcids":["https://orcid.org/0000-0002-4153-5568"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mabel Toribio","raw_affiliation_strings":["Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034813577","display_name":"Takara Leah Stanley","orcid":"https://orcid.org/0000-0002-2336-2958","observed_orcids":["https://orcid.org/0000-0002-2336-2958"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takara L. Stanley","raw_affiliation_strings":["Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049246976","display_name":"Colleen M. Hadigan","orcid":"https://orcid.org/0000-0003-0642-7817","observed_orcids":["https://orcid.org/0000-0003-0642-7817"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen M. Hadigan","raw_affiliation_strings":["National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD","National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063043469","display_name":"Steven Kyle Grinspoon","orcid":"https://orcid.org/0000-0002-6338-000X","observed_orcids":["https://orcid.org/0000-0002-6338-000X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven K. Grinspoon","raw_affiliation_strings":["Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007571350","display_name":"Kristine Mace Erlandson","orcid":"https://orcid.org/0000-0003-0808-6729","observed_orcids":["https://orcid.org/0000-0003-0808-6729"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristine M. Erlandson","raw_affiliation_strings":["Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007440108","display_name":"Lindsay T. Fourman","orcid":"https://orcid.org/0000-0001-8148-7858","observed_orcids":["https://orcid.org/0000-0001-8148-7858"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lindsay T. Fourman","raw_affiliation_strings":["Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","fax: +617 724 8998","to Lindsay T. Fourman, Assistant Professor of Medicine, Harvard Medical School, Metabolism Unit, Massachusetts General Hospital, 55 Fruit Street, S50, Boston, MA 02114. Tel: +617 643 4590"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"fax: +617 724 8998","institution_ids":[]},{"raw_affiliation_string":"to Lindsay T. Fourman, Assistant Professor of Medicine, Harvard Medical School, Metabolism Unit, Massachusetts General Hospital, 55 Fruit Street, S50, Boston, MA 02114. Tel: +617 643 4590","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007440108"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":1.7516,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.8240707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"38","issue":"12","first_page":"1758","last_page":"1764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tesamorelin","display_name":"tesamorelin","score":1.0},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.8799999952316284},{"id":"https://openalex.org/keywords/integrase-inhibitors","display_name":"integrase inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/abdominal-fat-accumulation","display_name":"abdominal fat accumulation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.8920000195503235},{"id":"https://openalex.org/keywords/liver-fat-content","display_name":"liver fat","score":0.8949999809265137},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7409999966621399},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7649937868118286},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.6267653703689575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6256672739982605},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5467357635498047},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46244198083877563},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4614025950431824},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37316951155662537},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08265462517738342},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019428","descriptor_name":"HIV Integrase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019428","descriptor_name":"HIV Integrase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/qad.0000000000003965","doi":"https://doi.org/10.1097/qad.0000000000003965","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0000000000003965","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},{"id":"pmid:38905488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38905488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11286525","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11365754","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11365754/pdf/nihms-2003686.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11365754","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11365754/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"AIDS","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:11286525","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11365754","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11365754/pdf/nihms-2003686.