{"id":"https://openalex.org/W4399749780","doi":"https://doi.org/10.3390/nu16121893","title":"Variation in the Conservation of Species-Specific Gene Sets for HMO Degradation and Its Effects on HMO Utilization in Bifidobacteria","display_name":"Variation in the Conservation of Species-Specific Gene Sets for HMO Degradation and Its Effects on HMO Utilization in Bifidobacteria","publication_year":2024,"publication_date":"2024-06-15","ids":{"openalex":"https://openalex.org/W4399749780","doi":"https://doi.org/10.3390/nu16121893","pmid":"https://pubmed.ncbi.nlm.nih.gov/38931248","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11206791"},"language":"en","primary_location":{"id":"doi:10.3390/nu16121893","doi":"https://doi.org/10.3390/nu16121893","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu16121893","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/nu16121893","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015350937","display_name":"Gerben D. A. Hermes","orcid":"https://orcid.org/0000-0003-4314-9553","observed_orcids":["https://orcid.org/0000-0003-4314-9553"]},"institutions":[{"id":"https://openalex.org/I4405271692","display_name":"Novonesis (Denmark)","ror":"https://ror.org/02vm0w635","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I4210159963","https://openalex.org/I4405271692"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Gerben D. A. Hermes","raw_affiliation_strings":["Human Health Research, Human Health Biosolutions, Novonesis, Kogle Alle 6, 2970 Hoersholm, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-4314-9553","affiliations":[{"raw_affiliation_string":"Human Health Research, Human Health Biosolutions, Novonesis, Kogle Alle 6, 2970 Hoersholm, Denmark","institution_ids":["https://openalex.org/I4405271692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christine Rasmussen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271692","display_name":"Novonesis (Denmark)","ror":"https://ror.org/02vm0w635","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I4210159963","https://openalex.org/I4405271692"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christine Rasmussen","raw_affiliation_strings":["Human Health Research, Human Health Biosolutions, Novonesis, Kogle Alle 6, 2970 Hoersholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Health Research, Human Health Biosolutions, Novonesis, Kogle Alle 6, 2970 Hoersholm, Denmark","institution_ids":["https://openalex.org/I4405271692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002696775","display_name":"Anja Wellejus","orcid":"https://orcid.org/0000-0003-4350-6063","observed_orcids":["https://orcid.org/0000-0003-4350-6063"]},"institutions":[{"id":"https://openalex.org/I4405271692","display_name":"Novonesis (Denmark)","ror":"https://ror.org/02vm0w635","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I4210159963","https://openalex.org/I4405271692"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anja Wellejus","raw_affiliation_strings":["Human Health Research, Human Health Biosolutions, Novonesis, Kogle Alle 6, 2970 Hoersholm, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-4350-6063","affiliations":[{"raw_affiliation_string":"Human Health Research, Human Health Biosolutions, Novonesis, Kogle Alle 6, 2970 Hoersholm, Denmark","institution_ids":["https://openalex.org/I4405271692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015350937"],"corresponding_institution_ids":["https://openalex.org/I4405271692"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":2.6076,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.88467375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"16","issue":"12","first_page":"1893","last_page":"1893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-milk-oligosaccharides","display_name":"human milk oligosaccharides","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":0.9129999876022339},{"id":"https://openalex.org/keywords/infant-gut-microbiota","display_name":"infant gut microbiota","score":0.871999979019165},{"id":"https://openalex.org/keywords/infant-health","display_name":"infant health","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7761767506599426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5755707621574402},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5736083984375},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.5287945866584778},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.4475633502006531},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4317851662635803},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.32104867696762085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13941091299057007},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08153703808784485},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.07590404152870178},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008895","descriptor_name":"Milk, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/nu16121893","doi":"https://doi.org/10.3390/nu16121893","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu16121893","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11206791","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11206791","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:38931248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38931248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/nu16121893","doi":"https://doi.org/10.3390/nu16121893","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu16121893","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.40450000762939453}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W1489381096","https://openalex.org/W1938329966","https://