{"id":"https://openalex.org/W4399673307","doi":"https://doi.org/10.1039/d4ra02163k","title":"Bioanalytical HPLC method with fluorescence detector for determination of Entresto\u2122 when co-administered with ibuprofen and fexofenadine: a pharmacokinetic study","display_name":"Bioanalytical HPLC method with fluorescence detector for determination of Entresto\u2122 when co-administered with ibuprofen and fexofenadine: a pharmacokinetic study","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4399673307","doi":"https://doi.org/10.1039/d4ra02163k","pmid":"https://pubmed.ncbi.nlm.nih.gov/38882479","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11177748"},"language":"en","primary_location":{"id":"doi:10.1039/d4ra02163k","doi":"https://doi.org/10.1039/d4ra02163k","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1039/d4ra02163k","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra02163k","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra02163k","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001078153","display_name":"Aya R. Ahmed","orcid":"https://orcid.org/0000-0001-8536-1507","observed_orcids":["https://orcid.org/0000-0001-8536-1507"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Aya R. Ahmed","raw_affiliation_strings":["Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-8536-1507","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020939550","display_name":"Shereen M. Galal","orcid":"https://orcid.org/0000-0003-0923-5546","observed_orcids":["https://orcid.org/0000-0003-0923-5546"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Shereen M. Galal","raw_affiliation_strings":["Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110258740","display_name":"Mohamed A. Korany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed A. Korany","raw_affiliation_strings":["Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009904033","display_name":"Manal A Elsheikh","orcid":"https://orcid.org/0000-0001-5704-2429","observed_orcids":["https://orcid.org/0000-0001-5704-2429"]},"institutions":[{"id":"https://openalex.org/I169744251","display_name":"Damanhour University","ror":"https://ror.org/03svthf85","country_code":"EG","type":"education","lineage":["https://openalex.org/I169744251"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Manal A Elsheikh","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt","institution_ids":["https://openalex.org/I169744251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071272448","display_name":"Asser F. Bedair","orcid":"https://orcid.org/0000-0001-6340-3745","observed_orcids":["https://orcid.org/0000-0001-6340-3745"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Asser F. Bedair","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-6340-3745","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066490538","display_name":"Marwa A.A. Ragab","orcid":"https://orcid.org/0000-0002-3233-3657","observed_orcids":["https://orcid.org/0000-0002-3233-3657"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Marwa A. A. Ragab","raw_affiliation_strings":["Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001078153"],"corresponding_institution_ids":["https://openalex.org/I84524832"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":0.2522,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.33478518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"14","issue":"27","first_page":"19197","last_page":"19205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.9200000166893005},{"id":"https://openalex.org/keywords/fexofenadine","display_name":"fexofenadine","score":1.0},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.824999988079071},{"id":"https://openalex.org/keywords/hplc-with-fluorescence-detection","display_name":"HPLC-fluorescence detection","score":0.777999997138977},{"id":"https://openalex.org/keywords/bioanalytical-method-development","display_name":"bioanalytical method development","score":0.7580000162124634},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.6489999890327454},{"id":"https://openalex.org/keywords/dose-spacing","display_name":"dose spacing","score":0.699999988079071},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.9373757243156433},{"id":"https://openalex.org/C2776711289","wikidata":"https://www.wikidata.org/wiki/Q415122","display_name":"Fexofenadine","level":2,"score":0.8344491720199585},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.775330126285553},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.6300369501113892},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6297934651374817},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.578710675239563},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5452083945274353},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.48476260900497437},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37112483382225037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20728334784507751},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d4ra02163k","doi":"https://doi.org/10.1039/d4ra02163k","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1039/d4ra02163k","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra02163k","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11177748","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11177748","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11177748/pdf/RA-014-D4RA02163K.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmid:38882479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38882479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d4ra02163k","doi":"https://doi.org/10.1039/d4ra02163k","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1039/d4ra02163k","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra02163k","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399673307.pdf","grobid_xml":"https://content.openalex.org/works/W4399673307.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W45232484","https://openalex.org/W1489237918","https://openalex.org/W1591138153","https://openalex.org/W2044203833","https://openalex.org/W2063909696","https://openalex.org/W2096523918","https://openalex.org/W2109979590","https://openalex.org/W2140563849","https://openalex.org/W2144438205","https://openalex.org/W2171167058","https://openalex.org/W2254798972","https://openalex.org/W2315852388","https://openalex.org/W2415731917","https://openalex.org/W2507850335","https://openalex.org/W2579160260","https://openalex.org/W2589103263","https://openalex.org/W2604558540","https://openalex.org/W2606289032","https://openalex.org/W2623933438","https://openalex.org/W2756385494","https://openalex.org/W2784283954","https://openalex.org/W2792224626","https://openalex.org/W2792760388","https://openalex.org/W2794006429","https://openalex.org/W2795335523","https://openalex.org/W2883726595","https://openalex.org/W2903894274","https://openalex.org/W2940478411","https://openalex.org/W3005539395","https://openalex.org/W3010358898","https://openalex.org/W3171560744","https://openalex.org/W4211230008","https://openalex.org/W4288808827"],"related_works":["https://openalex.org/W7221470452","https://openalex.org/W3015154747","https://openalex.org/W1691515836","https://openalex.org/W2114799638","https://openalex.org/W7159039080","https://openalex.org/W2092607472","https://openalex.org/W2902953792","https://openalex.org/W2152368506","https://openalex.org/W7171561596","https://openalex.org/W2616419041"],"abstract_inverted_index":{"kg,":[0],"respectively).":[1],"In":[2],"conclusion,":[3],"our":[4],"study":[5],"underscores":[6],"the":[7],"importance":[8],"of":[9,16,35],"cautious":[10],"administration":[11],"and":[12,18,30,49,57],"appropriate":[13],"dose":[14],"spacing":[15],"IBU":[17],"FEX":[19],"in":[20,39],"patients":[21],"treated":[22],"with":[23],"LCZ696":[24,56],"to":[25],"prevent":[26],"elevated":[27],"serum":[28],"concentrations":[29],"potential":[31],"toxicity.":[32],"The":[33],"novelty":[34],"this":[36],"work":[37],"lies":[38],"its":[40],"dual":[41],"contribution:":[42],"developing":[43],"a":[44],"highly":[45],"sensitive":[46],"HPLC-FLD":[47],"method":[48],"comprehensively":[50],"elucidating":[51],"significant":[52],"pharmacokinetic":[53],"interactions":[54],"between":[55],"common":[58],"OTC":[59],"drugs.":[60]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-06-15T00:00:00"}