{"id":"https://openalex.org/W4399863429","doi":"https://doi.org/10.1542/peds.2023-063635","title":"Neonatal Opioid Withdrawal Syndrome Treatment Guidelines and Birth Hospital Utilization","display_name":"Neonatal Opioid Withdrawal Syndrome Treatment Guidelines and Birth Hospital Utilization","publication_year":2024,"publication_date":"2024-06-20","ids":{"openalex":"https://openalex.org/W4399863429","doi":"https://doi.org/10.1542/peds.2023-063635","pmid":"https://pubmed.ncbi.nlm.nih.gov/38899388"},"language":"en","primary_location":{"id":"doi:10.1542/peds.2023-063635","doi":"https://doi.org/10.1542/peds.2023-063635","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2023-063635","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032954694","display_name":"Phillip D. Hahn","orcid":"https://orcid.org/0000-0002-7666-7632","observed_orcids":["https://orcid.org/0000-0002-7666-7632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillip D. Hahn","raw_affiliation_strings":["aProgram for Patient Safety and Quality"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aProgram for Patient Safety and Quality","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047822007","display_name":"Dionne A. Graham","orcid":"https://orcid.org/0000-0002-1526-547X","observed_orcids":["https://orcid.org/0000-0002-1526-547X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dionne A. Graham","raw_affiliation_strings":["aProgram for Patient Safety and Quality","bDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aProgram for Patient Safety and Quality","institution_ids":[]},{"raw_affiliation_string":"bDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082357489","display_name":"Al Ozonoff","orcid":"https://orcid.org/0000-0003-4233-5899","observed_orcids":["https://orcid.org/0000-0003-4233-5899"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Al Ozonoff","raw_affiliation_strings":["bDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts","cDivision of Infectious Diseases, Boston Children\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"cDivision of Infectious Diseases, Boston Children\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019670851","display_name":"Carly E. Milliren","orcid":"https://orcid.org/0000-0001-6280-8417","observed_orcids":["https://orcid.org/0000-0001-6280-8417"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carly E. Milliren","raw_affiliation_strings":["dInstitutional Centers for Clinical and Translational Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dInstitutional Centers for Clinical and Translational Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019670851"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0456,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.97577609,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"154","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12741","display_name":"Maternal and Neonatal Healthcare","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-opioid-withdrawal-syndrome","display_name":"neonatal opioid withdrawal syndrome","score":1.0},{"id":"https://openalex.org/keywords/treatment-guidelines","display_name":"treatment guidelines","score":0.625},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/non-pharmacological-treatment","display_name":"non-pharmacological treatment","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neonatal-intensive-care-unit-admission","display_name":"neonatal intensive care admission","score":0.7829999923706055},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.9610000252723694},{"id":"https://openalex.org/keywords/guideline-implementation","display_name":"guideline implementation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9233508110046387},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5056595802307129},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.45290476083755493},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44248074293136597},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.39930829405784607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26110219955444336},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007363","descriptor_name":"Intensive Care Units, Neonatal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007902","descriptor_name":"Length of Stay","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009357","descriptor_name":"Neonatal Abstinence Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009357","descriptor_name":"Neonatal Abstinence Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065186","descriptor_name":"Interrupted Time