{"id":"https://openalex.org/W4399629465","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.11542","title":"Molecular characterization of long-term and short-term survivors of metastatic uterine leiomyosarcoma.","display_name":"Molecular characterization of long-term and short-term survivors of metastatic uterine leiomyosarcoma.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399629465","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.11542"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.11542","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.11542","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.11542","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045219827","display_name":"Tiffany Sia","orcid":"https://orcid.org/0000-0001-7890-207X","observed_orcids":["https://orcid.org/0000-0001-7890-207X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Y. Sia","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David N Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David N Brown","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050042785","display_name":"Kathryn Miller","orcid":"https://orcid.org/0000-0002-7464-1981","observed_orcids":["https://orcid.org/0000-0002-7464-1981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn M Miller","raw_affiliation_strings":["Mid Atlantic Gynecologic Oncology and Pelvic Surgery Associates, Fairfax, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid Atlantic Gynecologic Oncology and Pelvic Surgery Associates, Fairfax, VA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046956876","display_name":"Mario M. Leit\u00e3o","orcid":"https://orcid.org/0000-0003-0818-3836","observed_orcids":["https://orcid.org/0000-0003-0818-3836"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario M. Leitao","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002011120","display_name":"Nadeem R. Abu\u2010Rustum","orcid":"https://orcid.org/0000-0001-9689-1298","observed_orcids":["https://orcid.org/0000-0001-9689-1298"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadeem Abu-Rustum","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006233974","display_name":"Sarah Chiang","orcid":"https://orcid.org/0000-0001-9698-0936","observed_orcids":["https://orcid.org/0000-0001-9698-0936"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Chiang","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040506127","display_name":"Britta Weigelt","orcid":"https://orcid.org/0000-0001-9927-1270","observed_orcids":["https://orcid.org/0000-0001-9927-1270"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Britta Weigelt","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032196793","display_name":"Martee Leigh Hensley","orcid":"https://orcid.org/0009-0004-9956-1306","observed_orcids":["https://orcid.org/0009-0004-9956-1306"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martee Leigh Hensley","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"11542","last_page":"11542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10989","display_name":"Uterine Myomas and Treatments","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10989","display_name":"Uterine Myomas and Treatments","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.39430001378059387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-term-survivors","display_name":"long-term survivors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/short-term-survivors","display_name":"short-term survivors","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tp53-alterations","display_name":"TP53 alterations","score":0.9160000085830688},{"id":"https://openalex.org/keywords/rb1-alterations","display_name":"RB1 alterations","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-genomic-profiling","display_name":"tumor genomic profiling","score":0.36899998784065247},{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8492907285690308},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6497188210487366},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4791647493839264},{"id":"https://openalex.org/C2777532014","wikidata":"https://www.wikidata.org/wiki/Q1504713","display_name":"Leiomyosarcoma","level":2,"score":0.4575175344944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39608484506607056},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24710172414779663},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.11542","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.11542","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.11542","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3046291396","https://openalex.org/W4223572120","https://openalex.org/W2673246151","https://openalex.org/W4410811887","https://openalex.org/W3168429751","https://openalex.org/W4388495137","https://openalex.org/W4415815226","https://openalex.org/W4214654083","https://openalex.org/W7165523172","https://openalex.org/W4414679313"],"abstract_inverted_index":{"11542":[0],"Background:":[1],"While":[2,225],"some":[3],"metastatic":[4,31,46,93,298],"uterine":[5],"leiomyosarcomas":[6],"(uLMS)":[7],"are":[8,309],"clinically":[9],"aggressive,":[10],"others":[11],"have":[12,231,244],"a":[13,69],"more":[14],"indolent":[15],"disease":[16,94],"pace,":[17],"suggesting":[18],"biologic":[19],"heterogeneity.":[20],"Our":[21,122],"objective":[22],"was":[23,85,104,153,203,219],"to":[24,68,77,142,156,251,258,272,305],"determine":[25],"whether":[26],"the":[27,88,96,198,275],"molecular":[28],"characteristics":[29],"of":[30,75,90,92,98,139,144,148,162,192,200,234,247,265,277],"uLMS":[32,47,226,241],"tumors":[33],"differed":[34],"between":[35,48,180,205],"long-term":[36],"survivors":[37,41],"(LS)":[38],"and":[39,58,110,127,172,229,237,282,289],"short-term":[40],"(SS).":[42],"Methods:":[43],"Patients":[44],"with":[45,297],"1/1/2000":[49],"\u2013":[50],"11/31/2020":[51],"who":[52],"received":[53],"care":[54],"at":[55],"our":[56],"institution":[57],"had":[59],"tumor":[60,238],"tissue":[61],"available":[62],"were":[63,66,119,178,188,267],"included.":[64],"uLMSs":[65,131],"subjected":[67],"targeted":[70],"DNA":[71],"next-generation":[72,293],"sequencing":[73,294],"panel":[74],"up":[76],"505":[78],"cancer-related":[79],"genes.":[80],"Metastatic":[81],"overall":[82],"survival":[83],"(mOS)":[84],"calculated":[86],"from":[87,132,227],"date":[89,97],"diagnosis":[91],"until":[95],"death":[99],"or":[100],"last":[101],"follow-up.":[102],"LS":[103,126,133,152,168,174,210,228,243,270,281],"defined":[105],"as":[106,112,195,254,256],"mOS":[107,113],">2":[108],"years":[109],"SS":[111,129,145,159,230,252,283],"<2":[114],"years.":[115],"Appropriate":[116],"statistical":[117],"tests":[118],"used.":[120],"Results:":[121],"cohort":[123],"included":[124],"17":[125],"10":[128],"(Table).":[130],"harbored":[134],"TP53":[135,248],"alterations":[136,150,165,249],"in":[137,151,158,209,213,221,242,262,269,279,295,302],"58%":[138],"cases":[140],"compared":[141,155,250,257,271],"90%":[143],"(P<0.001).":[146,160],"Rate":[147],"RB1":[149],"76%":[154],"50%":[157,176],"Rates":[161,264],"somatic":[163],"genetic":[164],"affecting":[166],"ATRX(11%":[167],"vs.":[169,175],"20%":[170],"SS)":[171,177],"BRCA2(47%":[173],"similar":[179,204,232],"groups":[181,206],"(P>0.05":[182],"for":[183,292],"both).":[184],"Most":[185],"BRCA2alterations":[186,278],"(92%)":[187],"homozygous":[189],"deletions.":[190],"Levels":[191],"chromosomal":[193,235],"instability":[194,236],"quantified":[196],"by":[197],"fraction":[199],"genome":[201],"altered":[202],"(median":[207],"27.3%":[208],"versus":[211],"22.9%":[212],"SS,":[214],"p=0.26).":[215],"Tumor":[216],"mutational":[217,239],"burden":[218],"low":[220],"both":[222,280],"groups.":[223],"Conclusions:":[224],"levels":[233],"burden,":[240],"lower":[245],"rates":[246,261],"patients,":[253],"well":[255],"previously":[259,287],"reported":[260,288],"uLMS.":[263,299],"RB1alterations":[266],"higher":[268,285],"SS.":[273],"Interestingly,":[274],"rate":[276],"is":[284],"than":[286],"provides":[290],"rationale":[291],"patients":[296],"Further":[300],"studies":[301],"larger":[303],"cohorts":[304],"validate":[306],"these":[307],"findings":[308],"warranted.":[310],"[Table:":[311],"see":[312],"text]":[313]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2024-06-14T00:00:00"}
