{"id":"https://openalex.org/W4399863722","doi":"https://doi.org/10.3390/ijms25126703","title":"Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K+ Efflux Induced by PLO via Signal Point Mutations","display_name":"Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K+ Efflux Induced by PLO via Signal Point Mutations","publication_year":2024,"publication_date":"2024-06-18","ids":{"openalex":"https://openalex.org/W4399863722","doi":"https://doi.org/10.3390/ijms25126703","pmid":"https://pubmed.ncbi.nlm.nih.gov/38928408","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11203744"},"language":"en","primary_location":{"id":"doi:10.3390/ijms25126703","doi":"https://doi.org/10.3390/ijms25126703","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25126703","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms25126703","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qiang Shan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]},{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Shan","raw_affiliation_strings":["College of Veterinary Medicine, China Agricultural University, Beijing 100093, China","College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, China Agricultural University, Beijing 100093, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101752213","display_name":"Wenbo Ma","orcid":"https://orcid.org/0000-0003-3273-5960","observed_orcids":["https://orcid.org/0000-0003-3273-5960"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbo Ma","raw_affiliation_strings":["College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100699620","display_name":"Bolin Li","orcid":"https://orcid.org/0000-0002-6733-2179","observed_orcids":["https://orcid.org/0000-0002-6733-2179"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bolin Li","raw_affiliation_strings":["College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340644","display_name":"Qian Li","orcid":"https://orcid.org/0000-0003-0359-5604","observed_orcids":["https://orcid.org/0000-0003-0359-5604"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Li","raw_affiliation_strings":["College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422598","display_name":"Xue Wang","orcid":"https://orcid.org/0000-0003-2902-1393","observed_orcids":["https://orcid.org/0000-0003-2902-1393"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Wang","raw_affiliation_strings":["College of Veterinary Medicine, China Agricultural University, Beijing 100093, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, China Agricultural University, Beijing 100093, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011438468","display_name":"Yanan Li","orcid":"https://orcid.org/0000-0001-7217-0680","observed_orcids":["https://orcid.org/0000-0001-7217-0680"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Li","raw_affiliation_strings":["College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089051933","display_name":"Jiufeng Wang","orcid":"https://orcid.org/0000-0002-0183-5611","observed_orcids":["https://orcid.org/0000-0002-0183-5611"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiufeng Wang","raw_affiliation_strings":["College of Veterinary Medicine, China Agricultural University, Beijing 100093, China"],"raw_orcid":"https://orcid.org/0000-0002-0183-5611","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, China Agricultural University, Beijing 100093, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091284214","display_name":"Yaohong Zhu","orcid":"https://orcid.org/0000-0003-0689-1679","observed_orcids":["https://orcid.org/0000-0003-0689-1679"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaohong Zhu","raw_affiliation_strings":["College of Veterinary Medicine, China Agricultural University, Beijing 100093, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, China Agricultural University, Beijing 100093, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100432408","display_name":"Ning Liu","orcid":"https://orcid.org/0000-0002-8610-1034","observed_orcids":["https://orcid.org/0000-0002-8610-1034"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]},{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ning Liu","raw_affiliation_strings":["College of Veterinary Medicine, China Agricultural University, Beijing 100093, China","College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China","Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, China Agricultural University, Beijing 100093, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100432408"],"corresponding_institution_ids":["https://openalex.org/I169572211","https://openalex.org/I52158045"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":0.6672,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59916993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"25","issue":"12","first_page":"6703","last_page":"6703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.09380000084638596,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trueperella-pyogenes","display_name":"Trueperella pyogenes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cholesterol-dependent-cytolysins","display_name":"cholesterol-dependent cytolysins","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9570000171661377},{"id":"https://openalex.org/keywords/potassium-efflux","display_name":"potassium efflux","score":0.8859999775886536},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.6230000257492065},{"id":"https://openalex.org/keywords/inflammatory-damage","display_name":"inflammatory damage","score":0.5210000276565552},{"id":"https://openalex.org/keywords/bacterial-virulence-factors","display_name":"bacterial virulence