{"id":"https://openalex.org/W4399780809","doi":"https://doi.org/10.1093/cvr/cvae122","title":"Lamin: guardian against DNA damage by transcription stress","display_name":"Lamin: guardian against DNA damage by transcription stress","publication_year":2024,"publication_date":"2024-06-15","ids":{"openalex":"https://openalex.org/W4399780809","doi":"https://doi.org/10.1093/cvr/cvae122","pmid":"https://pubmed.ncbi.nlm.nih.gov/38887919","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12391664"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvae122","doi":"https://doi.org/10.1093/cvr/cvae122","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvae122","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12391664/pdf/cvae122.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042332162","display_name":"James W.S. Jahng","orcid":"https://orcid.org/0000-0003-2367-6567","observed_orcids":["https://orcid.org/0000-0003-2367-6567"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James W S Jahng","raw_affiliation_strings":["Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305 ,","Stanford Cardiovascular Institute, Stanford University School of Medicine , 265 Campus Drive, G1120B , Stanford, CA 94305, USA","Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine , 291 Campus Drive, Stanford, CA 94305 , USA"],"raw_orcid":"https://orcid.org/0000-0003-2367-6567","affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305 ,","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Cardiovascular Institute, Stanford University School of Medicine , 265 Campus Drive, G1120B , Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine , 291 Campus Drive, Stanford, CA 94305 , USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047561254","display_name":"Joseph C. Wu","orcid":"https://orcid.org/0000-0002-6068-8041","observed_orcids":["https://orcid.org/0000-0002-6068-8041","https://orcid.org/0000-0003-4274-0413"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph C Wu","raw_affiliation_strings":["Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 ,","Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305 ,","Stanford Cardiovascular Institute, Stanford University School of Medicine , 265 Campus Drive, G1120B , Stanford, CA 94305, USA","Department of Radiology, Stanford University School of Medicine , 300 Pasteur Drive, Stanford, CA 94305 , USA","Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine , 291 Campus Drive, Stanford, CA 94305 , USA"],"raw_orcid":"https://orcid.org/0000-0002-6068-8041","affiliations":[{"raw_affiliation_string":"Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 ,","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305 ,","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Cardiovascular Institute, Stanford University School of Medicine , 265 Campus Drive, G1120B , Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiology, Stanford University School of Medicine , 300 Pasteur Drive, Stanford, CA 94305 , USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine , 291 Campus Drive, Stanford, CA 94305 , USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047561254"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"],"apc_list":{"value":4951,"currency":"EUR","value_usd":5358},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"121","issue":"10","first_page":"1468","last_page":"1470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-lamins","display_name":"nuclear lamins","score":0.5630000233650208},{"id":"https://openalex.org/keywords/nuclear-lamina","display_name":"nuclear lamina","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lmna-cardiomyopathy","display_name":"LMNA cardiomyopathy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/laminopathies","display_name":"laminopathies","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.7099999785423279},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.34200000762939453},{"id":"https://openalex.org/keywords/hutchinson-gilford-progeria-syndrome","display_name":"Hutchinson-Gilford