{"id":"https://openalex.org/W4399740985","doi":"https://doi.org/10.1097/js9.0000000000001800","title":"Optimum tacrolimus trough levels for enhanced graft survival and safety in kidney transplantation: a retrospective multicenter real-world evidence study","display_name":"Optimum tacrolimus trough levels for enhanced graft survival and safety in kidney transplantation: a retrospective multicenter real-world evidence study","publication_year":2024,"publication_date":"2024-06-17","ids":{"openalex":"https://openalex.org/W4399740985","doi":"https://doi.org/10.1097/js9.0000000000001800","pmid":"https://pubmed.ncbi.nlm.nih.gov/38884261","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11486932"},"language":"en","primary_location":{"id":"doi:10.1097/js9.0000000000001800","doi":"https://doi.org/10.1097/js9.0000000000001800","is_oa":true,"landing_page_url":"https://doi.org/10.1097/js9.0000000000001800","pdf_url":null,"source":{"id":"https://openalex.org/S67965910","display_name":"International Journal of Surgery","issn_l":"1743-9159","issn":["1743-9159","1743-9191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-3","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/js9.0000000000001800","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056542632","display_name":"Ahram Han","orcid":"https://orcid.org/0000-0001-7111-7095","observed_orcids":["https://orcid.org/0000-0001-7111-7095"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ahram Han","raw_affiliation_strings":["Division of Transplantation and Vascular Surgery, Department of Surgery, Seoul National University Hospital, Seoul","Division of Transplantation and Vascular Surgery, Department of Surgery, Seoul National University Hospital, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplantation and Vascular Surgery, Department of Surgery, Seoul National University Hospital, Seoul","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"raw_affiliation_string":"Division of Transplantation and Vascular Surgery, Department of Surgery, Seoul National University Hospital, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112902222","display_name":"Ae Jeong Jo","orcid":"https://orcid.org/0000-0003-1228-7021","observed_orcids":["https://orcid.org/0000-0003-1228-7021"]},"institutions":[{"id":"https://openalex.org/I113018520","display_name":"Gyeongkuk National University","ror":"https://ror.org/04wd10e19","country_code":"KR","type":"education","lineage":["https://openalex.org/I113018520"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ae Jeong Jo","raw_affiliation_strings":["Department of Information Statistics, Andong National University, Andong","Department of Information Statistics, Andong National University, Andong, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Statistics, Andong National University, Andong","institution_ids":["https://openalex.org/I113018520"]},{"raw_affiliation_string":"Department of Information Statistics, Andong National University, Andong, South Korea","institution_ids":["https://openalex.org/I113018520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101651710","display_name":"Hyunwook Kwon","orcid":"https://orcid.org/0000-0001-5018-5304","observed_orcids":["https://orcid.org/0000-0001-5018-5304"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunwook Kwon","raw_affiliation_strings":["Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul","Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]},{"raw_affiliation_string":"Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345283","display_name":"Young Hoon Kim","orcid":"https://orcid.org/0000-0003-3840-8426","observed_orcids":["https://orcid.org/0000-0003-3840-8426"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210148089","display_name":"Astellas Pharma (South Korea)","ror":"https://ror.org/04pchp455","country_code":"KR","type":"company","lineage":["https://openalex.org/I142395110","https://openalex.org/I4210148089"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Hoon Kim","raw_affiliation_strings":["Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul","Medical Affairs Department, Astellas Pharma Korea, Seoul","Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]},{"raw_affiliation_string":"Medical Affairs Department, Astellas Pharma Korea, Seoul","institution_ids":["https://openalex.org/I4210148089"]},{"raw_affiliation_string":"Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016727594","display_name":"Juhan Lee","orcid":"https://orcid.org/0000-0003-4910-2596","observed_orcids":["https://orcid.org/0000-0003-4910-2596"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210148089","display_name":"Astellas Pharma (South Korea)","ror":"https://ror.org/04pchp455","country_code":"KR","type":"company","lineage":["https://openalex.org/I142395110","https://openalex.org/I4210148089"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Juhan Lee","raw_affiliation_strings":["Department of Preventive Medicine, Seoul National University College of Medicine, Seoul","Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul","Medical Affairs Department, Astellas Pharma Korea, Seoul","Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Seoul National University College of