{"id":"https://openalex.org/W4399787698","doi":"https://doi.org/10.1093/neuonc/noae064.379","title":"IMMU-08. OUTCOME OF PATIENTS WITH RECURRENT MEDULLOBLASTOMA AND EPENDYMOMA TREATED WITH PEMBROLIZUMAB, AN IMMUNE CHECKPOINT INHIBITOR: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY (PBTC045)","display_name":"IMMU-08. OUTCOME OF PATIENTS WITH RECURRENT MEDULLOBLASTOMA AND EPENDYMOMA TREATED WITH PEMBROLIZUMAB, AN IMMUNE CHECKPOINT INHIBITOR: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY (PBTC045)","publication_year":2024,"publication_date":"2024-06-18","ids":{"openalex":"https://openalex.org/W4399787698","doi":"https://doi.org/10.1093/neuonc/noae064.379"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noae064.379","doi":"https://doi.org/10.1093/neuonc/noae064.379","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noae064.379","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/26/Supplement_4/0/58252438/noae064.379.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/26/Supplement_4/0/58252438/noae064.379.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039750788","display_name":"Eugene I. Hwang","orcid":"https://orcid.org/0000-0002-3923-1135","observed_orcids":["https://orcid.org/0000-0002-3923-1135"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene I Hwang","raw_affiliation_strings":["Children\u2019s National Hospital , Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital , Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044312349","display_name":"Lindsay Baker Kilburn","orcid":"https://orcid.org/0000-0003-1478-3619","observed_orcids":["https://orcid.org/0000-0003-1478-3619"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay B Kilburn","raw_affiliation_strings":["Children\u2019s National Hospital , Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital , Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087959258","display_name":"Duane A. Mitchell","orcid":"https://orcid.org/0000-0001-6049-213X","observed_orcids":["https://orcid.org/0000-0001-6049-213X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duane A Mitchell","raw_affiliation_strings":["University of Florida , Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida , Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101445046","display_name":"Tong Lin","orcid":"https://orcid.org/0000-0001-5390-2487","observed_orcids":["https://orcid.org/0000-0001-5390-2487"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Lin","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital , Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital , Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001841105","display_name":"Tina Young Poussaint","orcid":"https://orcid.org/0000-0002-0814-0791","observed_orcids":["https://orcid.org/0000-0002-0814-0791"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Young-Poussaint","raw_affiliation_strings":["Boston Children\u2019s Hospital , Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children\u2019s Hospital , Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056906928","display_name":"Giles W Robinson","orcid":"https://orcid.org/0000-0001-7441-9486","observed_orcids":["https://orcid.org/0000-0001-7441-9486"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giles Robinson","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital , Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital , Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039864062","display_name":"Amar J. Gajjar","orcid":"https://orcid.org/0000-0001-5019-0699","observed_orcids":["https://orcid.org/0000-0001-5019-0699"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amar Gajjar","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital , Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital , Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041376388","display_name":"Alicia C. Lenzen","orcid":"https://orcid.org/0000-0002-9123-419X","observed_orcids":["https://orcid.org/0000-0002-9123-419X"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Lenzen","raw_affiliation_strings":["Lurie Children\u2019s Hospital , Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lurie Children\u2019s Hospital , Chicago, IL, USA","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039734669","display_name":"Kathleen McCarthy O'Toole Dorris","orcid":"https://orcid.org/0000-0003-0753-2176","observed_orcids":["https://orcid.org/0000-0003-0753-2176"]},"institutions":[{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Dorris","raw_affiliation_strings":["Children\u2019s Hospital Colorado , Denver, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Colorado , Denver, CO, USA","institution_ids":["https://openalex.org/I4210096275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022276682","display_name":"Nathan John Robison","orcid":"https://orcid.org/0000-0001-8613-9772","observed_orcids":["https://orcid.org/0000-0001-8613-9772"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Robison","raw_affiliation_strings":["Children\u2019s Hospital Los Angeles, Los Angeles , CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Los Angeles, Los Angeles , CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002952095","display_name":"Jason Fangusaro","orcid":"https://orcid.org/0000-0003-3099-5259","observed_orcids":["https://orcid.org/0000-0003-3099-5259"]},"institutions":[{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason R Fangusaro","raw_affiliation_strings":["Children\u2019s Healthcare of Atlanta , Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Healthcare of Atlanta , Atlanta, GA, USA","institution_ids":["https://openalex.org/I4210146983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067969166","display_name":"Maryam Fouladi","orcid":"https://orcid.org/0000-0002-5693-035X","observed_orcids":["https://orcid.org/0000-0002-5693-035X","https://orcid.org/0009-0005-3039-3313"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Fouladi","raw_affiliation_strings":["Nationwide Children\u2019s Hospital , Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nationwide Children\u2019s Hospital , Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065578155","display_name":"Arzu Onar\u2010Thomas","orcid":"https://orcid.org/0000-0003-1005-2413","observed_orcids":["https://orcid.org/0000-0003-1005-2413"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arzu Onar-Thomas","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital , Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital , Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068118481","display_name":"Ira