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1346694083","display_name":"Tesamorelin Effects on Liver Fat and Histology in HIV: A Collaborative U01 Grant","funder_award_id":"U01AI115711","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1485989582","display_name":"Cardiometabolic Effects of Gender-Affirming Hormonal Therapy among Transgender Women with HIV","funder_award_id":"K23HL147799","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2212740556","display_name":"In Utero HIV Exposure and Metabolic Disease Risk in HIV-Uninfected Young Adults","funder_award_id":"K23HD100266","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000884917","display_name":"Colorado Nutrition Obesity Research Center","funder_award_id":"P30DK048520","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000907652","display_name":"Boston Area Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK040561","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000913581","display_name":"Mentoring Across Disciplines: Aging and Infectious Diseases with a Focus on Mobility","funder_award_id":"K24AG082527","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320318070","display_name":"Amryt Pharma","ror":"https://ror.org/02nph9e73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399879820.pdf","grobid_xml":"https://content.openalex.org/works/W4399879820.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1989400130","https://openalex.org/W2002980979","https://openalex.org/W2012567863","https://openalex.org/W2025538270","https://openalex.org/W2037216890","https://openalex.org/W2048331100","https://openalex.org/W2056139721","https://openalex.org/W2077744180","https://openalex.org/W2084608105","https://openalex.org/W2086823329","https://openalex.org/W2091239171","https://openalex.org/W2094241860","https://openalex.org/W2104357394","https://openalex.org/W2163256722","https://openalex.org/W2256545526","https://openalex.org/W2397560420","https://openalex.org/W2405901855","https://openalex.org/W2560323034","https://openalex.org/W2751534677","https://openalex.org/W2765628353","https://openalex.org/W2770067878","https://openalex.org/W2803388708","https://openalex.org/W2916766670","https://openalex.org/W2979687596","https://openalex.org/W2979917028","https://openalex.org/W3012221240","https://openalex.org/W3036631329","https://openalex.org/W3042037989","https://openalex.org/W3121390202","https://openalex.org/W3136890649","https://openalex.org/W3162042219","https://openalex.org/W4229027222","https://openalex.org/W4280551067","https://openalex.org/W4282039633","https://openalex.org/W4310567938","https://openalex.org/W4391932879","https://openalex.org/W6730763554"],"related_works":["https://openalex.org/W4389031537","https://openalex.org/W2061478685","https://openalex.org/W7095784048","https://openalex.org/W2048331100","https://openalex.org/W2010315307","https://openalex.org/W2091239171","https://openalex.org/W4311847175","https://openalex.org/W2037486981","https://openalex.org/W2012567863","https://openalex.org/W7124461237"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Tesamorelin":[1,146,196],"is":[2],"the":[3,25,58,80,143,216,221,233],"only":[4],"FDA-approved":[5],"therapy":[6],"to":[7,24,56,148],"treat":[8],"abdominal":[9],"fat":[10,85,89,93,153,171,184],"accumulation":[11],"in":[12,151],"people":[13],"with":[14,200,238,252],"HIV":[15,37],"(PWH).":[16],"Phase":[17],"III":[18],"clinical":[19,82],"trials":[20],"were":[21,95,119],"conducted":[22],"prior":[23],"introduction":[26],"of":[27,36,47,62,204,225,235,255],"integrase":[28],"inhibitors":[29],"(INSTIs),":[30],"which":[31],"are":[32],"now":[33],"a":[34,43,201],"mainstay":[35],"antiretroviral":[38],"therapy.":[39],"DESIGN:":[40],"We":[41],"leveraged":[42],"randomized":[44],"double-blind":[45],"trial":[46],"61":[48],"PWH":[49,228],"and":[50,60,91,105,112,116,137,182,223,241],"metabolic":[51],"dysfunction-associated":[52],"steatotic":[53],"liver":[54],"disease":[55],"evaluate":[57],"efficacy":[59,222],"safety":[61,117,224],"tesamorelin":[63,136,226,245],"2":[64,165],"mg":[65],"once":[66],"daily":[67],"vs.":[68,160,175,189],"identical":[69],"placebo":[70,141],"among":[71,227],"participants":[72,127],"on":[73,128,135,140,220,229,249],"INSTI-based":[74,129,230],"regimens":[75,130],"at":[76,110,131],"baseline.":[77],"METHODS:":[78],"In":[79],"parent":[81],"trial,":[83],"visceral":[84,152],"cross-sectional":[86],"area,":[87],"hepatic":[88,170],"fraction,":[90],"trunk-to-appendicular":[92,183],"ratio":[94,185],"quantified":[96],"using":[97],"magnetic":[98,102],"resonance":[99,103],"imaging,":[100],"proton":[101],"spectroscopy,":[104],"dual-energy":[106],"x-ray":[107],"absorptiometry,":[108],"respectively,":[109],"baseline":[111],"12":[113],"months.":[114],"Metabolic":[115],"outcomes":[118],"compared":[120],"between":[121,209],"treatment":[122],"arms.":[123],"RESULTS:":[124],"Among":[125],"38":[126],"baseline,":[132],"15":[133],"individuals":[134,139],"16":[138],"completed":[142],"12-month":[144],"study.":[145],"led":[147],"significant":[149],"declines":[150],"(median":[154],"[interquartile":[155],"range]:":[156],"-25":[157],"[-93,":[158],"-2]":[159],"14":[161],"[3,":[162],"41]":[163],"cm":[164],",":[166],"P":[167,179,193],"=":[168,180,194],"0.001),":[169],"(-4.2%":[172],"[-12.3%,":[173],"-2.7%]":[174],"-0.5%":[176],"[-3.9%,":[177],"2.7%],":[178],"0.01),":[181],"(-0.1":[186],"[-0.3,":[187],"0.0]":[188],"0.0":[190],"[-0.1,":[191],"0.1],":[192],"0.03).":[195],"was":[197],"well":[198],"tolerated":[199],"similar":[202],"frequency":[203],"adverse":[205],"events,":[206],"including":[207],"hyperglycemia,":[208],"groups.":[210],"CONCLUSIONS:":[211],"The":[212],"current":[213],"analysis":[214],"provides":[215],"first":[217],"dedicated":[218],"data":[219],"regimens.":[231],"Despite":[232],"association":[234],"INSTI":[236],"use":[237],"weight":[239],"gain":[240],"adipose":[242],"tissue":[243],"dysfunction,":[244],"had":[246],"beneficial":[247],"effects":[248],"body":[250],"composition":[251],"no":[253],"exacerbation":[254],"glycemic":[256],"control.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-06-22T00:00:00"}