progeria syndrome","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.5130000114440918},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.6449999809265137},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.3919999897480011},{"id":"https://openalex.org/keywords/lamin-a-c","display_name":"lamin A/C","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5144174695014954},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.5033473372459412},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4695506691932678},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4557376503944397},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.44705548882484436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41810423135757446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.380179226398468},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.35899847745895386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3480537235736847},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3307143449783325},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.149947851896286},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.10088786482810974},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/cvr/cvae122","doi":"https://doi.org/10.1093/cvr/cvae122","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvae122","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12391664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12391664","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12391664/pdf/cvae122.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Res","raw_type":"Text"},{"id":"pmid:38887919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38887919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Editorial"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12391664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12391664","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12391664/pdf/cvae122.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Res","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000867086","display_name":"Unraveling the Role of p53 in Endothelium Homeostasis after Ionizing Radiation Exposure","funder_award_id":"K99HL173685","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000877010","display_name":"Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy","funder_award_id":"R01HL141371","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000896374","display_name":"Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling","funder_award_id":"R01HL113006","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000909791","display_name":"Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs","funder_award_id":"R01HL130020","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399780809.pdf","grobid_xml":"https://content.openalex.org/works/W4399780809.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1978189157","https://openalex.org/W2070509435","https://openalex.org/W2495544654","https://openalex.org/W2958723445","https://openalex.org/W2991273885","https://openalex.org/W3031596611","https://openalex.org/W3045708127","https://openalex.org/W3088390260","https://openalex.org/W4307347374","https://openalex.org/W4393981288"],"related_works":["https://openalex.org/W2049900183","https://openalex.org/W2512639129","https://openalex.org/W1974862758","https://openalex.org/W2122860817","https://openalex.org/W2911602407","https://openalex.org/W7098948977","https://openalex.org/W4389022289","https://openalex.org/W4414564025","https://openalex.org/W2056074681","https://openalex.org/W2510772604"],"abstract_inverted_index":{"This":[0,945,1133],"editorial":[1],"refers":[2,783],"to":[3,61,81,238,286,359,370,407,429,468,530,535,577,602,723,762,784,802,834,853,862,943,977,1015,1160,1166],"\u2018DNA":[4],"double-stranded