{"id":"https://openalex.org/W4399685223","doi":"https://doi.org/10.2337/db24-515-p","title":"515-P: Do Circulating Sphingolipid Species Correlate with Age? A Study in a Normoglycemic Population","display_name":"515-P: Do Circulating Sphingolipid Species Correlate with Age? A Study in a Normoglycemic Population","publication_year":2024,"publication_date":"2024-06-14","ids":{"openalex":"https://openalex.org/W4399685223","doi":"https://doi.org/10.2337/db24-515-p"},"language":"en","primary_location":{"id":"doi:10.2337/db24-515-p","doi":"https://doi.org/10.2337/db24-515-p","is_oa":false,"landing_page_url":"http://dx.doi.org/10.2337/db24-515-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087691886","display_name":"Naser Aliye Feto","orcid":"https://orcid.org/0000-0002-6781-6683","observed_orcids":["https://orcid.org/0000-0002-6781-6683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NASER ALIYE FETO","raw_affiliation_strings":["Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memphis, TN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059082553","display_name":"Peace Asuzu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PEACE ASUZU","raw_affiliation_strings":["Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memphis, TN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026723909","display_name":"Frankie B. Stentz","orcid":"https://orcid.org/0000-0001-9268-9666","observed_orcids":["https://orcid.org/0000-0001-9268-9666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FRANKIE B. STENTZ","raw_affiliation_strings":["Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memphis, TN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076984214","display_name":"Jim Y. Wan","orcid":"https://orcid.org/0000-0001-6880-3772","observed_orcids":["https://orcid.org/0000-0001-6880-3772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JIM Y. WAN","raw_affiliation_strings":["Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memphis, TN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033587716","display_name":"Samuel E. Dagogo-Jack","orcid":"https://orcid.org/0000-0001-5318-9677","observed_orcids":["https://orcid.org/0000-0001-5318-9677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SAMUEL DAGOGO-JACK","raw_affiliation_strings":["Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memphis, TN","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005554901","display_name":"Nawajes A. Mandal","orcid":"https://orcid.org/0000-0003-4489-7748","observed_orcids":["https://orcid.org/0000-0003-4489-7748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NAWAJES MANDAL","raw_affiliation_strings":["Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memphis, TN","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06608496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9700000286102295},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8069999814033508},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.9430000185966492},{"id":"https://openalex.org/keywords/monohexosylceramide","display_name":"monohexosylceramide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sphingosine","display_name":"sphingosine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/normoglycemic-adults","display_name":"normoglycemic adults","score":0.824999988079071},{"id":"https://openalex.org/keywords/aging-biomarkers","display_name":"aging biomarkers","score":0.6259999871253967},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7542837858200073},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.7340648174285889},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7076555490493774},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5603059530258179},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4354918897151947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43008938431739807},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.41002756357192993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3751758337020874},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.21229660511016846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