{"id":"https://openalex.org/W4399708488","doi":"https://doi.org/10.1101/2024.06.12.597953","title":"Dual targeting of KDM1A and antioxidants is an effective anticancer strategy","display_name":"Dual targeting of KDM1A and antioxidants is an effective anticancer strategy","publication_year":2024,"publication_date":"2024-06-14","ids":{"openalex":"https://openalex.org/W4399708488","doi":"https://doi.org/10.1101/2024.06.12.597953","pmid":"https://pubmed.ncbi.nlm.nih.gov/38915482","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11195178"},"language":"en","primary_location":{"id":"doi:10.1101/2024.06.12.597953","doi":"https://doi.org/10.1101/2024.06.12.597953","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.06.12.597953","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2024.06.12.597953","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034920485","display_name":"Shaila Mudambi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shaila Mudambi","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103476291","display_name":"Megan E. Fitzgerald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan E Fitzgerald","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048370548","display_name":"Deschana Washington","orcid":"https://orcid.org/0000-0001-8276-9208","observed_orcids":["https://orcid.org/0000-0001-8276-9208"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deschana L Washington","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059765364","display_name":"Paula J. Pera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula J Pera","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067861660","display_name":"Wendy J. Huss","orcid":"https://orcid.org/0000-0002-0812-8696","observed_orcids":["https://orcid.org/0000-0002-0812-8696"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy J Huss","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463"],"raw_orcid":"https://orcid.org/0000-0002-0812-8696","affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040337000","display_name":"Gy\u00f6rgy Paragh","orcid":"https://orcid.org/0000-0002-6791-3870","observed_orcids":["https://orcid.org/0000-0002-6791-3870"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gyorgy Paragh","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 4263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States 1463","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034920485"],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lsd1","display_name":"LSD1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hif1a","display_name":"HIF1A","score":0.953000009059906},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9819999933242798},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7670000195503235},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.890999972820282},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/buthionine-sulfoximine","display_name":"buthionine sulfoximine","score":0.9549999833106995},{"id":"https://openalex.org/keywords/auranofin","display_name":"auranofin","score":1.0},{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/combination-cancer-therapy","display_name":"combination cancer therapy","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.5010957717895508},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2024.06.12.597953","doi":"https://doi.org/10.1101/2024.06.12.597953","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.06.12.597953","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38915482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38915482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11195178","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11195178","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11195178/pdf/nihpp-2024.06.12.597953v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2024.06.12.597953","doi":"https://doi.org/10.1101/2024.06.12.597953","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.06.12.597953","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W133186721","https://openalex.org/W1638088449","https://openalex.org/W1722494167","https://openalex.org/W1751718048","https://openalex.org/W1809723326","https://openalex.org/W1842046684","https://openalex.org/W1855916153","https://openalex.org/W1965862088","https://openalex.org/W1971100695","https://openalex.org/W1978253058","https://openalex.org/W1978992544","https://openalex.org/W1984