Series Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.2023-063635","doi":"https://doi.org/10.1542/peds.2023-063635","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2023-063635","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:38899388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38899388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W175885798","https://openalex.org/W1965307957","https://openalex.org/W2005498024","https://openalex.org/W2021256567","https://openalex.org/W2027672459","https://openalex.org/W2029540523","https://openalex.org/W2048870090","https://openalex.org/W2090458405","https://openalex.org/W2108536776","https://openalex.org/W2122173144","https://openalex.org/W2168090401","https://openalex.org/W2343977067","https://openalex.org/W2404237987","https://openalex.org/W2556153675","https://openalex.org/W2571302047","https://openalex.org/W2584817535","https://openalex.org/W2606393147","https://openalex.org/W2615198411","https://openalex.org/W2781572752","https://openalex.org/W2792207983","https://openalex.org/W2801866105","https://openalex.org/W2808729126","https://openalex.org/W2902220547","https://openalex.org/W2922150097","https://openalex.org/W2947680496","https://openalex.org/W2956193550","https://openalex.org/W2965518764","https://openalex.org/W2966363637","https://openalex.org/W2966941822","https://openalex.org/W2999724987","https://openalex.org/W3014729205","https://openalex.org/W3022297747","https://openalex.org/W3043337514","https://openalex.org/W3081365885","https://openalex.org/W3093906108","https://openalex.org/W3117513638","https://openalex.org/W3131950745","https://openalex.org/W3194981217","https://openalex.org/W4200469588","https://openalex.org/W4213291460","https://openalex.org/W4223440042","https://openalex.org/W4281619959","https://openalex.org/W4318475763"],"related_works":["https://openalex.org/W4404944632","https://openalex.org/W2903831580","https://openalex.org/W2965824626","https://openalex.org/W4223440042","https://openalex.org/W3120193233","https://openalex.org/W4385064569","https://openalex.org/W4322723323","https://openalex.org/W2945774952","https://openalex.org/W4405394969","https://openalex.org/W3083650740"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVES:":[2],"In":[3],"November":[4],"2020,":[5],"the":[6,25,45,48,81,136,165,192,226,239],"American":[7,242],"Academy":[8,243],"of":[9,15,47,52,55,129,149,209,216,228,241,244],"Pediatrics":[10,245],"published":[11],"guidelines":[12,49,246],"for":[13,33,60,70,234,247],"management":[14],"neonatal":[16],"opioid":[17],"withdrawal":[18],"syndrome":[19],"(NOWS),":[20],"recommending":[21],"nonpharmacologic":[22],"treatment":[23,30,92,131,207,230],"as":[24],"first-line":[26],"approach,":[27],"unless":[28],"pharmacologic":[29,91,130,206,229],"is":[31],"needed":[32],"severe":[34],"NOWS.":[35,63],"Using":[36],"data":[37,69],"from":[38,76,80,124],"tertiary":[39],"care":[40],"pediatric":[41],"hospitals,":[42],"we":[43],"examined":[44],"impact":[46],"on":[50],"use":[51,128,214,227],"pharmacotherapy,":[53],"length":[54,148],"stay,":[56],"and":[57,90,94,96,154,186,212,231],"NICU":[58,159,213,232],"admission":[59,160],"infants":[61,235],"with":[62,73,122,176,236],"METHODS:":[64],"We":[65,86,108],"extracted":[66],"birth":[67],"hospitalization":[68],"newborns":[71,113],"diagnosed":[72],"NOWS":[74,123,237,248],"discharged":[75],"2019":[77],"to":[78,102],"2022":[79],"Pediatric":[82],"Health":[83],"Information":[84],"System.":[85],"compared":[87],"hospital":[88],"utilization":[89,233],"pre-":[93],"postguidelines":[95,137,166,193],"used":[97],"interrupted":[98],"time":[99,190],"series":[100],"regression":[101],"examine":[103],"trends":[104],"over":[105,189],"time.":[106],"RESULTS:":[107],"included":[109],"N":[110],"=":[111,115,119,145,157,181,196,201],"824":[112],"(n":[114],"434":[116],"pre,":[117],"n":[118],"390":[120],"post)":[121],"11":[125],"hospitals.":[126],"The":[127],"was":[132,151,161,222],"significantly":[133,162],"lower":[134,163],"in":[135,164,191,225],"period":[138,167,194],"(59.0%":[139],"pre":[140,153,169],"versus":[141,170],"50.3%":[142],"post;":[143,172],"P":[144,173,183,200],".01).":[146],"Median":[147],"stay":[150],"similar":[152],"post":[155],"(P":[156],".55).":[158],"(78.6%":[168],"46.7%":[171],"<":[174,184],".001),":[175],"an":[177],"immediate":[178],"decrease":[179,188],"(\u03b2":[180,195],"-23.0%;":[182],".001)":[185],"a":[187,223],"-0.7%":[197],"per":[198],"month;":[199],".03).":[202],"Most":[203],"hospitals":[204],"reduced":[205],"(8":[208],"11;":[210,217],"73%)":[211],"(10":[215],"91%)":[218],"postguidelines.":[219],"CONCLUSIONS:":[220],"There":[221],"reduction":[224],"after":[238],"release":[240],"management.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-06-21T00:00:00"}