14672797918319702},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db24-515-p","doi":"https://doi.org/10.2337/db24-515-p","is_oa":false,"landing_page_url":"http://dx.doi.org/10.2337/db24-515-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410098541","https://openalex.org/W7156043645","https://openalex.org/W2012374994","https://openalex.org/W4212892395","https://openalex.org/W4399684790","https://openalex.org/W4399685334","https://openalex.org/W6886863052","https://openalex.org/W3119399564","https://openalex.org/W2017576582","https://openalex.org/W3153020845"],"abstract_inverted_index":{"Objective:":[0],"Sphingolipids":[1],"(SPL)":[2],"in":[3,35,63,112,119,251],"circulation":[4],"have":[5],"been":[6],"associated":[7],"with":[8,37,103,124,162,242,247],"pathological":[9],"outcomes":[10],"of":[11,31,46,110,129,139,167,182,206,213,221,235,294],"metabolic":[12],"and":[13,59,84,99,115,131,137,153,164,173,187,203,211,239,244,259,296,298,304],"cardiovascular":[14],"diseases":[15],"that":[16,92,100,231],"are":[17],"known":[18],"to":[19,26,257],"be":[20,255],"influenced":[21],"by":[22],"aging.":[23,104],"We":[24,41,106],"sought":[25],"determine":[27],"the":[28,96,108,165,232],"age":[29,74,97,121,243],"association":[30],"plasma":[32,43,233],"SPL":[33,48,90,214,222,237,252],"species":[34,91,128,238],"people":[36],"no":[38],"diabetes.":[39],"Methods:":[40],"determined":[42],"levels":[44,181],"(pmole/mL)":[45],"58":[47],"species,":[49],"including":[50],"ceramides":[51],"(Cer),":[52],"monohexosylceramides":[53],"(MHC),":[54],"sphingomyelins":[55],"(SM),":[56],"sphingosine":[57,60],"(So),":[58],"1-phosphate":[61],"(S1P)":[62],"239":[64],"normoglycemic":[65],"participants":[66],"using":[67],"LC-MS/MS":[68],"after":[69,144],"dividing":[70],"them":[71],"into":[72],"five":[73],"groups,":[75],"19-29y":[76],"(n=46),":[77],"30-39y":[78],"(n=47),":[79],"40-49y":[80],"(n=64),":[81],"50-59y":[82],"(n=67),":[83],"\u226560y":[85],"(n=15).":[86],"Correlation":[87],"analysis":[88],"identified":[89,107],"differ":[93,241],"significantly":[94,101,118],"among":[95],"groups":[98,122],"correlate":[102,245],"Results:":[105],"ratio":[109,166,205],"C18:0/C18:1":[111,169],"Cer,":[113],"MHC,":[114],"SM":[116,133],"differed":[117],"different":[120],"along":[123],"some":[125],"very-long-chain":[126],"(VLC)":[127],"MHC":[130,174,188,193,198,204],"SM,":[132,136],"C14:0,":[134],"total":[135],"SM%":[138,220],"SPL,":[140],"which":[141],"remained":[142],"significant":[143],"adjusting":[145],"for":[146],"gender,":[147],"race,":[148],"BMI,":[149],"waist":[150],"circumference,":[151],"FPG,":[152],"2hPG.":[154],"Interestingly,":[155],"Cer":[156,168],"C18:1":[157],"(r=0.20,":[158],"p<0.01)":[159,217],"positively":[160],"correlated":[161,178,218,225],"aging,":[163],"(r=":[170,175,184,190,195,200,208,215],"-0.27,":[171,209],"p<0.0001)":[172,186,210],"-0.23,":[176,201],"p<0.001)":[177,202,224],"negatively.":[179],"While":[180],"So":[183],"-0.29,":[185],"C26:0":[189],"-0.20,":[191,216],"p<0.01),":[192],"C28:0":[194],"-0.25,":[196],"p<0.0001),":[197],"C34:0":[199],"C26:0/C26:1":[207],"MHC%":[212],"negatively,":[219],"(r=0.21,":[223],"positively.":[226],"Conclusions:":[227],"Our":[228],"results":[229],"show":[230],"concentration":[234],"certain":[236],"ratios":[240],"differentially":[246],"age.":[248],"Thus,":[249],"alterations":[250],"metabolism":[253],"may":[254],"linked":[256],"aging":[258],"age-related":[260],"disorders.":[261],"Disclosure":[262],"N.":[263,288],"Feto:":[264],"None.":[265,268,271,274,290],"P.":[266],"Asuzu:":[267],"F.B.":[269],"Stentz:":[270],"J.Y.":[272],"Wan:":[273],"S.":[275],"Dagogo-Jack:":[276],"Consultant;":[277],"Merck":[278],"Sharp":[279],"&":[280],"Dohme":[281],"Corp.,":[282],"Medtronic,":[283],"Bayer":[284],"Inc.":[285],"Stock/Shareholder;":[286],"Aerami.":[287],"Mandal:":[289],"Funding":[291],"National":[292],"Institute":[293],"Diabetes":[295],"Digestive":[297],"Kidney":[299],"Diseases":[300],"(R01DK128129,":[301],"R01":[302],"DK067269,":[303],"DK":[305],"48411)":[306]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-06-15T00:00:00"}