{"id":"https://openalex.org/W4399786263","doi":"https://doi.org/10.1002/hsr2.2196","title":"Assessing placental membrane treatment efficiency in diabetic foot ulcers: Processing for retention versus lamination","display_name":"Assessing placental membrane treatment efficiency in diabetic foot ulcers: Processing for retention versus lamination","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399786263","doi":"https://doi.org/10.1002/hsr2.2196","pmid":"https://pubmed.ncbi.nlm.nih.gov/38895546","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11183911"},"language":"en","primary_location":{"id":"doi:10.1002/hsr2.2196","doi":"https://doi.org/10.1002/hsr2.2196","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/hsr2.2196","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hsr2.2196","source":{"id":"https://openalex.org/S4210188016","display_name":"Health Science Reports","issn_l":"2398-8835","issn":["2398-8835"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Science Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hsr2.2196","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014695877","display_name":"Robert G. Frykberg","orcid":"https://orcid.org/0000-0001-9095-303X","observed_orcids":["https://orcid.org/0000-0001-9095-303X"]},"institutions":[{"id":"https://openalex.org/I4405286448","display_name":"Open Wound Research (United States)","ror":"https://ror.org/025bc4w45","country_code":"US","type":"company","lineage":["https://openalex.org/I4405286448"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert G. Frykberg","raw_affiliation_strings":["Open Wound Research Puyallup Washington USA"],"raw_orcid":"https://orcid.org/0000-0001-9095-303X","affiliations":[{"raw_affiliation_string":"Open Wound Research Puyallup Washington USA","institution_ids":["https://openalex.org/I4405286448"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5099183896","display_name":"Zwelithini Tunyiswa","orcid":"https://orcid.org/0009-0008-6100-0828","observed_orcids":["https://orcid.org/0009-0008-6100-0828"]},"institutions":[{"id":"https://openalex.org/I4405286448","display_name":"Open Wound Research (United States)","ror":"https://ror.org/025bc4w45","country_code":"US","type":"company","lineage":["https://openalex.org/I4405286448"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zwelithini Tunyiswa","raw_affiliation_strings":["Open Wound Research Puyallup Washington USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Open Wound Research Puyallup Washington USA","institution_ids":["https://openalex.org/I4405286448"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014695877"],"corresponding_institution_ids":["https://openalex.org/I4405286448"],"apc_list":{"value":3120,"currency":"USD","value_usd":3120},"apc_paid":{"value":3120,"currency":"USD","value_usd":3120},"fwci":0.5237,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6256982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"7","issue":"6","first_page":"e2196","last_page":"e2196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-foot-ulcer","display_name":"diabetic foot ulcer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/wound-closure","display_name":"wound closure","score":0.6850000023841858},{"id":"https://openalex.org/keywords/wound-area-reduction","display_name":"wound area reduction","score":0.6320000290870667},{"id":"https://openalex.org/keywords/treatment-efficiency","display_name":"treatment efficiency","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8330815434455872},{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.7029027938842773},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5741119384765625},{"id":"https://openalex.org/C2993807428","wikidata":"https://www.wikidata.org/wiki/Q25324087","display_name":"Wound care","level":2,"score":0.5302578806877136},{"id":"https://openalex.org/C2778144972","wikidata":"https://www.wikidata.org/wiki/Q52859","display_name":"Diabetic foot ulcer","level":4,"score":0.5161420106887817},{"id":"https://openalex.org/C2776204877","wikidata":"https://www.wikidata.org/wiki/Q477415","display_name":"Amputation","level":2,"score":0.482557475566864},{"id":"https://openalex.org/C34008175","wikidata":"https://www.wikidata.org/wiki/Q975018","display_name":"Bioburden","level":2,"score":0.45187896490097046},{"id":"https://openalex.org/C2780646683","wikidata":"https://www.wikidata.org/wiki/Q473749","display_name":"Amnion","level":4,"score":0.4306759834289551},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40072324872016907},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.36864250898361206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3649161458015442},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.13454940915107727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/hsr2.2196","doi":"https://doi.org/10.1002/hsr2.2196","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/hsr2.2196","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hsr2.2196","source":{"id":"https://openalex.org/S4210188016","display_name":"Health Science Reports","issn_l":"2398-8835","issn":["2398-8835"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Science Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11183911","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11183911","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11183911/pdf/HSR2-7-e2196.