{"id":"https://openalex.org/W4399771964","doi":"https://doi.org/10.1158/2767-9764.26058224.v1","title":"Figure S12 from HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity","display_name":"Figure S12 from HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity","publication_year":2024,"publication_date":"2024-06-18","ids":{"openalex":"https://openalex.org/W4399771964","doi":"https://doi.org/10.1158/2767-9764.26058224.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.26058224.v1","doi":"https://doi.org/10.1158/2767-9764.26058224.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.26058224.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.26058224.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083063156","display_name":"Priyanka Shailendra Rana","orcid":"https://orcid.org/0000-0001-5774-4383","observed_orcids":["https://orcid.org/0000-0001-5774-4383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Priyanka S. Rana","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5774-4383","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012867231","display_name":"James John Ignatz-Hoover","orcid":"https://orcid.org/0000-0001-8196-2655","observed_orcids":["https://orcid.org/0000-0001-8196-2655"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James J. Ignatz-Hoover","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8196-2655","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018875127","display_name":"Byung\u2010Gyu Kim","orcid":"https://orcid.org/0000-0002-8921-5061","observed_orcids":["https://orcid.org/0000-0002-8921-5061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Byung-Gyu Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8921-5061","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083283435","display_name":"Ehsan Malek","orcid":"https://orcid.org/0000-0003-4719-4327","observed_orcids":["https://orcid.org/0000-0003-4719-4327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ehsan Malek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4719-4327","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109734528","display_name":"Yuriy Federov","orcid":"https://orcid.org/0000-0001-9513-8341","observed_orcids":["https://orcid.org/0000-0001-9513-8341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuriy Federov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9513-8341","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025223840","display_name":"Drew Adams","orcid":"https://orcid.org/0000-0002-3038-336X","observed_orcids":["https://orcid.org/0000-0002-3038-336X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Drew Adams","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3038-336X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080223712","display_name":"Timothy An-thy Chan","orcid":"https://orcid.org/0000-0002-9265-0283","observed_orcids":["https://orcid.org/0000-0002-9265-0283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Chan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9265-0283","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035898667","display_name":"James Joseph Driscoll","orcid":"https://orcid.org/0000-0001-8364-0617","observed_orcids":["https://orcid.org/0000-0001-8364-0617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James J. Driscoll","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8364-0617","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.18289999663829803,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.10869999974966049,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac6-inhibition","display_name":"HDAC6 inhibition","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hr23b","display_name":"HR23B","score":0.9890000224113464},{"id":"https://openalex.org/keywords/proteasome-activation","display_name":"proteasome activation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-immunopeptidome","display_name":"tumor immunopeptidome","score":0.9599999785423279},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6299999952316284},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4671458899974823},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3663572669029236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3343391418457031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31862181425094604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2712339758872986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.26058224.v1","doi":"https://doi.org/10.1158/2767-9764.26058224.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.26058224.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.26058224.v1","doi":"https://doi.org/10.1158/2767-9764.26058224.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.26058224.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399772574","https://openalex.org/W4399772852","https://openalex.org/W4399793491","https://openalex.org/W4399773132","https://openalex.org/W4399771914","https://openalex.org/W4399772219","https://openalex.org/W4399759976","https://openalex.org/W4399793497","https://openalex.org/W4399773528","https://openalex.org/W4399772832"],"abstract_inverted_index":{"Fig.":[0],"S12.":[1],"a.":[2],"Effect":[3,43,68,76,84],"of":[4,28,44,47,69,77,85],"the":[5,19,26,30,34],"top":[6],"pharmacologics":[7,35,51],"alone":[8],"on":[9,72,80,88],"E.G7-Ova":[10,39,56,73,89],"cell":[11],"viability":[12,59,90],"as":[13,65],"measured":[14,61],"by":[15,53,62],"LDH":[16],"release":[17],"into":[18],"culture":[20],"medium":[21],"(green).":[22],"Also":[23],"shown":[24],"is":[25],"effect":[27],"pre-treating":[29],"B3Z":[31,48,81,94],"cells":[32,40,49,95],"with":[33,38,50,55,93],"then":[36],"co-culturing":[37],"(red).":[41],"b.":[42],"pre-":[45],"treatment":[46],"followed":[52],"co-culture":[54,92],"cells.":[57],"Cell":[58],"was":[60],"annexin-V+":[63],"staining":[64],"above.":[66],"c.":[67],"HDAC6":[70,78,86],"inhibitors":[71,79,87],"viability.":[74,82],"d.":[75],"e.":[83],"after":[91],"at":[96],"E:T":[97],"2:1.":[98]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-06-19T00:00:00"}