{"id":"https://openalex.org/W4399863876","doi":"https://doi.org/10.3390/ijms25126704","title":"Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance","display_name":"Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance","publication_year":2024,"publication_date":"2024-06-18","ids":{"openalex":"https://openalex.org/W4399863876","doi":"https://doi.org/10.3390/ijms25126704","pmid":"https://pubmed.ncbi.nlm.nih.gov/38928409","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11203799"},"language":"en","primary_location":{"id":"doi:10.3390/ijms25126704","doi":"https://doi.org/10.3390/ijms25126704","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25126704","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms25126704","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Henry Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Kim","raw_affiliation_strings":["NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095770864","display_name":"Louis Kretz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louis Kretz","raw_affiliation_strings":["NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077506678","display_name":"C\u00e9line Ronin","orcid":"https://orcid.org/0000-0002-0930-5316","observed_orcids":["https://orcid.org/0000-0002-0930-5316"]},"institutions":[{"id":"https://openalex.org/I4210087734","display_name":"Stevenage Bioscience Catalyst","ror":"https://ror.org/003dca267","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087734"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Celine Ronin","raw_affiliation_strings":["Galecto Biotech AB , Stevenage Bioscience Catalyst , Gunnels Wood Road , Stevenage , Hertfordshire , UK SG1 2NY ,","NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galecto Biotech AB , Stevenage Bioscience Catalyst , Gunnels Wood Road , Stevenage , Hertfordshire , UK SG1 2NY ,","institution_ids":["https://openalex.org/I4210087734"]},{"raw_affiliation_string":"NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021112509","display_name":"Christina Starck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Starck","raw_affiliation_strings":["NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000245751","display_name":"James A. Roper","orcid":"https://orcid.org/0000-0002-8910-6033","observed_orcids":["https://orcid.org/0000-0002-8910-6033"]},"institutions":[{"id":"https://openalex.org/I4210087734","display_name":"Stevenage Bioscience Catalyst","ror":"https://ror.org/003dca267","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087734"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James A. Roper","raw_affiliation_strings":["Galecto Biotech AB , Stevenage Bioscience Catalyst , Stevenage , Hertfordshire , UK SG1","Galecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK"],"raw_orcid":"https://orcid.org/0000-0002-8910-6033","affiliations":[{"raw_affiliation_string":"Galecto Biotech AB , Stevenage Bioscience Catalyst , Stevenage , Hertfordshire , UK SG1","institution_ids":["https://openalex.org/I4210087734"]},{"raw_affiliation_string":"Galecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK","institution_ids":["https://openalex.org/I4210087734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061725949","display_name":"Barbro Kahl-Knutson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Barbro Kahl-Knutson","raw_affiliation_strings":["Department of Laboratory Medicine , Lund University , Box 124 , SE-221 00 , Lund , Sweden","Department of Laboratory Medicine, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine , Lund University , Box 124 , SE-221 00 , Lund , Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053034012","display_name":"Kristoffer Peterson","orcid":"https://orcid.org/0000-0002-4683-8293","observed_orcids":["https://orcid.org/0000-0002-4683-8293"]},"institutions":[{"id":"https://openalex.org/I4210104435","display_name":"Galecto (Denmark)","ror":"https://ror.org/01cjch873","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104435"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kristoffer Peterson","raw_affiliation_strings":["Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-4683-8293","affiliations":[{"raw_affiliation_string":"Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210104435"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083922144","display_name":"Hakon Leffler","orcid":"https://orcid.org/0000-0003-4482-8945","observed_orcids":["https://orcid.org/0000-0003-4482-8945"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hakon Leffler","raw_affiliation_strings":["Department of Laboratory Medicine , Lund University , Box 124 , SE-221 00 , Lund , Sweden","Department of Laboratory Medicine, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4482-8945","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine , Lund University , Box 124 , SE-221 00 , Lund , Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061685613","display_name":"Ulf J. Nilsson","orcid":"https://orcid.org/0000-0001-5815-9522","observed_orcids":["https://orcid.org/0000-0001-5815-9522","https://orcid.org/0000-0003-3075-5415"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210104435","display_name":"Galecto (Denmark)","ror":"https://ror.org/01cjch873","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104435"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"Ulf J. Nilsson","raw_affiliation_strings":["Department of Chemistry , Lund University , Box 124 , SE-221 00 , Lund , Sweden","Galecto Biotech AB, Cobis Science