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Sci Rep","raw_type":"Text"},{"id":"pmid:38895546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38895546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health science reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/hsr2.2196","doi":"https://doi.org/10.1002/hsr2.2196","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/hsr2.2196","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hsr2.2196","source":{"id":"https://openalex.org/S4210188016","display_name":"Health Science Reports","issn_l":"2398-8835","issn":["2398-8835"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Science Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399786263.pdf","grobid_xml":"https://content.openalex.org/works/W4399786263.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1496247663","https://openalex.org/W1534454884","https://openalex.org/W1572306833","https://openalex.org/W1593599570","https://openalex.org/W1870482595","https://openalex.org/W1897883013","https://openalex.org/W1969615670","https://openalex.org/W2040988138","https://openalex.org/W2049926043","https://openalex.org/W2061914961","https://openalex.org/W2067420120","https://openalex.org/W2105871752","https://openalex.org/W2110659551","https://openalex.org/W2141676073","https://openalex.org/W2145027378","https://openalex.org/W2185333371","https://openalex.org/W2271457371","https://openalex.org/W2520360513","https://openalex.org/W2531214373","https://openalex.org/W2544295598","https://openalex.org/W2750305587","https://openalex.org/W2791571938","https://openalex.org/W2888059637","https://openalex.org/W2909917934","https://openalex.org/W2959573331","https://openalex.org/W2982691394","https://openalex.org/W3013389260","https://openalex.org/W3034090076","https://openalex.org/W3087206479","https://openalex.org/W3115863349","https://openalex.org/W3164641856","https://openalex.org/W4292877275","https://openalex.org/W4312188510","https://openalex.org/W4366462695","https://openalex.org/W4384202074","https://openalex.org/W4386373863"],"related_works":["https://openalex.org/W4403386913","https://openalex.org/W4415750572","https://openalex.org/W2754300760","https://openalex.org/W3138429865","https://openalex.org/W4295898654","https://openalex.org/W3085071128","https://openalex.org/W4399390322","https://openalex.org/W7102748285","https://openalex.org/W3025770953","https://openalex.org/W3035580551"],"abstract_inverted_index":{"Background:":[0],"Diabetic":[1],"foot":[2,76],"ulcers":[3,77],"are":[4,32],"a":[5,50,137,147],"severe":[6],"complication":[7],"in":[8,72,155,174,185,191,208,219,240],"diabetic":[9,75],"patients,":[10,36],"significantly":[11],"impact":[12],"healthcare":[13,241],"systems":[14],"and":[15,24,67,119,193,236],"patient":[16,231],"quality":[17],"of":[18,28,57,91,122,133,179,223],"life,":[19],"often":[20],"leading":[21],"to":[22,53,158,229],"hospitalization":[23],"amputation.":[25],"Traditional":[26],"Standard":[27],"Care":[29],"(SOC)":[30],"treatments":[31],"inadequate":[33],"for":[34,94],"many":[35],"necessitating":[37],"advanced":[38],"wound":[39,99,116,176,181],"care":[40,100],"products":[41],"(AWCPs)":[42],"like":[43],"human":[44,59],"placental":[45,60],"membranes.":[46],"This":[47,225],"study":[48,81],"conducts":[49],"retrospective":[51,83],"analysis":[52,126,132],"compare":[54],"the":[55,110,120,221],"effectiveness":[56],"two":[58,106],"membrane":[61],"products,":[62],"retention-processed":[63],"amnion":[64,69],"chorion":[65,70],"(RE-AC)":[66],"lamination-processed":[68],"(L-AC)":[71],"managing":[73],"chronic":[74],"(DFUs).":[78],"Methods:":[79],"The":[80,125,197],"collected":[82],"observational":[84],"data":[85],"from":[86],"electronic":[87],"health":[88],"records":[89],"(EHRs)":[90],"patients":[92],"treated":[93],"DFU":[95],"at":[96,160],"three":[97],"outpatient":[98],"centers.":[101],"Patients":[102],"were":[103],"categorized":[104],"into":[105],"cohorts":[107],"based":[108],"on":[109],"treatment":[111,216,234],"received.":[112],"Key":[113],"metrics":[114],"included":[115],"size":[117],"progression":[118],"number":[121],"product":[123],"applications.":[124,224],"employed":[127],"Bayesian":[128],"estimation,":[129],"utilizing":[130],"an":[131],"covariance":[134],"model":[135],"with":[136],"Hurdle":[138],"Gamma":[139],"likelihood.":[140],"Results:":[141],"We":[142],"found":[143],"that":[144,200],"RE-AC":[145,166,192,212],"achieved":[146],"marginally":[148],"higher":[149],"expected":[150],"Percent":[151],"Area":[152],"Reduction":[153],"(xPAR)":[154],"DFUs":[156],"compared":[157],"L-AC":[159,202],"12":[161],"weeks":[162],"(67.3%":[163],"vs.":[164],"52.6%).":[165],"also":[167],"required":[168],"fewer":[169],"applications,":[170],"suggesting":[171],"greater":[172],"efficiency":[173,226],"general":[175],"closure.":[177],"Probability":[178],"full":[180],"closure":[182],"was":[183],"similar":[184],"both":[186],"groups":[187],"(0.738":[188],"vs":[189],"0.740":[190],"L-AC,":[194],"respectively).":[195],"Conclusion:":[196],"findings":[198],"suggest":[199],"while":[201],"might":[203],"be":[204],"slightly":[205],"more":[206],"effective":[207],"complete":[209],"ulcer":[210],"healing,":[211],"offers":[213],"overall":[214],"better":[215],"efficiency,":[217],"especially":[218],"reducing":[220],"frequency":[222],"can":[227],"lead":[228],"improved":[230],"comfort,":[232],"reduced":[233],"costs,":[235],"optimized":[237],"resource":[238],"utilization":[239],"settings.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-06-19T00:00:00"}
