{"id":"https://openalex.org/W4399689647","doi":"https://doi.org/10.2337/db24-1629-p","title":"1629-P: Seven-Month HFD Feeding Abolishes the Protective Effect of STING Disruption on Obesity-Associated Hepatic Steatosis, Inflammation, and Insulin Resistance","display_name":"1629-P: Seven-Month HFD Feeding Abolishes the Protective Effect of STING Disruption on Obesity-Associated Hepatic Steatosis, Inflammation, and Insulin Resistance","publication_year":2024,"publication_date":"2024-06-14","ids":{"openalex":"https://openalex.org/W4399689647","doi":"https://doi.org/10.2337/db24-1629-p"},"language":"en","primary_location":{"id":"doi:10.2337/db24-1629-p","doi":"https://doi.org/10.2337/db24-1629-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db24-1629-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112305572","display_name":"XINLEI GUO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"XINLEI GUO","raw_affiliation_strings":["College Station, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College Station, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051788670","display_name":"Honggui Li","orcid":"https://orcid.org/0000-0002-6294-1581","observed_orcids":["https://orcid.org/0000-0002-6294-1581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HONGGUI LI","raw_affiliation_strings":["College Station, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College Station, TX","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078136816","display_name":"Chaodong Wu","orcid":"https://orcid.org/0000-0001-8569-8070","observed_orcids":["https://orcid.org/0000-0001-8569-8070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHAODONG WU","raw_affiliation_strings":["College Station, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College Station, TX","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.14980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.12620000541210175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.9879999756813049},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7210000157356262},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7850000262260437},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.6200000047683716},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8568482398986816},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8564925789833069},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8356208801269531},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.7160107493400574},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6382489204406738},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5753785371780396},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5737600326538086},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5649902820587158},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.5135393142700195},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5100106000900269},{"id":"https://openalex.org/C2779113265","wikidata":"https://www.wikidata.org/wiki/Q107525054","display_name":"Insulin tolerance test","level":5,"score":0.48493340611457825},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.45802411437034607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.421515554189682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3840746283531189},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3546912670135498},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.10643064975738525}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db24-1629-p","doi":"https://doi.org/10.2337/db24-1629-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db24-1629-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402536065","https://openalex.org/W3035518973","https://openalex.org/W4388078249","https://openalex.org/W7064879577","https://openalex.org/W2288746230","https://openalex.org/W2139039423","https://openalex.org/W3177022677","https://openalex.org/W1992580566","https://openalex.org/W2891103014","https://openalex.org/W2165268648"],"abstract_inverted_index":{"Insulin":[0],"resistance":[1],"(IR)":[2],"means":[3],"the":[4,77,89,103,148,202,219,270],"failure":[5],"of":[6,29,33,80,91,106,145,186,237,244,273,306],"cells":[7],"to":[8,11,172,195,252],"respond":[9],"normally":[10],"insulin,":[12],"commonly":[13],"associated":[14],"with":[15,43,76,192],"obesity":[16,129,166],"and":[17,47,54,114,126,130,153,163,167,183,189,206,241,248,280],"causing":[18],"various":[19],"metabolic":[20,291],"dysregulations":[21],"in":[22,37,62,65,95,201,218,288],"type":[23],"2":[24],"diabetes.":[25],"As":[26,282],"a":[27,68,142],"mediator":[28],"innate":[30],"immunity,":[31],"stimulator":[32],"interferon":[34],"genes":[35],"(STING)":[36],"human":[38,107],"subjects":[39],"is":[40,60,86,286],"positively":[41],"correlated":[42],"excessive":[44],"fat":[45],"deposition":[46],"liver":[48],"inflammation,":[49,190,242],"which":[50,101,245],"both":[51],"trigger":[52],"hepatic":[53,138,187,239,247,278],"systemic":[55,81,168,249],"IR.":[56,131,281],"Also,":[57],"STING":[58,92,274],"expression":[59],"increased":[61,193,235],"insulin-responsive":[63],"tissues":[64,221],"mice":[66,96,118,134,155,178,212,232,256],"fed":[67,120,157],"high-fat":[69],"diet":[70],"(HFD)":[71],"for":[72,123,128,137,160,165,266],"3":[73,124],"months,":[74],"coupled":[75],"decreased":[78,184],"sensitivity":[79],"insulin":[82,139,146,169],"signaling.":[83],"However,":[84,226],"it":[85],"unknown":[87],"about":[88],"effect":[90,272],"on":[93,276],"IR":[94],"upon":[97,141,227,257],"prolonged":[98,228],"HFD":[99,122,159,229,259,264],"feeding,":[100,230],"reflects":[102],"long-term":[104],"course":[105],"obesity.":[108],"In":[109],"this":[110],"study,":[111],"wild-type":[112],"(WT)":[113],"STING-disrupted":[115],"(STgt)":[116],"male":[117,173,176,210,223],"were":[119,135,156,213],"an":[121,158],"months":[125,162,268],"examined":[127,136,164],"Some":[132],"HFD-fed":[133],"signaling":[140],"bolus":[143],"injection":[144],"into":[147],"portal":[149],"vein.":[150],"Additional":[151],"STgt":[152,231,255],"WT":[154,253],"7":[161,267],"sensitivity.":[170],"Compared":[171],"3-m-HFD-WT":[174,224],"mice,":[175],"3-m-HFD-STgt":[177,211],"gained":[179],"smaller":[180],"body":[181],"weights":[182],"levels":[185],"steatosis":[188,240],"along":[191],"response":[194],"insulin.":[196],"Consistently,":[197],"insulin-stimulated":[198],"Akt":[199],"phosphorylation":[200],"liver,":[203],"adipose":[204],"tissue,":[205],"skeletal":[207],"muscle":[208],"from":[209,222],"much":[214],"greater":[215],"than":[216],"those":[217],"respective":[220],"mice.":[225],"displayed":[233],"notably":[234],"severity":[236],"obesity,":[238],"all":[243],"cause":[246],"IR,":[250],"relative":[251],"or":[254],"3-month":[258],"feeding.":[260],"These":[261],"results":[262],"indicate":[263],"feeding":[265],"abolishes":[269],"protective":[271],"deletion":[275],"obesity-associated":[277],"steatosis/inflammation,":[279],"such,":[283],"diets":[284],"approach":[285],"key":[287],"managing":[289],"obesity-induced":[290],"diseases.":[292],"Disclosure":[293],"X.":[294],"Guo:":[295],"None.":[296,299,302],"H.":[297],"Li:":[298],"C.":[300],"Wu:":[301],"Funding":[303],"National":[304],"Institutes":[305],"Health":[307],"(DK124854)":[308]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2024-06-15T00:00:00"}