799406","https://openalex.org/W1985159629","https://openalex.org/W1988655372","https://openalex.org/W2005253752","https://openalex.org/W2011376105","https://openalex.org/W2016018631","https://openalex.org/W2017188188","https://openalex.org/W2020414099","https://openalex.org/W2021541624","https://openalex.org/W2022928403","https://openalex.org/W2028540899","https://openalex.org/W2029462077","https://openalex.org/W2050313963","https://openalex.org/W2072534984","https://openalex.org/W2072677280","https://openalex.org/W2079481037","https://openalex.org/W2083662317","https://openalex.org/W2085288412","https://openalex.org/W2087930304","https://openalex.org/W2101893151","https://openalex.org/W2140464899","https://openalex.org/W2145460819","https://openalex.org/W2147268550","https://openalex.org/W2154200968","https://openalex.org/W2157771031","https://openalex.org/W2169979796","https://openalex.org/W2322116467","https://openalex.org/W2322691983","https://openalex.org/W2415945663","https://openalex.org/W2416868341","https://openalex.org/W2501083185","https://openalex.org/W2536817740","https://openalex.org/W2554954289","https://openalex.org/W2589372735","https://openalex.org/W2591735127","https://openalex.org/W2619266720","https://openalex.org/W2619437071","https://openalex.org/W2622821813","https://openalex.org/W2627044895","https://openalex.org/W2760255113","https://openalex.org/W2761393041","https://openalex.org/W2762543394","https://openalex.org/W2791963264","https://openalex.org/W2793828178","https://openalex.org/W2794180511","https://openalex.org/W2805337998","https://openalex.org/W2898994124","https://openalex.org/W2980951622","https://openalex.org/W3215489950","https://openalex.org/W4245895651","https://openalex.org/W4281929992","https://openalex.org/W4291779161"],"related_works":["https://openalex.org/W1992963525","https://openalex.org/W2343881187","https://openalex.org/W2520154031","https://openalex.org/W2407348458","https://openalex.org/W2973221342","https://openalex.org/W4235432140","https://openalex.org/W3006537390","https://openalex.org/W2143182501","https://openalex.org/W1971403257","https://openalex.org/W3174804635"],"abstract_inverted_index":{"Lysine":[0],"Specific":[1],"Demethylase":[2],"1":[3],"(KDM1A":[4],"/":[5],"LSD1)":[6],"regulates":[7],"mitochondrial":[8,98],"respiration":[9,99],"and":[10,29,56,79,100,135,153,160,179,186],"stabilizes":[11],"HIF-1A":[12,16,104,110,134,174],"(hypoxia-inducible":[13],"factor":[14],"1A).":[15],"modulates":[17],"reactive":[18],"oxygen":[19],"species":[20],"(ROS)":[21],"levels":[22],"by":[23,87,133],"increasing":[24],"cellular":[25,37,82],"glucose":[26],"uptake,":[27],"glycolysis,":[28],"endogenous":[30,138],"antioxidants.":[31],"The":[32],"role":[33,48,169],"of":[34,49,59,103,109,126,137,184],"KDM1A":[35,50,60,72,94,114,129,171,185],"in":[36,51,62,155,172],"ROS":[38,54,106,127],"response":[39,55],"has":[40],"not":[41],"previously":[42],"been":[43],"described.":[44],"We":[45,140],"determined":[46],"the":[47,53,57,90],"regulating":[52,173],"utility":[58],"inhibitors":[61],"combination":[63,194],"with":[64,89,148],"ROS-inducing":[65],"cancer":[66],"therapies.":[67],"Our":[68],"results":[69],"show":[70,142],"that":[71,123,143,181],"inhibition":[73,95,115,130],"sensitized":[74],"cells":[75,112],"to":[76,118],"oxidative":[77,177],"stress":[78,178],"increased":[80,124],"total":[81],"ROS,":[83],"which":[84],"was":[85,131],"mitigated":[86],"treatment":[88],"antioxidant":[91,187],"N-acetyl":[92],"cysteine.":[93],"decreased":[96],"basal":[97],"impaired":[101],"induction":[102],"after":[105,128],"exposure.":[107],"Overexpression":[108],"salvaged":[111],"from":[113],"enhanced":[116],"sensitivity":[117,125],"ROS.":[119],"Thus":[120],"we":[121,165],"found":[122,180],"mediated":[132],"depletion":[136],"glutathione.":[139],"also":[141],"KDM1A-specific":[144],"inhibitor":[145],"bizine":[146],"synergized":[147],"antioxidant-depleting":[149],"therapies,":[150],"buthionine":[151],"sulfoximine,":[152],"auranofin":[154],"rhabdomyosarcoma":[156],"cell":[157],"lines":[158],"(Rh28":[159],"Rh30).":[161],"In":[162],"this":[163],"study,":[164],"describe":[166],"a":[167],"novel":[168],"for":[170],"functions":[175],"under":[176],"dual":[182],"targeting":[183],"systems":[188],"may":[189],"serve":[190],"as":[191],"an":[192],"effective":[193],"anticancer":[195],"strategy.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-06-16T00:00:00"}