J. Dunkel","orcid":"https://orcid.org/0000-0001-8091-6067","observed_orcids":["https://orcid.org/0000-0001-8091-6067"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira J Dunkel","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York , NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York , NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5389,"currency":"USD","value_usd":5389},"apc_paid":{"value":5389,"currency":"USD","value_usd":5389},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"Supplement_4","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-medulloblastoma","display_name":"recurrent medulloblastoma","score":0.8330000042915344},{"id":"https://openalex.org/keywords/recurrent-ependymoma","display_name":"recurrent ependymoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.9309999942779541},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8980000019073486},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.8069999814033508},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9800000190734863},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.8701497912406921},{"id":"https://openalex.org/C2781432949","wikidata":"https://www.wikidata.org/wiki/Q1346753","display_name":"Ependymoma","level":2,"score":0.7542231678962708},{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.7192871570587158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6951834559440613},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48738962411880493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46096867322921753},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.31687813997268677},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2394125759601593},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1685621738433838},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09975442290306091}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noae064.379","doi":"https://doi.org/10.1093/neuonc/noae064.379","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noae064.379","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/26/Supplement_4/0/58252438/noae064.379.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11184075","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11184075","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11184075/pdf/noae064.379.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noae064.379","doi":"https://doi.org/10.1093/neuonc/noae064.379","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noae064.379","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/26/Supplement_4/0/58252438/noae064.379.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399787698.pdf","grobid_xml":"https://content.openalex.org/works/W4399787698.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2585407512","https://openalex.org/W3094500874","https://openalex.org/W2365318417","https://openalex.org/W4387015957","https://openalex.org/W2012013780","https://openalex.org/W3021378736","https://openalex.org/W2119664506","https://openalex.org/W4322616609","https://openalex.org/W2099577209","https://openalex.org/W4221123017"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND":[1],"Children":[2],"with":[3,38,50,63,69,126,201,269],"recurrent":[4],"medulloblastoma":[5,67,133,213],"and":[6,27,53,68,79,100,111,113,151,165,178,198,212,219,240],"ependymoma":[7,52,65,128,211,271],"typically":[8],"have":[9],"a":[10,25,33,242],"dismal":[11],"prognosis.":[12],"Immune":[13,225,231],"checkpoint":[14,232,253,277],"blockade":[15],"has":[16],"revolutionized":[17],"treatment":[18,280],"of":[19,31,276],"some":[20],"resistant":[21],"cancers.":[22],"PBTC045":[23],"is":[24,245],"safety":[26],"preliminary":[28],"efficacy":[29],"study":[30,161],"pembrolizumab,":[32],"PD-1":[34],"inhibitor,":[35],"in":[36,175,249,267],"children":[37,49,268],"recurrent/progressive":[39,51,64,270],"brain":[40],"tumors.":[41],"Here":[42],"we":[43],"present":[44],"the":[45,180,250,294],"strata":[46],"that":[47,289],"included":[48,57,109,193],"medulloblastoma.":[54,273],"METHODS":[55],"Eligibility":[56],"patients":[58,283],"aged":[59],"1-21":[60],"years":[61,148,153],"old":[62],"or":[66,132,188,263,272],"functional":[70],"scores":[71],">70,":[72],"no":[73,171,202],"greater":[74,189],"than":[75],"physiologic":[76],"steroid":[77],"usage":[78],"standard":[80],"washout":[81],"periods,":[82],"among":[83],"other":[84],"eligibility":[85],"criteria.":[86],"Pembrolizumab":[87],"was":[88,146,163],"administered":[89],"at":[90,144,160],"2mg/kg":[91],"IV":[92],"every":[93],"three":[94],"weeks.":[95],"Tumor":[96],"tissue":[97],"(if":[98],"available)":[99],"serum":[101],"were":[102,116,139,170,183,214],"collected":[103],"for":[104,121,210,236,281],"correlative":[105,226,295],"studies.":[106],"Primary":[107],"endpoints":[108],"toxicity":[110],"response,":[112],"two":[114],"stages":[115],"planned":[117],"requiring":[118],"objective":[119,173],"responses":[120,174,266],"potential":[122,235],"expansion.":[123],"RESULTS":[124],"Patients":[125],"progressive":[127],"(Stratum":[129,134],"D,":[130],"n=13)":[131],"E,":[135],"n=14,":[136],"one":[137],"ineligible)":[138],"enrolled.":[140],"The":[141,157,205],"median":[142,158,206],"age":[143,159],"diagnosis":[145],"3.37":[147],"(range,":[149,154,217,222],"1-12.7)":[150],"7":[152],"2.2-13.1),":[155],"respectively.":[156,168,224],"entry":[162],"8.5":[164],"11.4":[166],"years,":[167],"There":[169],"first-stage":[172],"either":[176],"stratum,":[177],"thus":[179],"expansion":[181],"arms":[182],"not":[184,257],"initiated.":[185],"Grade":[186],"3":[187],"treatment-related":[190],"adverse":[191],"events":[192],"rash":[194],"(n=1),":[195],"anemia":[196],"(n=1)":[197],"neutropenia":[199],"(n=2),":[200],"dose-limiting":[203],"toxicities.":[204],"progression-free":[207],"survival":[208,262],"(PFS)":[209],"1.38":[215],"months":[216,221],"1.08-1.51)":[218],"1.41":[220],"1.22-3.45),":[223],"analyses":[227],"are":[228],"ongoing.":[229],"CONCLUSIONS":[230],"inhibition":[233,254],"holds":[234],"CNS":[237],"cancer":[238],"treatment,":[239],"as":[241],"single":[243],"agent,":[244],"well":[246],"tolerated.":[247],"However,":[248],"current":[251],"study,":[252],"monotherapy":[255],"does":[256],"appear":[258],"to":[259],"significantly":[260],"prolong":[261],"induce":[264],"radiographic":[265],"Potential":[274],"incorporation":[275],"inhibitors":[278],"into":[279],"these":[282],"will":[284],"likely":[285],"require":[286],"combinatorial":[287],"approaches":[288],"may":[290],"be":[291],"informed":[292],"by":[293],"science.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}