openalex.org/W1977455677","https://openalex.org/W1983194790","https://openalex.org/W1984600160","https://openalex.org/W1985504995","https://openalex.org/W1986245298","https://openalex.org/W2008825357","https://openalex.org/W2011452259","https://openalex.org/W2040249819","https://openalex.org/W2044496774","https://openalex.org/W2044837335","https://openalex.org/W2045745337","https://openalex.org/W2048550695","https://openalex.org/W2054330389","https://openalex.org/W2055379078","https://openalex.org/W2055567175","https://openalex.org/W2057901324","https://openalex.org/W2058595703","https://openalex.org/W2067845342","https://openalex.org/W2071626786","https://openalex.org/W2074754685","https://openalex.org/W2078403019","https://openalex.org/W2079031212","https://openalex.org/W2079477175","https://openalex.org/W2081200151","https://openalex.org/W2085367624","https://openalex.org/W2096093282","https://openalex.org/W2096495272","https://openalex.org/W2109360402","https://openalex.org/W2111839060","https://openalex.org/W2111873101","https://openalex.org/W2114081120","https://openalex.org/W2120902911","https://openalex.org/W2122927972","https://openalex.org/W2123486819","https://openalex.org/W2132366863","https://openalex.org/W2133534580","https://openalex.org/W2139737383","https://openalex.org/W2144824427","https://openalex.org/W2146560246","https://openalex.org/W2148236942","https://openalex.org/W2152942352","https://openalex.org/W2167768477","https://openalex.org/W2170904778","https://openalex.org/W2298077113","https://openalex.org/W2314088936","https://openalex.org/W2406250479","https://openalex.org/W2424275162","https://openalex.org/W2470154003","https://openalex.org/W2474139832","https://openalex.org/W2534256653","https://openalex.org/W2535264497","https://openalex.org/W2560268514","https://openalex.org/W2580442288","https://openalex.org/W2588823770","https://openalex.org/W2598642800","https://openalex.org/W2604910991","https://openalex.org/W2783183417","https://openalex.org/W2787902098","https://openalex.org/W2801125329","https://openalex.org/W2804315773","https://openalex.org/W2835587310","https://openalex.org/W2890807142","https://openalex.org/W2902904448","https://openalex.org/W2905300057","https://openalex.org/W2921170206","https://openalex.org/W2947129834","https://openalex.org/W2971114933","https://openalex.org/W2987820200","https://openalex.org/W2989821387","https://openalex.org/W2997389823","https://openalex.org/W3013999313","https://openalex.org/W3016418278","https://openalex.org/W3037634897","https://openalex.org/W3042749484","https://openalex.org/W3048398081","https://openalex.org/W3088232571","https://openalex.org/W3094521183","https://openalex.org/W3196063466","https://openalex.org/W3199372667","https://openalex.org/W3211825579","https://openalex.org/W3217216416","https://openalex.org/W4220769026","https://openalex.org/W4223922708","https://openalex.org/W4280552539","https://openalex.org/W4281862167","https://openalex.org/W4283032507","https://openalex.org/W4295292702","https://openalex.org/W4323543731","https://openalex.org/W4385302529","https://openalex.org/W4386838004"],"related_works":["https://openalex.org/W2132366863","https://openalex.org/W1985504995","https://openalex.org/W2997389823","https://openalex.org/W3094521183","https://openalex.org/W2987820200","https://openalex.org/W1938329966","https://openalex.org/W3011193048","https://openalex.org/W2005501354","https://openalex.org/W4322727554","https://openalex.org/W3211825579"],"abstract_inverted_index":{"Human":[0],"milk":[1,12],"provides":[2],"essential":[3],"nutrients":[4],"for":[5,33,173],"infants":[6],"but":[7],"also":[8],"consists":[9],"of":[10,62,80,98,107,112,134,138,143,154,163,178],"human":[11,99],"oligosaccharides":[13],"(HMOs),":[14],"which":[15,124],"are":[16,24],"resistant":[17],"to":[18,43,150,160,183],"digestion":[19],"by":[20,40,57,66],"the":[21,26,34,63,70,78,105,113,118,132,141,155,161,174],"infant.":[22],"Bifidobacteria":[23],"among":[25],"first":[27],"colonizers,":[28],"providing":[29],"various":[30],"health":[31],"benefits":[32],"host.":[35],"This":[36],"is":[37,128],"largely":[38,129],"facilitated":[39],"their":[41],"ability":[42],"efficiently":[44],"metabolize":[45],"HMOs":[46,91],"in":[47,84,92,125],"a":[48,135,169],"species-specific":[49,121],"way.":[50],"Nevertheless,":[51],"these":[52],"abilities":[53],"can":[54],"vary":[55],"significantly":[56],"strain,":[58],"and":[59,116,166,176],"our":[60,152],"understanding":[61,153],"mechanisms":[64],"applied":[65],"different":[67],"strains":[68,94,111,165],"from":[69,95],"same":[71,114],"species":[72,97,115,127],"remains":[73],"incomplete.":[74],"Therefore,":[75],"we":[76],"assessed":[77],"effects":[79,119],"strain-level":[81],"genomic":[82],"variation":[83],"HMO":[85,122],"utilization":[86],"genes":[87,139],"on":[88,90,120],"growth":[89],"130":[93],"10":[96],"associated":[100],"bifidobacteria.":[101],"Our":[102],"findings":[103],"highlight":[104],"extent":[106],"genetic":[108,156],"diversity":[109],"between":[110],"demonstrate":[117],"utilization,":[123],"most":[126],"retained":[130],"through":[131],"conservation":[133],"core":[136],"set":[137],"or":[140],"presence":[142],"redundant":[144],"pathways.":[145],"These":[146],"data":[147],"will":[148,167],"help":[149],"refine":[151],"factors":[157],"that":[158],"contribute":[159],"persistence":[162],"individual":[164],"provide":[168],"better":[170],"mechanistic":[171],"rationale":[172],"development":[175],"optimization":[177],"new":[179],"early-life":[180],"microbiota-modulating":[181],"products":[182],"improve":[184],"infant":[185],"health.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-06-18T00:00:00"}