Park, Ole Maaloes Vej 3, DK-2200 Copenhagen, Denmark","Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-5815-9522","affiliations":[{"raw_affiliation_string":"Department of Chemistry , Lund University , Box 124 , SE-221 00 , Lund , Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Galecto Biotech AB, Cobis Science Park, Ole Maaloes Vej 3, DK-2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210104435"]},{"raw_affiliation_string":"Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anders Pedersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104435","display_name":"Galecto (Denmark)","ror":"https://ror.org/01cjch873","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104435"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders Pedersen","raw_affiliation_strings":["Galecto Biotech AB, Cobis Science Park, Ole Maaloes Vej 3, DK-2200 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galecto Biotech AB, Cobis Science Park, Ole Maaloes Vej 3, DK-2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210104435"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017079205","display_name":"Fredrik R. Zetterberg","orcid":"https://orcid.org/0000-0002-7789-8782","observed_orcids":["https://orcid.org/0000-0002-7789-8782"]},"institutions":[{"id":"https://openalex.org/I4210104435","display_name":"Galecto (Denmark)","ror":"https://ror.org/01cjch873","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104435"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Fredrik R. Zetterberg","raw_affiliation_strings":["Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210104435"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076843523","display_name":"Robert J. Slack","orcid":"https://orcid.org/0000-0002-4372-9438","observed_orcids":["https://orcid.org/0000-0002-4372-9438"]},"institutions":[{"id":"https://openalex.org/I4210087734","display_name":"Stevenage Bioscience Catalyst","ror":"https://ror.org/003dca267","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087734"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Robert J. Slack","raw_affiliation_strings":["Galecto Biotech AB , Stevenage Bioscience Catalyst , Stevenage , Hertfordshire , UK SG1","Galecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK"],"raw_orcid":"https://orcid.org/0000-0002-4372-9438","affiliations":[{"raw_affiliation_string":"Galecto Biotech AB , Stevenage Bioscience Catalyst , Stevenage , Hertfordshire , UK SG1","institution_ids":["https://openalex.org/I4210087734"]},{"raw_affiliation_string":"Galecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK","institution_ids":["https://openalex.org/I4210087734"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076843523"],"corresponding_institution_ids":["https://openalex.org/I4210087734"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":0.4753,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.56735671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"25","issue":"12","first_page":"6704","last_page":"6704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-1","display_name":"galectin-1","score":1.0},{"id":"https://openalex.org/keywords/carbohydrate-recognition-domain","display_name":"carbohydrate recognition domain","score":0.8980000019073486},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/association-and-dissociation-kinetics","display_name":"association and dissociation kinetics","score":0.8970000147819519},{"id":"https://openalex.org/keywords/carbohydrate-mimetics","display_name":"carbohydrate mimetics","score":0.8040000200271606},{"id":"https://openalex.org/keywords/carbohydrates","display_name":"carbohydrates","score":0.734000027179718},{"id":"https://openalex.org/keywords/drug-discovery-screening","display_name":"drug discovery screening","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.8381847143173218},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.733310341835022},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5958703756332397},{"id":"https://openalex.org/C139210041","wikidata":"https://www.wikidata.org/wiki/Q2145840","display_name":"Resonance (particle physics)","level":2,"score":0.4850963354110718},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.473438024520874},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44246193766593933},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4388411045074463},{"id":"https://openalex.org/C136676167","wikidata":"https://www.wikidata.org/wiki/Q1151829","display_name":"Surface plasmon","level":3,"score":0.4370936155319214},{"id":"https://openalex.org/C152900378","wikidata":"https://www.wikidata.org/wiki/Q7302366","display_name":"Receptor\u2013ligand kinetics","level":3,"score":0.41449978947639465},{"id":"https://openalex.org/C110879396","wikidata":"https://www.wikidata.org/wiki/Q58392","display_name":"Plasmon","level":2,"score":0.3919908404350281},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3672465682029724},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2918820381164551},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.24407696723937988},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19690915942192078},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15389865636825562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14648300409317017},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.14575135707855225},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.12375521659851074},{"id":"https://openalex.org/C184779094","wikidata":"https://www.wikidata.org/wiki/Q26383","display_name":"Atomic physics","level":1,"score":0.09898576140403748},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06279623508453369},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005454","descriptor_name":"Fluorescence Polarization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms25126704","doi":"https://doi.org/10.3390/ijms25126704","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25126704","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202404.1027.v1","doi":"https://doi.org/10.20944/preprints202404.1027.