Medicine, Seoul","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Medical Affairs Department, Astellas Pharma Korea, Seoul","institution_ids":["https://openalex.org/I4210148089"]},{"raw_affiliation_string":"Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028461835","display_name":"Kyu Ha Huh","orcid":"https://orcid.org/0000-0003-1364-6989","observed_orcids":["https://orcid.org/0000-0003-1364-6989"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyu Ha Huh","raw_affiliation_strings":["Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul","Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039231309","display_name":"Kyo Won Lee","orcid":"https://orcid.org/0000-0002-2722-7817","observed_orcids":["https://orcid.org/0000-0002-2722-7817"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyo Won Lee","raw_affiliation_strings":["Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul","Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081578294","display_name":"Jae Berm Park","orcid":"https://orcid.org/0000-0001-9117-2278","observed_orcids":["https://orcid.org/0000-0001-9117-2278"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Berm Park","raw_affiliation_strings":["Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul","Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032127943","display_name":"Eunju Jang","orcid":"https://orcid.org/0000-0002-6155-7318","observed_orcids":["https://orcid.org/0000-0002-6155-7318"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunju Jang","raw_affiliation_strings":["Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul","Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081819083","display_name":"Sun Cheol Park","orcid":"https://orcid.org/0000-0003-2701-0180","observed_orcids":["https://orcid.org/0000-0003-2701-0180"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun Cheol Park","raw_affiliation_strings":["Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul","Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049115188","display_name":"Joongyub Lee","orcid":"https://orcid.org/0000-0003-2784-3772","observed_orcids":["https://orcid.org/0000-0003-2784-3772"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210148089","display_name":"Astellas Pharma (South Korea)","ror":"https://ror.org/04pchp455","country_code":"KR","type":"company","lineage":["https://openalex.org/I142395110","https://openalex.org/I4210148089"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joongyub Lee","raw_affiliation_strings":["Department of Preventive Medicine, Seoul National University College of Medicine, Seoul","Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul","Medical Affairs Department, Astellas Pharma Korea, Seoul","Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Seoul National University College of Medicine, Seoul","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Medical Affairs Department, Astellas Pharma Korea, Seoul","institution_ids":["https://openalex.org/I4210148089"]},{"raw_affiliation_string":"Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104329652","display_name":"Jeongyun Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210148089","display_name":"Astellas Pharma (South Korea)","ror":"https://ror.org/04pchp455","country_code":"KR","type":"company","lineage":["https://openalex.org/I142395110","https://openalex.org/I4210148089"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeongyun Lee","raw_affiliation_strings":["Department of Preventive Medicine, Seoul National University College of Medicine, Seoul","Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul","Medical Affairs Department, Astellas Pharma Korea, Seoul","Medical Affairs Department, Astellas Pharma Korea, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Seoul National University College of Medicine, Seoul","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Medical Affairs Department, Astellas Pharma Korea, Seoul","institution_ids":["https://openalex.org/I4210148089"]},{"raw_affiliation_string":"Medical Affairs Department, Astellas Pharma Korea, South Korea","institution_ids":["https://openalex.org/I4210148089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049273599","display_name":"Younghye Kim","orcid":"https://orcid.org/0000-0003-1299-5378","observed_orcids":["https://orcid.org/0000-0003-1299-5378"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210148089","display_name":"Astellas Pharma (South Korea)","ror":"https://ror.org/04pchp455","country_code":"KR","type":"company","lineage":["https://openalex.org/I142395110","https://openalex.org/I4210148089"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Younghye Kim","raw_affiliation_strings":["Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul","Medical Affairs Department, Astellas Pharma Korea, Seoul","Medical Affairs Department, Astellas Pharma Korea, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kidney and Pancreases Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]},{"raw_affiliation_string":"Medical Affairs Department, Astellas Pharma Korea, Seoul","institution_ids":["https://openalex.org/I4210148089"]},{"raw_affiliation_string":"Medical Affairs Department, Astellas Pharma Korea, South