":[5],"breaks,":[6],"a":[7,74,160,205,240,345,356,388,417,625,821,824,855,986,1122],"hallmark":[8],"of":[9,76,150,162,168,183,189,235,297,303,313,334,362,410,455,499,504,518,523,555,570,622,665,706,793,799,843,932,939,961,968,1009,1017,1021,1036,1053,1073,1078,1112,1125,1143,1163,1177],"aging,":[10],"defined":[11],"at":[12,139,351,374,440,599,690,698,815,1039],"the":[13,23,99,125,128,140,144,147,267,310,321,332,360,365,375,408,452,465,493,512,670,673,683,691,699,707,730,751,772,775,785,791,803,844,899,905,930,936,966,1007,1040,1051,1071,1076,1109,1140,1161],"nucleotide":[14,352],"resolution,":[15],"are":[16,65,122,137,186,202,219,260,473,497,516,721,747,760,912,935],"increased":[17],"and":[18,42,52,79,94,111,121,136,164,180,193,201,216,226,256,278,327,393,485,496,515,561,567,607,672,718,726,741,778,807,1075,1131,1149],"associated":[19,92,261,579,641,764],"with":[20,262,324,396,501,520,580,765,828,948,1093],"transcription":[21,469,551,573,655,700,712,779,927,979,1042,1081],"in":[22,26,177,245,283,292,318,337,421,443,464,492,511,553,563,615,631,858,866,878,910,914,915,1029,1065,1083,1090,1115,1116,1127,1175],"cardiac":[24,436,724,727],"myocytes":[25],"LMNA-cardiomyopathy\u2019,":[27],"by":[28,155,250,341,354,538,547,585,668,735,790,894,971,1003,1080,1137],"B.":[29],"Cathcart":[30,306,378,586,658,817],"et":[31,307,379,587,659,818],"al.,":[32],"https://doi.org/10.1093/cvr/cvae063.":[33],"The":[34,583,846,1024],"human":[35,1091],"genome":[36,466],"spans":[37],"3.2":[38],"billion":[39],"base":[40],"pairs,":[41],"more":[43],"than":[44],"20":[45],"000":[46],"genes":[47,909],"govern":[48],"various":[49,83,263],"cellular":[50],"processes":[51,179],"functions.":[53],"A":[54,110,114,191,484,488,703],"linear":[55],"DNA":[56,545,565,805],"is":[57,153,248,344,946,1006,1027],"wrapped":[58],"around":[59],"histones":[60],"form":[62,82],"nucleosomes":[63],"that":[64,158,218,247,478,590,612,757,885,908,952,1030,1120],"further":[66,770,983],"compacted":[67],"into":[68,107,331,475,483,924],"chromatin":[69,89,102],"fibres.":[70],"Chromatin":[71,471],"fibres":[72,103,472],"undergo":[73],"series":[75],"additional":[77],"compression":[78],"condensation":[80],"three-dimensional":[84],"structural":[85],"units":[86],"such":[87,265,558,1097],"as":[88,266,559,985,989,1098],"loops,":[90],"topologically":[91],"domains,":[93],"chromosome":[95],"territory.":[96],"Based":[97],"on":[98,383,403,1049],"gene":[100,207,254,505,524,671,694],"activity,":[101],"can":[104,479,888,963],"be":[105,480,578,763,982,1088],"grouped":[106],"two":[108,187,222],"compartments:":[109],"B":[112,131,194,486,507],"compartments.":[113,487],"compartments":[115,132,489,508],"generally":[116],"contain":[117,133],"transcriptionally":[118],"active":[119,1041],"euchromatin":[120,500],"found":[123,611,1121],"inside":[124],"nucleus.":[126],"On":[127],"other":[129,1154],"hand,":[130],"inactive":[134],"heterochromatin":[135,519],"located":[138,749],"nuclear":[141,145,151,156,165,178,242,251,335,494,513,629,776,886],"periphery.1":[142],"At":[143],"periphery,":[146],"inner":[148],"side":[149],"envelop":[152],"coated":[154],"lamina":[157,336,777,887],"contains":[159],"complex":[161],"protein":[163],"lamins,":[166,190],"members":[167],"type":[169,192],"V":[170],"intermediate":[171],"filament,":[172],"which":[173,720,811,839,934],"play":[174],"important":[175,1000],"roles":[176],"mechanical":[181],"properties":[182],"nuclei.":[184],"There":[185],"types":[188],"type.":[195],"A-type":[196],"lamins":[197,199,212,214,230,236],"include":[198,213],"A/C":[200],"transcribed":[203,220,1129],"from":[204,221,387,592,596,682,868,891,1139],"single":[206],"called":[208],"LMNA,":[209,643],"whereas":[210],"B-type":[211],"B1":[215],"B2":[217],"separate":[223],"genes,":[224],"LMNB1":[225],"LMNB2.":[227],"Cells":[228],"lacking":[229],"or":[231,294,874,958,1173],"expressing":[232],"mutant":[233],"forms":[234],"fail":[237],"establish":[239],"proper":[241],"lamina,":