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.20944/preprints202404.1027.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/e9fca350b9086d0f5ceb18374a688176/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11203799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11203799","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11203799/pdf/ijms-25-06704.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:38928409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38928409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:ed96fba4-09ea-4d08-8941-2e26a6408927","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/ed96fba4-09ea-4d08-8941-2e26a6408927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1422-0067","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms25126704","doi":"https://doi.org/10.3390/ijms25126704","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25126704","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317585","display_name":"Galecto","ror":"https://ror.org/01cjch873"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399863876.pdf","grobid_xml":"https://content.openalex.org/works/W4399863876.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2046148841","https://openalex.org/W2065129695","https://openalex.org/W2078959323","https://openalex.org/W2090602226","https://openalex.org/W2117832286","https://openalex.org/W2128441998","https://openalex.org/W2138790009","https://openalex.org/W2155848597","https://openalex.org/W2463944685","https://openalex.org/W2617113644","https://openalex.org/W2911896280","https://openalex.org/W3044506099","https://openalex.org/W3102870960","https://openalex.org/W3196418723","https://openalex.org/W4213376649","https://openalex.org/W4297238919","https://openalex.org/W4315709039","https://openalex.org/W4319754207","https://openalex.org/W4361187326","https://openalex.org/W4382393595","https://openalex.org/W4387956191","https://openalex.org/W4389452515","https://openalex.org/W4399091839"],"related_works":["https://openalex.org/W4361187326","https://openalex.org/W4221083421","https://openalex.org/W2079070671","https://openalex.org/W2411620058","https://openalex.org/W1989639700","https://openalex.org/W2038996493","https://openalex.org/W2172055696","https://openalex.org/W2128441998","https://openalex.org/W4386914214","https://openalex.org/W1984174645"],"abstract_inverted_index":{"The":[0],"beta-galactoside-binding":[1],"mammalian":[2],"lectin":[3],"galectin-1":[4,103,119,175,226],"can":[5],"bind,":[6],"via":[7],"its":[8],"carbohydrate":[9],"recognition":[10],"domain":[11],"(CRD),":[12],"various":[13],"cell":[14,35,49],"surface":[15,36,108],"glycoproteins":[16],"and":[17,51,58,75,94,117,143,153,160,203,212],"has":[18,39,65,126],"been":[19,40,128],"implicated":[20],"in":[21,54,218],"a":[22,27,44,62,69,139,146,193,219],"range":[23,148],"of":[24,29,141],"cancers.":[25],"As":[26,61],"consequence":[28],"binding":[30],"to":[31,42,67,88,92,101,114,196,215],"sugar":[32],"residues":[33],"on":[34],"receptors":[37],"it":[38,64,208],"shown":[41,165],"have":[43,82],"pleiotropic":[45],"effect":[46],"across":[47],"many":[48],"types":[50],"mechanisms":[52],"resulting":[53],"immune":[55],"system":[56],"modulation":[57],"cancer":[59],"progression.":[60],"result,":[63],"started":[66],"become":[68],"therapeutic":[70],"target":[71],"for":[72,130,138,157,181,198,223],"both":[73,158],"small":[74,96,224],"large":[76],"molecules.":[77],"In":[78,105],"previous":[79],"studies,":[80],"we":[81],"used":[83,113],"fluorescence":[84],"polarisation":[85],"(FP)":[86],"assays":[87],"determine":[89],"KD":[90],"values":[91],"screen":[93],"triage":[95],"molecule":[97,225],"glycomimetics":[98],"that":[99,166,190],"bind":[100],"the":[102,170,182],"CRD.":[104],"this":[106,134],"study":[107,188],"plasmon":[109],"resonance":[110],"(SPR)":[111],"was":[112,164,179],"compare":[115],"human":[116,159,174],"mouse":[118,161,185],"affinity":[120,172,205],"measures":[121],"with":[122],"FP":[123,152,197],"as":[124],"SPR":[125,154,191],"not":[127],"applied":[129],"compound":[131],"screening":[132,202],"against":[133],"galectin.":[135],"Binding":[136],"affinities":[137],"selection":[140],"mono-":[142],"di-saccharides":[144],"covering":[145],"1,000-fold":[147],"correlated":[149],"well":[150],"between":[151],"assay":[155],"formats":[156],"galectin-1.":[162,186],"It":[163],"slower":[167],"dissociation":[168,213],"drove":[169],"increased":[171],"at":[173,184],"whilst":[176],"faster":[177],"association":[178,211],"responsible":[180],"effects":[183],"This":[187],"demonstrates":[189],"is":[192],"sound":[194],"alternative":[195],"early":[199],"drug":[200],"discovery":[201],"determining":[204],"estimates.":[206],"Consequently,":[207],"also":[209],"allows":[210],"constants":[214],"be":[216],"measured":[217],"high":[220],"throughput":[221],"manner":[222],"inhibitors.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-06-21T00:00:00"}