Korea","institution_ids":["https://openalex.org/I4210148089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065636402","display_name":"Mohamed Soliman","orcid":"https://orcid.org/0000-0002-5061-9624","observed_orcids":["https://orcid.org/0000-0002-5061-9624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Soliman","raw_affiliation_strings":["Medical Affairs Department, Astellas Pharma Singapore Pte Ltd., Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Astellas Pharma Singapore Pte Ltd., Singapore","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088758105","display_name":"Sangil Min","orcid":"https://orcid.org/0000-0002-0688-0278","observed_orcids":["https://orcid.org/0000-0002-0688-0278"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sangil Min","raw_affiliation_strings":["Division of Transplantation and Vascular Surgery, Department of Surgery, Seoul National University Hospital, Seoul","Division of Transplantation and Vascular Surgery, Department of Surgery, Seoul National University Hospital, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplantation and Vascular Surgery, Department of Surgery, Seoul National University Hospital, Seoul","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"raw_affiliation_string":"Division of Transplantation and Vascular Surgery, Department of Surgery, Seoul National University Hospital, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5088758105"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":4.6922,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.95610619,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"110","issue":"10","first_page":"6711","last_page":"6722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11163","display_name":"Organ Donation and Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9810000061988831},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.7319999933242798},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7649999856948853},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.8640000224113464},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.7419999837875366},{"id":"https://openalex.org/keywords/donor-specific-antibodies","display_name":"donor-specific antibodies","score":0.6650000214576721},{"id":"https://openalex.org/keywords/graft-failure","display_name":"graft failure","score":0.597000002861023},{"id":"https://openalex.org/keywords/drug-exposure","display_name":"drug exposure","score":0.37599998712539673},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.36000001430511475},{"id":"https://openalex.org/keywords/infection-risk","display_name":"infection risk","score":0.5139999985694885},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6710000038146973},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.5049999952316284},{"id":"https://openalex.org/keywords/coefficient-of-variation","display_name":"coefficient of variation","score":0.628000020980835},{"id":"https://openalex.org/keywords/time-in-therapeutic-range","display_name":"time in therapeutic range","score":0.8050000071525574},{"id":"https://openalex.org/keywords/marginal-structural-models","display_name":"marginal structural models","score":0.7490000128746033},{"id":"https://openalex.org/keywords/inverse-probability-of-treatment-weighting","display_name":"inverse probability of treatment weighting","score":0.9390000104904175},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9359279274940491},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.8137712478637695},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7753912210464478},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.6009867191314697},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5814741253852844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5159252882003784},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4780983626842499},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4643784761428833},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.45968860387802124},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.44628000259399414},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4038304090499878},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34647804498672485},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1981475055217743}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/js9.0000000000001800","doi":"https://doi.org/10.1097/js9.0000000000001800","is_oa":true,"landing_page_url":"https://doi.org/10.1097/js9.0000000000001800","pdf_url":null,"source":{"id":"https://openalex.org/S67965910","display_name":"International Journal of Surgery","issn_l":"1743-9159","issn":["1743-9159","1743-9191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-3","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11486932","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11486932","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11486932/pdf/js9-110-6711.