factors","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.8327977657318115},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.6811667680740356},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6326171159744263},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5980517864227295},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5967691540718079},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5420575737953186},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46776148676872253},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46732297539711},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.41440466046333313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.391550213098526},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3670407235622406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34166276454925537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3341231346130371},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21061739325523376},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10897383093833923},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006460","descriptor_name":"Hemolysin Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006460","descriptor_name":"Hemolysin Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms25126703","doi":"https://doi.org/10.3390/ijms25126703","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25126703","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11203744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11203744","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11203744/pdf/ijms-25-06703.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:38928408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38928408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms25126703","doi":"https://doi.org/10.3390/ijms25126703","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25126703","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3938459727","display_name":null,"funder_award_id":"31873034","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4290703658","display_name":null,"funder_award_id":"2023YFD1801100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325186","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399863722.pdf","grobid_xml":"https://content.openalex.org/works/W4399863722.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1561041814","https://openalex.org/W2009392293","https://openalex.org/W2010992031","https://openalex.org/W2017403969","https://openalex.org/W2048553944","https://openalex.org/W2054531793","https://openalex.org/W2068633454","https://openalex.org/W2079648669","https://openalex.org/W2087453197","https://openalex.org/W2087563064","https://openalex.org/W2110573136","https://openalex.org/W2138270253","https://openalex.org/W2146089032","https://openalex.org/W2149412525","https://openalex.org/W2150652968","https://openalex.org/W2162343763","https://openalex.org/W2167832951","https://openalex.org/W2174867861","https://openalex.org/W2183663489","https://openalex.org/W2220848304","https://openalex.org/W2318705338","https://openalex.org/W2464176930","https://openalex.org/W2593452438","https://openalex.org/W2750839456","https://openalex.org/W2803338329","https://openalex.org/W2884445384","https://openalex.org/W2885821687","https://openalex.org/W2899542989","https://openalex.org/W2902435763","https://openalex.org/W2951063320","https://openalex.org/W3004459705","https://openalex.org/W3104250374","https://openalex.org/W4205854576","https://openalex.org/W4221023429","https://openalex.org/W4295078833","https://openalex.org/W4304118643","https://openalex.org/W4309740555"],"related_works":["https://openalex.org/W2885821687","https://openalex.org/W4221023429","https://openalex.org/W3122171013","https://openalex.org/W4411221445","https://openalex.org/W2583230423","https://openalex.org/W4388412061","https://openalex.org/W2048553944","https://openalex.org/W850424502","https://openalex.org/W2009392293","https://openalex.org/W2948523793"],"abstract_inverted_index":{"Trueperella":[0],"pyogenes":[1,22],"is":[2,15,31],"an":[3],"important":[4],"opportunistic":[5],"pathogenic":[6,68],"bacterium":[7],"widely":[8],"distributed":[9],"in":[10,135],"the":[11,35,42,66,124],"environment.":[12],"Pyolysin":[13],"(PLO)":[14],"a":[16,32,47,77,141],"primary":[17,43],"virulence":[18],"factor":[19],"of":[20,25,34,40,50,70,100,108,127],"T.":[21],"and":[23,87,93,96,111,144,152],"capable":[24],"lysing":[26],"many":[27],"different":[28],"cells.":[29],"PLO":[30,85,128],"member":[33],"cholesterol-dependent":[36],"cytolysin":[37],"(CDC)":[38],"family":[39,72],"which":[41],"structure":[44],"only":[45],"presents":[46],"low":[48],"level":[49],"homology":[51],"with":[52,83],"other":[53],"members":[54],"from":[55],"31%":[56],"to":[57,118],"45%.":[58],"By":[59],"deeply":[60],"studying":[61],"PLO,":[62],"we":[63],"can":[64],"understand":[65],"overall":[67],"mechanism":[69,99,126],"CDC":[71],"proteins.":[73],"This":[74,120],"study":[75,121],"established":[76],"mouse":[78],"muscle":[79],"tissue":[80],"model":[81],"infected":[82],"recombinant":[84],"(rPLO)":[86],"its":[88,98,131],"single-point":[89],"mutations,":[90],"rPLO":[91,94,109,112],"N139K":[92,110],"F240A,":[95],"explored":[97],"causing":[101],"inflammatory":[102,105,125],"damage.":[103],"The":[104],"injury":[106],"abilities":[107],"F240A":[113],"are":[114],"significantly":[115],"reduced":[116],"compared":[117],"rPLO.":[119],"elaborated":[122],"on":[123,150],"by":[129],"examining":[130],"unit":[132],"point":[133],"mutations":[134],"detail.":[136],"Our":[137],"data":[138],"also":[139],"provide":[140],"theoretical":[142],"basis":[143],"practical":[145],"significance":[146],"for":[147],"future":[148],"research":[149],"toxins":[151],"bacteria.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-06-21T00:00:00"}