[243],"resulting":[244],"laminopathies":[246],"characterized":[249],"distortion,":[252],"aberrant":[253,926],"expression,":[255],"impaired":[257],"mechanotransduction.":[258],"Laminopathies":[259],"diseases":[264],"premature":[268],"aging":[269],"syndrome,":[270,274],"including":[271,714],"Hutchinson\u2013Gilford":[272],"progeria":[273],"restrictive":[275],"dermopathy,":[276],"lipodystrophy,":[277],"muscular":[279],"dystrophy.":[280],"Notably,":[281],"mutations":[282,1096],"LMNA":[284,298,832,972,1066],"lead":[285],"arrhythmogenic":[287],"and/or":[288],"dilated":[289],"cardiomyopathy":[290],"(DCM)":[291],"patients":[293],"animal":[295],"models":[296,1092],"cardiomyopathy.2":[299],"In":[300,549,1059],"this":[301,446,1004,1061,1106,1164,1178],"issue":[302],"Cardiovascular":[304],"Research,":[305],"al.3":[308,380,588,660,819],"revealed":[309,416],"genome-wide":[311,376],"distribution":[312,373,454,463,667,860],"double":[314,540,636,738,794],"stranded":[315,541,637,795],"breaks":[316],"(DSBs)":[317],"cardiomyocytes":[319,386,591,867,917],"for":[320,348,628,841],"first":[322,1110],"time":[323],"END-sequencing":[325],"(END-seq)":[326],"provided":[328],"novel":[329,987],"insights":[330,923],"role":[333,627],"regulating":[338,632],"baseline":[339,600],"DSBs":[340,350,363,456,598,686,814,892,962,1037,1054,1079,1126],"transcription.":[342],"END-seq":[343,382,400,415,606],"sensitive":[346],"method":[347],"detecting":[349],"resolution":[353],"ligating":[355],"sequencing":[357,369,679],"adaptor":[358],"ends":[361],"enabling":[364],"subsequent":[366,954],"next":[367],"generation":[368],"map":[371],"DSB":[372,462,666,708,733,745,859,1113],"level.4":[377],"performed":[381,662,1064,1089],"1":[384],"million":[385],"well-established":[389],"LMNA-DCM":[390,593,616,869],"model":[391],"(Myh6-Cre:LmnaF/F)5,6":[392],"compared":[394,428,861],"them":[395],"wild-type":[397],"(WT)":[398],"mice.":[399],"was":[401,1063,1135],"conducted":[402,820],"3-week-old":[404,441],"mice,":[405,870],"close":[406],"end":[409],"their":[411],"4-week":[412],"lifespan.":[413],"Here,":[414],"relatively":[418],"modest":[419],"increase":[420],"total":[422],"DSBs,":[423,623,635,883,933],"approximately":[424],"three":[425],"times":[426],"higher":[427],"WT":[430,879],"(2.2%":[431],"vs.":[432],"0.8%).":[433],"Given":[434,756],"severe":[435],"phenotypes":[437],"typically":[438,490,509],"observed":[439],"animals":[442],"earlier":[444,684],"studies,5,6":[445],"change":[447],"may":[448,981],"seem":[449],"mild":[450],"yet":[451],"spatial":[453],"remains":[457],"intriguing":[458],"(Figure":[459],"1).":[460],"Excessive":[461],"due":[467,534,601,942,1014],"stress.":[470,604,634,780,896],"organized":[474],"distinct":[476],"territories":[477],"largely":[481],"classified":[482,732],"reside":[491,510],"interior":[495],"composed":[498,517],"high":[502,620],"level":[503,522],"expression.":[506,525],"periphery":[514],"low":[521],"Transcription":[526,781],"has":[527,574,991],"been":[528,575,992],"known":[529,761],"cause":[531,938],"genomic":[532,581],"instability":[533],"torsional":[536,787],"stress":[537,782,788,980,1082],"unwinding":[539,792],"DNA,":[542,796],"inducing":[543],"transient":[544,797],"damage":[546],"TOP2.":[548],"addition,":[550,1060],"results":[552,950],"formation":[554],"non-B-DNA":[556,571,742,752,758,809],"structures":[557,753,759],"G-quadruplex":[560],"Z-DNA":[562],"non-transcribed":[564,800],"strand,":[566],"excessive":[568,597,882,1010],"presence":[569],"during":[572],"reported":[576],"instability.":[582],"study":[584,1005,1026,1062,1107],"demonstrated":[589,993],"mice":[594,617],"suffered":[595],"transcriptional":[603,633,766,895],"Combining":[605],"CUT&RUN":[608,822],"assay,":[609,823],"they":[610],"juxta-positioned":[613],"LADs":[614,890,911,1074],"samples":[618,880,1119],"had":[619],"levels":[621],"suggesting":[624,884],"significant":[626,856],"laminins":[630],"breaks;":[638],"LADs,":[639],"laminin":[640,644],"domains;":[642],"A;":[645],"RNA":[646,678],"polymerase":[647],"II,":[648],"Pol":[649],"II;":[650],"TOP2,":[651],"topoisomerase":[652,1022],"2;":[653],"TSS,":[654],"start":[656,701],"site.":[657,702,1043],"also":[661,920],"in-depth":[663],"profiling":[664],"classifying":[669],"intergenic":[674],"regions.":[675,864],"By":[676],"comparing":[677],"(RNA-seq)":[680],"data":[681,1170],"study,5":[685],"were":[687,1171],"preferentially":[688,748],"localized":[689],"highly":[692],"expressed":[693],"regions":[695,852,873,877,1130],"sites,":[696],"especially":[697],"motif":[704],"analysis":[705],"sites":[709,734,746,1114],"identified":[710],"26":[711],"factors,":[713],"ETS,":[715],"ETV4,":[716],"GATA4,":[717],"NFATC3,":[719],"related":[722],"development":[725],"function.":[728],"Additionally,":[729],"authors":[731,847,1155],"distinguishing":[736],"canonical":[737],"helical":[739],"B-DNA":[740],"structures.":[743],"Intriguingly,":[744],"near":[750],"like":[754],"Z-DNA.":[755],"stress,7":[767],"Cathcart\u2019s":[768],"team":[769],"investigated":[771,984],"relationship":[773],"between":[774],"physical":[786],"imposed":[789],"exposure":[798],"strand":[801],"extrinsic":[804],"damages,":[806],"secondary":[808],"structures,":[810],"collectively":[812],"accumulate":[813],"R-loops.":[816],"chip-seq":[825],"equivalent":[826],"technique":[827],"lower":[829],"background,":[830],"against":[831,995],"antibody":[833],"identify":[835],"\u2018lamina-associated":[836],"domains\u2019":[837],"(LADs)":[838],"accounted":[840],"30\u201340%":[842],"genome.1":[845],"delineated":[848],"constitutive":[849],"LAD":[850,872],"(cLAD)":[851],"reveal":[854],"reduction":[857],"non-LAD":[863],"Conversely,":[865],"juxtaposed":[871],"originally":[875],"cLAD":[876],"exhibited":[881],"protect":[889],"induced":[893,1099],"Taken":[897],"together,":[898],"current":[900,1025],"study3":[901],"not":[902],"only":[903,1033],"confirms":[904],"conventional":[906],"understanding":[907],"repressed":[913],"vivo":[916,1117],"but":[918],"it":[919,990,1013,1031],"provides":[921,1032],"new":[922,1169],"how":[925],"activations":[928],"increases":[929],"burden":[931,1077],"underlying":[937],"heart":[940,969,997,1118],"failure":[941,970],"laminopathies.":[944],"consistent":[947],"previous":[949],"showing":[951],"targeting":[953],"pathway":[955],"(cGAS-STING,":[956],"TP53)":[957],"epigenetic":[959],"regulator":[960],"successfully":[964],"reverse":[965],"progression":[967],"deficiency.5,6":[973],"Particularly,":[974],"BRD4":[975],"inhibition":[976],"target":[978],"approach":[988],"effective":[994],"non-LMNA":[996],"failure.8":[998],"One":[999],"question":[1001],"raised":[1002],"source":[1008],"DSBs.":[1011],"Is":[1012],"accumulation":[1016,1038,1055],"R-loops?":[1018],"Or":[1019],"lack":[1020],"activity?":[1023],"limited":[1028],"observational":[1034],"evidence":[1035],"Future":[1044],"follow-up":[1045],"investigations":[1046],"should":[1047],"focus":[1048],"identifying":[1050],"causality":[1052],"through":[1056],"mechanistic":[1057],"studies.":[1058],"depletion":[1067],"models.":[1068],"To":[1069],"expedite":[1070],"significance":[1072],"LMNA-DCM,":[1084],"future":[1085],"efforts":[1086],"could":[1087],"clinically":[1094],"relevant":[1095,1159],"pluripotent":[1100],"stem":[1101],"cell":[1102],"derived":[1103],"cardiomyocytes.9,10":[1104],"Overall,":[1105],"represents":[1108],"exploration":[1111],"site-specific":[1123],"localization":[1124],"actively":[1128],"LADs.":[1132],"publication":[1134],"supported":[1136],"grants":[1138],"National":[1141],"Institutes":[1142],"Health":[1144],"R01":[1145,1147,1150],"HL113006,":[1146],"HL130020,":[1148],"HL141371":[1151],"(J.C.W.).":[1152],"All":[1153],"report":[1156],"no":[1157],"relationships":[1158],"contents":[1162],"paper":[1165],"disclose.":[1167],"No":[1168],"generated":[1172],"analysed":[1174],"support":[1176],"research.":[1179]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-06-19T00:00:00"}