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Surg","raw_type":"Text"},{"id":"pmid:38884261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38884261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of surgery (London, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/js9.0000000000001800","doi":"https://doi.org/10.1097/js9.0000000000001800","is_oa":true,"landing_page_url":"https://doi.org/10.1097/js9.0000000000001800","pdf_url":null,"source":{"id":"https://openalex.org/S67965910","display_name":"International Journal of Surgery","issn_l":"1743-9159","issn":["1743-9159","1743-9191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-3","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1586488555","https://openalex.org/W1722431364","https://openalex.org/W1891520818","https://openalex.org/W1925483030","https://openalex.org/W1982564580","https://openalex.org/W1988652338","https://openalex.org/W2000174571","https://openalex.org/W2008557562","https://openalex.org/W2026021213","https://openalex.org/W2030703473","https://openalex.org/W2035276049","https://openalex.org/W2041808051","https://openalex.org/W2042260375","https://openalex.org/W2129055135","https://openalex.org/W2162387780","https://openalex.org/W2298338128","https://openalex.org/W2302802827","https://openalex.org/W2433496571","https://openalex.org/W2530893030","https://openalex.org/W2597535653","https://openalex.org/W2598159059","https://openalex.org/W2739465434","https://openalex.org/W2755751925","https://openalex.org/W2765312142","https://openalex.org/W2908222615","https://openalex.org/W2922034038","https://openalex.org/W2946301278","https://openalex.org/W2968619753","https://openalex.org/W3009348385","https://openalex.org/W3039578012","https://openalex.org/W3112655860","https://openalex.org/W3157272465","https://openalex.org/W3168551559","https://openalex.org/W3191007709","https://openalex.org/W3202032708","https://openalex.org/W3202421714","https://openalex.org/W3212080866","https://openalex.org/W3212282753","https://openalex.org/W4214539121","https://openalex.org/W4308292299","https://openalex.org/W4322489713","https://openalex.org/W4381252533","https://openalex.org/W4391954041","https://openalex.org/W6810015587"],"related_works":["https://openalex.org/W4391532806","https://openalex.org/W3202669827","https://openalex.org/W7125916709","https://openalex.org/W3039578012","https://openalex.org/W4310963778","https://openalex.org/W2884900267","https://openalex.org/W2932133395","https://openalex.org/W4403834577","https://openalex.org/W2970978130","https://openalex.org/W2804747786"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,41],"current":[2],"study":[3,30,232],"aimed":[4],"to":[5,181],"determine":[6],"the":[7,119,138,142,186,242],"optimal":[8,212,237],"tacrolimus":[9,44,238],"trough":[10,48,239],"levels":[11,111,182,240],"for":[12,147,158,167,177,198,208,236],"balancing":[13],"graft":[14,70],"survival":[15],"and":[16,57,69,82,93,115,122,170,201,225,245],"patient":[17],"safety":[18,75],"following":[19,248],"kidney":[20,34,67,249],"transplantation.":[21,250],"MATERIALS":[22],"AND":[23],"METHODS:":[24],"We":[25],"conducted":[26],"a":[27],"retrospective":[28],"cohort":[29],"involving":[31],"11":[32],"868":[33],"transplant":[35],"recipients":[36],"from":[37,89],"five":[38],"medical":[39],"centers.":[40],"association":[42],"between":[43],"exposures":[45],"(periodic":[46],"mean":[47],"level,":[49],"coefficient":[50],"of":[51,112,133,217],"variability,":[52],"time":[53],"in":[54],"therapeutic":[55],"range)":[56],"composite":[58,134,148,188],"allograft":[59,135,149],"outcome":[60],"(de":[61],"novo":[62],"donor-specific":[63],"antibody,":[64],"biopsy-proven":[65],"rejection,":[66],"dysfunction,":[68],"failure),":[71],"as":[72,74],"well":[73],"outcomes":[76,150],"(severe":[77],"infection,":[78],"cardiovascular":[79],"events,":[80],"malignancy,":[81],"mortality)":[83],"were":[84,87,128,151,191],"assessed.":[85],"Data":[86,91],"sourced":[88],"Clinical":[90],"Warehouses":[92],"analyzed":[94],"using":[95],"advanced":[96],"statistical":[97],"methods,":[98],"including":[99],"Cox":[100],"marginal":[101],"structural":[102],"models":[103],"with":[104,130],"inverse":[105],"probability":[106],"treatment":[107],"weighting.":[108],"RESULTS:":[109],"Tacrolimus":[110],"5.0-7.9":[113],"ng/ml":[114,117,179,200],"5.0-6.9":[116],"during":[118,241],"2-12":[120,244],"month":[121,124],"12-72":[123,246],"post-transplantation":[125],"periods,":[126],"respectively,":[127],"associated":[129],"reduced":[131,215],"risks":[132],"outcomes.":[136],"During":[137],"first":[139],"post-transplant":[140],"year,":[141],"adjusted":[143],"hazard":[144],"ratios":[145],"(aHR)":[146],"0.69":[152],"(95%":[153,162,172,193,203],"CI":[154,163,173,194,204],"0.55-0.85,":[155],"P":[156,165,175,196,206],"<0.001)":[157],"5.0-5.9":[159,199],"ng/ml;":[160,169],"0.81":[161],"0.67-0.98,":[164],"=0.033)":[166],"6.0-6.9":[168,209],"0.73":[171],"0.60-0.89,":[174],"=0.002)":[176,197],"7.0-7.9":[178],"(compared":[180],"\u22658.0":[183],"ng/ml).":[184],"For":[185],"6-year":[187],"outcomes,":[189],"aHRs":[190],"0.68":[192],"0.53-0.87,":[195],"0.65":[202],"0.50-0.85,":[205],"=0.001)":[207],"ng/ml.":[210],"These":[211],"ranges":[213],"showed":[214],"rates":[216],"severe":[218],"infection":[219],"(6":[220,223],"years),":[221,224],"malignancy":[222],"mortality":[226],"(1":[227],"year).":[228],"CONCLUSION:":[229],"This":[230],"multicenter":[231],"provides":[233],"robust":[234],"evidence":[235],"periods":[243],"months":[247]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-06-18T00:00:00"}
